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Stock-Based Compensation and Warrants - Options outstanding and exercisable (Details)
12 Months Ended
Dec. 31, 2020
$ / shares
shares
Range of Exercise Price 0.00-40.00 [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Options Outstanding, Range of Exercise Price Lower $ 0.00
Options Outstanding, Range of Exercise Price Upper $ 40.00
Options Outstanding, Options | shares 3,929,257
Options Outstanding, Weighted Average Exercise Price $ 0.99
Options Outstanding, Weighted Average Remaining Contractual Life 4 years 5 months 1 day
Options Exercisable, Options | shares 1,251,251
Options Exercisable, Weighted Average Exercise Price $ 2.18
Options Exercisable, Weighted Average Remaining Contractual Life 4 years 5 months 1 day
Range of Exercise Price 41.00-70.00 [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Options Outstanding, Range of Exercise Price Lower $ 41.00
Options Outstanding, Range of Exercise Price Upper $ 70.00
Options Outstanding, Options | shares 8,364
Options Outstanding, Weighted Average Exercise Price $ 50.29
Options Outstanding, Weighted Average Remaining Contractual Life 2 years 6 months 11 days
Options Exercisable, Options | shares 8,364
Options Exercisable, Weighted Average Exercise Price $ 50.29
Options Exercisable, Weighted Average Remaining Contractual Life 2 years 6 months 11 days
Range Of Exercise Price 71.09-102.00 [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Options Outstanding, Range of Exercise Price Lower $ 71.00
Options Outstanding, Range of Exercise Price Upper $ 102.00
Options Outstanding, Options | shares 59,797
Options Outstanding, Weighted Average Exercise Price $ 85.19
Options Outstanding, Weighted Average Remaining Contractual Life 3 years 1 month 17 days
Options Exercisable, Options | shares 59,797
Options Exercisable, Weighted Average Exercise Price $ 85.19
Options Exercisable, Weighted Average Remaining Contractual Life 3 years 1 month 17 days