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Stock-Based Compensation and Warrants - Summary of stock option activity (Details) - Stock Option [Member] - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Options, Beginning Balance 2,502,012 938,982  
Options, Granted 1,540,000 1,725,000  
Options, Exercised 0    
Options, Expired (14,944) (94,738)  
Options, Forfeited (29,650) (67,232)  
Options, Ending Balance 3,997,418 2,502,012 938,982
Options, Exercisable 1,319,412    
Weighted Average Exercise Price, Beginning Balance $ 3.62 $ 15.18  
Weighted Average Exercise Price, Granted 0.42 0.42  
Weighted Average Exercise Price, Exercised 0.00    
Weighted Average Exercise Price, Expired 17.57 58.25  
Weighted Average Exercise Price, Forfeited 0.55 5.95  
Weighted Average Exercise Price, Ending Balance 2.35 $ 3.62 $ 15.18
Weighted Average Exercise Price, Exercisable $ 6.25    
Weighted Average Remaining Contractual Life, Balance Outstanding 6 years 1 month 2 days 6 years 6 months 4 days 6 years 2 months 9 days
Weighted Average Remaining Contractual Life, Exercisable 4 years 4 months 6 days    
Aggregate Intrinsic Value, Exercised $ 0    
Aggregate Intrinsic Value, Ending Balance 0 $ 153,353  
Aggregate Intrinsic Value, Exercisable 0    
Grant date fair value of options granted $ 412,000 $ 470,000  
Weighted average grant date fair value $ 0.27 $ 0.27