License, Collaborative and Employment Agreements and Commitments - Maturity analysis of operating leases (Details) - USD ($)	Dec. 31, 2019	Jan. 01, 2019	Dec. 31, 2018
Commitments and Contingencies
2020	$ 309,000
2021	321,000
2022	192,000
Total	822,000
Discount factor	(100,000)
Lease liability	722,000
Amount due within 12 months	(249,000)	$ (939,000)	$ 0
Non-current lease liability	$ 473,000		$ 0
Operating Lease, Liability, Statement of Financial Position [Extensible List]	us-gaap:OperatingLeaseLiabilityCurrent us-gaap:OperatingLeaseLiabilityNoncurrent