Stock-Based Compensation and Warrants - Options outstanding and exercisable (Details)	12 Months Ended
	Dec. 31, 2019 $ / shares shares
Range of Exercise Price 0.00-40.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options Outstanding, Range of Exercise Price Lower	$ 0.00
Options Outstanding, Range of Exercise Price Upper	$ 40.00
Options Outstanding, Options | shares	2,431,708
Options Outstanding, Weighted Average Exercise Price	$ 1.38
Options Outstanding, Weighted Average Remaining Contractual Life	6 years 6 months 29 days
Options Exercisable, Options | shares	288,645
Options Exercisable, Weighted Average Exercise Price	$ 7.56
Options Exercisable, Weighted Average Remaining Contractual Life	5 years 5 months 16 days
Range of Exercise Price 41.00-70.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options Outstanding, Range of Exercise Price Lower	$ 41.00
Options Outstanding, Range of Exercise Price Upper	$ 70.00
Options Outstanding, Options | shares	8,364
Options Outstanding, Weighted Average Exercise Price	$ 50.29
Options Outstanding, Weighted Average Remaining Contractual Life	3 years 7 months 6 days
Options Exercisable, Options | shares	8,364
Options Exercisable, Weighted Average Exercise Price	$ 50.29
Options Exercisable, Weighted Average Remaining Contractual Life	3 years 7 months 6 days
Range Of Exercise Price 71.09-102.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options Outstanding, Range of Exercise Price Lower	$ 71.00
Options Outstanding, Range of Exercise Price Upper	$ 102.00
Options Outstanding, Options | shares	61,940
Options Outstanding, Weighted Average Exercise Price	$ 85.02
Options Outstanding, Weighted Average Remaining Contractual Life	4 years 26 days
Options Exercisable, Options | shares	61,940
Options Exercisable, Weighted Average Exercise Price	$ 85.02
Options Exercisable, Weighted Average Remaining Contractual Life	4 years 26 days