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Stock-Based Compensation and Warrants - Summary of stock option activity (Details) - Stock Option [Member] - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Options, Beginning Balance 938,982 359,076  
Options, Granted 1,725,000 671,500  
Options, Exercised 0    
Options, Expired (94,738) (78,667)  
Options, Forfeited (67,232) (12,927)  
Options, Ending Balance 2,502,012 938,982 359,076
Options, Exercisable 358,949    
Weighted Average Exercise Price, Beginning Balance $ 15.18 $ 53.93  
Weighted Average Exercise Price, Granted 0.42 0.69  
Weighted Average Exercise Price, Exercised 0.00    
Weighted Average Exercise Price, Expired 58.25 67.02  
Weighted Average Exercise Price, Forfeited 5.95 23.72  
Weighted Average Exercise Price, Ending Balance 3.62 $ 15.18 $ 53.93
Weighted Average Exercise Price, Exercisable $ 21.92    
Weighted Average Remaining Contractual Life, Balance Outstanding 6 years 6 months 4 days 6 years 2 months 9 days 4 years 7 months 6 days
Weighted Average Remaining Contractual Life, Exercisable 5 years 2 months 5 days    
Aggregate Intrinsic Value, Exercised $ 0    
Aggregate Intrinsic Value, Ending Balance 153,353   $ 1,800
Aggregate Intrinsic Value, Exercisable 0    
Grant date fair value of options granted $ 470,000 $ 301,000  
Weighted average grant date fair value $ 0.27 $ 0.45