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                         September 9, 2022

       Steven A. Shallcross
       Chief Executive Officer
       Synthetic Biologics, Inc.
       9605 Medical Center Drive, Suite 270
       Rockville, Maryland 20850

                                                        Re: Synthetic
Biologics, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed September 6,
2022
                                                            File No. 333-267294

       Dear Mr. Shallcross:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Abby
Adams at (202) 551-6902 with any questions.




                         Sincerely,


                         Division of Corporation Finance

                         Office of Life Sciences
       cc:                                              Leslie Marlow, Esq.