CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014
Operating activities
Net loss	$ (94,747)	$ (52,315)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	12,997	17,022
Depreciation and amortization	757	875
Loss on debt extinguishment	1,211
Provision for inventory reserve	754
Noncash interest expense	351	547
Change in value of warrant liability	(135)	886
Other	(128)	317
Changes in operating assets and liabilities:
Accounts receivable	1,253	(1,033)
Other receivable		(17,674)
Inventory	510	115
Prepaid expenses and other current assets	(652)	851
Other assets	771	(753)
Accounts payable	7,119	1,384
Accrued expenses	(2,504)	6,106
Deferred revenue	(681)	278
Other liabilities	3	(5)
Total adjustments	21,626	8,916
Net cash used in operating activities	(73,121)	(43,399)
Investing activities
Purchases of property and equipment	(31)	(258)
Net cash used in investing activities	(31)	(258)
Financing activities
Proceeds from common stock offering	15,700
Proceeds from Hercules debt, net of issuance costs	5,870	(73)
Repayment of Hercules debt	(4,659)
Proceeds from Baxalta milestone advance	32,000
Payment of tax withholding obligations related to stock compensation	(580)	(167)
Other	83	61
Net cash provided by (used in) financing activities	48,187	(179)
Effect of exchange rate changes on cash and cash equivalents	387	2,107
Net decrease in cash and cash equivalents	(24,578)	(41,729)
Cash and cash equivalents at beginning of period	70,933	71,639
Cash and cash equivalents at end of period	46,355	29,910
Supplemental disclosure of cash flow information
Cash paid during the period for interest	1,507	1,383
Supplemental disclosure of noncash financing and investing activities
Issuance of common stock upon exercise of common stock purchase warrants		$ 1,877
Repayment and issuance of Hercules debt	13,815
Series 21 Preferred Stock
Financing activities
Cash paid for Series 21 preferred stock issuance costs	$ (227)