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Long-term Debt - Additional Information (Detail)
$ / shares in Units, shares in Millions
1 Months Ended 9 Months Ended
Jun. 30, 2015
USD ($)
Payment
Installment
$ / shares
shares
Sep. 30, 2015
USD ($)
May. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Debt Instrument [Line Items]        
Loss on debt extinguishment   $ 1,211,000    
Borrowing Associated With License Agreement        
Debt Instrument [Line Items]        
Debt outstanding $ 32,000,000      
Milestone advance interest rate 9.00%      
Baxalta | Borrowing Associated With License Agreement        
Debt Instrument [Line Items]        
Number of milestone payments | Payment 2      
Frequency of periodic payment   Quarterly installments    
Period of milestone payment 30 days      
Debt issuance cost $ 100,000      
Debt instrument outstanding amount   $ 32,000,000    
Debt instrument unamortized issuance cost   100,000    
Baxalta | EMA Milestone | Borrowing Associated With License Agreement        
Debt Instrument [Line Items]        
Debt outstanding $ 12,000,000      
Milestone advance repayment number of quarterly installments | Installment 8      
Milestone advance quarterly repayment amount $ 1,500,000      
Baxalta | PERSIST-2 Milestone | Borrowing Associated With License Agreement        
Debt Instrument [Line Items]        
Debt outstanding $ 20,000,000      
Milestone advance repayment number of quarterly installments | Installment 8      
Milestone advance quarterly repayment amount $ 2,500,000      
Hercules Technology Growth Capital, Inc | Secured Debt        
Debt Instrument [Line Items]        
Warrant exercisable period 5 years      
Number of warrant issued | shares 0.3      
Warrant exercise price | $ / shares $ 1.71      
Hercules Technology Growth Capital, Inc | Secured Debt | Warrant        
Debt Instrument [Line Items]        
Warrant liability $ 400,000 200,000    
Hercules Technology Growth Capital, Inc | Term Loan | Secured Debt        
Debt Instrument [Line Items]        
Debt instrument outstanding amount 20,000,000 20,000,000 $ 13,800,000 $ 18,500,000
Debt instrument unamortized issuance cost   $ 100,000   200,000
Loan agreement, maximum borrowing capacity 25,000,000      
Drew upon closing amendment 6,200,000      
Remaining available for borrowing 5,000,000      
Commitment fee 15,000      
Facility charge 300,000      
Fee amount on term loan $ 1,300,000      
Interest rate terms   The interest rate on the Term Loan Borrowings floats at a rate per annum equal to 10.95% plus the amount by which the prime rate exceeds 3.25%.    
Debt instrument stated interest rate percentage, minimum 10.95%      
Debt instrument number of monthly installments | Installment 36      
Principal and interest payment commencing date Jan. 01, 2016      
Interest-only extension period 6 months      
Debt instrument unamortized discount   $ 300,000   $ 1,100,000
Hercules Technology Growth Capital, Inc | Term Loan | Secured Debt | Other Non-operating Income Expense        
Debt Instrument [Line Items]        
Loss on debt extinguishment   $ 1,200,000    
Hercules Technology Growth Capital, Inc | Term Loan | Secured Debt | Prime Rate        
Debt Instrument [Line Items]        
Debt instrument, basis spread on variable rate 3.25%