0001564590-14-004532.txt : 20141027 0001564590-14-004532.hdr.sgml : 20141027 20141027085249 ACCESSION NUMBER: 0001564590-14-004532 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 7 CONFORMED PERIOD OF REPORT: 20141024 ITEM INFORMATION: Entry into a Material Definitive Agreement ITEM INFORMATION: Completion of Acquisition or Disposition of Assets ITEM INFORMATION: Unregistered Sales of Equity Securities ITEM INFORMATION: Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year ITEM INFORMATION: Regulation FD Disclosure ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20141027 DATE AS OF CHANGE: 20141027 FILER: COMPANY DATA: COMPANY CONFORMED NAME: CTI BIOPHARMA CORP CENTRAL INDEX KEY: 0000891293 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 911533912 STATE OF INCORPORATION: WA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 001-12465 FILM NUMBER: 141173600 BUSINESS ADDRESS: STREET 1: 3101 WESTERN AVENUE STREET 2: SUITE 600 CITY: SEATTLE STATE: WA ZIP: 98121 BUSINESS PHONE: 2062827100 MAIL ADDRESS: STREET 1: 3101 WESTERN AVENUE STREET 2: SUITE 600 CITY: SEATTLE STATE: WA ZIP: 98121 FORMER COMPANY: FORMER CONFORMED NAME: CELL THERAPEUTICS INC DATE OF NAME CHANGE: 19960321 8-K 1 ctic-8k_20141022.htm FORM 8-K

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report: (Date of earliest event reported): October 27, 2014 (October 24, 2014)

 

CTI BIOPHARMA CORP.

(Exact name of registrant as specified in its charter)

 

 

Washington

 

001-12465

 

91-1533912

(State or other jurisdiction of

incorporation or organization)

 

(Commission

File Number)

 

(I.R.S. Employer

Identification Number)

3101 Western Avenue, Suite 600

Seattle, Washington 98121

(Address of principal executive offices)

Registrant’s telephone number, including area code: (206) 282-7100

Not applicable

(Former name or former address, if changed since last report).

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

¨Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

¨Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

¨Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

¨Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

 

 

 

 

 


 

Item 1.01. Entry into a Material Definitive Agreement.

Chroma APA

On October 24, 2014 (the “Effective Date”), CTI BioPharma Corp. (the “Company”) entered into an Asset Purchase Agreement (the “Chroma APA”) with Chroma Therapeutics Limited (“Chroma”), pursuant to which the Company acquired all of Chroma’s right, title and interest in the compound tosedostat and certain related assets.  Concurrently, the Company and Chroma terminated their Co-Development and License Agreement relating to tosedostat (the “Chroma License Agreement”) previously entered into on March 11, 2011, thereby eliminating potential future developmental and sales milestone payments thereunder of up to $209 million, and the Company acquired an exclusive worldwide license with respect to tosedostat directly from Vernalis R&D Limited (“Vernalis”) (as discussed below).  Pursuant to the Chroma License Agreement, the Company had held an exclusive license with respect to tosedostat, including the right to develop and commercialize tosedostat in North, Central and South America.  The Chroma License Agreement was effectively a sublicense of rights to the Company, as Chroma had held its rights to tosedostat pursuant to an exclusive license agreement between Vernalis and Chroma (the “Vernalis/Chroma Agreement”). The Chroma APA contains various representations and warranties, covenants, indemnification obligations and other provisions.  

As consideration under the Chroma APA, the Company issued an aggregate of 9,000 shares of the Company’s Series 20 convertible preferred stock (the “Series 20 Preferred Stock”), of which 7,920 have been delivered to Chroma.  The remaining 1,080 shares are being held in escrow for nine (9) months and will be applied towards any indemnification obligations of Chroma as set forth in the Chroma APA.  For a discussion of the terms of the Series 20 Preferred Stock and the Company’s associated registration rights obligations and lock-up terms, please see Item 3.02 below.  

Vernalis License Agreement

In connection with the termination of the Chroma License Agreement and the consummation of the Chroma APA, on the Effective Date, the Company also entered into an amended and restated license agreement with Vernalis (the “Vernalis License Agreement”) for the exclusive worldwide right to use certain patents and other intellectual property rights to develop, market and commercialize tosedostat and certain other compounds, as well as a deed of novation pursuant to which all rights of Chroma under the Vernalis/Chroma Agreement were novated to the Company.  Under the Vernalis License Agreement, the Company has agreed to make tiered royalty payments of no more than a high single digit percentage of net sales of products containing licensed compounds, with such obligation to continue on a country-by-country basis for the longer of ten years following commercial launch or the expiry of relevant patent claims.

The Vernalis License Agreement will terminate when the royalty obligations expire, although the parties have early termination rights under certain circumstances, including the following: (i) the Company has the right to terminate, with three months’ notice, upon the belief that the continued development of tosedostat or any of the other licensed compounds is not commercially viable; (ii) Vernalis has the right to terminate in the event of the Company’s uncured failure to pay sums due; and (iii) either party has the right to terminate in event of the other party’s uncured material breach or insolvency. The Vernalis License Agreement contains various representations and warranties, covenants, indemnification obligations and other provisions.

The descriptions of the Chroma APA and the Vernalis License Agreement contained herein are not purported to be complete and are qualified in their respective entirety by the full text of such agreements, which are intended to be filed with the SEC as exhibits to the Company’s Quarterly Report on Form 10-Q for the quarter ending September 30, 2014 or a future Current Report on Form 8-K or an amendment to this Current Report on Form 8-K (together with a request for confidential treatment of certain of their respective terms).  Upon their respective filing, the Chroma APA and the Vernalis License Agreement shall be deemed incorporated herein by reference.

 

Item 2.01.  Completion of Acquisition or Disposition of Assets.

The information set forth in Items 1.01 and 3.02 hereof is incorporated herein by reference.

 

Item 3.02.  Unregistered Sales of Equity Securities.

The Series 20 Preferred Stock is convertible in certain circumstances, at the option of the holder at any time prior to the automatic conversion of such shares, into a total of 9 million shares of common stock at a conversion price of $2.37 per share of common stock. Shares of the Series 20 Preferred Stock will receive dividends in the same amount as any dividends declared and paid on shares of common stock, but are entitled to a liquidation preference over the common stock in certain liquidation events.  A copy of the form of the Series 20 Preferred Stock Certificate is attached hereto as Exhibit 4.1. The issuance of the Series 20 Preferred Stock was made pursuant to an exemption from registration under the Securities Act of 1933, as amended (the “Securities Act”) in reliance on Section 4(2) thereunder.  

 


 

The shares of Series 20 Preferred Stock (and the underlying common shares) are subject to a lock-up agreement that calls for the shares to be eligible for sale or transfer on the following timeline: 44% of such shares after the date on which the resale registration statement (discussed below) is declared effective; an additional 44% of such shares on the earlier of (i) 30 days after the date of effectiveness of such resale registration statement and (ii) December 31, 2014; and the remaining 12% of such shares nine (9) months following the Effective Date.  

The Company has also agreed to file a registration statement with the U.S. Securities and Exchange Commission (the “SEC”) within thirty (30) days of the Effective Date to register the resale of the common stock issued or upon conversion of the Series 20 Preferred Stock. The Company has agreed to use its commercially reasonable efforts to have the registration statement declared effective by the SEC within no less than one hundred twenty (120) days of the Effective Date (subject to reasonable extension in certain limited circumstances). The Company has, among other things, also agreed to indemnify Chroma under the registration statement from certain losses and to pay all fees and expenses (excluding legal fees of Chroma).

The description of the lock-up agreement and the registration rights agreement contained herein is not intended to be complete and is qualified in its entirety by reference to the lock-up agreement and registration rights agreement, attached hereto as Exhibits 10.1 and 10.2, respectively, and incorporated by reference herein.

 

Item 5.03.  Amendments to Article of Incorporation or Bylaws; Change in Fiscal Year.

The Articles of Amendment to Amended and Restated Articles of CTI BioPharma Corp. (the “Articles of Amendment”), dated October 24, 2014 establish and designate the Series 20 Preferred Stock and the rights, preferences and privileges thereof. A copy of the Articles of Amendment is attached hereto as Exhibit 3.1 and is incorporated herein by reference.

 

Item 7.01.  Regulation FD Disclosure.

The information provided pursuant to this Item 7.01 shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, and shall not be incorporated by reference into any filing or other document filed by the Company pursuant to the Exchange Act or the Securities Act, as amended, except as shall be expressly set forth by specific reference in such filing or document. The information provided pursuant to this Item 7.01 shall instead be deemed “furnished.”

On October 27, 2014, the Company issued a press release entitled “CTI Acquires Exclusive Worldwide License to Tosedostat, a Selective, Oral Anti-Cancer Therapy”. The full text of such press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

 

Item 9.01. Financial Statements and Exhibits.

 

(d) Exhibits

 

Exhibit
No.

 

Description

  

Location

 

 

 

  3.1

  

Articles of Amendment to Amended and Restated Articles of Incorporation of CTI BioPharma Corp. (Series 20 Preferred Stock).

  

Filed herewith.

 

 

 

  4.1

  

Form of Series 20 Preferred Stock Certificate.

  

Filed herewith.

 

 

 

 

 

10.1

  

Registration Rights Agreement, among CTI BioPharma Corp. and Chroma Therapeutics Limited, dated October 24, 2014.

  

Filed herewith.

 

 

 

 

 

10.2

 

Lock-Up Agreement, between CTI BioPharma Corp. and Chroma Therapeutics Limited, dated October 24, 2014.

 

Filed herewith.

 

 

 

 

 

99.1

  

Press release dated October 27, 2014.

 

Furnished herewith.

 

 

 

 


 

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

 

 

 

 

 

 

 

CTI BIOPHARMA CORP.

 

 

 

Date: October 27, 2014

 

By:

 

/s/ Louis A. Bianco

 

 

 

 

Louis A. Bianco

Executive Vice President, Finance and

Administration

 

 

 

 


 

EXHIBIT INDEX

 

Exhibit
No.

  

Description

  

Location

 

 

 

  3.1

  

Articles of Amendment to Amended and Restated Articles of Incorporation of CTI BioPharma Corp. (Series 20 Preferred Stock).

  

Filed herewith.

 

 

 

  4.1

  

Form of Series 20 Preferred Stock Certificate.

  

Filed herewith.

 

 

 

 

 

10.1

  

Registration Rights Agreement, among CTI BioPharma Corp. and Chroma Therapeutics Limited, dated October 24, 2014.

  

Filed herewith.

 

 

 

 

 

10.2

 

Lock-Up Agreement, between CTI BioPharma Corp. and Chroma Therapeutics Limited, dated October 24, 2014.

 

Filed herewith.

 

 

 

 

 

99.1

  

Press release dated October 27, 2014.

 

Furnished herewith.

 

 

 

EX-3 2 ctic-ex3_2014102288.htm EX-3.1

Exhibit 3.1

 

EXECUTION VERSION

 

ARTICLES OF AMENDMENT TO

AMENDED AND RESTATED ARTICLES OF

CTI BIOPHARMA CORP.

DESIGNATION OF PREFERENCES,

RIGHTS AND LIMITATIONS

OF

SERIES 20 PREFERRED STOCK

Pursuant to the Washington Business Corporation Act, Chapter 23B.10, the undersigned officer of CTI Biopharma Corp., a Washington corporation (the “Corporation”), does hereby submit for filing these Articles of Amendment:

FIRST: The name of the Corporation is CTI Biopharma Corp.

SECOND: This amendment to the Corporation’s Amended and Restated Articles of Incorporation, as amended to date (the “Restated Articles”), was adopted on the authority of the Board of Directors of the Corporation on October 22, 2014. Shareholder action was not required on this amendment pursuant to Article II.2 of the Restated Articles.

THIRD: A new Section 2(aa) of Article II is added to the Restated Articles to add the designations, rights and preferences of a new series of preferred stock as follows, such Section to be effective as of October 24, 2014:

“(aa) Series 20 Preferred Stock

TERMS OF PREFERRED STOCK

Section 1. Definitions. For the purposes hereof, the following terms shall have the following meanings:

Affiliate” means any person or entity controlling, controlled by or under common control with a Holder.

Alternate Consideration” has the meaning set forth in Section 7(d).

Business Day” means any day except Saturday, Sunday, any day which shall be a federal legal holiday in the United States or any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to close.

Change of Control Transaction” means the occurrence after the date hereof of any of (i) an acquisition by an individual, legal entity or “group” (as described in Rule 13d-5(b)(1) promulgated under the Exchange Act) of effective control (whether through legal or beneficial ownership of capital stock of the Corporation, by contract or otherwise) of in excess of 33% of the voting securities of the Corporation (other than by means of conversion of shares of Series 20 Preferred Stock), or (ii) the Corporation merges into or consolidates with any other person, or any person merges into or consolidates with the Corporation

 

1

OMM_US:72091741.9


and, after giving effect to such transaction, the shareholders of the Corporation immediately before such transaction own less than 66% of the aggregate voting power of the Corporation or the successor entity of such transaction, or (iii) the Corporation sells or transfers all or substantially all of its assets to another person and the shareholders of the Corporation immediately before such transaction own less than 66% of the aggregate voting power of the acquiring entity immediately after the transaction, or (iv) a replacement at one time or within a one-year period of more than one-half of the members of the Board which is not approved by a majority of those individuals who are members of the Board on the date hereof (or by those individuals who are serving as members of the Board on any date whose nomination to the Board was approved by a majority of the members of the Board who are members on the date hereof), or (v) the execution by the Corporation of an agreement to which the Corporation is a party or by which it is bound, providing for any of the events set forth in clauses (i) through (iv) herein.

Common Stock” means the Corporation’s common stock, no par value per share, and stock of any other class of securities into which such securities may hereafter be reclassified or changed into.

Common Stock Equivalents” means any securities which would entitle the holder thereof to acquire at any time Common Stock, including, without limitation, any preferred stock, rights, options, warrants or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock; provided, however, that Common Stock Equivalents shall not include any debt securities of the Corporation.

Conversion Amount” means the sum of the Stated Value at issue.

Conversion Date” has the meaning set forth in Section 6(a).

Conversion Price” has the meaning set forth in Section 6(c).

Conversion Shares” means, collectively, the shares of Common Stock issuable upon conversion of the shares of Series 20 Preferred Stock in accordance with the terms hereof.

Exchange Act” means the Securities Exchange Act of 1934 and the rules and regulations promulgated thereunder.

Fundamental Transaction” means, at any time while the Series 20 Preferred Stock is outstanding, (i) the Corporation effects any merger or consolidation of the Corporation with or into another person in which the Corporation is not the surviving person, (ii) the Corporation effects any sale of all or substantially all of its assets in one transaction or a series of related transactions, (iii) any tender offer or exchange offer (whether by the Corporation or another person) is completed pursuant to which holders of Common Stock are permitted to tender or exchange a material portion of the Corporation’s shares for other securities, cash or property, or (iv) the Corporation effects any reclassification of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is effectively converted into or exchanged for other securities, cash or property; provided, however, that for the purposes of clause (ii) above, a “Fundamental Transaction” shall not include the Corporation entering into a license or other agreement that licenses any intellectual property to an unaffiliated and unrelated person so long as the Corporation and its subsidiaries continue to have bona fide, substantial and continuing business operations and activities after such license or other agreement is entered into; provided, further, however, that a “Fundamental Transaction” shall not include a reverse stock split with respect to the Common Stock.

Holder” means a holder of shares of Series 20 Preferred Stock.

 

2

OMM_US:72091741.9


Junior Securities” means (i) the Common Stock and all other Common Stock Equivalents of the Corporation other than those securities which are explicitly senior to or pari passu with the Series 20 Preferred Stock as to dividend rights or liquidation preference and (ii) the Series ZZ Junior Participating Cumulative Preferred Stock of the Corporation.

Liquidation” has the meaning set forth in Section 5.

Notice of Conversion” has the meaning set forth in Section 6(a).

Non-Senior Securities” means (i) the Common Stock and all other Common Stock Equivalents of the Corporation other than those securities which are explicitly senior to the Series 20 Preferred Stock as to dividend rights or liquidation preference and (ii) the Series ZZ Junior Participating Cumulative Preferred Stock of the Corporation.

Original Issue Date” means the date of the first issuance of any shares of Series 20 Preferred Stock regardless of the number of transfers of any particular shares of Series 20 Preferred Stock and regardless of the number of certificates which may be issued to evidence such Series 20 Preferred Stock.

Series 20 Preferred Stock” has the meaning set forth in Section 2.

Stated Value” has the meaning set forth in Section 2, as the same may be increased pursuant to Section 3(a).

Trading Day” means a day on which the New York Stock Exchange is open for business.

Trading Market” means the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date in question: The NYSE Amex, The NASDAQ Capital Market, The NASDAQ Global Market, The NASDAQ Global Select Market, the New York Stock Exchange or the Mercato Telematico Azionario (MTA) organized and managed by Borsa Italiana S.p.A.

Transfer” has the meaning set forth in Section 9.

VWAP” means, for any date, the price determined by the first of the following clauses that applies: (i) if the Common Stock is then listed or quoted on a national securities exchange, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the national securities exchange on which the Common Stock is then listed or quoted for trading as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)); (ii) if the Common Stock is then listed or traded on the OTC Bulletin Board and the OTC Bulletin Board is not a Trading Market, the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the OTC Bulletin Board; (iii) if the Common Stock is not then quoted for trading on a national securities exchange or the OTC Bulletin Board and if prices for the Common Stock are then reported in the “Pink Sheets” published by Pink OTC Markets, Inc. (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price per share of the Common Stock so reported; or (iv) in all other cases, the fair market value of a share of Common Stock as determined by an independent appraiser selected in good faith by a majority in interest of the Holders and reasonably acceptable to the Corporation, the fees and expenses of which shall be paid by the Corporation.

 

3

OMM_US:72091741.9


Section 2. Designation, Amount, Par Value and Rank. The series of preferred stock shall be designated as the Corporation’s Series 20 Preferred Stock (the “Series 20 Preferred Stock”) and the number of shares so designated shall be 9,000. Each share of Series 20 Preferred Stock shall have no par value per share and a stated value equal to $2,370, subject to increase as set forth in Section 3(a) below (the “Stated Value”).

Section 3. Dividends. Holders shall be entitled to receive, and the Corporation shall pay, dividends on shares of Series 20 Preferred Stock equal (on an as-if-converted-to-Common-Stock basis) to and in the same form as dividends (other than dividends in the form of Common Stock) actually paid on shares of the Common Stock or other Non-Senior Securities when, as and if such dividends (other than dividends in the form of Common Stock) are paid on shares of the Common Stock or other Non-Senior Securities. Other than as set forth in the previous sentence, no other dividends shall be paid on shares of Series 20 Preferred Stock; and the Corporation shall pay no dividends (other than dividends in the form of Common Stock) on shares of the Common Stock or other Non-Senior Securities unless it simultaneously complies with the previous sentence. All declared but unpaid dividends on shares of Series 20 Preferred Stock shall increase the Stated Value of such shares, but when such dividends are actually paid any such increase in the Stated Value shall be rescinded.

Section 4. Voting Rights. Except as otherwise expressly provided herein or as otherwise required by law, Holders of shares of Series 20 Preferred Stock shall have no voting rights.

Section 5. Liquidation. Upon any liquidation, dissolution or winding-up of the Corporation, whether voluntary or involuntary (a “Liquidation”), the Holders shall be entitled to receive out of the assets, whether capital or surplus, of the Corporation an amount equal to the Stated Value for each outstanding share of Series 20 Preferred Stock before any distribution or payment shall be made to the holders of any Junior Securities, and if the assets of the Corporation shall be insufficient to pay in full such amounts, then the entire assets to be distributed to the Holders shall be ratably distributed among the Holders and the holders of all securities which are pari passu with the Series 20 Preferred Stock as to liquidation in accordance with the respective amounts that would be payable on all such securities if all amounts payable thereon were paid in full. A Fundamental Transaction or Change of Control Transaction shall not be deemed a Liquidation unless the Corporation expressly declares that such Fundamental Transaction or Change of Control Transaction shall be treated as if it were a Liquidation. The Corporation shall mail written notice of any such Liquidation, not less than 25 days before the payment date stated therein, to each Holder.

Section 6. Conversion and Exchange Rights.

(a)    Conversions at Option of Holder.

         (i)Each share of Series 20 Preferred Stock shall be convertible at any time and from time to time from and after the Original Issue Date, at the option of the Holder thereof, into that number of shares of Common Stock determined by dividing the Stated Value of such share of Series 20 Preferred Stock by the Conversion Price. Holders shall effect conversions by providing the Corporation or its designated conversion agent with the form of conversion notice attached hereto as Annex A (a “Notice of Conversion”), which may be delivered before the date of conversion. Each Notice of Conversion shall specify the number of shares of Series 20 Preferred Stock to be converted, the number of shares of Series 20 Preferred Stock owned before the conversion at issue, the number of shares of Series 20 Preferred Stock owned subsequent to the conversion at issue and the date on which such conversion is to be effected, which date must be on or after the Original Issue Date and may not be before the date the applicable Holder delivers such Notice of Conversion to the Corporation in accordance with Section 10(a) (such date, the “Conversion Date”); provided,

 

4

OMM_US:72091741.9


however, that in the case of an automatic conversion pursuant to Section 6(b), the “Conversion Date” shall be the first to occur of the dates set forth in clauses (A) through (C) of Section 6(b)(i). If no Conversion Date is specified in a Notice of Conversion, the Conversion Date shall be the date that such Notice of Conversion to the Corporation is deemed delivered hereunder (or the first date thereafter that conversion is permitted pursuant to this Section 6(a) or Section 6(b), as applicable). The calculations and entries set forth in the Notice of Conversion shall control in the absence of manifest or mathematical error. To effect conversions of shares of Series 20 Preferred Stock, a Holder shall be required to (and by delivering a Notice of Conversion shall thereby be deemed to agree to) forthwith surrender the certificate(s) representing such shares of Series 20 Preferred Stock to the Corporation. Notwithstanding anything to the contrary set forth herein, upon conversion of shares of Series 20 Preferred Stock in accordance with the terms hereof, no Holder thereof shall be required to physically surrender the certificate representing such Holder’s shares of Series 20 Preferred Stock to the Corporation unless (A) the full or remaining number of shares of Series 20 Preferred Stock represented by such certificate are being converted or (B) such Holder has provided the Corporation with prior written notice (which notice may be included in a Notice of Conversion) requesting reissuance of a certificate representing the remaining shares of Series 20 Preferred Stock upon physical surrender of any certificate representing the shares of Series 20 Preferred Stock being converted. Each Holder and the Corporation shall maintain records showing the number of shares of Series 20 Preferred Stock so converted by such Holder and the dates of such conversions or shall use such other method, reasonably satisfactory to such Holder and the Corporation, so as not to require physical surrender of the certificate representing the shares of Series 20 Preferred Stock upon each such conversion. In the event of any dispute or discrepancy, such records of the Corporation establishing the number of shares of Series 20 Preferred Stock to which the record holder is entitled shall be controlling and determinative in the absence of manifest error.

         (ii)Notwithstanding the foregoing, no shares of Series 20 Preferred Stock shall be convertible by a Holder to the extent (but only to the extent) that such conversion would result in such Holder and its affiliates beneficially owning more than 19.99% of the Common Stock (the “Beneficial Ownership Limitation”). To the extent the Beneficial Ownership Limitation applies, the determination of whether the shares of Series 20 Preferred Stock held by such Holder shall be convertible (vis-à-vis other convertible, exercisable or exchangeable securities owned by such Holder) shall, subject to such Beneficial Ownership Limitation, be determined on the basis of the first submission to the Corporation for conversion, exercise or exchange (as the case may be). No prior inability of a Holder to convert shares of Series 20 Preferred Stock pursuant to this paragraph shall have any effect on the applicability of the provisions of this paragraph with respect to any subsequent determination of convertibility or issuance (as the case may be). For purposes of this paragraph, beneficial ownership and all determinations and calculations (including, without limitation, with respect to calculations of percentage ownership) shall be determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder; provided, however, that in effecting any conversion, the Corporation shall be entitled to assume that no Holder, together with its affiliates, beneficially owns more than 19.99% of the Common Stock unless written notice specifying the number of shares of Common Stock beneficially held by such Holder and its affiliates is sent to the Corporation by the Holder within the three Business Day period before the date of the automatic conversion. The provisions of this paragraph shall be implemented in a manner otherwise than in strict conformity with the terms of this paragraph to correct this paragraph (or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership Limitation herein contained or to make changes or supplements necessary or desirable to properly give effect to such Beneficial Ownership Limitation. The limitations contained in this paragraph shall apply to a successor Holder. The holders of Common Stock shall be third party beneficiaries of this paragraph and the Corporation may not waive this paragraph without the consent of holders of a majority of its Common Stock. For any reason at any

 

5

OMM_US:72091741.9


time, upon the written or oral request of a Holder, the Corporation shall within two Business Days confirm orally and in writing to such Holder the number of shares of Common Stock then outstanding, including by virtue of any prior conversion or exercise of convertible or exercisable securities into Common Stock.

(b)     Automatic Conversion.

         (i)Upon the earliest to occur of the events described in the following clauses (A), (B) and (C) of this Section 6(b)(i), each outstanding share of Series 20 Preferred Stock shall automatically convert into that number of shares of Common Stock determined by dividing the Stated Value of such share of Series 20 Preferred Stock by the Conversion Price (A) on the 30th day after the Original Issue Date, (B) on the date on which 5,000 or less shares of Series 20 Preferred Stock remain outstanding, or (C) immediately upon the adoption by the Board of a resolution that it intends to adopt an amendment to the Restated Articles without shareholder approval to effect a reverse stock split of the outstanding Common Stock and the number of authorized shares of Common Stock in the same proportions in order to achieve compliance with the listing rules of The NASDAQ Capital Market or for other good-faith business reasons.

         (ii)Upon a Conversion Date, a Holder shall be required to forthwith surrender any certificate(s) representing such shares of Series 20 Preferred Stock to the Corporation within two Trading Days of the date established for such conversion and set forth in a written notice from the Corporation; provided, however, that the failure by a Holder to surrender the certificate(s) representing such converted shares of Series 20 Preferred Stock shall not prevent the Corporation from delivering the shares of Common Stock issuable upon automatic conversion thereof and, upon receipt of such consideration by such Holder, such shares of Series 20 Preferred Stock shall be converted for all purposes hereunder.

(c)     Conversion Price. The conversion price for the Series 20 Preferred Stock shall equal $2.37, subject to adjustment as provided herein (the “Conversion Price”).

(d)     Mechanics of Conversion.

         (i)Delivery of Certificate upon Conversion. Not later than three Trading Days after each Conversion Date, whether pursuant to Section 6(a) or (b), the Corporation shall deliver, or cause to be delivered, to the converting Holder a certificate or certificates, which shall be free of restrictive legends and issuer-imposed trading restrictions (provided that a registration statement covering resales of the Conversion Shares is then in effect), representing the number of shares of Common Stock being acquired upon the conversion of shares of Series 20 Preferred Stock. The Corporation shall use its best efforts to, if the Holder is not an affiliate of the Corporation, deliver any certificate(s) required to be delivered by the Corporation under this Section 6 electronically through The Depository Trust Company or its nominee (“DTC”) or another established clearing corporation performing similar functions (provided that a registration statement covering resales of the Conversion Shares is then in effect). If, in the case of any Notice of Conversion, such certificate(s) are not delivered to or as directed by the applicable Holder by the seventh Trading Day after the Conversion Date, then (without limiting the Holder’s other rights and remedies hereunder for the Corporation’s failure to comply with its obligations under the preceding portion of this paragraph) the applicable Holder shall be entitled to elect to rescind such Conversion Notice by written notice to the Corporation at any time on or before its receipt of such certificate(s), in which event the Corporation shall promptly return to such Holder any original Series 20 Preferred Stock certificate delivered to the Corporation and such Holder shall promptly return any Common Stock certificates representing the shares of Series 20 Preferred Stock tendered for conversion to the Corporation.

 

6

OMM_US:72091741.9


         (ii)Obligation Absolute. The Corporation’s obligation to issue and deliver the Conversion Shares upon conversion of shares of Series 20 Preferred Stock in accordance with the terms hereof is absolute and unconditional, irrespective of any action or inaction by a Holder to enforce the same, any waiver or consent with respect to any provision hereof, the recovery of any judgment against any person or any action to enforce the same, or any setoff, counterclaim, recoupment, limitation or termination, or any breach or alleged breach by such Holder or any other person of any obligation to the Corporation or any violation or alleged violation of law by such Holder or any other person, and irrespective of any other circumstance which might otherwise limit such obligation of the Corporation to such Holder in connection with the issuance of such Conversion Shares; provided, however, that such delivery shall not operate as a waiver by the Corporation of any such action that the Corporation may have against such Holder. In the event a Holder shall elect to convert any or all of the Stated Value of its Series 20 Preferred Stock, the Corporation may not refuse conversion based on any claim that such Holder or anyone associated or affiliated with such Holder has been engaged in any violation of law, agreement or for any other reason, unless an injunction from a court, on notice to Holder, restraining and/or enjoining conversion of all or part of the Series 20 Preferred Stock of such Holder shall have been sought and obtained. In the absence of such an injunction, the Corporation shall issue Conversion Shares upon a properly noticed conversion. Nothing herein shall limit a Holder’s right to pursue actual damages for the Corporation’s failure to deliver Conversion Shares within the period specified herein and such Holder shall have the right to pursue all remedies available to it hereunder, at law or in equity, including, without limitation, a decree of specific performance and/or injunctive relief. The exercise of any such rights shall not prohibit a Holder from seeking to enforce damages pursuant to any other Section hereof or under applicable law.

         (iii)Reservation of Shares Issuable upon Conversion. The Corporation covenants that it will at all times use reasonable best efforts to reserve and keep available out of its authorized and unissued shares of Common Stock, for the sole purpose of issuance upon conversion of the Series 20 Preferred Stock, as herein provided, free from preemptive rights or any other actual contingent purchase rights of persons other than the Holders of the Series 20 Preferred Stock, not less than such aggregate number of shares of the Common Stock as shall be issuable (taking into account the adjustments and restrictions of Section 7) upon the conversion of all outstanding shares of Series 20 Preferred Stock. The Corporation covenants that all shares of Common Stock that shall be so issuable shall, upon issue, be duly authorized, validly issued, fully paid and nonassessable.

         (iv)Fractional Shares. Upon a conversion of the Series 20 Preferred Stock hereunder, the Corporation shall not be required to issue fractions of shares of Common Stock, but shall instead, if otherwise permitted, round the total number of Conversion Shares for such conversion up or down to the nearest whole number of shares of Common Stock.

         (v)Transfer Taxes. The issuance of certificates for shares of the Common Stock issued upon conversion of shares of Series 20 Preferred Stock shall be made without charge to any Holder for any documentary stamp, issuance or similar taxes that may be payable in respect of the issue or delivery of such certificates, provided that the Corporation shall not be required to pay any tax that may be payable in respect of any transfer involved in the issuance and delivery of any such certificate upon conversion in a name other than that of the Holder of such shares of Series 20 Preferred Stock so converted and the Corporation shall not be required to issue or deliver such certificates unless or until the person or persons requesting the issuance thereof shall have paid to the Corporation the amount of such tax or shall have established to the satisfaction of the Corporation that such tax has been paid.

 

7

OMM_US:72091741.9


Section 7. Certain Adjustments.

(a)     Stock Dividends and Stock Splits. If the Corporation, at any time while the Series 20 Preferred Stock is outstanding: (A) pays a stock dividend or otherwise makes a distribution or distributions payable in shares of Common Stock on shares of Common Stock or any other Common Stock Equivalents (which, for avoidance of doubt, shall not include any shares of Common Stock issued by the Corporation upon conversion of the Series 20 Preferred Stock); (B) subdivides outstanding shares of Common Stock into a larger number of shares; (C) combines (including by way of a reverse stock split) outstanding shares of Common Stock into a smaller number of shares; or (D) issues, in the event of a reclassification of shares of the Common Stock, any shares of capital stock of the Corporation, then the Conversion Price shall be multiplied by a fraction of which the numerator shall be the number of shares of Common Stock outstanding immediately before such event and of which the denominator shall be the number of shares of Common Stock outstanding immediately after such event and any other adjustments to the Holders’ conversion rights necessary to reflect such event shall be made. Any adjustment made pursuant to this Section 7(a) shall become effective immediately after the record date for the determination of shareholders entitled to receive such dividend or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or reclassification.

(b)     Subsequent Rights Offerings. If the Corporation, at any time while the Series 20 Preferred Stock is outstanding, shall issue rights, options or warrants to all holders of Common Stock (and not proportionately to the Holders) entitling them to subscribe for or purchase shares of Common Stock at a price per share that is lower than the VWAP on the record date for such issuance, and does not offer the same rights to the Holders, then the Conversion Price shall be adjusted to reflect such rights, options or warrants offering by multiplying the Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding before the record date for such issuance plus the number of shares of Common Stock which the aggregate offering price of the total number of shares of Common Stock so offered (assuming delivery to the Corporation in full of all consideration payable upon exercise of such rights, options or warrants) would purchase at such VWAP on the record date for such issuance and the denominator of which shall be the number of shares of the Common Stock outstanding on such record date plus the aggregate number of additional shares of Common Stock offered for subscription or purchase. Such adjustment shall be made whenever such rights, options or warrants are issued, and shall become effective immediately after the record date for the determination of shareholders entitled to receive such rights, options or warrants.

(c)     Pro Rata Distributions. If the Corporation, at any time while the Series 20 Preferred Stock is outstanding, distributes (other than as a dividend) to all holders of Common Stock (and not proportionately to the Holders) evidences of its indebtedness or assets or rights or warrants to subscribe for or purchase any security (other than Common Stock, which shall be subject to Section 7(b)), then in each such case the Conversion Price shall be adjusted by multiplying such Conversion Price in effect immediately before the record date fixed for determination of shareholders entitled to receive such distribution by a fraction of which the denominator shall be the VWAP determined as of the record date mentioned above, and of which the numerator shall be such VWAP on such record date less the then fair market value at such record date of the portion of such assets, evidence of indebtedness or rights or warrants so distributed applicable to one outstanding share of the Common Stock as determined by the Board in good faith. In either case the adjustments shall be described in a statement delivered to the Holders describing the portion of assets or evidences of indebtedness so distributed or such subscription rights applicable to one share of Common Stock. Such adjustment shall be made whenever any such distribution is made and shall become effective immediately after the record date mentioned above. For avoidance of doubt, distributions that are dividends shall be subject to Section 3(a) and not subject to this Section 7(c).

 

8

OMM_US:72091741.9


(d)     Fundamental Transaction. If, at any time while the Series 20 Preferred Stock is outstanding, a Fundamental Transaction occurs, then, upon any subsequent conversion of the Series 20 Preferred Stock, the Holders shall have the right to receive, for each Conversion Share that would have been issuable upon such conversion immediately before the occurrence of such Fundamental Transaction, the same kind and amount of securities, cash or property as it would have been entitled to receive upon the occurrence of such Fundamental Transaction if it had been, immediately before such Fundamental Transaction, the holder of one share of Common Stock (the “Alternate Consideration”); and the Holders shall no longer have the right to receive Conversion Shares per se upon such conversion. For purposes of any such conversion, the determination of the Conversion Price shall be appropriately adjusted to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one share of Common Stock in such Fundamental Transaction, and the Corporation shall apportion the Conversion Price among the Alternate Consideration in a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Common Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holders shall be given the same choice as to the Alternate Consideration it receives upon any conversion of the Series 20 Preferred Stock following such Fundamental Transaction. To the extent necessary to effectuate the foregoing provisions, any successor to the Corporation or surviving entity in such Fundamental Transaction shall adopt articles of incorporation or an amendment to its articles of incorporation with the same terms and conditions and issue to the Holders new preferred stock consistent with the foregoing provisions and evidencing the Holders’ right to convert such preferred stock into Alternate Consideration. Unless the Corporation elects to treat such Fundamental Transaction as a Liquidation, the terms of any agreement pursuant to which a Fundamental Transaction is effected shall include terms requiring any such successor or surviving entity to comply with the provisions of this Section 7(d) and ensuring that the Series 20 Preferred Stock (or any such replacement security) will be similarly adjusted upon any subsequent transaction analogous to a Fundamental Transaction.

(e)     Calculations. All calculations under this Section 7 shall be made to the nearest cent or the nearest 1/100th of a share, as the case may be.

(f)     Notice to the Holders.

         (i)Adjustment to Conversion Price. Whenever the Conversion Price is adjusted pursuant to any provision of this Section 7, the Corporation shall promptly deliver to each Holder a notice setting forth the Conversion Price after such adjustment and setting forth a brief statement of the facts requiring such adjustment.

         (ii)Notice to Allow Conversion by Holder. If (A) the Corporation shall declare a dividend (or any other distribution in whatever form) on the Common Stock, (B) the Corporation shall declare a special nonrecurring cash dividend on or a redemption of the Common Stock, (C) the Corporation shall authorize the granting to all holders of the Common Stock of rights or warrants to subscribe for or purchase any shares of capital stock of any class or of any rights, (D) the approval of any shareholders of the Corporation shall be required in connection with any reclassification of the Common Stock, any consolidation or merger to which the Corporation is a party, any sale or transfer of all or substantially all of the assets of the Corporation, of any compulsory share exchange whereby the Common Stock is converted into other securities, cash or property, or (E) the Corporation shall authorize the voluntary or involuntary dissolution, liquidation or winding up of the affairs of the Corporation, then, in each case, the Corporation shall cause to be filed at each office or agency maintained for the purpose of conversion of the Series 20 Preferred Stock, and shall cause to be delivered to each Holder at its last address as it shall appear upon the stock books of the Corporation, at least 20 calendar days before the applicable record or effective date hereinafter specified, a notice stating (x) the date on which a record is to be taken for the purpose of such

 

9

OMM_US:72091741.9


dividend, distribution, redemption, rights or warrants, or if a record is not to be taken, the date as of which the holders of the Common Stock of record to be entitled to such dividend, distributions, redemption, rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale, transfer or share exchange is expected to become effective or close, and the date as of which it is expected that holders of the Common Stock of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale, transfer or share exchange, provided that the failure to deliver such notice or any defect therein or in the delivery thereof shall not affect the validity of the corporate action required to be specified in such notice. To the extent that any notice provided hereunder constitutes, or contains, material, non-public information regarding the Corporation or any of its subsidiaries, the Corporation shall simultaneously file such notice with the Commission pursuant to a Current Report on Form 8-K. The Holder is entitled to convert the Stated Value of its Series 20 Preferred Stock during the 20-day period commencing on the date of such notice through the effective date of the event triggering such notice.

Section 8. Negative Covenants. As long as at least 20% of the aggregate number of originally issued shares of Series 20 Preferred Stock are outstanding (as appropriately adjusted for share splits and similar transactions), the Corporation shall not, without the Corporation obtaining the affirmative written consent of Holders of a majority of the then outstanding shares of the Series 20 Preferred Stock, amend these articles of incorporation, its bylaws or other charter documents so as to materially, specifically and adversely affect any rights of any Holder with respect to the Series 20 Preferred Stock.

Section 9. Transferability. The Series 20 Preferred Stock may only be sold, transferred, assigned, pledged or otherwise disposed of (any of the foregoing, a “Transfer”) in accordance with U.S. state and federal securities laws. The Corporation shall keep at its principal office, or at the offices of the transfer agent, a register of the Series 20 Preferred Stock. In connection with any such permitted Transfer, upon the surrender of any certificate representing Series 20 Preferred Stock at such place, the Corporation, at the request of the record Holder of such certificate, shall execute and deliver (at the Corporation’s expense) a new certificate or certificates in exchange therefor representing in the aggregate the number of shares represented by the surrendered certificate; provided that the Corporation shall not be required to pay any tax that may be payable in respect of any such Transfer involved in the issuance and delivery of any such new certificate in a name other than that of Holder and the Corporation shall not be required to issue or deliver such new certificate(s) unless or until the person or persons requesting the issuance thereof shall have paid to the Corporation the amount of such tax or shall have established to the satisfaction of the Corporation that such tax has been paid. Each such new certificate shall be registered in such name and shall represent such number of shares as is requested by the Holder of the surrendered certificate and shall be substantially identical in form to the surrendered certificate.

Section 10. Miscellaneous.

(a)     Notices. Any and all notices or other communications or deliveries to be provided by the Holders hereunder shall be in writing and delivered personally, by facsimile or by email, or sent by a nationally recognized overnight courier service, addressed to the Corporation, at 3101 Western Avenue, Suite 600, Seattle, Washington 98121, facsimile number (206) 282-7100, or email legaladministrative@ctibiopharma.com, Attention: Legal Department, or such other street address, facsimile number or email address as the Corporation may specify for such purposes by notice to the Holders delivered in accordance with this Section 10(a). Any and all notices or other communications or deliveries to be provided by the Corporation hereunder shall be in writing and delivered personally, by facsimile, by email or sent by a nationally recognized overnight courier service addressed to each Holder at the facsimile number, email address or street address of such Holder appearing on the books of the Corporation, or if no such facsimile number, email address or street address appears on the books of the Corporation, at the

 

10

OMM_US:72091741.9


principal place of business of the Holder. Any notice or other communication or deliveries hereunder shall be deemed given and effective on the earliest of (i) the date of transmission, if such notice or communication is delivered via facsimile or email to the facsimile number or email address specified in this Section 10(a) before 5:30 p.m. (New York City time) on any date, (ii) the date immediately following the date of transmission, if such notice or communication is delivered via facsimile or email to the facsimile number or email address specified in this Section 10(a) between 5:30 p.m. and 11:59 p.m. (New York City time) on any date, (iii) the second Business Day following the date of dispatch, if sent by nationally recognized overnight courier service, or (iv) upon actual receipt by the party to whom such notice is required to be given.

(b)     Lost or Mutilated Series 20 Preferred Stock Certificate. If a Holder’s Series 20 Preferred Stock certificate shall be mutilated, lost, stolen or destroyed, the Corporation shall execute and deliver, in exchange and substitution for and upon cancellation of a mutilated certificate, or in lieu of or in substitution for a lost, stolen or destroyed certificate, a new certificate for the shares of Series 20 Preferred Stock so mutilated, lost, stolen or destroyed, but only upon receipt of evidence of such loss, theft or destruction of such certificate, and of the ownership thereof reasonably satisfactory to the Corporation.

(c)     Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this instrument shall be governed by and construed and enforced in accordance with the internal laws of the State of Washington, without regard to the principles of conflict of laws thereof.

(d)     Waiver. Any waiver by the Corporation or a Holder of a breach of any provision of this instrument shall not operate as or be construed to be a waiver of any other breach of such provision or of any breach of any other provision of this instrument or a waiver by any other Holders. The failure of the Corporation or a Holder to insist upon strict adherence to any term of this instrument on one or more occasions shall not be considered a waiver or deprive that party (or any other Holder) of the right thereafter to insist upon strict adherence to that term or any other term of this instrument. Any waiver by the Corporation or a Holder must be in writing.

(e)     Severability. If any provision of this Article II.2(aa) is invalid, illegal or unenforceable, the balance of this Article II.2(aa) shall remain in effect, and if any provision is inapplicable to any person or circumstance, it shall nevertheless remain applicable to all other persons and circumstances.

(f)     Next Business Day. Whenever any payment or other obligation hereunder shall be due on a day other than a Business Day, such payment shall be made on the next succeeding Business Day.

(g)     Headings. The headings contained herein are for convenience only, do not constitute a part of this Article II.2(aa) and shall not be deemed to limit or affect any of the provisions hereof.

(h)     Status of Converted or Redeemed Series 20 Preferred Stock. If any shares of Series 20 Preferred Stock are converted, redeemed or reacquired by the Corporation, such shares shall resume the status of authorized but unissued shares of preferred stock and shall no longer be designated as Series 20 Preferred Stock.

(i)     Remedies, Characterizations, Other Obligations, Breaches and Injunctive Relief. The remedies provided herein shall be cumulative and in addition to all other remedies available hereunder, at law or in equity (including a decree of specific performance and/or other injunctive relief), and no remedy contained herein shall be deemed a waiver of compliance with the provisions giving rise to such remedy. Nothing herein shall limit a Holder’s right to pursue actual damages for any failure by the Corporation to comply with the terms hereof. The Corporation covenants to each Holder that there shall be no

 

11

OMM_US:72091741.9


characterization concerning this instrument other than as expressly provided herein. Amounts set forth or provided for herein with respect to payments, conversion and the like (and the computation thereof) shall be the amounts to be received by a Holder and shall not, except as expressly provided herein, be subject to any other obligation of the Corporation (or the performance thereof). The Corporation acknowledges that a breach by it of its obligations hereunder will cause irreparable harm to the Holders and that the remedy at law for any such breach may be inadequate. The Corporation therefore agrees that, in the event of any such breach or threatened breach, the Holders shall be entitled, in addition to all other available remedies, to an injunction restraining any breach, without the necessity of showing economic loss and without any bond or other security being required.

[Signature page follows.]

 

 

 

 

12

OMM_US:72091741.9


 

I certify that I am a duly appointed and incumbent officer of the above named Corporation and that I am authorized to execute these Articles of Amendment on behalf of the Corporation.

EXECUTED, this 24 day of October, 2014.

 

 

CTI BIOPHARMA CORP.,

 

a Washington corporation

 

 

 

By:

  /s/ James Bianco

 

 

Name:  James Bianco, M.D.

 

 

Title: President & CEO

 

 

 

 

[Articles of Amendment (Series 20)]

OMM_US:72091741.9

 


 

ANNEX A

NOTICE OF CONVERSION

(TO BE EXECUTED BY THE HOLDER IN ORDER TO CONVERT SHARES

OF SERIES 20 PREFERRED STOCK)

The undersigned hereby elects to convert the number of shares of Series 20 Preferred Stock, no par value per share (the “Preferred Stock”), of CTI Biopharma Corp., a Washington corporation (the “Corporation”), indicated below into shares of common stock, no par value per share (the “Common Stock”), of the Corporation, according to the conditions hereof, as of the date written below. If shares of Common Stock are to be issued in the name of a person other than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto and is delivering herewith such certificates and opinions as may be reasonably required by the Corporation. No fee will be charged to the Holders for any conversion of Preferred Stock, except for any such transfer taxes.

Conversion calculations:

Date to Effect Conversion:                                                                                                                    

Number of shares of Preferred Stock owned before Conversion:                        CUSIP 12648L 205

Number of shares of Preferred Stock to be Converted:                                                                        

Stated Value of shares of Preferred Stock to be Converted:                                                                 

Number of shares of Common Stock to be Issued:                                               CUSIP 150934 883

Applicable Conversion Price per share of Common Stock:                                                                 

Number of shares of Preferred Stock subsequent to Conversion:                                                        

Address of Record:                                                                                                                                  

 

 

By: 

 

 

 

Name:

 

 

 

Title:

 

 

 

EX-4 3 ctic-ex4_2014102289.htm EX-4.1

 

Exhibit 4.1

P20-

Series 20 Preferred Stock

CTI BIOPHARMA CORP.

A Washington Corporation

THIS CERTIFIES THAT *                      * is the record holder of *                                                     * shares of Series 20 Preferred Stock of CTI BioPharma Corp. (the “Corporation”) transferable only on the share register of the Corporation by the holder, in person or by such holder’s duly authorized attorney, upon surrender of this certificate properly endorsed or assigned.

This certificate and the shares represented hereby shall be held subject to all of the provisions of the Amended and Restated Articles of Incorporation, as amended, and the Second Amended and Restated Bylaws of the Corporation, and any amendments thereto, a copy of each of which is on file at the office of the Corporation and made a part hereof as fully as though the provisions of said Amended and Restated Articles of Incorporation and Second Amended and Restated Bylaws were imprinted in full on this Certificate, to all of which the holder of this Certificate, by acceptance hereof, assents and agrees to be bound.

The shares represented by this Certificate are convertible into shares of Common Stock as set forth in the Amended and Restated Articles of Incorporation of the Corporation.

The Corporation will furnish without charge to each shareholder who so requests, the powers, designations, preferences and relative, participating, optional or other special rights of each class of stock or series thereof and the qualifications, limitations or restrictions of such preferences or rights.

IN WITNESS WHEREOF, the Corporation has caused this Certificate to be signed by its duly authorized officers this              day of October, 2014.

 

 

 

 

By:

 

By:

Title:

 

Title:

 

 

 

 


 

FOR VALUE RECEIVED, THE UNDERSIGNED HEREBY SELLS, ASSIGNS AND TRANSFERS UNTO                                                                   SHARES REPRESENTED BY THE WITHIN CERTIFICATE AND DOES HEREBY IRREVOCABLY CONSTITUTE AND APPOINT                      ATTORNEY TO TRANSFER THE SAID SHARES ON THE SHARE REGISTER OF THE WITHIN NAMED CORPORATION WITH FULL POWER OF SUBSTITUTION IN THE PREMISES.

 

DATED

 

 

 

 

 

 

 

 

 

 

(Signature)

NOTICE:  THE SIGNATURE ON THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THIS CERTIFICATE, IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT, OR ANY CHANGE WHATEVER.

THE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED.  THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED, OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT REGISTRATION IS NOT REQUIRED UNDER SUCH ACT OR UNLESS SOLD PURSUANT TO RULE 144 UNDER SUCH ACT.

 

EX-10 4 ctic-ex10_2014102290.htm EX-10.1

Exhibit 10.1

 

EXECUTION VERSION

 

 

REGISTRATION RIGHTS AGREEMENT

             This REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of October 24, 2014, by and among (i) CTI Biopharma Corp. (formerly known as Cell Therapeutics, Inc.), a Washington corporation (the “Company”), (ii) Chroma Therapeutics Limited (“Chroma”) (the “Initial Holder”), and (iii) each person or entity that subsequently becomes a party to this Agreement pursuant to, and in accordance with, the provisions of Section 12 hereof (collectively, the “Holder Permitted Transferees,” and each individually, a “Holder Permitted Transferee”).

             WHEREAS, pursuant to the terms and conditions set forth in that certain Asset Purchase Agreement, dated as of October 24, 2014, between the Company and the Initial Holder (the “APA”), the Company has agreed to issue to the Initial Holder certain shares of the Company’s Series 20 Preferred Stock upon the terms and conditions set forth in the APA.

             WHEREAS, the terms of the APA provide for the Company and the Initial Holder to execute and deliver this Agreement.

             NOW, THEREFORE, in consideration of the premises and mutual covenants contained herein, the parties hereto hereby agree as follows:

1.          Definitions. The following terms shall have the meanings provided therefor below or elsewhere in this Agreement as described below:

            Agreement” has the meaning set forth in the Preamble.

            APA” has the meaning set forth in the recitals.

            Board” means the board of directors of the Company.

            Business Day” means any day other than a Saturday, a Sunday or a day on which banks in New York are authorized or obligated by law or executive order to close.

            Company” has the meaning set forth in the Preamble.

            Effective Date” has the meaning set forth in the APA.

            Exchange Act” means the Securities Exchange Act of 1934, as amended, and all of the rules and regulations promulgated thereunder.

            Holder Indemnified Person” has the meaning set forth in Section 9.1.

            Holder Permitted Transferee” and “Holder Permitted Transferees” have the meanings set forth in the Preamble.

OMM_US:72091733.11

 


            Holders” means, collectively, the Initial Holder and the Holder Permitted Transferees; provided, however, that the term “Holders” shall not include the Initial Holder or any of the Holder Permitted Transferees if at any time such Holder does not or ceases to own or hold any Registrable Shares.

            Initial Holder” has the meaning set forth in the Preamble.

            Loss” has the meaning set forth in Section 9.1.

            Mandatory Registration Termination Date” has the meaning set forth in Section 3.2.

            Majority Holders” means, at the relevant time of reference thereto, those Holders holding more than fifty percent (50%) of the Registrable Shares held by all of the Holders.

            Qualifying Holder” has the meaning set forth in Section 12.

            Registrable Shares” means (i) any shares of common stock of the Company issued to the Initial Holder pursuant to the APA, (ii) any shares of common stock of the Company issuable upon conversion of any shares of Series 20 Preferred Stock issued to the Initial Holder pursuant to the APA or (iii) any common stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such common stock or Series 20 Preferred Stock (including, in each case, any such shares held in escrow pursuant to the APA). For the avoidance of doubt, a security shall cease to be a Registrable Share once it has been sold in an SEC-registered transaction or pursuant to Rule 144.

            Registration Statement” has the meaning set forth in Section 3.1.

            Rule 144” means Rule 144 promulgated under the Securities Act and any successor or substitute rule, law or provision.

            SEC” means the U.S. Securities and Exchange Commission.

            Securities Act” means the Securities Act of 1933, as amended, and all of the rules and regulations promulgated thereunder.

            Suspension Period” has the meaning set forth in Section 11.

2.         Effectiveness. This Agreement shall become effective and legally binding on the Effective Date.

3.         Mandatory Registration.

            3.1.Within thirty (30) calendar days after the Effective Date, the Company will prepare and file with the SEC a registration statement on Form S-3, or any other available form if the Company is not eligible to use Form S-3, for the purpose of registering under the Securities Act all of the Registrable Shares for resale by, and for the account of, the Holders as selling stockholders thereunder (the “Registration Statement”).  The Registration Statement shall permit

2

OMM_US:72091733.11


the Holders to offer and sell, on a delayed or continuous basis pursuant to Rule 415 under the Securities Act, any or all of the Registrable Shares.  The Company agrees to use commercially reasonable efforts to cause the Registration Statement to become effective as soon as practicable after the filing thereof, and in no event later than the earlier of (i) one hundred twenty (120) calendar days following the Effective Date (subject to reasonable extension to the extent necessary to accommodate a delay resulting from unresolved SEC comments or the need to file financial statements within the time periods prescribed by the SEC) and (ii) five (5) Business Days following the date on which the Company is notified by the SEC that (a) such Registration Statement will not be reviewed or is no longer subject to further review and comments and that (b) the SEC is willing to declare the Registration Statement effective.  The Registration Statement filed pursuant to this Section 3.1 (and each amendment or supplement thereto, and each request for acceleration of effectiveness thereof) shall be provided to each Holder and its counsel prior to its filing or other submission.

            3.2.The Company shall be required to keep the Registration Statement continuously effective until such date that is the earliest to occur of (i) the date as of which all of the Holders may sell all of the Registrable Shares to the public without restriction pursuant to Rule 144 (or the successor rule thereto) promulgated under the Securities Act, (ii) the date when all of the Registrable Shares registered thereunder shall have been sold pursuant to the Registration Statement or Rule 144, or (iii) the two (2) year anniversary of the Effective Date (such date is referred to herein as the “Mandatory Registration Termination Date”).  Thereafter, the Company shall be entitled to withdraw the Registration Statement and the Holders shall have no further right to offer or sell any of the Registrable Shares pursuant to the Registration Statement (or any prospectus relating thereto).  The Company shall not be required to register the offer and sale of the Registrable Shares pursuant to the Registration Statement in an underwritten offering.

            3.3.The Company shall not, and shall not agree to (i) allow the holders of any securities of the Company, other than holders of the Registrable Shares, to include any of their securities in the Registration Statement under Section 3.1 hereof or any amendment or supplement thereto without the consent of the Holders or (ii) offer any securities for its own account or the account of others in the Registration Statement under Section 3.1 hereof or any amendment or supplement thereto without the consent of the Holders, in each such case, subject to, and other than with respect to, any registration obligations of the Company under any agreement entered into prior to the Effective Date; provided, however, that the Company at all times reserves the right to provide registration rights, pursuant to a separate registration statement, to the holders of any securities of the Company.

4.          Notification of Effectiveness.  The Company shall notify the Holders by facsimile or e-mail (as provided by Holders) as promptly as practicable, and in any event, within twenty-four (24) hours, after the Registration Statement is declared effective and shall simultaneously provide the Holders with copies of any related prospectus to be used in connection with the sale or other disposition of the securities covered thereby.

5.          Obligations of the Company.  In connection with the Company’s obligation under Sections 3 and 4 hereof to file the Registration Statement with the SEC and to use commercially reasonable efforts to cause the Registration Statement to become effective as soon as practicable, the Company shall, as expeditiously as reasonably practicable:

3

OMM_US:72091733.11


            5.1.Prepare and file with the SEC such amendments and supplements to the Registration Statement and the prospectus used in connection therewith as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all Registrable Shares covered by the Registration Statement, and furnish to each Holder and the single firm of counsel designated by the Holders to the extent requested by such Holder or counsel, without charge, at least one conformed copy of each Registration Statement and each amendment thereto, including financial statements and schedules, and all exhibits (including those previously furnished or incorporated by reference) promptly after the filing of such documents with the SEC;

            5.2.Furnish to the Holders such number of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents (including, without limitation, prospectus amendments and supplements as are prepared by the Company in accordance with Section 5.1 above) as the Holders may reasonably request in order to facilitate the disposition of such Holders’ Registrable Shares. The Company hereby consents to the use of such prospectus and each amendment or supplement thereto by each of the selling Holders in connection with the offering and sale of the Registrable Shares covered by such prospectus and any amendment or supplement thereto.

            5.3.Notify the Holders as promptly as reasonably practicable, at any time when a prospectus relating to the Registration Statement is required to be delivered under the Securities Act, of the happening of any event as a result of which the prospectus included in or relating to the Registration Statement contains an untrue statement of a material fact or omits any fact necessary to make the statements therein not misleading; and, thereafter, the Company will promptly prepare (and, when completed, give notice to each Holder) a supplement or amendment to such prospectus so that, as thereafter delivered to the purchasers of such Registrable Shares, such prospectus will not contain an untrue statement of a material fact or omit to state any fact necessary to make the statements therein not misleading; upon such notification by the Company, the Holders will not offer or sell Registrable Shares until the Company has notified the Holders that it has prepared a supplement or amendment to such prospectus and delivered copies of such supplement or amendment to the Holders (it being understood and agreed by the Company that the foregoing clause shall in no way diminish or otherwise impair the Company’s obligation to promptly prepare a prospectus amendment or supplement as above provided in this Section 5.3 and deliver copies of same as above provided in Section 5.2 hereof);

            5.4.Promptly respond to any and all comments received from the SEC, with a view towards causing the Registration Statement or any amendment thereto to be declared effective by the SEC as soon as practicable, and file an acceleration request as soon as practicable, but no later than five (5) Business Days, following the resolution or clearance of all SEC comments or, if applicable, notification by the SEC that any such Registration Statement or any amendment thereto will not be subject to review;

            5.5.Use commercially reasonable efforts to register and qualify the Registrable Shares covered by the Registration Statement under such other securities or Blue Sky laws of such states where such registration and/or qualification is required as shall be reasonably requested by a Holder, provided that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any

4

OMM_US:72091733.11


such states or jurisdictions, and provided further that (notwithstanding anything in this Agreement to the contrary with respect to the bearing of expenses) if any jurisdiction in which any of such Registrable Shares shall be qualified shall require that expenses incurred in connection with the qualification therein of any such Registrable Shares be borne by the Holders, then the Holders shall, to the extent required by such jurisdiction, pay their pro rata share of such qualification expenses;

            5.6.Subject to the terms and conditions of this Agreement, use commercially reasonable efforts to (i) prevent the issuance of any stop order or other suspension of effectiveness of a Registration Statement, or the suspension of the qualification of any of the Registrable Shares for sale in any jurisdiction in the United States, and (ii) if such an order or suspension is issued, obtain the withdrawal of such order or suspension at the earliest practicable moment and notify each holder of Registrable Shares of the issuance of such order and the resolution thereof or its receipt of notice of the initiation or threat of any proceeding such purpose;

            5.7.Permit a single firm of counsel designated by the Holders to review the Registration Statement and all amendments and supplements thereto (as well as all requests for acceleration or effectiveness thereof), at Holders’ own cost, a reasonable period of time prior to their filing with the SEC (not less than five (5) Business Days) and use commercially reasonable efforts to reflect in such documents any comments as such counsel may reasonably propose (so long as such comments are provided to the Company at least (2) Business Days prior to the expected filing date) and will not request acceleration of such Registration Statement without prior notice to such counsel;

            5.8.Cooperate with the Holders to facilitate the timely preparation and delivery of certificates representing Registrable Shares to be delivered to a transferee pursuant to the Registration Statement, which certificates shall be free, to the extent permitted by law, of all restrictive legends, and to enable such Registrable Shares to be in such denominations and registered in such names as any such Holders may request;

            5.9.Comply with all applicable rules and regulations of the SEC;

            5.10.Use commercially reasonable efforts to cause all the Registrable Shares covered by the Registration Statement to be listed on the NASDAQ National Market, or such other securities exchange on which the Company’s common stock is then listed; and

            5.11.Comply with all requirements of the Financial Industry Regulatory Authority, Inc. with regard to the issuance of the Registrable Shares and the listing thereof on the NASDAQ National Market, and engage a transfer agent and registrar to maintain the Company’s stock ledger for all Registrable Shares covered by the Registration Statement not later than the effective date of the Registration Statement.

6.          Furnish Information.  It shall be a condition precedent to the obligations of the Company to take any action pursuant to this Agreement that the Holders shall furnish to the Company such information regarding them and the securities held by them as the Company shall reasonably request and as shall be required in order to effect any registration by the Company

5

OMM_US:72091733.11


pursuant to this Agreement. Each Holder shall promptly notify the Company of any changes in the information furnished to the Company.

7.          Expenses of Registration.  All fees and expenses incurred by the Company in connection with the registration of the Registrable Shares pursuant to this Agreement, including, without limitation, all registration and qualification and filing fees, printing and fees and disbursements of counsel for the Company shall be borne by the Company.  Any expenses incurred by a Holder, including, without limitation, fees and disbursements of counsel for such Holder or any brokerage and other selling commissions and discounts shall be borne by such Holder.

8.          Delay of Registration.  The Holders shall not take any action to restrain, enjoin or otherwise delay any registration as the result of any controversy which might arise with respect to the interpretation or implementation of this Agreement.  In the event such a delay occurs because of such action, the dates by which the Registration Statement is required to be filed and become effective pursuant to this Agreement shall be extended by the same number of days of such delay.

9.          Indemnification.

            9.1.The Company will indemnify and hold harmless each Holder, each person who controls each Holder within the meaning of the Securities Act or the Exchange Act, if any (in each case, a “Holder Indemnified Person”), from and  against any loss, claim, damage, cost (including, without limitation, reasonable costs of preparation and reasonable attorneys’ fees), expenses, or liability (“Loss”), to which such Holder Indemnified Person may become subject under the Securities Act or otherwise, insofar as such Loss arises out of or is based upon (i) any untrue or alleged untrue statement of any material fact contained in the Registration Statement, in any preliminary prospectus or final prospectus relating thereto or in any amendments or supplements to the Registration Statement or any such preliminary prospectus or final prospectus, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, (iii) any required “blue sky” application or other document filed in any state or other jurisdiction by the Company in order to qualify any or all of the Registrable Securities under the securities laws thereof (each a “Blue Sky Application”), (iv) the omission or alleged omission to state in a Blue Sky Application a material fact required to be stated therein or necessary to make the statements therein not misleading; (v) any violation by the Company or its agents of any rule or regulation promulgated under the Securities Act applicable to the Company or its agents and relating to action or inaction required of the Company in connection with such registration; provided, however, that the indemnity agreement contained in this Section 9.1 shall not apply to amounts paid in settlement of any such Loss if such settlement is effected without the consent of the Company, nor shall the Company be liable in any such case for any such Loss to the extent that it arises out of or is based upon (1) an untrue statement or alleged untrue statement or omission or alleged omission made in connection with the Registration Statement, any preliminary prospectus or final prospectus relating thereto or any amendments or supplements to the Registration Statement or any such preliminary prospectus or final prospectus, in reliance upon and in conformity with written information furnished expressly for use in connection with the Registration Statement or any such preliminary prospectus or final prospectus by a Holder, any

6

OMM_US:72091733.11


underwriter for such Holder or controlling person with respect to such Holder, or (2) any breach by any Holder of this Agreement, related to the failure of such Holder to comply with the covenants and agreements contained in this Agreement respecting sales of the Registrable Shares.

            9.2.Each Holder will severally and not jointly indemnify and hold harmless the Company, each of its directors, each of its officers who have signed the Registration Statement, each person, if any, who controls the Company within the meaning of the Securities Act, and all other Holders against any Loss to which the Company or any such director, officer, controlling person, or such other Holder may become subject to, under the Securities Act or otherwise, insofar as such Loss arises solely out of or is based solely upon any untrue or alleged untrue statement of any material fact contained in the Registration Statement or any preliminary prospectus or final prospectus, relating thereto or in any amendments or supplements to the Registration Statement or any such preliminary prospectus or final prospectus, or arises out of or is based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, in each case to the extent and only to the extent that such untrue statement or alleged untrue statement or omission or alleged omission was made in the Registration Statement, in any preliminary prospectus or final prospectus relating thereto or in any amendments or supplements to the Registration Statement or any such preliminary prospectus or final prospectus, in reliance upon and in conformity with written information furnished by the Holder expressly for inclusion in the Registration Statement, or any preliminary prospectus or final prospectus; and provided, further, however, that the indemnity agreement contained in this Section 9.2 shall not apply to amounts paid in settlement of any such Loss if such settlement is effected without the consent of those Holder(s) against which the request for indemnity is being made; provided, however, that each Holder’s indemnification obligation pursuant to this Section 9.2 shall be limited to the net proceeds (after underwriting fees, commissions or discounts) received by such Holder from the sale of Registrable Shares.

            9.3.Promptly after receipt by an indemnified party under this Section 9 of notice of the commencement of any action, such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 9, notify the indemnifying party in writing of the commencement thereof and the indemnifying party shall have the right to participate in and, to the extent the indemnifying party desires, jointly with any other indemnifying party similarly noticed, to assume at its expense the defense thereof with counsel mutually satisfactory to the indemnifying parties and the indemnified parties. In the event that the indemnifying party assumes any such defense, the indemnified party may participate in such defense with its own counsel and at its own expense, provided, however, that the counsel for the indemnifying party shall act as lead counsel in all matters pertaining to such defense or settlement of such claim. The failure to notify an indemnifying party promptly of the commencement of any such action shall not relieve such indemnifying party of any liability to the indemnified party under this Section 9, except to the extent the indemnifying party is actually prejudiced in its ability to defend such action.

            9.4.If the indemnification provided for in this Section 9 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any Loss referred to therein, then the indemnifying party, in lieu of indemnifying such indemnified party

7

OMM_US:72091733.11


hereunder, shall, to the extent permitted by applicable law, contribute to the amount paid or payable by such indemnified party as a result of such Loss in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the statements or omissions that resulted in such Loss as well as any other relevant equitable considerations.  The relative fault of the indemnifying party and of the indemnified party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission. Each Holder’s contribution obligation pursuant to this Section 9.4 shall be limited to the net proceeds (after underwriting fees, commissions or discounts) received by such Holder from the sale of Registrable Shares.

10.        Reports Under The Exchange Act.  With a view to making available to the Holders the benefits of Rule 144 and any other rule or regulation of the SEC that may at any time permit the Holders to sell the Registrable Shares to the public without registration until the Mandatory Registration Termination Date, the Company agrees to use commercially reasonable efforts: (i) to make and keep public information available as those terms are understood in Rule 144, (ii) to file with the SEC in a timely manner all reports and other documents required to be filed by an issuer of securities registered under the Securities Act or the Exchange Act, (iii) as long as any Holder owns any Registrable Shares, to furnish in writing upon such Holder’s request a written statement by the Company that it has complied with the reporting requirements of Rule 144 and of the Securities Act and the Exchange Act, and (iv) undertake any additional actions reasonably necessary to maintain the availability of the Registration Statement or the use of Rule 144.

11.        Suspension. Notwithstanding anything in this Agreement to the contrary, if the Company shall furnish to the Holders a certificate signed by the President or Chief Executive Officer of the Company stating that the Board has made the good faith determination (i) that continued use by the Holders of the Registration Statement for purposes of effecting offers or sales of Registrable Shares pursuant thereto would require, under the Securities Act, premature disclosure in the Registration Statement (or the prospectus relating thereto) of material, nonpublic information concerning the Company, its business or prospects or any proposed material transaction involving the Company, (ii) that such premature disclosure would be materially adverse to the Company, its business or prospects or any such proposed material transaction or would make the successful consummation by the Company of any such material transaction significantly less likely and (iii) that it is therefore essential to suspend the use by the Holders of such Registration Statement (and the prospectus relating thereto) for purposes of effecting offers or sales of Registrable Shares pursuant thereto, then the right of the Holders to use the Registration Statement (and the prospectus relating thereto) for purposes of effecting offers or sales of Registrable Shares pursuant thereto shall be suspended for a period (the “Suspension Period”) of not more than forty-five (45) days after delivery by the Company of the certificate referred to above in this Section 11; provided that the Company shall be entitled to no more than two (2) such Suspension Periods during any twelve (12) month period. During the Suspension Period, none of the Holders shall offer or sell any Registrable Shares pursuant to or in reliance upon the Registration Statement (or the prospectus relating thereto). The Company shall use commercially reasonable efforts to terminate any Suspension Period as promptly as reasonably practicable.

8

OMM_US:72091733.11


12.        Transfer of Registration Rights.  None of the rights of any Holder under this Agreement shall be transferred or assigned to any person unless (i) such person acquires Registrable Shares from such Holder concurrently with such transfer or assignment, (ii) such person is a Qualifying Holder (as defined below), and (iii) such person agrees to become a party to, and bound by, all of the terms and conditions of, this Agreement by duly executing and delivering to the Company an Instrument of Adherence in the form attached as Exhibit A hereto. For purposes of this Section 12, the term “Qualifying Holder” shall mean, (a) with respect to the Initial Holder, any holder of equity securities of such Initial Holder as of the date of this Agreement (provided, that any transfer or assignment of any rights of the Initial Holder under this Agreement shall be transferred to any such holder of equity securities of the Initial Holder in such proportion as the Initial Holder and such holders of equity securities of the Initial Holder have determined as of the date of this Agreement) and (b) with respect to any Holder other than the Initial Holder, any corporation, partnership controlling, controlled by, or under common control with, such Holder or any partner thereof. None of the rights of any Holder under this Agreement shall be transferred or assigned to any Person (including, without limitation, a Qualifying Holder) that acquires Registrable Shares in the event that and to the extent that such Person is eligible to immediately resell such Registrable Shares pursuant to Rule 144 of the Securities Act or any other exemption from the registration provisions of the Securities Act. After any transfer in accordance with this Section 12, the rights and obligations of a Holder as to any transferred Registrable Shares shall be the rights and obligations of the Holder Permitted Transferee holding such Registrable Shares.

13.        Confidentiality of Records.   Each Holder agrees not to disclose any material non-public information provided by the Company in connection with a registration (including, without limitation, the contemplated filing and timing of filing of a Registration Statement).

14.        Entire Agreement. This Agreement constitutes and contains the entire agreement and understanding of the parties with respect to the subject matter hereof, and it also supersedes any and all prior negotiations, correspondence, agreements or understandings with respect to the subject matter hereof.

15.        Miscellaneous.

             15.1.Amendment.  This Agreement may not be amended, modified or terminated, and no rights or provisions may be waived, except with the written consent of the Majority Holders and the Company.

             15.2.Governing Law.  This Agreement shall be governed by and construed and enforced in accordance with the laws of the State of New York, and shall be binding upon and inure to the benefit of the parties hereto and their respective heirs, personal representatives, successors or assigns, provided that the terms and conditions of Section 12 hereof are satisfied.

             15.3.Waiver of Jury Trial.  EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND IRREVOCABLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY ACTION, SUIT OR PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.  EACH OF THE PARTIES UNCONDITIONALLY AND IRREVOCABLY CONSENTS TO THE

9

OMM_US:72091733.11


EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK LOCATED IN NEW YORK COUNTY AND THE FEDERAL DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK WITH RESPECT TO ANY SUIT, ACTION OR PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY, AND EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND IRREVOCABLY WAIVES ANY OBJECTION TO VENUE IN NEW YORK COUNTY OR SUCH DISTRICT, AND AGREES THAT SERVICE OF ANY SUMMONS, COMPLAINT, NOTICE OR OTHER PROCESS RELATING TO SUCH SUIT, ACTION OR OTHER PROCEEDING MAY BE EFFECTED IN THE MANNER PROVIDED IN SECTION 4.

             15.4.Severability.  The parties agree that if any provision of this Agreement be held to be invalid, illegal or unenforceable in any jurisdiction, that holding shall be effective only to the extent of such invalidity, illegally or unenforceability without invalidating or rendering illegal or unenforceable the remaining provisions hereof, and any such invalidity, illegally or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction.  It is the intent of the parties that this Agreement be fully enforced to the fullest extent permitted by applicable law.

             15.5.Binding Effect.  This Agreement shall be binding upon and inure to the benefit of any transferee of any of the Registrable Shares provided that the terms and conditions of Section 12 hereof are satisfied. Notwithstanding anything in this Agreement to the contrary, if at any time any Holder shall cease to own any Registrable Shares, all of such Holder’s rights under this Agreement shall immediately terminate.

             15.6.Notices.  All notices and communications hereunder shall be deemed to have been duly given and made if in writing and if served by personal delivery upon the party for whom it is intended or delivered by registered or certified mail, return receipt requested, or if sent by facsimile or email, provided that the facsimile or email is promptly confirmed by telephone confirmation thereof, to the person at the address set forth below, or such other address as may be designated in writing hereafter, in the same manner, by such person:

             If to the Company:

CTI Biopharma Corp.

3101 Western Avenue, Suite 600

Seattle, Washington 98121

Telephone: (206) 282-7100

Facsimile: (206) 272-4302

Email: legaladministrative@ctibiopharma.com

Attention: Legal Department

10

OMM_US:72091733.11


             with copies to counsel, provided that such copies shall not constitute legal notice to the Company:

O’Melveny & Myers LLP

Two Embarcadero Center

San Francisco, CA 94111-3823

Telephone: (415) 984-8700

Facsimile: (415) 984-8701

Email: bchristensen@omm.com

Attention: C. Brophy Christensen, Esq.

             and

CTI Legal Affairs

Attention: Lisa Luebeck, Director, Legal Corporate Development & Securities

             If to the Initial Holder:

Chroma Therapeutics Limited

93 Innovation Drive

Milton Park

Abingdon

Oxfordshire

OX14 4RZ, United Kingdom

Telephone: +44 (0)1235 829137

Facsimile: +44 (0)1235 829125

Email: r.bungay@chromatherapeutics.com

Attention:  Richard Bungay, CEO

             15.7.      Change of Address.  Any person may change the address to which correspondence to it is to be addressed by notification as provided for herein.

             15.8.      Headings.  The section headings contained in this Agreement (including, without limitation, section headings and headings in the exhibits and schedules) are inserted for reference purposes only and shall not affect in any way the meaning, construction or interpretation of this Agreement.  Any reference to the masculine, feminine, or neuter gender shall be a reference to such other gender as is appropriate.  References to the singular shall include the plural and vice versa.

             15.9.      Specific Performance; Injunctive Relief.  The parties acknowledge and agree that in the event of any breach of this Agreement, remedies at law may be inadequate, and each of the parties hereto shall be entitled to seek specific performance of the obligations of the other parties hereto and such appropriate injunctive relief as may be granted by a court of competent jurisdiction, without the necessity of showing economic loss and without any bond or other security being required.

11

OMM_US:72091733.11


             15.10.      Counterparts.  This Agreement may be executed in a number of counterparts, including by electronic transmission, any of which together shall for all purposes constitute one Agreement, binding on all the parties hereto notwithstanding that all such parties have not signed the same counterpart.  

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

 

 

 

12

OMM_US:72091733.11


 

             IN WITNESS WHEREOF, the Initial Holder and the Company have caused their respective signature pages to this Registration Rights Agreement to be duly executed as of the day and year first above written.

 

 

CTI BIOPHARMA CORP.

 

 

 

 

 

By:

/s/ James Bianco

 

Name:

James Bianco, M.D.

 

Title:

President & CEO

 

 

 

 

 

CHROMA THERAPEUTICS LIMITED

 

 

 

 

 

By:

/s/ Richard Bungay

 

Name:

   Richard Bungay

 

Title:

   CEO

 

 

 

 

[Signature Page to Registration Rights Agreement]

OMM_US:72091733.11


 

EXHIBIT A

Instrument of Adherence

             Reference is hereby made to that certain Registration Rights Agreement, dated as of October 24, 2014, among CTI Biopharma Corp., a Washington corporation (the “Company”), the Initial Holders and the Holder Permitted Transferees, as amended and in effect from time to time (the “Registration Rights Agreement”).  Capitalized terms used herein without definition shall have the respective meanings ascribed thereto in the Registration Rights Agreement.

             The undersigned, in order to become the owner or holder of [___________] shares of Series 20 Preferred Stock (the “Preferred Stock”) or shares of common stock of the Company issued or issuable upon conversion of the Preferred Stock (collectively, “Subject Securities”), of the Company, hereby represents and warrants that the undersigned is a Qualifying Holder and hereby agrees that, from and after the date hereof, the undersigned has become a party to the Registration Rights Agreement in the capacity of a Holder Permitted Transferee, and is entitled to all of the benefits under, and is subject to all of the obligations, restrictions and limitations set forth in, the Registration Rights Agreement that are applicable to Holder Permitted Transferees.  The notice information for purposes of the Registration Rights Agreement is provided below.  This Instrument of Adherence shall take effect and shall become a part of the Registration Rights Agreement immediately upon execution.

             Executed as of the date set forth below under the laws of New York.

 

Signature:

 

 

 

 

Name:

 

 

Title:

 

 

Telephone:

 

 

Facsimile:

 

 

Email:

 

 

Attention:  

 

Accepted:

 

CTI BIOPHARMA CORP.

 

By:

 

 

Name:

 

Title:

 

Date:

 

 

 

[Exhibit A to Registration Rights Agreement]

OMM_US:72091733.11

EX-10 5 ctic-ex10_2014102291.htm EX-10.2

Exhibit 10.2

EXECUTION VERSION

LOCK-UP AGREEMENT

THIS AGREEMENT (this “Agreement”) is dated as of October 24, 2014 by and between CTI Biopharma Corp. (formerly known as Cell Therapeutics, Inc.), a Washington corporation (the “Company”), and Chroma Therapeutics Limited (“Shareholder”).

WHEREAS, the Company has entered into an asset purchase agreement dated October 24, 2014 (the “Asset Purchase Agreement”) and a registration rights agreement dated October 24, 2014 (the “Registration Rights Agreement”), in each case with Shareholder, whereby, among other things, the Company has agreed to issue to Shareholder 9,000 shares of Series 20 Preferred Stock of the Company (including any such shares held in escrow pursuant to the Asset Purchase Agreement) (collectively, and together with any shares of common stock of the Company issued or issuable to Shareholder pursuant to any conversion thereof or as a result of any distribution thereon, the “Lock-Up Shares”).

WHEREAS, in connection with the Asset Purchase Agreement and Registration Rights Agreement, Shareholder has agreed, among other things, not to undertake certain actions with respect to the Lock-Up Shares, except in accordance with the terms and conditions set forth herein.  Capitalized terms used herein without definition shall have the meanings assigned to such terms in the Registration Rights Agreement.

NOW, THEREFORE, in consideration of the covenants and conditions hereinafter contained, the parties hereto agree as follows:

1.Restriction on Transfer; Term.  Shareholder hereby agrees with the Company that such Shareholder will not offer, sell, contract to sell, assign, transfer, hypothecate, pledge or grant a security interest in, or otherwise dispose of any Lock-up Shares, or enter into any transaction which is designed to, or might reasonably be expected to, have any such effect, directly or indirectly, or enter into any swap, hedge or other arrangement that transfers, in whole or in part, any of the economic consequences of ownership of the Lock-Up Shares (any of the foregoing actions, a “transfer”), or publicly disclose any intention to make any such transfer, in each case until the date that is nine (9) months after the date of this Agreement (the “Final Release Date”); provided, however, that (i) up to 44% of the Lock-Up Shares in the aggregate may be transferred by such Shareholder after the date on which the Registration Statement is declared effective (the “Initial Release Date”) and (ii) up to an additional 44% of the Lock-Up Shares in the aggregate may be transferred by such Shareholder on the earlier of (a) 30 days after the Initial Release Date and (b) December 31, 2014 (the “Second Release Date” and, together with the Final Release Date and the Initial Release Date, the “Release Dates” and each of them, a “Release Date”); provided, however, that the restrictions contained in this Section 1 shall not apply to (i) transfers of the Lock-Up Shares to any Qualifying Holder (as defined in the

 

OMM_US:72091735.13

1

 

 


Registration Rights Agreement) (provided that such Qualifying Holder enters into a Lock-Up Agreement with the Company in substantially the same form as this Agreement, except that such Qualifying Holder shall not be permitted to transfer any Lock-Up Shares prior to the Second Release Date (a “Qualifying Holder Lock-Up Agreement”), prior to or concurrently with any such transfer) and (ii) transfers of the Lock-Up Shares pursuant to a Change of Control Transaction (as defined below). “Change of Control Transaction” shall mean the occurrence after the date hereof of any of (i) an acquisition by an individual, legal entity or “group” (as described in Rule 13d-5(b)(1) promulgated under the Securities Exchange Act of 1934, as amended, and all of the rules and regulations promulgated thereunder (the “Exchange Act”), of effective control (whether through legal or beneficial ownership of capital stock of the Company, by contract or otherwise) of in excess of 50% of the voting securities of the Company (other than by means of conversion of shares of Series 20 Preferred Stock), or (ii) the merger into or consolidation with any other person by the Company, or the merger into or consolidation with the Company by any other person in which, after giving effect to such transaction, the shareholders of the Company immediately before such transaction own less than 50% of the aggregate voting power of the Company or the successor entity of such transaction, or (iii) the sale or transfer of all or substantially all of the assets of the Company to another person in which the shareholders of the Company immediately before such transaction own less than 50% of the aggregate voting power of the acquiring entity immediately after the transaction.   In the event that Shareholder does not wish to transfer the maximum entitlement of 44% of the Lock-up Shares in the aggregate at any Release Date (other than the Final Release Date), Shareholder may, effective as of such Release Date, assign the right to transfer up to 44% of the Lock-Up Shares in the aggregate (or any lesser number of Lock-Up Shares) to any Qualifying Holder that has executed a Qualifying Holder Lock-Up Agreement by providing written notice of such assignment to the Company together with an executed assignment and assumption agreement between Shareholder and any such Qualifying Holder, in each case in a form reasonably acceptable to the Company in its sole discretion, prior to such Release Date.

2.Agreement to Vote Shares; Grant of Proxy.  Shareholder, on behalf of itself and each Qualifying Holder, hereby agrees that at every meeting of the shareholders of the Company prior to the Final Release Date, and at any and every adjournment thereof, such Shareholder (or any such Qualifying Holder) shall vote the Lock-Up Shares consistent with the recommendations of the board of directors of the Company, as such recommendations are set forth in the applicable proxy statement delivered in connection with such meeting; provided, however, that the provisions of this Section 2 shall not apply to a vote on any matter if the approval of such matter would have a disproportionate adverse effect on the Lock-up Shares as compared to the other shares of common stock of the Company.  Shareholder, on behalf of itself and each Qualifying Holder, contemporaneously with the execution and delivery of this Agreement, hereby grants an irrevocable proxy for purposes of any such meeting of the shareholders of the Company, and any and every adjournment thereof, to the officers of the Company to vote the Lock-Up Shares on the Shareholder’s (or any Qualifying Holder’s) behalf in a manner consistent and in accordance with this Agreement.  Shareholder, on behalf of itself and each Qualifying Holder, acknowledges and agrees that, during the term of this Agreement, the proxy granted hereunder is irrevocable.  Until the applicable Release Date, Shareholder shall retain all rights of

 

OMM_US:72091735.13

2

 

 


ownership in the Lock-Up Shares, including, without limitation, voting rights and the right to receive any dividends, if any, that may be declared in respect thereof.

3.Company and Transfer Agent.  The Company and its transfer agent are hereby authorized by Shareholder (on its own behalf and on behalf of each Qualifying Holder) to decline to make any transfer of the Lock-Up Shares if such transfer would constitute a violation or breach of this Agreement or any Lock-Up Agreement entered into between the Company and any Qualifying Holder.

4.Notices.  All notices and communications hereunder shall be deemed to have been duly given and made if in writing and if served by personal delivery upon the party for whom it is intended or delivered by registered or certified mail, return receipt requested, or if sent by facsimile or email, provided that the facsimile or email is promptly confirmed by telephone confirmation thereof, to the person at the address set forth below, or such other address as may be designated in writing hereafter, in the same manner, by such person:

If to the Company:

CTI Biopharma Corp.

3101 Western Avenue, Suite 600

Seattle, Washington 98121

Telephone: (206) 282-7100

Facsimile: (206) 272-4302

Email: legaladministrative@ctibiopharma.com

Attention: Legal Department

with copies (which copies shall not constitute notice) to:

O’Melveny & Myers LLP

Two Embarcadero Center

San Francisco, CA 94111-3823

Telephone: (415) 984-8700

Facsimile: (415) 984-8701

Email: bchristensen@omm.com

Attention: C. Brophy Christensen, Esq.

and

CTI Legal Affairs

Attention: Lisa Luebeck, Director, Legal Corporate Development & Securities

 

OMM_US:72091735.13

3

 

 


If to Shareholder,

Chroma Therapeutics Limited

93 Innovation Drive

Milton Park

Abingdon

Oxfordshire

OX14 4RZ, United Kingdom

Telephone: +44 (0)1235 829137

Facsimile: +44 (0)1235 829125

Email: r.bungay@chromatherapeutics.com

Attention:  Richard Bungay, CEO

or to such other address as any party may specify by notice given to the other party in accordance with this Section 4.

5.Change of Address.  Any person may change the address to which correspondence to it is to be addressed by notification as provided for herein.

6.Amendment.  This Agreement may not be amended, modified or terminated, and no rights or provisions may be waived, except with the written consent of Shareholder and the Company.

7.Entire Agreement.  This Agreement constitutes and contains the entire agreement and understanding of the parties with respect to the subject matter hereof, and it also supersedes any and all prior negotiations, correspondence, agreements or understandings with respect to the subject matter hereof.

8.Governing Law.  This Agreement shall be governed by and construed and enforced in accordance with the laws of the State of New York.

9.Waiver of Jury Trial.  EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND IRREVOCABLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY ACTION, SUIT OR PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.  EACH OF THE PARTIES UNCONDITIONALLY AND IRREVOCABLY CONSENTS TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK LOCATED IN NEW YORK COUNTY AND THE FEDERAL DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK WITH RESPECT TO ANY SUIT, ACTION OR PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY, AND EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND IRREVOCABLY WAIVES ANY OBJECTION TO VENUE IN NEW YORK COUNTY OR SUCH DISTRICT, AND AGREES THAT SERVICE OF ANY SUMMONS, COMPLAINT, NOTICE OR OTHER PROCESS RELATING TO SUCH SUIT, ACTION OR OTHER PROCEEDING MAY BE EFFECTED IN THE MANNER PROVIDED IN SECTION 4.

 

OMM_US:72091735.13

4

 

 


10.Severability.  The parties agree that if any provision of this Agreement be held to be invalid, illegal or unenforceable in any jurisdiction, that holding shall be effective only to the extent of such invalidity, illegally or unenforceability without invalidating or rendering illegal or unenforceable the remaining provisions hereof, and any such invalidity, illegally or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction.  It is the intent of the parties that this Agreement be fully enforced to the fullest extent permitted by applicable law.

11.Binding Effect; Assignment.  This Agreement and the rights and obligations hereunder may not be assigned by any party hereto without the prior written consent of the other parties hereby.  This Agreement shall be binding upon and shall inure to the benefit of the parties hereto and their respective successors and permitted assigns.

12.Headings.  The section headings contained in this Agreement (including, without limitation, section headings and headings in the exhibits and schedules) are inserted for reference purposes only and shall not affect in any way the meaning, construction or interpretation of this Agreement.  Any reference to the masculine, feminine, or neuter gender shall be a reference to such other gender as is appropriate.  References to the singular shall include the plural and vice versa.

13.Counterparts.  This Agreement may be executed in a number of counterparts, including by electronic transmission, any of which together shall for all purposes constitute one Agreement, binding on all the parties hereto notwithstanding that all such parties have not signed the same counterpart.

14.Specific Performance; Injunctive Relief.  The parties acknowledge and agree that in the event of any breach of this Agreement, remedies at law may be inadequate, and each of the parties hereto shall be entitled to seek specific performance of the obligations of the other parties hereto and such appropriate injunctive relief as may be granted by a court of competent jurisdiction, without the necessity of showing economic loss and without any bond or other security being required.

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

 

 

 

 

OMM_US:72091735.13

5

 

 


 

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above herein.

 

 

CTI BIOPHARMA CORP.

 

 

 

 

 

By:

  /s/ James Bianco

 

Name:

  James Bianco, M.D.

 

Title:

President & CEO

 

 

 

 

 

CHROMA THERAPEUTICS LIMITED

 

 

 

 

 

By:

   /s/ Richard Bungay

 

Name:

  Richard Bungay

 

Title:

  CEO

 

 

[Signature Page to Lock-up Agreement]

EX-99 6 ctic-ex99_2014102292.htm EX-99.1

Exhibit 99.1

 

 

CTI Acquires Exclusive Worldwide License to Tosedostat, a Selective Oral Anti-Cancer Therapy

- Tosedostat Currently in Phase 2 Development for Patients with AML and MDS -

- Acquisition Eliminates Potential $209 Million in Future Developmental and Sales Milestone
Payments by CTI Under Prior Agreement with Chroma -

SEATTLE, Wash., October 27, 2014-CTI BioPharma Corp. (CTI) (NASDAQ and MTA: CTIC) today announced that it has acquired worldwide rights to tosedostat through concurrent transactions with Vernalis R&D Limited (Vernalis), the originator of tosedostat, and Chroma Therapeutics Ltd. (Chroma), through which CTI previously held a sublicense with respect to tosedostat in North, Central and South America. Tosedostat is a first-in-class selective inhibitor of aminopeptidases, which are required by tumor cells to provide amino acids necessary for growth and tumor cell survival. Tosedostat is currently being evaluated in multiple Phase 2 clinical trials for the treatment of patients with Acute Myeloid Leukemia (AML) or high-risk Myelodysplastic Syndrome (MDS), which are intended to inform the design for a Phase 3 registration study to support potential regulatory approval.  

“Our portfolio strategy is to acquire novel best-in-class agents that, either as monotherapy or in combination with other therapies, can have a profound effect in the treatment of patients with blood related cancers,” said James A. Bianco, M.D., President and CEO of CTI. “We are committed to building our blood-related cancer franchise. We feel there is strong interest in this oral, once-daily drug candidate, which we believe is attributable to the positive clinical results to date, and we are pleased to have exclusive worldwide rights to develop tosedostat for patients in areas where there remains an unmet medical need. Over the next year, CTI and its advisors intend to develop a registration path for tosedostat in the US and Europe. In the event of positive clinical data and productive regulatory discussions, we would intend to start a pivotal program commencing in 2016.”

Under the terms of an asset purchase agreement with Chroma, CTI acquired all of Chroma’s right, title and interest in tosedostat and certain related assets in exchange for issuing to Chroma $21.3 million in shares of CTI’s preferred stock convertible into 9 million shares of CTI common stock, 12 percent of which has been placed in escrow pending expiry of Chroma’s indemnification obligations. Chroma and CTI also terminated their prior license agreement relating to tosedostat, thereby eliminating potential future developmental and sales milestone payments by CTI of up $209 million thereunder. Concurrently, CTI entered into a license agreement with Vernalis for the exclusive worldwide right to use certain patents and other intellectual property rights to develop, market and commercialize tosedostat and certain other analogues. Under the Vernalis license agreement, CTI agreed to make tiered royalty payments of no more than a high single-digit percentage, on a country-by-country basis, for the longer of ten years following commercial launch or the expiration of relevant patents.

Additional Information

CTI will be filing a Current Report Form 8-K with the U.S. Securities and Exchange Commission (SEC) with further information on the transaction.

An aggregate of 9,000 shares of CTI’s convertible preferred stock (Series 20 Preferred Stock) were issued as consideration in the transaction with Chroma, 1,080 shares of which have been placed in escrow pending expiry of Chroma’s indemnification obligations. Each share of Series 20 Preferred Stock, no par value per share, has a stated value of $2,370 per share and is convertible, subject to certain conditions, at the option of the holder at any time prior to the automatic conversion that will take place following the occurrence of certain circumstances. The Series 20 Preferred Stock is convertible into a total of 9 million shares of common stock at a conversion price of $2.37 per share of common stock. Shares of the Series 20 Preferred Stock will receive dividends in the same amount as any dividends declared and paid on shares of common stock, but are entitled to a liquidation preference over the common stock in certain liquidation events. The Series 20 Preferred Stock has no voting rights on general corporate matters.

The shares of Series 20 Preferred Stock (and the underlying shares of common stock) are subject to a lock-up agreement that calls for the shares to be eligible for sale or transfer on the following timeline: 44 percent of such shares after the date on which the SEC declares effective a resale registration statement that CTI has agreed to file to register the common stock underlying the Series 20 Preferred Stock; an additional 44 percent of such shares on the earlier of (i) 30 days after the date of effectiveness of such resale registration statement and (ii) December 31, 2014; and the remaining 12 percent of such shares nine months following October 24, 2014.  


About Tosedostat

Tosedostat is an oral aminopeptidase inhibitor that has demonstrated anti-tumor responses in blood-related cancers and solid tumors in Phase 1–2 clinical trials. Presently, an ongoing Phase 2/3 trial is being conducted by the National Cancer Research Institute Haematological Oncology Study Group under the sponsorship of Cardiff University. In this Phase 2/3 trial, referred to as the AML Less Intensive (LI-1) trial, patients will be randomized to standard treatment, low dose cytarabine, versus one of five novel investigational treatments, one of which is tosedostat, each in combination with low dose cytarabine. The trial will utilize a “Pick a Winner” trial design.1 Overall survival will serve as the primary endpoint of this trial.  

About Acute Myeloid Leukemia

Approximately 18,860 new cases of AML are expected to be diagnosed in the United States in 2014.2 As of January 2008 an estimated 30,993 people were living with (or were in remission from) AML.3 While AML may occur at any age, adults at least 60 years of age are more likely to develop the disease than younger people.3 AML is a cancer characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML may develop from the progression of other diseases, such as MDS, a blood cancer that also affects the bone marrow leading to a decrease in circulating red blood cells. AML is the most common acute leukemia affecting adults, and its incidence increases with age.3 The symptoms of AML are caused by the replacement of normal bone marrow with leukemic cells, which causes a drop in red blood cells, platelets and normal white blood cells, leading to infections and bleeding. AML progresses rapidly and is typically fatal within weeks or months if left untreated. Although a substantial proportion of younger individuals who develop AML can be cured, AML in the elderly typically responds poorly to standard therapy with few complete remissions.

About CTI BioPharma

CTI BioPharma Corp. (NASDAQ and MTA: CTIC) is a biopharmaceutical company focused on the acquisition, development and commercialization of novel targeted therapies covering a spectrum of blood-related cancers that offer a unique benefit to patients and healthcare providers. CTI has a commercial presence in Europe and a late-stage development pipeline, including pacritinib, CTI’s lead product candidate that is currently being studied in a Phase 3 program for the treatment of patients with myelofibrosis. CTI is headquartered in Seattle, Washington, with offices in London and Milan under the name CTI Life Sciences Limited. For additional information and to sign up for email alerts and get RSS feeds, please visit www.ctibiopharma.com.

Forward-Looking Statements

This press release includes “forward-looking” statements within the meaning of the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. Such statements are subject to a number of risks and uncertainties, the outcome of which could materially and/or adversely affect actual future results and the trading price of CTI’s securities. Such statements include, but are not limited to, statements regarding CTI’s expectations with respect to the development of CTI and its product and product candidate portfolio, the potential royalty payments or other obligations under the asset purchase agreement with Chroma or the license agreement with Vernalis, the expected benefits of having acquired additional rights to tosedostat, the expected progress of Phase 2 clinical trials for tosedostat and the potential for a Phase 3 registration study of tosedostat, the expected efficacy and potential benefits of tosedostat and the expected attributes of the AML Less Intensive (LI-1) trial. Risks that contribute to the uncertain nature of the forward-looking statements include, among others, risks associated with the biopharmaceutical industry in general and with CTI and its product and product candidate portfolio in particular including, among others, risks associated with the following: that CTI cannot predict or guarantee the pace or geography of enrollment of its clinical trials, that CTI cannot predict or guarantee the timely commencement or outcome of expected preclinical and clinical studies, that the AML Less Intensive (LI-1) trial will not proceed as planned, that CTI may not obtain favorable determinations by other regulatory, patent and administrative governmental authorities or will not be in a position to submit regulatory submissions as or when projected, risks related to the cost of developing tosedostat and CTI’s other product candidates, and other risks, including, without limitation, competitive factors and technological developments as well as other risks listed or described from time to time in CTI’s most recent filings with the SEC on Forms 10-K, 10-Q and 8-K.  Except as required by law, CTI does not intend to update any of the statements in this press release upon future developments.

References:

1. Hills RK, Burnett AK. Applicability of a “Pick a Winner” trial design to acute myeloid leukemia.  Blood. Sept 2011. Vol 118:2389-2394.

2. American Cancer Society, Cancer Facts & Figures 2014. Available at http://tinyurl.com/m3nxmhl. Accessed October 2014.

3. The Leukemia and Lymphoma Society, Acute Myeloid Leukemia, Rev. 2011. http://tinyurl.com/d72ycja. Accessed October 2014.

Source: CTI BioPharma Corp.

# # #


Contacts:

Monique Greer

+1 206-272-4343

mgreer@ctibiopharma.com

Ed Bell

+1 206-282-7100

ebell@ctibiopharma.com

In Europe:

CTI Life Sciences Limited, Milan Branch

Laura Villa

+39 02 94751572

lvilla@cti-lifesciences.com

GRAPHIC 7 g201410261650172261.jpg GRAPHIC begin 644 g201410261650172261.jpg M_]C_X``02D9)1@`!`0$`8`!@``#_X0!:17AI9@``34T`*@````@`!0,!``4` M```!````2@,#``$````!`````%$0``$````!`0```%$1``0````!`````%$2 M``0````!`````````````8:@``"QC__;`$,`"`8&!P8%"`<'!PD)"`H,%`T, M"PL,&1(3#Q0=&A\>'1H<'"`D+B<@(BPC'!PH-RDL,#$T-#0?)SD].#(\+C,T M,O_;`$,!"0D)#`L,&`T-&#(A'"$R,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R M,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R,O_``!$(`+,!+`,!(@`"$0$#$0'_ MQ``?```!!0$!`0$!`0```````````0(#!`4&!P@)"@O_Q`"U$``"`0,#`@0# M!04$!````7T!`@,`!!$%$B$Q008346$'(G$4,H&1H0@C0K'!%5+1\"0S8G*" M"0H6%Q@9&B4F)R@I*C0U-C+CY.7FY^CIZO'R\_3U]O?X^?K_Q``?`0`#`0$! M`0$!`0$!`````````0(#!`4&!P@)"@O_Q`"U$0`"`0($!`,$!P4$!``!`G<` M`0(#$00%(3$&$D%1!V%Q$R(R@0@40I&AL<$)(S-2\!5B7J" M@X2%AH>(B8J2DY25EI>8F9JBHZ2EIJ>HJ:JRL[2UMK>XN;K"P\3%QL?(RKR\_3U]O?X^?K_V@`,`P$``A$#$0`_`/?Z***0 M#6.%).>/2HX+B&ZA66"19(R2`RGN#@CZ@Y'X5+7+>(4O-`FDU_2QYD/#:A9_ MPRJ./,7T<#J>X'/W131,Y MXR.>^?4$GNZAJS.JG452/,@HHHI&@4444`%%%%`!1110`4444`%%%%`!1110 M`4444`4-4UG3M$MTN-2NX[:*1_+5I#P6P3C\@?RK+7QYX58X_MRS'U?%MZ=)25S"=5Q=CZGL[VTU"V6YLKJ&Y@?.V6&0.IQP>1Q M5BO+/@O*WV+6(,G8LT:_ M$KQS=:/(NBZ3)Y5VZ;[BX&"8E/15]&..3V&,/2W-Q/-YTUQ-+,3DR22% MF/XGFND^(L5&YE^'OC& M6%0QT>Z(?R\$X0]Q_M(>' MEO57,UDX8$#G8V`P^GW3_P`!JI\--;-S8RZ1.^9+4;X,GDQGM_P$_HRCM5M7 M5SCIR]G5=-[/8X+Q+:2V7B?4X91AFN9)1[J[%Q^C5EU[?XD\)V'B-$:8M#=1 MC"3Q@9QZ$=QG^N",FN2C^%5QYV)=7C\H'DK;GGK70Z'\/=4U,+->YL+8\XD7,K?1?X?^!<^U/D2W,?KB-HTZSUG+[CDK63Q]-M::+0H%/57$A8?DQ M'ZUT-B-2`_T]K5CC_E@&&/SS5RH+N]M-/MVN+VZAMH%^])-($4?4GBIOSS77_LH7 M^M6JN45XD_QJU7=\MEIJCT9F/\`6IX/C1J.09-*LY1W$M_[T/\GKU:O*?@M_J];_ M`-Z'^3UZM7-5^-G12^!!11169H%%%%`'%>//`B^*HXKJTEC@U.!=BM)G9*G7 M:Q'(P22#SC)XYKR:7P)XIAG\EM$N2V>J%74_B#BOHVBM85915C*5*,G<\J\# M_#*ZM-1@U;7@D;0,)(+-6#$..C.1QP>0`3S@YXQ7JU%)42DY.[+C%15D+111 M4E!1110!5U&T6_TRZLW/RW$+Q'Z,"/ZUXCX2U)M-\2:==9*J\@BD'3Y7^4Y] M@2#_`,!KW<]*^<[C_63&,E?F;:1VYXK2&J//QKY91DCZ,J.::*V@DGGD6.*- M2SNQP%`ZDGTI+687%I#.!@2('`^HS7EGQ`\3-J-\VD6LA%I;-B8@\2R`]/<* M1_WU]`:E1NSJJUE3AS,J>+?&D^O2/:69>'3`<8Y#3^[>B^B_GZ#F[.SN-0NX M[2TA::>0X5%_SP/>HHXWED2*)&>1V"HB]6)X`%>T^$O"T/AVPW/MDOYE'G2C MM_LK_LC]>OH!HVHH\RG">)G>6Q7\+^";/0E2ZN0MSJ.,F0CY8SZ(/TW=3ST! MQ75TM)63=SUH0C!6B+3'=8XV=V"HH)9F.`!ZT/(D4;22,$1!N9F.``.Y->$^ M//'DOB2=[#3W:/1XV[<&Y(_B;_9]%_$\X"U"#F]`G-11TWBGXLQPN]GX<5)F M!*M>R#,8_P!P?Q?[QXXX#`UYG-/JWB75HQ+).$EU&5?\`2+C'7_97 MT4?KU-=#Y:2TW.=?LELV`/9GZG_`(#CZFN]L/"' MAW3%46NC6:,O21H@[_\`?398_G6W17/*I*6YT1A&.R(UAB1=J1(J^@4"J5YH M6DZ@I6\TRRN!_P!-8%;^8K1I*F[*LCRWQ5\)X'A>[\-YBF49-G(^4?\`W&/W M3]3CI]WK7E"/<65X)(VFMKJ!R`RDQR1L."/4'J"*^J:\9^+N@+9ZK;:W`FV. M\_=3XZ>:H^4_5E!'_`/>NBE4;?*S"K327,C8\#_$W[=-'I7B!T2Y++G5[6;1]0D,MQ:('AF8Y:2+. M,-ZE3@9[@C/()*JTK>\@I5;^ZSN-98IH>H,K%6%M(00<$?*:^9UU?4-H_P") MG>=/^?E_\:^I6574JP#*1@@C@U2_L32?^@99?]^%_P`*BG44=T:5(.74^99K MZZND"3WEQ.H.X+),S@'UY-0UZS\7K&SM-*TPVUK!`6N&#&.,+GY3Z5Y-75"7 M,KG)./*[$T-W5*R9^N/K3UU?4'&5U2\8>HN7/\`6NW^%'A^ MRUC5[Z\OX$G2R1/*CD4,A=RWS$=RH7C/][/4"O;0H4````=!6W78OV+[F5 MX:DU";PUITFJJRWS6ZF8.NUMV/XAV;U'KGI6HRAE*L`5(P01UIU%8&R/*_B- MX;O-+L3K>CZEJ4,*,!.IS5E9Z'1>'?%>M:;KMG*-3O)HF MF1)89YVD1T+`-P2<''0]OTKZ-KY7LO\`D(6O_79/_0A7U145TDU8N@VTPHHH MKG-PHHHH`I:M>C3=(O+UND$+28]2!D#\:^>N(X<$\*O4UZC\3-;6*SBT6)OW MDY$L_P#LH#\H_%A_XZ?6N#\/Z:VK:_8V07B_%.\.[3;!3P M-\[CWX53^KUYRQ"J6/0#)IP6ER,9.]3E['H'PTT,3WE>GUE^'=-_LCP_8V)`#Q1#S,?WSRQ_[Z)K4K.3NSTJ%/V=-(6BBHKB M>*UMI;B=PD42%W<]%4#)-2;'F/Q:\4M#&GAVTD(:9/,O&4_P'[L?XXR?8`I3:QJMWJ5QGS;J4R,"<[1V7_@(P/H*J88\(I9SPJCJ3Z5WPCRQL<, MY8_&?_D$Z5_U\M_Z":\>KV'XS_\`()TK_KY;_P!!->/5VT?@..M\ M9ZS\%O\`5ZW_`+T/\GKU:O*?@M_J];_WH?Y/7JUWZ55\1>,--\/HT;-]HO?0&O']5U:\UK4&O+V3?*WRJHX5!V51_G-7&-SDQ&)4%RQW(;V]GU"]GO;M] M\\S;W;M^'H`.!["O4/AYX<;3K%M5NX]MS=+B-3UCBZ_@6X/T"]#FLKPAX"D> M2/4=:BV1KAHK1NK'L7'8?[/Y]Q7IE.4NB,L+AW?VDSR'XEMN\6(.?EM(QC_@ M3G^M%-6OA.2JKU[/N>\#I1116![85R?Q)O39>`M2VD;IE6W`)ZAV"L/^ M^2U=97GWQA+-'A/0WL)(/ M-M&)_Y^5_K7;+9G%'<^D:***\\[PHHHH`****`"BBB@`H MHHH`****`/,?C/\`\@G2O^OEO_037CU>P_&?_D$Z5_U\M_Z":\>KMH_`<=;X MSUGX+?ZO6_\`>A_D]>K5Y3\%O]7K?^]#_)Z]6KFJ_&SHI?`@HHHK,T"BBB@# M$\9?\B/K_P#V#KC_`-%M7S77TIXR_P"1'U__`+!UQ_Z+:OFNNK#[,Y:^Y/9? M\A"U_P"NR?\`H0KZH[5\KV7_`"$+7_KLG_H0KZH[4L1T*H=3(OKG78BWV+3+ M*=>Q>\9&_P"^?+Q_X]7):C#\0M4)CVPV<1XQ;2A,_5LEORQ7HE)6"=BYTN?= ML\LLOA?J,KYOKZV@4G)$0,C'UY.W!_.NUT3P?I&A,);>`RW(_P"7B<[G'T[# M\`*WJ6AR;)AAZ<'=(****DW/.OBG9$PZ=?J.$=H'P/[PW#/_`'RWYUPWA^7R M/$FEO_T]Q+^;`?UKVGQ'I(UO0;NPX$DB9B)/1QROX9`S[9KP?,L$F0#'/$W` M8HG= M"UPGQ;MS+X)\T#B"ZBD/MG*?S<5W=8OBS2VUGPKJ5@B[I98&,2^L@^9/_'@* MJ#M),4U>+1\U5=T>[6PUW3KQVVI;W44KG_95P3^F:HJP90PZ$9%!`92I&01@ MBN]ZJQPIV9]845S_`(+UDZ[X2T^\=]\_E^5.<\^8ORL3Z9(S]"*Z"O/:L['> MG=7"BBBD,****`"BBB@`HHHH`****`/,?C/_`,@G2O\`KY;_`-!->/5[#\9_ M^03I7_7RW_H)KQZNVC\!QUOC/6?@M_J];_WH?Y/7JU>4_!;_`%>M_P"]#_)Z M]6KFJ_&SHI?`@HHHK,T"BBB@#$\9?\B/K_\`V#KC_P!%M7S77TIXR_Y$?7_^ MP='6K5/]'G8"X51]Q^@;Z-W]_7= M7J=1S0QW$,D,T:R12*5=&&0P/4$=ZJ+LS*M256/*SC/AKJXNM&DTV1OWUF^5 MR>L;$D?D=P]ABNWKRV_T2\\!Z]'K>GI)<:4"5E4K>EVEW M!?VD5U:RB6"5=R..XHEW1GAY-1Y);HL4445)TGSQ\0-`;0/%=PJ)MM+PFXMR M!QR?F4?[K'IV!6N7KZ,\9^%XO%6AM:@I'>1'S+:5NBOZ''\)'!Z^N,@5\[W% MO/:74MKNVE/F5CCJPY7<[GX7>)UT?6FTJZ?;9Z@X"$ M]$GZ#_OH87ZA/>O?T7]3VZ$AW@;Q:WBW2I)I;-X+BW81S,H_=.V,_(?I@D'D9'7J:Y7 M:Y/,KV.JHHHJ2CS+XS#_`(DVEG_IZ8?^.&O':]G^,R_\4UIK]Q?A?SBD_P`* M\8KMH_`<=;XSUGX+?A_]GKU:O(O@M,!=ZW`2-S1P.H]<&0'^:_G7KM< MU;XV=%+X$%%%%9F@4444`8GC+_D1]?\`^P=3:R-N>TQ^ M[![LG]SZ#Y>.@))K4HIB:3=Q:***0PKB?'/@&'Q/']LLV2WU6-RV=];R6]S$3:[\)]9T]FDTITU*W' M(3(291]#\K?4$$]A77"LGN3'>CRL?\"^[^35X)=VUQ83^1>V\UM-_SSGC,;?D M:BHE2C+5"C5E'0^J+>\MKR/S+:XBGC/\4;AA^8J8D`9)X%?)YCC+;BBD]B10 MT:,/F13]1FH^K^9I[?R/I34O&7AW20WVO6+577K'&_F2?]\KEOTKSSQ#\7KB M=6M_#]L;=3Q]KN%!?ZJG('U;/TKSK3=*O]7F\G3+&>Z?."(4R%/N>B_B17I/ MAOX12,R7/B.8!>HL[=^3_ON/QX7_`+ZHY(0W%SSGLC*1@C\J^=O%7A*_\`"E^T M+OS(/!GB`>&?$UO?R9^S,##"5)89%#I(C`JP/0@CJ#7RK6EIGB#6-%4II MNIW-M&3DQH^4SZ[3D9]\5=2ES:HFG5Y=&?34DB11M)(ZHB#.IA;K->ZA M'N&XN^V!".[8P@(Z^OI7K/@SX?V?AC;>7#K=ZH5P9$8CE0V!G![X%3T45@;&)XR_Y$?7_ M`/L'7'_HMJ^:Z^H=9L/[5T/4-.W;/M=M)!N]-RE<_K7S%/!/:7,MMOFKPGI,VM^*=/LXD+*)EEF M('W8E(+$^GI]6%?2U+$-72*H+1A1117.;A1110`4444`%%%%`!1110`4444` M%%%%`!1110!%/;074)AN(8YHVZI(@8'\#6#<^`_"MT?GT.T3_K@OE?\`H&*Z M.BFFUL)I/U/HHJ2@HHHH`2L+6O!V@>()A/J6G)) M,!CS4=HW([`LI!(]C6[2TTVMA-)[F7HWA[2?#T#PZ59);JY!=@2S/CIEF))Q MD]3WK4HHI/4:5A*6DKQ+P1X?U;Q=IMQ=-XJU6U,$WE;1-(^[Y09W'P[\26L+3Z;XTU"2Y3YDCFDD"N?0G>1^8-;?PZ\4W?B70Y? M[04?;;23RI'"[?,&,AB!P#U!`XR,C&<`<5:Z8*6MFCLJ2EKSE+R[_P"%WR6O MVNX^S?9L^1YK>7GRQSMSBE&-QMV/1J**PO%?B:V\*Z(^H7"F20MY<$(./,<@ MX&>PP"2?0'J<`I*^B&VDKLW:*\KL?"WBOQG`NI>(-8;XK*W!7"GD97( M"^V[7#1# M]CU.BN5\#^,(_%NEN\D:PW]L0MS$N=O.<.N>=IP>#R"".<9/55#33LRTTU=" M45Y3XU2_U+XJ:;HMMJ][817-BG,$K@`@SG.T,`3\H%76^&>M!.M35QT.9 M?Z2U?(K:LCG?1'I-%><>%O$.NZ1XM_X1'Q+*+F25-]I=#DL-I/)P,J0KIE&Q49!^0KT:A MQM8:=Q:*\W^+5Y=V=MHYM;NXMR]PP;R963=P.N#S7H]#C9)B4KMH6BBN3^(? MB$^'O"5Q)%(4NKG_`$>`CJI8'+#W5=Q'N!ZTDKNPV[*YU=+7EWPYU'4=(U^] M\+:W)*9W1;F#S7+8;8"R@GK\I'`X!1Z]1IRCRNPHRYE<***\G\7Q:AJOQ5LM M%MM8O;&*YM1\T,S@*0LK9VA@"3MQ1&-PE*R/5Z6O-C\,M8Q\OCG5`W8YDX_\ MBU7TW5_$7@OQ;9:#K]Z=2T^_81VURQ)<,6VCD\D[BH923@,"#U!KD3V8N=K= M'J-%%>=?%Z[NK71---I=7%NSW>TF"9HR1L;@E2*F,>9V'*7*KGHM)7(?#_Q2 MWB+1VM[TD:K8D17*LNTMV#X]3@@CC#`\`8K?UO6+70-'N=3O"?)@7.U>KL>` MH]R<#\:'%IV!235S1HKQOP!KFKZQ\1))M1NKC%Q;23?9S(WE*#L*[4SC&W&# MCD<\YS7L=.<>5V80ES*XM)2UY=\1M1U'5]?LO"VB22"X2-KF;RI"I+!6*J2. MG`/!X)9*48\SL$IHT5R7PZ\0GQ!X2MWED+W=K_H\Y)Y8@#:Q]=RX)]\^ ME=;2:L[,:=U<2O"_`/BK4?#^E74-CX:O=566?>TMNKD(=H&T[4;GC/XU[IVK MR_X-W$$&@:B)9HXR;H8#L!GY%K2'PLSFO>5B+5OB7XE73IC!X0O=/.T_Z5<1 MRE8_?!C4?F<>QK;^%EKI5MX8;^S]16]N))-]VVTJ4?&`N&&[``X)^\.]^(_B"_TF,QZ.T9&`NT%BZE3CWQ* M0.P;M3WB]+"U4E=W/5Z\R3_DO4G_`%Z_^TQ7IM>9)_R7J3_KU_\`:8J:?7T* MGT]3TRO+OB$HU'X@^%],N<&T+JS*>C[I!N!].&^*_O;1W& M]3WV_P!Y?0C\<'(%S7O$^D^&[5IM0ND63:2ENA!ED]E7O]>@[D4N5WL/F5KG M":*BZ=\<]6MK?`AGB9G4=`62.0D^^[/_`'U7J=>;?#C3;[4]7U'QGJ49C>_R MELI/5"021_LX5%4]PI/0C/I-54WL33V/*O%5Y;:?\;=%N[N9(+>*Q0O(YPJY M^T#G\2*[*7Q[X5BC9SKEHP`R0C%S^`&2:XSQ796VI?&O1K.\A6:VFL4#QMT; M!N#_`#`KLD\`>%4<,-$MC@]'RP_$$XJGRV5R8\UW8XS2)Y/'/Q3BUZS@DCTK M3(_*\V1<>80'P/9B9"<=E`S@MBO5ZBMK:"RMTM[6"."&,82.)`JJ/8#I4U9R MEFUI)I)71$4VW9GA?CCQ/J/B"/3DOO#MWI M2PS%E>NB_P#7PW\A7IU*;3BK!!-2=PKS&[QXU^+$ M-J/GTS01ND/9I01D?]]A1@]HW]:[3Q9KB^'?#5[J.5\U$VP*?XI&X7\,\GV! M/:O./#'PXUB[T2WU./Q/>:9+?()7C@W@L#DJ699%R2#GD<;B*())783;;LC: M^*%E/IT^E>+K!1]JT^58Y3G&Y"?E!/IDE./^>IKOM.OH-3TZVO[5BT%Q&LL9 M(P<$9Y]#[5Y[-\+]9N(FAG\Z;L-CU`;G/I(*&DXZ/8$VI:K<](KR7Q3J=IHWQGTW4KZ0QVL%H#(P0 ML1E)E'`&>I%>M5Y9K=O#=?'32(+B&.:%[7YHY%#*W[N<\@]>:5/=W[#J7LK& M\?BKX2P<7T[$#H+63G]*YQ9[OXD^-M*U"TLI[;0])D$JW$RX,C!E8@=CDHHP M"<`$D@D+79:]X(T;6M'FLX[*ULYF&Z*XA@56C<=#QC([$=P3TZU@?#SQ)=17 M$OA'7?W>IV.4@+GF1`,[<]R!@@_Q+@]B:I6LW'<3O>TCT6O,_C/_`,@'3/\` MK[/_`*`U>F5YG\9_^0#IG_7V?_0&J:?Q(JI\+(O&FG7/@_Q+!XTTB/,#N([^ M!>`V[`)/H&X^CA3SDU6OKD_%'QA!I]JSCP]IX6:>3YE,A(_0GE1T(`<@]!7J M=W:P7UG-:748E@F0QR(W1E(P169X9\.6?A;21I]F7<%S))+)C?(Q[G''0`?0 M"FIJWF3R._D<1I<<@`EP*<4E'5[BDVY:+8BM,>"OBU-:GY- M,UT!D]%D).!_WV6``Z"1?2O4*\=\4?#C5[/1+C5)?$UYJ&;/42R^&X[<\CV(HFDTF@@VG9FYVK MP3_A&])*@FTSQWD;_&BBKH=2:W0O:/X2T.ZU6V@FLLQR/M8"9UR/J&R*]@TW M2['1K);33K6.V@4YV1C&3ZGN3[GFBBIK-CI)%VN)2QMO^%IR7GE_Z1Y&-^X_ MW`.F<445$.II+H=M1114%'D7Q1\,:+8VJ7UKI\4,\[-YFS(5L8YV9VYY.3CG MO5#X8>&-%U:226^T^*U@`<`8`Z4M% M%/-Q';!5?<>!^^[9QW-=OVHHJY[(B/4****@LXK4["V MD^*6E7KQYN([8*K[CP,3=LX[FNUHHJY]"(]3B?B'86U_!IPN8]X29BOS$8X' MH:[8=***'\*!?$SB/B!8V^IRZ/9WB&2W:9F,>\J"?E7/!'9F'XFNU4!5`4`` M<`#M111+X4"^)CJX:^TZU@^*-G?PQ%+F:-?,=7(WY5UY&<'A5'X"BBB`3Z'< MUQ%]8VS_`!4TZ\:/-PD!"ON/'R2CIG'O//B+IUJ-1T[5%BVWT2 M.4G1BK#859>AYP2>OK113I_$%3X3T.N+^(]C;7^E627,>]5N-P&XCG8WH:** M4/B"?PG:4445!9Q-K86R_%.^O1'_`*0T&"^X_P!Q!TSCL*[:BBKGT(AU.'L= M/M9_BE>WTL>^YBA/ENS$[/E1>!G`X9O^^CZUW%%%$P@-=5=&5E#*1@@C((KQ BZSC_`+#^T6FF2SVL!F9BDO7``_"BBM*/4FH?_V3\_ ` end