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Termination of Servier Agreement (Details)
€ in Thousands, $ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 28, 2019
EUR (€)
Mar. 31, 2019
USD ($)
Mar. 31, 2018
USD ($)
Dec. 31, 2018
EUR (€)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Total revenues | $   $ 640 $ 10,846  
Collaborative Arrangement, Product | Servier        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Reimbursement of costs incurred € 620      
Receivable required upon counterparty entering asset purchase agreement 2,000      
Extends Beyond May 31, 2019, Monthly Amount | Collaborative Arrangement, Product | Servier        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Reimbursement of costs incurred 50      
Extends Beyond May 31, 2019 | Collaborative Arrangement, Product | Servier        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Reimbursement of costs incurred € 200      
License and contract revenue | Collaborative Arrangement, Product | Servier        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Total revenues   $ 400   € 65