CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Revenues:
Total revenues	$ 26,290	$ 25,146
Operating costs and expenses:
Cost of product sold	879	364
Research and development	36,467	32,866
Selling, general and administrative	21,183	31,435
Restructuring expenses	660	0
Total operating costs and expenses	59,189	64,665
Loss from operations	(32,899)	(39,519)
Non-operating expense:
Interest income	1,219	0
Interest expense	(1,209)	(1,872)
Amortization of debt discount and issuance costs	(525)	(163)
Foreign exchange (loss) gain	(233)	817
Other non-operating income (expense)	4,295	(94)
Total non-operating income (expense), net	3,547	(1,312)
Net loss before noncontrolling interest	(29,352)	(40,831)
Noncontrolling interest	32	161
Net loss	(29,320)	(40,670)
Deemed dividends on preferred stock	(80)	(4,350)
Net loss attributable to common stockholders	$ (29,400)	$ (45,020)
Basic and diluted net loss per common share (in USD per share)	$ (0.52)	$ (1.24)
Shares used in calculation of basic and diluted net loss per common share (in shares)	56,073	36,445
Product sales, net
Revenues:
Total revenues	$ 0	$ 853
License and contract revenue
Revenues:
Total revenues	$ 26,290	$ 24,293