CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Operating activities
Net loss	$ (46,392)	$ (94,747)
Adjustments to reconcile net loss to net cash used in operating activities:
Baxalta milestone revenue	(32,000)	0
Share-based compensation expense	11,225	12,997
Depreciation and amortization	636	757
Loss on debt extinguishment	0	1,211
Provision for bad debt	1,736	176
Reserve for excess, obsolete or unsalable inventory	1	754
Other-than-temporary impairment on available-for-sale securities	519	0
Noncash interest expense	177	351
Change in value of warrant liability	0	(135)
Noncash rent benefit	(346)	(304)
Changes in operating assets and liabilities:
Accounts receivable	(372)	1,253
Receivables from collaborative arrangements	(3,024)	0
Inventory	339	510
Prepaid expenses and other current assets	2,011	(652)
Other assets	324	771
Accounts payable	3,341	7,119
Accrued expenses	636	(2,504)
Deferred revenue	(923)	(681)
Other liabilities	1	3
Total adjustments	(15,719)	21,626
Net cash used in operating activities	(62,111)	(73,121)
Investing activities
Purchases of property and equipment	(137)	(31)
Net cash used in investing activities	(137)	(31)
Financing activities
Proceeds from common stock offering	0	15,700
Repayment of Hercules debt	(3,578)	(4,659)
Payment of tax withholding obligations related to stock compensation	(311)	(580)
Cash paid for preferred stock issuance costs	(314)	(227)
Other	21	83
Net cash (used in) provided by financing activities	(4,182)	48,187
Effect of exchange rate changes on cash and cash equivalents	(157)	387
Net decrease in cash and cash equivalents	(66,587)	(24,578)
Cash and cash equivalents at beginning of period	128,182	70,933
Cash and cash equivalents at end of period	61,595	46,355
Supplemental disclosure of cash flow information
Cash paid during the period for interest	3,848	1,507
Cash paid during the period for taxes	0	0
Supplemental disclosure of noncash financing and investing activities
Baxalta milestone advance - earned in lieu of repayment	(32,000)	0
Repayment and issuance of Hercules debt	0	13,815
Hercules
Financing activities
Proceeds from debt	0	5,870
Baxalta
Financing activities
Proceeds from debt	$ 0	$ 32,000