CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
Product sales, net	$ 986	$ 745	$ 3,260	$ 2,409
License and contract revenue	3,447	219	45,009	2,383
Total revenues	4,433	964	48,269	4,792
Operating costs and expenses:
Cost of product sold	163	831	513	1,204
Research and development	17,716	18,404	55,259	55,195
Selling, general and administrative	15,218	13,682	36,101	38,603
Other operating expense	0	0	0	253
Total operating costs and expenses	33,097	32,917	91,873	95,255
Loss from operations	(28,664)	(31,953)	(43,604)	(90,463)
Non-operating income (expense):
Interest expense	(634)	(1,288)	(2,025)	(2,379)
Amortization of debt discount and issuance costs	(38)	(40)	(177)	(351)
Foreign exchange loss	(69)	(18)	(107)	(561)
Other non-operating income (expense)	44	203	(479)	(993)
Total non-operating expense, net	(697)	(1,143)	(2,788)	(4,284)
Net loss before noncontrolling interest	(29,361)	(33,096)	(46,392)	(94,747)
Noncontrolling interest	178	504	755	962
Net loss	$ (29,183)	$ (32,592)	$ (45,637)	$ (93,785)
Basic and diluted net loss per common share (in dollars per share)	$ (0.10)	$ (0.19)	$ (0.16)	$ (0.54)
Shares used in calculation of basic and diluted net loss per common share (in shares)	280,018	176,004	279,187	175,143