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Milestone Payments (Detail)
3 Months Ended 9 Months Ended
Sep. 30, 2016
USD ($)
Mar. 31, 2016
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Jun. 30, 2015
USD ($)
payment
Debt Instrument [Line Items]            
License and contract revenue $ 3,447,000   $ 219,000 $ 45,009,000 $ 2,383,000  
Borrowing Associated With License Agreement            
Debt Instrument [Line Items]            
Milestone payment           $ 32,000,000.0
Milestone advance interest rate           9.00%
Baxalta            
Debt Instrument [Line Items]            
Gain on termination of agreement $ 4,200,000     $ 4,200,000    
Baxalta | Borrowing Associated With License Agreement            
Debt Instrument [Line Items]            
Number of milestone payments | payment           2
License and contract revenue   $ 32,000,000        
Baxalta | PERSIST-2 Milestone | Borrowing Associated With License Agreement            
Debt Instrument [Line Items]            
Milestone payment           $ 20,000,000.0
Baxalta | European Medicines Agency Milestone | Borrowing Associated With License Agreement            
Debt Instrument [Line Items]            
Milestone payment           $ 12,000,000.0