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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GBq/hOfv7rpC2LUbl7IEWFCSL5Rg3KyYvArA6mgGKxGyabLLc5FbY4ZkR38N9r7D
 d56tRwr31VFYkppy2BuaXg==

<SEC-DOCUMENT>0001219016-05-000003.txt : 20050111
<SEC-HEADER>0001219016-05-000003.hdr.sgml : 20050111
<ACCEPTANCE-DATETIME>20050111170148
ACCESSION NUMBER:		0001219016-05-000003
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050103
FILED AS OF DATE:		20050111
DATE AS OF CHANGE:		20050111

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BONNEY MICHAEL W
		CENTRAL INDEX KEY:			0001219016

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23272
		FILM NUMBER:		05524004

	MAIL ADDRESS:	
		STREET 1:		65 HAYDEN AVE
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NPS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000890465
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				870439579
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		420 CHIPETA WAY STE 240
		CITY:			SALT LAKE CITY
		STATE:			UT
		ZIP:			84108-1256
		BUSINESS PHONE:		8015834939
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2005-01-03</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000890465</issuerCik>
        <issuerName>NPS PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>NPSP</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001219016</rptOwnerCik>
            <rptOwnerName>BONNEY MICHAEL W</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>383 COLOROW DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SALT LAKE CITY</rptOwnerCity>
            <rptOwnerState>UT</rptOwnerState>
            <rptOwnerZipCode>84108</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Michael W. Bonney</signatureName>
        <signatureDate>2005-01-05</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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