Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenues:
Product sales, net	$ 101,195	$ 31,752	$ 0
Royalties	122,867	123,804	105,587
Sale of royalty rights	0	0	25,000
License fees	0	36	57
Total revenues	224,062	155,592	130,644
Cost of sales	14,648	3,596	0
Operating expenses:
Research and development	90,109	85,421	94,839
Selling, general and administrative	114,255	68,070	36,929
Total operating expenses	204,364	153,491	131,768
Operating income (loss)	5,050	(1,495)	(1,124)
Other income (expense)
Interest income, net	406	340	292
Interest expense	(13,728)	(11,938)	(18,198)
Gain on sale of marketable investment securities, net	12	4	4
Foreign currency transaction (loss) gain	22	(233)	54
Other	299	0	237
Total other expense, net	(12,989)	(11,827)	(17,611)
Loss before income tax expense	(7,939)	(13,322)	(18,735)
Income tax expense	766	182	0
Net loss	$ (8,705)	$ (13,504)	$ (18,735)
Net loss per common and potential common share
Basic	$ (0.08)	$ (0.14)	$ (0.22)
Diluted	$ (0.08)	$ (0.14)	$ (0.22)
Weighted average common and potential common shares outstanding
Basic	106,341	97,750	86,999
Diluted	106,341	97,750	86,999