Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2014	Sep. 30, 2013
Cash flows from operating activities:
Net loss	$ (6,730)	$ (21,272)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	2,433	1,871
Accretion of premium (discount) on marketable investment securities	2,534	1,962
Shares issued for payment of services	0	549
Non-cash interest expense	6,036	8,674
Non-cash royalties	(30,387)	(29,831)
Compensation expense on share-based awards	11,249	7,343
Realized gain on sale of marketable investment securities	(12)	(2)
(Increase) decrease in operating assets:
Accounts receivable	1,124	(4,041)
Inventory	(4,239)	6,118
Prepaid expenses, other current assets and other assets	(1,119)	528
(Decrease) increase in operating liabilities:
Accounts payable and accrued expenses	3,003	4,263
Other liabilities	3,791	(1,242)
Net cash used in operating activities	(12,317)	(25,080)
Cash flows from investing activities:
Sales of marketable investment securities	8,661	6,451
Maturities of marketable investment securities	91,108	58,251
Purchases of marketable investment securities	(89,008)	(114,738)
Acquisitions of property and equipment	(1,883)	(608)
Net cash provided by (used in) investing activities	8,878	(50,644)
Cash flows from financing activities:
Net proceeds from the sale of common stock	0	93,454
Net proceeds from the exercise of stock options	8,517	11,684
Excess tax benefit from stock options	227	0
Shares withheld for the payment of taxes	(2,154)	(618)
Net cash provided by financing activities	6,590	104,520
Effect of exchange rate changes on cash	(987)	0
Net increase in cash and cash equivalents	2,164	28,796
Cash and cash equivalents at beginning of period	51,204	17,471
Cash and cash equivalents at end of period	53,368	46,267
Supplemental Disclosures of Cash Flow Information
Cash paid for interest	256	712
Cash paid for income taxes	218	4
Supplemental Disclosure of Non-cash Investing and Financing Activities
6.1 million shares of NPS common stock issued in connection with the Takeda Termination and Transition agreement	0	55,403
Unrealized (loss) gain on marketable investment securities	(9)	14
Accrued acquisition of property and equipment	699	69
Noncash reductions of debt	25,111	20,245
Conversion of 5.75% convertible notes	$ 16,535	$ 0