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Collaborative and License Agreements (Tables)
12 Months Ended
Dec. 31, 2013
Collaborative And License Agreements Tables  
Revenues from Takeda related to the Preotact agreement

Revenues from Takeda related to the Preotact agreement, for the years ended December 31, are as follows (in thousands):

      2012     2011     2010
Royalties   $ 4,786    $ 9,116    $ 9,467 
Product sales             452 
     Total revenues                                                      $ 4,786    $ 9,116    $ 9,919