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Stock Option Plans, Shares Reserved and Warrants (Details) - 2009 Equity Incentive Plan [Member] - $ / shares
6 Months Ended
Jun. 30, 2019
Dec. 31, 2018
Jun. 30, 2019
Number of options      
Outstanding Options, beginning     9,298,101
Options Granted     90,000
Options Cancelled/Expired     (1,042,043)
Outstanding Options, ending 8,346,058 9,298,101 8,346,058
Exercisable Options 6,551,706 6,130,337 6,551,706
Weighted average exercise price      
Outstanding options, beginning     $ 4.40
Options Granted     3.09
Options Canceled/Expired     4.34
Outstanding Options, ending $ 4.38 $ 4.40 4.38
Exercisable Options $ 4.72   $ 4.72
Weighted average remaining contractual life      
Outstanding Options 6 years 10 months 21 days 7 years 11 months 1 day  
Options Granted     9 years 7 months 2 days
Exercisable Options 6 years 5 months 15 days