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Stock Option Plans, Shares Reserved and Warrants (Details) - 2009 Equity Incentive Plan [Member] - $ / shares
1 Months Ended 3 Months Ended
Jan. 30, 2019
Mar. 31, 2019
Number of options    
Outstanding Options, beginning 9,298,101 9,298,101
Options Granted 90,000 90,000
Options Canceled/Expired   (442,223)
Outstanding Options ending   8,945,878
Exercisable Options   6,653,303
Weighted average exercise price    
Outstanding options, beginning $ 4.40 $ 4.40
Options Granted $ 3.09 3.09
Options Canceled/Expired   3.31
Outstanding Options ending   4.43
Exercisable Options   $ 4.84
Weighted average remaining contractual life    
Balance   7 years 11 months 1 day
Options Granted   9 years 10 months 2 days
Outstanding Options   6 years 9 months 22 days
Exercisable Options   6 years 2 months 5 days