STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	12 Months Ended		89 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2011
OPERATING ACTIVITIES
Net loss	$ (9,711)	$ (10,871)	$ (146,392)
Non cash items:
Deferred tax expense	0	0	770
Depreciation and amortization	117	135	3,942
Non-cash stock-based compensation	159	275	4,824
Gain on sale of bone device business	0	0	(2,298)
In-process research and development	0	0	34,311
Change in other operating items:
Interest, income taxes and other current assets	(115)	1,017	950
Accounts payable	(169)	(473)	(894)
Accrued liabilities	(871)	(778)	(2,975)
Cash flows used in operating activities	(10,590)	(10,695)	(107,762)
INVESTING ACTIVITIES
Expenditures for furniture and equipment, net	(19)	(60)	(1,044)
Proceeds from sale of assets	0	0	7,000
Cash paid for assets of AzERx/CBI	0	0	(4,058)
Cash paid for patent assignment rights	0	0	(650)
Purchases of investments	0	(25,140)	(282,538)
Maturities of investments	0	47,408	340,476
Cash flows provided by investing activities	(19)	22,208	59,186
FINANCING ACTIVITIES
Net proceeds from stock option exercises	0	0	4,612
Net proceeds from sale of stock	0	0	3,376
Common stock purchases	0	0	(1,041)
Cash flows provided by financing activities	0	0	6,947
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	(10,609)	11,513	(41,629)
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD	24,387	12,874	55,407
CASH AND CASH EQUIVALENTS, END OF YEAR	13,778	24,387	13,778
Supplemental Disclosure of Non-Cash Investing Activities
Current assets acquired	0	0	29
Patents acquired	0	0	2,142
Liabilities acquired, and accrued acquisition costs	0	0	(457)
Original investment reversal	0	0	(750)
In-process research and development acquired	0	0	34,311
Common stock issued for acquisitions	0	0	(31,217)
Cash paid for acquisitions	$ 0	$ 0	$ 4,058