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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2023

Dec. 31, 2022

Dec. 31, 2021

Dec. 31, 2020


							Value of Initial Fixed $100 Investment Based on:
Year	Summary Compensation Table Total for PEO Todd C. Davis ($)	Summary Compensation Table Total for PEO John L. Higgins ($)	Compensation Actually Paid to PEO Todd C. Davis ($)(1)	Compensation Actually Paid for PEO John L. Higgins ($)	Average Summary Compensation Table Total for Non-PEO NEOs ($)	Average Compensation Actually Paid to Non-PEO NEOs ($)(2)(3)	Total Shareholder Return ($)	Peer Group Total Shareholder Return ($)(4)	Net Income (Loss) ($ thousands)	Revenue ($ thousands)
2023	6,216,518	—	5,060,695	—	2,788,000	2,366,969	98.71	118.87	52,154	131,314
2022	5,195,169	16,764,990	4,977,510	12,243,958	3,852,731	2,922,612	92.32	113.65	(33,361)	196,245
2021	—	9,587,211	—	15,958,534	4,996,210	7,722,154	148.11	126.45	57,138	241,544
2020	—	5,842,767	—	6,788,815	2,846,812	3,246,826	95.36	126.42	(2,985)	163,562

Company Selected Measure Name

Revenue

Named Executive Officers, Footnote

Amounts represent compensation actually paid to our PEO and the average compensation actually paid to our remaining NEOs for the relevant fiscal year, as determined under SEC rules (and described below), which includes the individuals indicated in the table below for each fiscal year:


Year	PEO	Non-PEO NEOs
2023	Todd C. Davis	Matthew Korenberg, Tavo Espinoza, and Andrew Reardon
2022	Todd C. Davis, John L. Higgins	Matthew Korenberg, Tavo Espinoza, Andrew Reardon, Matthew W. Foehr, and Charles S. Berkman
2021	John L. Higgins	Matthew Korenberg, Matthew W. Foehr, and Charles S. Berkman
2020	John L. Higgins	Matthew Korenberg, Matthew W. Foehr, and Charles S. Berkman

Peer Group Issuers, Footnote

(4) For the relevant fiscal year, the Peer Group TSR is from the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2023. The calculation of the TSR assumes an initial investment of $100 on January 1, 2019 through December 31 of the applicable year in the table above, assuming all dividends are reinvested.

Adjustment To PEO Compensation, Footnote

Compensation actually paid to our current PEO, Todd C. Davis for the current fiscal year is presented in the following table:


Year	Summary Compensation Table Total for Todd C. Davis ($)	Exclusion of Stock Awards and Option Awards for Todd C. Davis ($)	Inclusion of Equity Values for Todd C. Davis ($)	Compensation Actually Paid to Todd C. Davis ($)
2023	6,216,518	(5,166,551)	4,010,728	5,060,695

ompensation actually paid to our NEOs represents the “Total” compensation reported in the Summary Compensation Table, as adjusted as follows:


		Adjustments(1)
	Year	Year-End ASC 718 Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for ($)	Change in ASC 718 Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards ($)	Vesting-Date ASC 718 Fair Value of Equity Awards Granted During Year that Vested During Year ($)	Change in ASC 718 Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year ($)	ASC 718 Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year ($)	Total - Inclusion of Equity Value ($)
Todd C. Davis	2023	4,302,070	(354,271)	246,646	(183,717)	—	4,010,728
Non-PEO NEOs	2023	1,751,529	(69,868)	100,496	(98,262)	—	1,683,895

(1) Fair value or change in fair value, as applicable, of equity awards in the “Compensation Actually Paid” columns was determined by reference to (i) for solely service-vesting RSU awards, the closing price per share on the applicable year-end dates or, in the case of vesting dates, the closing price per share on the applicable vesting dates; (ii) for stock options, a Black-Scholes value as of the applicable year-end or vesting dates, determined based on the same methodology as used to determine grant date fair value but using the closing stock price on the applicable revaluation date as the current market price and with an expected life set equal to the remaining life of the award in the case of underwater stock options and, in the case of in the money options, an expected life equal to the original ratio of expected life relative to the ten year contractual life times the remaining life as of the applicable revaluation date, and in all cases based on volatility and risk free rates determined as of the revaluation date based on the expected life period and based on an expected dividend yield based on our dividend yield methodology used for valuing stock options generally; and (iii) for PSUs, calculated by a Monte Carlo simulation model as of the applicable revaluation dates, which utilizes multiple input variables, including expected volatility of our stock price and other assumptions appropriate for determining fair value, to estimate the probability of satisfying the performance objective established for the award, including the expected volatility of our stock price relative to the applicable comparative index and a risk-free interest rate. For additional information about the assumptions used to value our stock and option awards, please see Note 10 of the Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2023, filed with the SEC on February 29, 2024, and our Annual Report on Form 10-K for prior years.

Non-PEO NEO Average Total Compensation Amount

$ 2,788,000

$ 3,852,731

$ 4,996,210

$ 2,846,812

Non-PEO NEO Average Compensation Actually Paid Amount

$ 2,366,969

2,922,612

7,722,154

3,246,826

Adjustment to Non-PEO NEO Compensation Footnote

Average compensation actually paid to our non-PEO NEOs for the current fiscal year is presented in the following table:


Year	Average Summary Compensation Table Total for Non-PEO NEOs	Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs	Average Inclusion of Equity Values for Non-PEO NEOs	Average Compensation Actually Paid to Non-PEO NEOs
2023	2,788,000	(2,104,926)	1,683,895	2,366,969

ompensation actually paid to our NEOs represents the “Total” compensation reported in the Summary Compensation Table, as adjusted as follows:


		Adjustments(1)
	Year	Year-End ASC 718 Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for ($)	Change in ASC 718 Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards ($)	Vesting-Date ASC 718 Fair Value of Equity Awards Granted During Year that Vested During Year ($)	Change in ASC 718 Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year ($)	ASC 718 Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year ($)	Total - Inclusion of Equity Value ($)
Todd C. Davis	2023	4,302,070	(354,271)	246,646	(183,717)	—	4,010,728
Non-PEO NEOs	2023	1,751,529	(69,868)	100,496	(98,262)	—	1,683,895