Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Basis of Presentation [Line Items]
Share-based compensation expense	$ 12,597	$ 9,754	$ 31,140	$ 28,375
SBC - Research and development expenses
Basis of Presentation [Line Items]
Share-based compensation expense	6,104	4,480	14,519	12,975
SBC - General and administrative expenses
Basis of Presentation [Line Items]
Share-based compensation expense	$ 6,493	$ 5,274	$ 16,621	$ 15,400