Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Basis of Presentation [Line Items]
Share-based compensation expense	$ 9,499	$ 10,216	$ 18,543	$ 18,621
SBC - Research and development expenses
Basis of Presentation [Line Items]
Share-based compensation expense	4,501	4,556	8,415	8,495
SBC - General and administrative expenses
Basis of Presentation [Line Items]
Share-based compensation expense	$ 4,998	$ 5,660	$ 10,128	$ 10,126