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Stockholders' Equity
 12 Months Ended
Dec. 31, 2021
Equity [Abstract]  
Stockholders' Equity Stockholders’ Equity
Share-based Compensation Expense

The following table summarizes non-cash share-based compensation expense (in thousands):
December 31,
202120202019
Share-based compensation expense as a component of:
Research and development expenses$17,436 $13,497 $9,641 
General and administrative expenses21,347 17,230 14,874 
$38,783 $30,727 $24,515 

Stock Plans

In December 2020, our 2002 Stock Incentive Plan was amended to increase the number of shares available for issuance by 1.1 million shares. As of December 31, 2021, there were 0.7 million shares available for future option grants or direct issuance under the Amended 2002 Plan.
Following is a summary of our stock option plan activity and related information:
 
Shares
Weighted
Average
Exercise
Price
Weighted
Average
Remaining
Contractual
Term in
Years
Aggregate
Intrinsic
Value
(In thousands)
Balance at January 1, 20191,736,304 $66.71 5.47$125,858 
Granted338,617 $116.69 
Exercised(112,011)$23.65 
Forfeited(6,531)$139.37 
Balance at December 31, 20191,956,379 $77.54 5.4572,002 
Exercisable at December 31, 20191,454,726 $61.82 4.4270,345 
Options vested and expected to vest as of December 31, 20191,956,379 $77.54 5.45$72,002 
Granted806,300 $92.93 
Exercised(156,845)$21.26 
Forfeited(44,012)$91.30 
Balance at December 31, 20202,561,822 $85.59 6.0959,033 
Exercisable at December 31, 20201,611,830 $76.05 4.5453,286 
Options vested and expected to vest as of December 31, 20202,561,822 $85.59 6.09$59,033 
Granted393,589 $159.12 
Exercised(619,731)$54.28 
Forfeited(136,082)$110.83 
Balance at December 31, 2021 2,199,598 $106.00 6.34113,302 
Exercisable at December 31, 20211,391,952 $98.16 5.1280,849 
Options vested and expected to vest as of December 31, 20212,199,598 $106.00 6.34$113,302 

The weighted-average grant-date fair value of all stock options granted during 2021, 2020 and 2019 was $80.08, $41.39 and $48.65 per share, respectively. The total intrinsic value of all options exercised during 2021, 2020 and 2019 was approximately $77.3 million, $11.9 million and $10.4 million, respectively.
Cash received from options exercised, net of fees paid, in 2021, 2020 and 2019 was $33.0 million, $2.5 million and $2.6 million, respectively.
Following is a further breakdown of the options outstanding as of December 31, 2021:
 
Range of exercise prices
Options
outstanding
Weighted
average
remaining  life
in years
Weighted average
exercise price
Options
exercisable
Weighted average
exercise price
$12.53-$56.26
253,824 1.94$37.55 239,824 $38.90 
$67.53-$74.42
278,281 4.04$72.10 217,587 $73.17 
$82.90-$95.35
159,988 5.06$86.11 132,963 $86.24 
$95.68
266,263 8.12$95.68 109,154 $95.68 
$98.20-$100.38
294,772 7.33$99.10 160,120 $99.79 
$101.07-$117.58
159,204 7.45$111.26 99,488 $111.18 
$117.97237,292 7.12$117.97 158,958 $117.97 
$119.08-$159.01
299,585 7.00$149.40 205,098 $152.50 
$159.81-$171.28
6,881 6.51$166.28 5,828 $165.62 
$177.50-$195.91
243,508 8.91$178.62 62,932 $181.84 
2,199,598 6.34$106.00 1,391,952 $98.16 
The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:
 Year Ended December 31,
 202120202019
Risk-free interest rate
0.4%-1.2%
0.2%-1.4%
1.4%-2.6%
Expected volatility
47%-63%
47%-71%
40%-49%
Expected term
4.7 to 6.3 years
4.7 to 5.1 years
4.6 to 5.9 years

As of December 31, 2021, there was $40.7 million of total unrecognized compensation cost related to non-vested stock options. That cost is expected to be recognized over a weighted average period of 2.4 years.
Restricted Stock Activity
The following is a summary of our restricted stock activity and related information: 
Shares
Weighted-Average
Grant Date Fair
Value
Outstanding at January 1, 2019132,273 $130.63 
Granted118,498 $115.90 
Vested(102,846)$121.55 
Forfeited(666)$134.36 
Outstanding at December 31, 2019147,259 $125.11 
Granted111,306 $89.73 
Vested(52,363)$121.69 
Forfeited— $— 
Outstanding at December 31, 2020206,202 $106.88 
Granted167,292 $169.63 
Vested(98,501)$125.59 
Forfeited(10,850)$141.85 
Outstanding at December 31, 2021264,143 $138.21 
As of December 31, 2021, unrecognized compensation cost related to non-vested stock awards amounted to $20.6 million. That cost is expected to be recognized over a weighted average period of 1.6 years.

Employee Stock Purchase Plan

As of December 31, 2021, 44,360 shares of our common stock are available for future issuance under the Amended Employee Stock Purchase Plan, or ESPP. The ESPP permits eligible employees to purchase up to 1,250 shares of Ligand common stock per calendar year at a discount through payroll deductions. The price at which stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first of a six month offering period or purchase date, whichever is lower. There were 8,448, 6,455 and 4,745 shares issued under the ESPP in 2021, 2020 and 2019, respectively.

Share Repurchases

On September 11, 2019, our Board of Directors approved a stock repurchase program authorizing the repurchase of up to $500.0 million of our common stock from time to time over the next three years. We expect to acquire shares primarily through open-market transactions and have entered into a Rule 10b5-1 trading plan, and may enter into additional Rule 10b5-1 trading plans in the future, to facilitate open-market repurchases. The timing and amount of repurchase transactions will be determined by management based on our evaluation of market conditions, share price, legal requirements and other factors. Our prior $350.0 million stock repurchase program was terminated in connection with the approval of the new stock repurchase program. Authorization to repurchase $248.8 million of our common stock remained available as of December 31, 2021.
During the twelve months ended December 31, 2021, we did not repurchase any common stock. During the twelve months ended December 31, 2020 and 2019, we repurchased 934,079 shares for $78.0 million, and 4,122,133 shares for $448.4 million, respectively.