Lease Obligations (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2013
Payments expected to received from sublease agreements
Total operating lease obligations	$ 14,398
Net operating lease obligations	12,004
Corporate headquarters-San Diego, CA
Payments expected to received from sublease agreements
Lease Termination Date	Jul. 01, 2019
Total operating lease obligations	3,874
Bioscience and Technology Business Center-Lawrence, KS
Payments expected to received from sublease agreements
Lease Termination Date	Dec. 01, 2014
Total operating lease obligations	57
Vacated office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Lease Termination Date	Jul. 01, 2015
Total operating lease obligations	3,572
Vacated office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Lease Termination Date	Aug. 01, 2016
Total operating lease obligations	6,895
Office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Lease Termination Date	Jul. 01, 2015
Net operating lease obligations	1,451
Office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Net operating lease obligations	943
Less than 1 year
Payments expected to received from sublease agreements
Total operating lease obligations	5,524
Net operating lease obligations	4,250
Less than 1 year | Corporate headquarters-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations	664
Less than 1 year | Bioscience and Technology Business Center-Lawrence, KS
Payments expected to received from sublease agreements
Total operating lease obligations	57
Less than 1 year | Vacated office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations	2,240
Less than 1 year | Vacated office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Total operating lease obligations	2,563
Less than 1 year | Office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Net operating lease obligations	906
Less than 1 year | Office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Net operating lease obligations	368
2-3 years
Payments expected to received from sublease agreements
Total operating lease obligations	7,045
Net operating lease obligations	5,925
2-3 years | Corporate headquarters-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations	1,381
2-3 years | Bioscience and Technology Business Center-Lawrence, KS
Payments expected to received from sublease agreements
Total operating lease obligations
2-3 years | Vacated office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations	1,332
2-3 years | Vacated office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Total operating lease obligations	4,332
2-3 years | Office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Net operating lease obligations	545
2-3 years | Office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Net operating lease obligations	575
4-5 years
Payments expected to received from sublease agreements
Total operating lease obligations	1,455
Net operating lease obligations	1,455
4-5 years | Corporate headquarters-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations	1,455
4-5 years | Bioscience and Technology Business Center-Lawrence, KS
Payments expected to received from sublease agreements
Total operating lease obligations
4-5 years | Vacated office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations
4-5 years | Vacated office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Total operating lease obligations
4-5 years | Office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Net operating lease obligations
4-5 years | Office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Net operating lease obligations
More than 5 years
Payments expected to received from sublease agreements
Total operating lease obligations	374
Net operating lease obligations	374
More than 5 years | Corporate headquarters-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations	374
More than 5 years | Bioscience and Technology Business Center-Lawrence, KS
Payments expected to received from sublease agreements
Total operating lease obligations
More than 5 years | Vacated office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Total operating lease obligations
More than 5 years | Vacated office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Total operating lease obligations
More than 5 years | Office and research facility-San Diego, CA
Payments expected to received from sublease agreements
Net operating lease obligations
More than 5 years | Office and research facility-Cranbury, NJ
Payments expected to received from sublease agreements
Net operating lease obligations