10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

________________________________________________________________________________________

FORM 10-Q

________________________________________________________________________________________

Mark One

x Quarterly Report Pursuant to Section 13 or 15 (d) of the Securities Exchange Act of 1934

For the quarterly period ended September 30, 2012 or

o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the Transition Period From ______ to ______ . Commission File Number: 001-33093

________________________________________________________________________________________

LIGAND PHARMACEUTICALS INCORPORATED

(Exact name of registrant as specified in its charter)

________________________________________________________________________________________

Delaware	77-0160744
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)
11119 North Torrey Pines Road, Suite 200 La Jolla, CA	92037 (Zip Code)
(Address of principal executive offices)

Registrant's Telephone Number, Including Area Code: (858) 550-7500

________________________________________________________________________________________

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No o

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes x No o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one)

Large Accelerated Filer	o		Accelerated Filer	x
Non-Accelerated Filer	o	(Do not check if a smaller reporting company)	Smaller Reporting Company	o

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes o No x

As of November 6, 2012, the registrant had 19,964,456 shares of common stock outstanding.

LIGAND PHARMACEUTICALS INCORPORATED

QUARTERLY REPORT

FORM 10-Q

TABLE OF CONTENTS

PART I. FINANCIAL INFORMATION
	ITEM 1. Financial Statements
	Condensed Consolidated Balance Sheets as of September 30, 2012 (Unaudited) and December 31, 2011	3
	Condensed Consolidated Statements of Operations for the three and nine months ended September 30, 2012 and 2011 (Unaudited)	4
	Condensed Consolidated Statements of Comprehensive Income for the the three and nine months ended September 30, 2012 and 2011 (Unaudited)	5
	Condensed Consolidated Statements of Cash Flows for the nine months ended September 30, 2012 and 2011 (Unaudited)	6
	Notes to Condensed Consolidated Financial Statements	7
	ITEM 2. Management's Discussion and Analysis of Financial Condition and Results of Operations	22
	ITEM 3. Quantitative and Qualitative Disclosures about Market Risk	32
	ITEM 4. Controls and Procedures	33
PART II. OTHER INFORMATION
	ITEM 1. Legal Proceedings	34
	ITEM 1A. Risk Factors	35
	ITEM 2. Unregistered Sales of Equity Securities and Use of Proceeds	47
	ITEM 3. Defaults Upon Senior Securities	47
	ITEM 4. Mine Safety Disclosures	47
	ITEM 5. Other Information	47
	ITEM 6. Exhibits	47
SIGNATURE		48

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PART I. FINANCIAL INFORMATION

ITEM 1. FINANCIAL STATEMENTS

LIGAND PHARMACEUTICALS INCORPORATED

CONDENSED CONSOLIDATED BALANCE SHEETS

(in thousands, except share data)

	September 30,			December 31,
	2012			2011
	(Unaudited)			(Restated)
ASSETS
Current assets:
Cash and cash equivalents	$	7,046		$	7,041
Short-term investments	—			10,000
Accounts receivable	2,157			6,110
Inventory	2,548			1,301
Deferred income taxes	237			237
Other current assets	1,015			1,344
Current portion of co-promote termination payments receivable	4,431			6,197
Total current assets	17,434			32,230
Restricted cash and investments	1,341			1,341
Property and equipment, net	853			455
Intangible assets, net	56,580			58,326
Goodwill	12,238			12,238
Long-term portion of co-promote termination payments receivable	8,644			15,255
Other assets	416			738
Total assets	$	97,506		$	120,583
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable	$	6,027		$	11,065
Accrued liabilities	5,381			5,054
Current portion of contingent liabilities	323			6,879
Bank line of credit	—			10,000
Current portion of note payable	10,272			—
Current portion of co-promote termination liability	4,431			6,197
Current portion of lease exit obligations	2,987			3,208
Current portion of deferred revenue	458			1,240
Total current liabilities	29,879			43,643
Long-term portion of note payable	17,876			20,286
Long-term portion of co-promote termination liability	8,644			15,255
Long-term portion of deferred revenue, net	2,538			3,466
Long-term portion of lease exit obligations	6,534			8,367
Deferred income taxes	2,662			2,230
Long-term portion of contingent liabilities	7,735			10,419
Other long-term liabilities	403			388
Total liabilities	76,271			104,054
Commitments and contingencies
Common stock subject to conditional redemption; 0 and 112,371 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively	—			8,344
Stockholders’ equity:
Common stock, $0.001 par value; 33,333,333 shares authorized; 21,082,678 and 20,682,506 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively	21			21
Additional paid-in capital	747,316			732,676
Accumulated deficit	(683,822		)	(682,232		)
Treasury stock, at cost; 1,118,222 shares at September 30, 2012 and December 31, 2011, respectively	(42,280		)	(42,280		)
Total stockholders' equity	21,235			8,185
Total liabilities and stockholders' equity	$	97,506		$	120,583

See accompanying notes.

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LIGAND PHARMACEUTICALS INCORPORATED

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited)

(in thousands, except share data)

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2012			2011			2012			2011
Revenues:				(Restated)						(Restated)
Royalties	$	3,213		$	2,431		$	9,256		$	6,597
Material sales	1,818			1,679			4,150			5,713
Collaborative research and development and other revenues	1,344			1,631			4,347			4,791
Total revenues	6,375			5,741			17,753			17,101
Operating costs and expenses:
Cost of sales	683			703			1,273			2,851
Research and development	2,647			2,471			8,315			7,693
General and administrative	4,382			3,962			11,824			11,261
Write-off of in-process research and development	—			2,282			—			2,282
Lease exit and termination costs	(15		)	(2		)	159			(168		)
Total operating costs and expenses	7,697			9,416			21,571			23,919
Accretion of deferred gain on sale leaseback	—			426			—			1,277
Loss from operations	(1,322		)	(3,249		)	(3,818		)	(5,541		)
Other income (expense):
Interest expense, net	(838		)	(699		)	(2,460		)	(1,762		)
Decrease (increase) in contingent liabilities	2,093			(198		)	1,191			(1,317		)
Other, net	15			(10		)	272			74
Total other income (expense), net	1,270			(907		)	(997		)	(3,005		)
Income (loss) before income taxes	(52		)	(4,156		)	(4,815		)	(8,546		)
Income tax benefit (expense)	(142		)	(22		)	(445		)	13,572
Income (loss) from continuing operations	(194		)	(4,178		)	(5,260		)	5,026
Discontinued operations:
Gain on sale of Avinza Product Line before income taxes	—			—			3,656			—
Gain on sale of Oncology Product Line before income taxes	—			—			—			3
Income tax benefit on discontinued operations	—			—			14			—
Discontinued operations	—			—			3,670			3
Net income (loss):	$	(194	)	$	(4,178	)	$	(1,590	)	$	5,029
Basic and diluted per share amounts:
Income (loss) from continuing operations	$	(0.01	)	$	(0.21	)	$	(0.27	)	$	0.26
Discontinued operations	—			—			0.19			—
Net income (loss)	$	(0.01	)	$	(0.21	)	$	(0.08	)	$	0.26
Weighted average number of common shares-basic	19,917,676			19,673,160			19,791,793			19,648,947
Weighted average number of common shares-diluted	19,917,676			19,673,160			19,791,793			19,686,353

See accompanying notes.

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LIGAND PHARMACEUTICALS INCORPORATED

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

(Unaudited)

(in thousands)

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2012			2011			2012			2011
				(Restated)						(Restated)
Net income (loss)	$	(194	)	$	(4,178	)	$	(1,590	)	$	5,029
Unrealized net loss on available-for-sale securities	—			—			—			(31		)
Comprehensive income (loss)	$	(194	)	$	(4,178	)	$	(1,590	)	$	4,998

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LIGAND PHARMACEUTICAL INCORPORATED

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(in thousands)

	Nine Months Ended
	September 30,
	2012			2011
				(Restated)
Operating activities
Net income (loss )	$	(1,590	)	$	5,029
Less: gain from discontinued operations	3,670			3
Income (loss) from continuing operations	(5,260		)	5,026
Adjustments to reconcile net income (loss) to net cash used in operating activities, including effects of business acquired:
Non-cash change in estimated fair value of contingent liabilities	(1,191		)	1,317
Accretion of deferred gain on sale leaseback	—			(1,277		)
Depreciation and amortization	1,978			2,099
Non-cash lease costs	—			(135		)
Share-based compensation	3,116			2,646
Deferred income taxes	446			(13,905		)
Write-off in-process research and development	—			2,282
Other	348			201
Changes in operating assets and liabilities, net of acquisition:
Accounts receivable	3,953			476
Inventory	(798		)	455
Other current assets	329			4,545
Other long-term assets	322			566
Accounts payable and accrued liabilities	(3,009		)	(7,110		)
Other liabilities	15			(4,129		)
Deferred revenue	(1,710		)	(1,246		)
Net cash used in operating activities of continuing operations	(1,461		)	(8,189		)
Net cash used in operating activities of discontinued operations	(550		)	—
Net cash used in operating activities	(2,011		)	(8,189		)
Investing activities
Acquisition of CyDex, net of cash acquired	—			(32,024		)
Payments to CVR holders	(8,049		)	—
Purchases of property, equipment and building	(633		)	(116		)
Proceeds from sale of property, and equipment and building	17			—
Purchases of short-term investments	—			(10,000		)
Proceeds from sale of short-term investments	10,000			19,346
Other, net	—			(59		)
Net cash provide by (used in) investing activities	1,335			(22,853		)
Financing activities
Proceeds from issuance of debt	7,500			30,000
Repayment of debt	(10,000		)	—
Net proceeds from issuance of common stock, net	3,181			2
Share repurchases	—			(55		)
Net cash provided by financing activities	681			29,947
Net increase in cash and cash equivalents	5			(1,095		)
Cash and cash equivalents at beginning of period	7,041			3,346
Cash and cash equivalents at end of period	$	7,046		$	2,251
Supplemental Disclosure of cash flow information
Interest paid	1,854			1,749
Taxes paid	15			27

See accompanying notes.

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LIGAND PHARMACEUTICALS INCORPORATED

Notes to Condensed Consolidated Financial Statements

(Unaudited)

1. Basis of Presentation

Ligand Pharmaceuticals Incorporated, a Delaware corporation (the "Company" or "Ligand"), is a biotechnology company that focuses on drug discovery and early-stage development and partnering of pharmaceuticals that address critical unmet medical needs or that are more effective and/or safer than existing therapies, more convenient to administer and are cost effective. The Company sold its Oncology Product Line (“Oncology”) and Avinza Product Line (“Avinza”) on October 25, 2006 and February 26, 2007, respectively. The operating results for Oncology and Avinza have been presented in the accompanying consolidated financial statements as “Discontinued Operations”.

The Company has incurred significant losses since its inception. At September 30, 2012, the Company’s accumulated deficit was $683.8 million and the Company had negative working capital of $12.4 million. Based on recent product approvals and regulatory developments, as well as management’s plans including expense reductions, if necessary, the Company believes its currently available cash, cash equivalents, and short-term investments as well as its current and future royalty, license and milestone revenues will be sufficient to satisfy its anticipated operating and capital requirements through at least the next twelve months. The Company’s future operating and capital requirements will depend on many factors, including, but not limited to: the pace of scientific progress in its research and development programs; the potential success of these programs; the scope and results of preclinical testing and clinical trials; the time and costs involved in obtaining regulatory approvals; the costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims; competing technological and market developments; the amount of royalties on sales of the commercial products of its partners; the efforts of its collaborative partners; obligations under its operating lease agreements; and the capital requirements of any companies the Company previously acquired, including Pharmacopeia, Inc. (“Pharmacopeia”), Neurogen Corporation (“Neurogen”), Metabasis Therapeutics, Inc. (“Metabasis”) and CyDex Pharmaceuticals, Inc. (“CyDex”). Management’s plans and efforts may not fully address any significant adverse impact from any or all of these factors and the Company may be required to obtain additional financing, which may not be available at acceptable terms, or at all.

Principles of Consolidation

The condensed consolidated financial statements include the Company’s wholly owned subsidiaries, Seragen, Inc. (“Seragen”), Nexus Equity VI LLC (“Nexus”), Pharmacopeia, Neurogen, Metabasis and CyDex. All significant intercompany accounts and transactions have been eliminated in consolidation.

Basis of Presentation

The Company’s accompanying unaudited consolidated condensed financial statements as of September 30, 2012 and for the three and nine months endedSeptember 30, 2012 and 2011 have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial information. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for annual financial statements. The Company’s consolidated condensed balance sheet at December 31, 2011 has been derived from the audited financial statements at that date, but does not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation of the financial position and results of operations of the Company, and its subsidiaries have been included. Operating results for the three and nine months ended September 30, 2012 are not necessarily indicative of the results that may be expected for the year ending December 31, 2012. These financial statements should be read in conjunction with the consolidated financial statements and notes therein included in the Company’s amended annual report on Form 10-K/A for the year ended December 31, 2011.

As discussed in Note 11, the Company has restated its previously issued condensed consolidated financial statements as of December 31, 2011 and for the three and nine months ended September 30, 2011 included in this Form 10-Q.

Use of Estimates

The preparation of consolidated financial statements in conformity with generally accepted accounting principles requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and liabilities, at the date of the consolidated financial statements, and the reported amounts of revenue and

7

expenses during the reporting period. The Company’s critical accounting policies are those that are both most important to the Company’s financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results may materially vary from these estimates.

Income (Loss) Per Share

Basic earnings per share is calculated by dividing net income or loss by the weighted average number of common shares and vested restricted stock units outstanding. Diluted earnings per share is computed by dividing net income or loss by the weighted average number of common shares and vested restricted stock units outstanding and the weighted average number of dilutive common stock equivalents, including stock options and non-vested restricted stock units. Common stock equivalents are only included in the diluted earnings per share calculation when their effect is dilutive. For the three and nine months ended September 30, 2012, no potential common shares are included in the computation of any diluted per share amounts, including income (loss) per share from discontinued operations and net loss per share, as the Company reported a loss from continuing operations. For the nine months ended September 30, 2011, 37,406 common shares are included in the computation of diluted income per share. Potential common shares, the shares that would be issued upon the exercise of outstanding stock options and warrants and the vesting of restricted shares that would be excluded from the computation of diluted loss per share, were 2.0 million and 1.6 million at September 30, 2012 and 2011, respectively.

The following table sets forth the computation of basic and diluted net income (loss) per share for the periods indicated (in thousands, except per share amounts):

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2012			2011			2012			2011
				(Restated)						(Restated)
Net income (loss) from continuing operations	$	(194	)	$	(4,178	)	$	(5,260	)	$	5,026
Net income from discontinued operations	—			—			3,670			3
Net income (loss)	(194		)	(4,178		)	(1,590		)	5,029
Shares used to compute basic and diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,648,947
Dilutive potential common shares:
Restricted stock	—			—			—			37,406
Shares used to compute diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,686,353
Basic and diluted per share amounts:
Income (loss) from continuing operations	$	(0.01	)	$	(0.21	)	$	(0.27	)	$	0.26
Income from discontinued operations	—			—			0.19			—
Net income (loss)	$	(0.01	)	$	(0.21	)	$	(0.08	)	$	0.26

Revenue Recognition

Royalties on sales of products commercialized by the Company’s partners are recognized in the quarter reported by the respective partner.

Material sales revenue is recognized upon transfer of title, which normally passes to the buyer upon shipment to the customer. The Company’s credit and exchange policy includes provisions for the return of product between 30 to 90 days, depending on the specific terms of the individual agreement, when that product (1) does not meet specifications, (2) is damaged in shipment (in limited circumstances where title does not transfer until delivery), or (3) is exchanged for an alternative grade of Captisol.

Revenue from research funding under the Company’s collaboration agreements is earned and recognized on a percentage-of-completion basis as research hours are incurred in accordance with the provisions of each agreement.

8

Nonrefundable, up-front license fees and milestone payments with standalone value that are not dependent on any future performance by the Company under the Company’s collaboration agreements are recognized as revenue upon the earlier of when payments are received or collection is assured, but are deferred if the Company has continuing performance obligations. If the Company is unable to determine the stand alone value under multiple-element arrangements, revenue is recognized over the period of services or performance. Amounts received under multiple-element arrangements requiring ongoing services or performance by the Company are recognized over the period of such services or performance.

Revenue from milestones are recognized when earned, as evidenced by written acknowledgement from the collaborator, provided that (i) the milestone event is substantive, its achievability was not reasonably assured at the inception of the agreement, and the Company has no further performance obligations relating to that event, and (ii) collectability is reasonably assured. If these criteria are not met, the milestone payment is recognized over the remaining period of the Company’s performance obligations under the arrangement.

Income Taxes

The Company recognizes liabilities or assets for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements. These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. A valuation allowance is established when management determines that it is more likely than not that all or a portion of a deferred tax asset will not be realized. Management evaluates the realizability of its net deferred tax assets on a quarterly basis and valuation allowances are provided, as necessary. During this evaluation, management reviews its forecasts of income in conjunction with other positive and negative evidence surrounding the realizability of its deferred tax assets to determine if a valuation allowance is required. Adjustments to the valuation allowance will increase or decrease the Company’s income tax provision or benefit. Management also applies the relevant guidance to determine the amount of income tax expense or benefit to be allocated among continuing operations, discontinued operations, and items charged or credited directly to stockholders’ equity.

A tax position must meet a minimum probability threshold before a financial statement benefit is recognized. The minimum threshold is a tax position that is more likely than not to be sustained upon examination by the applicable taxing authority, including resolution of any related appeals or litigation processes, based on the technical merits of the position.  The Company recognizes interest and penalties related to uncertain tax positions in income tax expense.

Accounting for Share-Based Compensation

Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests. Compensation cost for consultant awards is recognized over each separate tranche’s vesting period. The following table summarizes share-based compensation expense recorded as components of research and development expenses and general and administrative expenses for the periods indicated (in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2012		2011		2012		2011
Share-based compensation expense as a component of:
Research and development expenses	$	263	$	300	$	1,211	$	808
General and administrative expenses	750		650		1,905		1,838
	$	1,013	$	950	$	3,116	$	2,646

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The fair-value for options that were awarded to employees and directors was estimated at the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions:

	Three Months Ended		Nine Months Ended
	September 30,		September 30,
	2012	2011	2012	2011
Risk-free interest rate	0.8%	1.7%	1.0%	2.5%
Dividend yield	—	—	—	—
Expected volatility	69%	68%	69%	69%
Expected term	6.2 years	6.1 years	6.3 years	6.1 years
Forfeiture rate	8.2%	8.8%	8.0%-11.2%	8.8%-14.1%

The expected term of the employee and non-employee director options is the estimated weighted-average period until exercise or cancellation of vested options (forfeited unvested options are not considered) based on historical experience. The expected term for consultant awards is the remaining period to contractual expiration.

Volatility is a measure of the expected amount of variability in the stock price over the expected life of an option expressed as a standard deviation. In selecting this assumption, management used the historical volatility of the Company's stock price over a period approximating the expected term.

Cash, Cash Equivalents and Short-term Investments

Cash and cash equivalents consist of cash and highly liquid securities with maturities at the date of acquisition of three months or less. Non-restricted equity and debt securities with a maturity of more than three months are considered short term investments. Restricted cash and investments consist of certificates of deposit held with financial institutions as collateral under a facility lease and third-party service provider arrangement. The following table summarizes the various investment categories at September 30, 2012 and December 31, 2011 (in thousands):

	Cost		Gross unrealized gains		Gross unrealized losses		Estimated fair value
September 30, 2012
Certificates of deposit	$	—	$	—	$	—	$	—
Certificates of deposit - restricted	1,341		—		—		1,341
	$	1,341	$	—	$	—	$	1,341
December 31, 2011
Certificates of deposit	$	10,000	$	—	$	—	$	10,000
Certificates of deposit - restricted	1,341		—		—		1,341
	$	11,341	$	—	$	—	$	11,341

Concentrations of Credit Risk

Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash equivalents and investments and accounts receivable.

The Company invests its excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. The Company has established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates. The Company has not experienced any significant losses on its cash equivalents, short-term investments or restricted investments for the periods ending September 30, 2012 and December 31, 2011.

As of September 30, 2012 and December 31, 2011, cash deposits held at financial institutions in excess of FDIC insured amounts of $250,000 were approximately $6.8 million and $13.1 million, respectively.

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Accounts receivable from one customer was 60% and accounts receivable from two customers was 67% of total accounts receivable at September 30, 2012 and December 31, 2011, respectively. 

The Company currently obtains Captisol from a sole-source supplier.  If this supplier was not able to supply the requested amounts of Captisol, the Company would be unable to continue to derive revenues from the sale of Captisol until it obtained an alternative source, which might take a considerable length of time.

Allowance for Doubtful Accounts

The Company maintains an allowance for doubtful accounts based on the best estimate of the amount of probable losses in the Company’s existing accounts receivable. Accounts receivable that are outstanding longer than their contractual payment terms, ranging from 30 to 90 days, are considered past due. When determining the allowance for doubtful accounts, several factors are taken into consideration, including historical write-off experience and review of specific customer accounts for collectability. Account balances are charged off against the allowance after collection efforts have been exhausted and the potential for recovery is considered remote. There was no allowance for doubtful accounts included in the balance sheets at September 30, 2012 and December 31, 2011.

Inventory

Inventory is stated at the lower of cost or market. The Company determines cost using the first-in, first-out method. The Company analyzes its inventory levels periodically and writes down inventory to its net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements.

Other Current Assets

Other current assets consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Prepaid expenses	$	889	$	905
Advanced manufacturing payments	2		312
Other receivables	124		127
	$	1,015	$	1,344

Property and Equipment

Property and equipment is stated at cost and consists of the following (in thousands):

	September 30,			December 31,
	2012			2011
Lab and office equipment	$	4,503		$	4,110
Leasehold improvements	—			62
Computer equipment and software	1,150			1,054
	5,653			5,226
Less accumulated depreciation and amortization	(4,800		)	(4,771		)
	$	853		$	455

Depreciation of equipment is computed using the straight-line method over the estimated useful lives of the assets, which range from three to ten years. Leasehold improvements are amortized using the straight-line method over their estimated useful lives or their related lease term, whichever is shorter.

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Goodwill and Other Identifiable Intangible Assets

Goodwill and other identifiable intangible assets consist of the following (in thousands):

	September 30,			December 31,
	2012			2011
				(Restated)
Acquired in-process research and development	$	13,036		$	13,036
Complete technology	15,227			15,227
Trade name	2,642			2,642
Customer relationships	29,600			29,600
Goodwill	12,238			12,238
	72,743			72,743
Accumulated amortization	(3,925		)	(2,179		)
	$	68,818		$	70,564

Intangible assets related to IPR&D are considered to be indefinite-lived until the completion or abandonment of the associated research and development efforts. During the period the assets are considered to be indefinite-lived, they will not be amortized but will be tested for impairment on an annual basis and between annual tests if the Company becomes aware of any events occurring or changes in circumstances that would indicate a reduction in the fair value of the IPR&D projects below their respective carrying amounts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Amortization expense of $1.7 million and $1.9 million was recognized for the nine months endedSeptember 30, 2012 and 2011, respectively. Estimated amortization expense for the years ending December 31, 2012 through 2016 is $2.3 million per year.

Impairment of Long-Lived Assets

Management reviews long-lived assets for impairment annually or whenever events or changes in circumstances indicate the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured as the amount by which the carrying amount of the assets exceeds the fair value of the assets. Fair value for the Company’s long-lived assets is determined using the expected cash flows discounted at a rate commensurate with the risk involved. As of September 30, 2012, management does not believe there have been any events or circumstances indicating that the carrying amount of its long-lived assets may not be recoverable.

During 2011, the impairment analysis performed by management resulted in the write-off of certain acquired in process research and development assets.  The Company recorded a non-cash impairment charge of $1.1 million for the write-off of IPR&D and interests in future milestones and royalties for MEDI-528, an IL-9 antibody program by AstraZeneca's subsidiary, MedImmune.  The asset was impaired upon receipt of notice from MedImmune in September that it was exercising its right to terminate the collaboration and license agreement. 

Additionally, in 2011, the Company recorded a non-cash impairment charge of $1.2 million for the write-off of IPR&D and interests in future milestones for TRPV1, a collaborative research and licensing program between the Company and Merck, related to the physiology, pharmacology, chemistry and potential therapeutic applications and potential clinical utilities related to Vanilloid Receptors, subtype 1. The asset was impaired upon receipt of notice from Merck in October 2011 that it was exercising its right to terminate the collaboration and license agreement. Subsequent to the termination of the agreement, the Company will receive an exclusive, perpetual, irrevocable, royalty-free (but subject to any third party royalty obligations), fully-paid world-wide license, with the right to sub-license, under specified patents and technology for the research, development, or commercialization of specified compounds and products in a limited field of use.

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Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Compensation	$	1,157	$	1,806
Professional fees	485		355
Other	3,739		2,893
	$	5,381	$	5,054

Other Long-Term Liabilities

Other long-term liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Deposits	$	284	$	388
Other	119		—
	$	403	$	388

Sale of Royalty Rights

The Company previously sold to third parties the rights to future royalties of certain of its products. As part of the underlying royalty agreements, the partners have the right to offset a portion of any future royalty payments owed to the Company to the extent of previous milestone payments. Accordingly, the Company deferred a portion of the revenue associated with each tranche of royalty right sold, equal to the pro-rata share of the potential royalty offset. Such amounts associated with the offset rights against future royalty payments will be recognized as revenue upon receipt of future royalties from the respective partners. As of September 30, 2012 and December 31, 2011, the Company had deferred $0.9 million and $1.2 million, respectively, of revenue related to the sale of royalty rights. As of September 30, 2012, $0.4 million is included in current portion of deferred revenue and $0.5 million is included in long-term portion of deferred revenue.

Recently Adopted Accounting Pronouncements

In June 2011, the FASB issued ASU No. 2011-05, Comprehensive Income (Topic 220) - Presentation of Comprehensive Income. This ASU amends Topic 220, Comprehensive Income, to allow an entity the option to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. In both choices, an entity is required to present each component of net income along with total net income, each component of other comprehensive income along with a total for other comprehensive income, and a total amount for comprehensive income. ASU No. 2011-05 eliminates the option to present the components of other comprehensive income as part of the statement of changes in shareholders’ investment. The amendments to the Codification in the ASU do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income. The ASU was effective for fiscal years beginning after December 15, 2011 for the Company. In 2012, the Company has elected to present comprehensive income in a separate statement.

In September 2011, the FASB issued ASU 2011-08, Intangibles – Goodwill and other: testing for goodwill impairment, which, among other things, amends Accounting Standards Codification 350 Intangibles – Goodwill and Other, to allow entities to use a qualitative approach to test goodwill for impairment. ASU 2011-08 permits an entity to first perform a qualitative assessment to determine whether it is more likely than not that the fair value of a reporting unit is less than its carrying value. If it is concluded that this is the case, it is necessary to perform the currently prescribed two-step goodwill impairment test. Otherwise, the two-step goodwill impairment test is not required. Our adoption of this standard had no impact on our consolidated financial position, results of operations or cash flows.

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In December 2011, the FASB issued ASU 2011-12, Deferral of the Effective Date for Amendments to the Presentation of Reclassifications of Items Out of Accumulated Other Comprehensive Income in ASU 2011-12. The amendments in ASU 2011-12 defer the changes in ASU 2011-05 that relate to the presentation of reclassification adjustments out of accumulated other comprehensive income. The amendments in this ASU are effective for public entities for fiscal years, and interim periods within those years, beginning after December 15, 2011. See above for the provisions of ASU 2011-05.

2. Business Combinations

On January 24, 2011, the Company acquired CyDex Pharmaceuticals, Inc., a specialty pharmaceutical company developing products and licensing its Captisol® technology. Captisol is currently incorporated in six FDA-approved medications and marketed by three of CyDex’s licensees: Pfizer, Bristol-Myers Squibb, Onyx Pharmaceuticals, Inc., and Baxter International. In addition, CyDex is supporting drug development efforts with more than 40 companies worldwide.

Under the terms of the agreement, the Company paid $31.6 million to the CyDex shareholders and issued a series of Contingent Value Rights. Additionally, the Company assumed certain contractual obligations for potential milestone payments to license holders. These contingent liabilities were recorded at an initial fair value of $17.6 million. The initial fair value of the liability was determined using a discounted cash flow analysis incorporating the estimated future cash flows from potential milestones and revenue sharing. These cash flows were then discounted to present value using a discount rate of 21.6%. The liability will be evaluated at each reporting period based on events and circumstances related to the underlying milestones, and the change in fair value will be recorded in the Company’s consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. The fair value of the liability at September 30, 2012 was $7.6 million.

The Company paid the CyDex shareholders $4.3 million in January 2012, $2.0 million in December 2011, and $3.5 million in July 2012 and may be required to pay up to an additional $4.0 million upon achievement of certain clinical and regulatory milestones, net of payments made to former license holders upon achievement of milestones. Additionally, the Company assumed certain contractual obligations for milestone payments potentially due in connection with CAPTISOL enabled intravenous formulation of Clopidogrel. We may be required to pay up to $4.0 million upon achievement of certain milestones to former license holders. In addition, the Company will pay CyDex shareholders, for each respective year from 2011 through 2016, 20% of all CyDex-related revenue, but only to the extent that and beginning only when CyDex-related revenue for such year exceeds $15.0 million; plus an additional 10% of all CyDex-related revenue recognized during such year, but only to the extent that and beginning only when aggregate CyDex-related revenue for such year exceeds $35.0 million. The Company paid $0.3 million to the CyDex shareholders in March 2012 for 20% of all 2011 CyDex-related revenue in excess of $15 million.

Ligand is required by the CyDex Contingent Value Rights Agreement (“CVR”) to dedicate at least five experienced full-time employee equivalents per year to the acquired business and to invest at least $1.5 million per year, inclusive of such employee expenses, in the acquired business, through 2015. As of September 30, 2012, the Company estimates it has exceeded this amount.

Had the merger with CyDex been completed as of the beginning of 2011, the Company’s pro forma results for the nine months ended September 30, 2011 would have been as follows:

(in thousands, except per share data)	(Restated)
Revenue	$	17,290
Operating loss	(5,549		)
Net income	4,886
Basic and diluted earnings per share:
Continuing operations	$	0.25
Discontinued operations	—
Net income	$	0.25
Basic and diluted weighted average shares	19,649

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The primary adjustments relate to interest expense on long-term debt, the loss of interest income due to the timing of transaction related payments and amortization of intangible assets. The above pro forma information was determined based on historical results adjusted for the purchase price allocation and estimated related changes in income associated with the merger of CyDex.

3. Financial Instruments

The Company measures certain financial assets and liabilities at fair value on a recurring basis, including available-for-sale fixed income and equity securities and other equity securities. The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of September 30, 2012 (in thousands):

Fair Value Measurements at Reporting Date Using
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Assets:
Certificates of deposit	$	—	$	—	$	—	$	—
Liabilities:
Current portion of contingent liabilities - CyDex	$	323	$	—	$	—	$	323
Liability for contingent value rights - Metabasis	—		—		—		—
Liability for contingent value rights – Neurogen	500		—		—		500
Long-term portion of contingent liabilities - CyDex	7,235		—		—		7,235
Total liabilities	$	8,058	$	—	$	—	$	8,058

The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December 31, 2011 (in thousands):

Fair Value Measurements at Reporting Date Using
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Assets:	(Restated)						(Restated)
Certificates of deposit	$	10,000	$	10,000	$	—	$	—
Liabilities:
Current portion of contingent liabilities - CyDex	$	6,879	$	—	$	—	$	6,879
Liability for contingent value rights - Metabasis	1,068		1,068		—		—
Liability for contingent value rights – Neurogen	700		—		—		700
Long-term portion of contingent liabilities - CyDex	8,651		—		—		8,651
Total liabilities	$	17,298	$1,068		$	—	$	16,230

The Company’s short-term investments are fixed income available-for-sale securities and include Corporate Notes, Corporate Discount Commercial Paper and certificates of deposit. The fair value of the Company’s short-term investments and liability for contingent value rights- Metabasis are determined using quoted market prices in active markets.

4. AVINZA Co-Promotion

In February 2003, Ligand and Organon Pharmaceuticals USA Inc. (“Organon”) announced that they had entered into an agreement for the co-promotion of Avinza. Subsequently in January 2006, Ligand signed an agreement with Organon that terminated the Avinza co-promotion agreement between the two companies and returned Avinza co-promotion rights to Ligand. In consideration of the early termination, Ligand agreed to make quarterly royalty payments to Organon equal to 6.5% of

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Avinza net sales through December 31, 2012 and thereafter 6.0% through patent expiration, currently anticipated to be November of 2017.

In February 2007, Ligand and King Pharmaceuticals, Inc., (“King”), executed an agreement pursuant to which King acquired all of the Company’s rights in and to Avinza. King also assumed the Company’s co-promote termination obligation to make royalty payments to Organon based on net sales of Avinza. In connection with King’s assumption of this obligation, Organon did not consent to the legal assignment of the co-promote termination obligation to King. Accordingly, Ligand remains liable to Organon in the event of King’s default of the obligation. Therefore, Ligand recorded an asset as of February 26, 2007 to recognize King’s assumption of the obligation, while continuing to carry the co-promote termination liability in the Company’s consolidated financial statements to recognize Ligand’s legal obligation as primary obligor to Organon. This asset represents a non-interest bearing receivable for future payments to be made by King and is recorded at its fair value. The receivable and liability will remain equal and adjusted each quarter for changes in the fair value of the obligation including for any changes in the estimate of future net Avinza product sales. This receivable will be assessed on a quarterly basis for impairment (e.g. in the event King defaults on the assumed obligation to pay Organon).

On a quarterly basis, management reviews the carrying value of the co-promote termination liability. Due to assumptions and judgments inherent in determining the estimates of future net Avinza sales through November 2017, the actual amount of net Avinza sales used to determine the current fair value of the Company’s co-promote termination asset and liability may be materially different from current estimates.

A summary of the co-promote termination liability as of September 30, 2012 is as follows (in thousands):

Net present value of payments based on estimated future net Avinza product sales as of December 31, 2011	$	21,452
Assumed payments made by King or assignee	(2,533		)
Fair value adjustments	(5,844		)
Total co-promote termination liability as of September 30, 2012	13,075
Less: current portion of co-promote termination liability as of September 30, 2012	4,431
Long-term portion of co-promote termination liability as of September 30, 2012	$	8,644

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5. Lease obligations

The Company leases office and laboratory facilities in California, Kansas, and New Jersey. These leases expire between 2014 and 2019 and are subject to annual increases which range from 3.0% and 3.5%. The Company currently subleases office and laboratory space in California and New Jersey. The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of September 30, 2012 (in thousands):

Operating lease obligations:	Square Footage	Lease Termination Date	Less than 1 year		1-3 years		3-5 years		More than 5 years		Total
Corporate headquarters-San Diego, CA	16,500	July 2019	$	430	$	1,354	$	1,436	$	1,326	$	4,546
Bioscience and Technology Business Center-Lawrence, KS	1,500	December 2014	57		71		—		—		128
Vacated office and research facility-San Diego, CA	52,800	July 2015	2,159		4,126		—		—		6,285
Vacated office and research facility-Cranbury, NJ	99,000	August 2016	2,581		5,397		2,580		—		10,558
Total operating lease obligations			$	5,227	$	10,948	$	4,016	$	1,326	$	21,517
Sublease payments expected to be received:			Less than 1 year		1-3 years		3-5 years		More than 5 years		Total
Office and research facility-San Diego, CA	52,800	July 2015	$	876	$	1,676	$	—	$	—	$	2,552
Office and research facility-Cranbury, NJ	5,100	August 2016	332		751		319		—		1,402
Net operating lease obligations			$	4,019	$	8,521	$	3,697	$	1,326	$	17,563

6. Segment Reporting

Under Accounting Standards Codification 280, “Segment Reporting”, operating segments are defined as components of an enterprise about which separate financial information is available that is regularly evaluated by the entity’s chief operating decision maker, in deciding how to allocate resources and in assessing performance. The Company has evaluated this Codification and has identified two reportable segments: the development and commercialization of drugs using Captisol technology by CyDex Pharmaceuticals, Inc. and the traditional biotechnology operations including drug discovery and development of Ligand Pharmaceuticals, Inc. We evaluate performance based on the operating profit (loss) of the respective business segments. The segment results may not represent actual results that would be expected if they were independent, stand-alone businesses. Segment information was as follows (in thousands):

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Balance Sheet Data:	As of September 30, 2012
	Ligand			CyDex			Total
Total assets	$	65,289		$	32,217		$	97,506
	As of December 31, 2011
	Ligand			CyDex			Total
	(Restated)			(Restated)			(Restated)
Total assets	$	111,431		$	9,152		$	120,583
Operating Data:	For the three months ended September 30, 2012
	Ligand			CyDex			Total
Net revenues from external customers	$	3,708		$	2,667		$	6,375
Operating income (loss)	(1,498		)	176			(1,322		)
Depreciation and amortization expense	34			604			638
Income tax expense from continuing operations	142			—			142
Interest expense, net	838			—			838
	For the three months ended September 30, 2011
	Ligand			CyDex			Total
Net revenues from external customers	$	3,291		$	2,450		$	5,741
Operating income (loss)	(3,381		)	132			(3,249		)
Depreciation and amortization expense	134			609			743
Income tax expense from continuing operations	22			—			22
Interest expense, net	699			—			699
Write-off of in-process research and development	2,282						2,282
	For the nine months ended September 30, 2012
	Ligand			CyDex			Total
Net revenues from external customers	$	11,728		$	6,025		$	17,753
Operating loss	(3,298		)	(520		)	(3,818		)
Depreciation and amortization expense	162			1,816			1,978
Income tax expense from continuing operations	445			—			445
Income tax benefit from discontinuing operations	14			—			14
Interest expense, net	2,460			—			2,460
	For the nine months Ended September 30, 2011
	Ligand			CyDex			Total
	(Restated)			(Restated)			(Restated)
Net revenues from external customers	$	8,718		$	8,383		$	17,101
Operating loss	(6,507		)	966			(5,541		)
Depreciation and amortization expense	407			1,692			2,099
Income tax expense from continuing operations	(13,572		)	—			(13,572		)
Interest expense, net	1,762			—			1,762
Write off of in-process research and development	2,282			—			2,282

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7. Financing Arrangements

The Company has a secured term loan credit facility (“secured debt”). Under the terms of the secured debt, the Company will make interest only payments through March 2013. Subsequent to the interest only payments, the note will amortize with principal and interest payments through the remaining term of the loan. Additionally, the Company must also make an additional final payment equal to 6% of the total amount borrowed which is due at maturity and is being accreted over the life of the loan. The Company also has a cash-collateralized revolving credit facility under which the Company may elect to borrow up to $10 million. All outstanding amounts under the credit facility may become due and payable if the Company fails to maintain a cash balance equal to the amount outstanding under the credit facility. The carrying values and the fixed contractual coupon rates of our financing arrangements are as follows (dollars in millions):

	September 30, 2012		December 31, 2011
Bank line of credit, Prime + 2.0%, due March 29, 2013	$	—	$	10,000
Current portion notes payable, 8.64%, due August 1, 2014	$	7,473	$	—
Current portion notes payable, 8.9012%, due August 1, 2014	2,799		—
Total current portion of notes payable	$	10,272	$	10,000
Long-term portion notes payable, 8.64%, due August 1, 2014	$	13,070	$	20,286
Long-term portion notes payable, 8.9012%, due August 1, 2014	4,806		—
Total long-term portion of notes payable	$	17,876	$	20,286

8. Stockholders’ Equity

On May 31, 2012, the Company’s stockholders approved the amendment and restatement of the Company’s 2002 Stock Incentive Plan to increase the number of shares available for issuance by 1.8 million shares.

Stock Option Activity

The following is a summary of the Company’s stock option plan activity and related information:

	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term in Years	Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2011	1,146,046		$	14.61	7.96	$	1,489
Granted	710,345		14.73
Exercised	(46,799	)	9.96
Forfeited	(83,374	)	10.69
Cancelled	(13,481	)	39.73
Balance at September 30, 2012	1,712,737		14.84
Exercisable at September 30, 2012	781,738		16.58		7.10	2,983
Options vested and expected to vest as of September 30, 2012	1,712,737		14.77		8.1	6,729

The weighted-average grant date fair value of all stock options granted during the nine months endedSeptember 30, 2012 was $14.73 per share. The total intrinsic value of all options exercised during the nine months endedSeptember 30, 2012 and 2011 was approximately $0.3 million and $4,000, respectively. As of September 30, 2012, there was $6.6 million of total unrecognized compensation cost related to nonvested stock options. That cost is expected to be recognized over a weighted-average period of 2.8 years.

As of September 30, 2012, 1.8 million shares were available for future option grants or direct issuance under the Company’s 2002 Stock Incentive Plan, as amended.

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Restricted Stock Activity

Restricted stock activity for the nine months ended September 30, 2012 is as follows:

	Shares		Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2011	115,506		$	10.63
Granted	108,661		13.75
Vested	(71,825	)	11.48
Forfeited	(4,012	)	10.57
Nonvested at September 30, 2012	148,330		$	12.51

The weighted-average grant-date fair value of restricted stock granted during the nine months ended September 30, 2012 was $13.75 per share. As of September 30, 2012, there was $1.2 million of total unrecognized compensation cost related to nonvested restricted stock. That cost is expected to be recognized over a weighted-average period of 1.7 years.

Employee Stock Purchase Plan

The Company’s Employee Stock Purchase Plan, as amended and restated (the “Amended ESPP”) allows participants to purchase up to 1,250 shares of Ligand common stock during each offering period, but in no event may a participant purchase more than 1,250 shares of common stock during any calendar year. The length of each offering period is six months, and employees are eligible to participate in the first offering period beginning after their hire date.

The Amended ESPP allows employees to purchase Ligand common stock at the end of each six month period at a price equal to 85% of the lesser of fair market value on either the start date of the period or the last trading day of the period (the “Lookback Provision”). The 15% discount and the Lookback Provision make the Amended ESPP compensatory.  There were 7,374 and 2,404 shares of common stock issued and $75,000 and $18,000 of proceeds received under the Amended ESPP during the nine months ended September 30, 2012 and 2011, respectively. The Company recorded compensation expense related to the ESPP of $29,000 and $700 for the nine months endedSeptember 30, 2012 and 2011, respectively. As of September 30, 2012, 89,917 shares were available for future purchases under the Amended ESPP.

Warrants

As of September 30, 2012, 163,568 warrants with an exercise price of $179.40 per warrant and an expiration date of April 2013 were outstanding to purchase an aggregate of 129,360 shares of the Company’s common stock. If exercised, these warrants are also entitled to receive $0.1 million in cash and 981,411 of each of the Company's four contingent value rights issued to Neurogen shareholders in December 2009.  The series of warrants was assumed in the acquisition of Neurogen Corporation.

Public Offering

During the quarter ended September 30, 2012, the Company issued, pursuant to an at-the-market registered public offering, 150,000 common shares at a weighted average price of $18.19 per share. Total net proceeds to the Company after underwriting discounts and expenses were approximately $2.6 million.

9. Litigation

From time to time the Company is subject to various lawsuits and claims with respect to matters arising out of the normal course of its business. If, based on the Company’s assessment, it is probable that a liability has been incurred and can be reasonably estimated, then such loss is accrued and charged to operations. Management believes all costs that can be reasonably estimated will not exceed the related existing accruals.

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10. Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement

In April 1996, the Company and Pfizer entered into a settlement agreement with respect to a lawsuit filed in December 1994 by the Company against Pfizer. In connection with a collaborative research agreement the Company entered into with Pfizer in 1991, Pfizer purchased shares of the Company’s common stock. Under the terms of the settlement agreement, at the option of either the Company or Pfizer, milestone and royalty payments owed to the Company can be satisfied by Pfizer by transferring to the Company shares of the Company’s common stock at an exchange ratio of $74.25 per share, for revenue related to lasofoxifene and drolofoxifene. The remaining common stock issued and outstanding to Pfizer following the settlement was reclassified as common stock subject to conditional redemption (between liabilities and equity) since Pfizer has the option to settle milestone and royalties payments owed to the Company with the Company’s shares, and such option is not within the Company’s control. The remaining shares of the Company’s common stock that could be redeemed totaled 112,371 and are reflected at the exchange ratio price of $74.25. Pfizer has notified Ligand that the development of the two compounds covered under the 1996 settlement agreement have been terminated and thus the Company reclassified the shares and the current carrying amount of $8.3 million to permanent equity in the first quarter of 2012.

11. Restatement of Financial Statements

The Company restated its previously issued consolidated financial statements as of December 31, 2011, to correct errors in the calculation of certain contingent liabilities related to the acquisition of CyDex. Specifically, the initial fair value of the contingent liability was overstated by $1.6 million resulting in an initial overstatement of goodwill by $2.7 million, an understatement of the income tax benefit of $0.1 million, and overstatement of the deferred tax liability of $0.3 million, and an understatement of intangible assets of $0.9 million. As of December 31, 2011, goodwill was overstated by $2.7 million, intangible assets were understated by $0.9 million, long-term portion of contingent liabilities was overstated by $1.0 million and deferred income taxes was overstated by $0.3 million. For the three months ended September 30, 2011, decrease (increase) in contingent liabilities increased $0.4 million from a decrease in contingent liabilities of $0.2 million to an increase in contingent liabilities of $0.2 million and loss from continuing operations increased $0.02 per share from $0.19 per share to $0.21 per share. For the nine months ended September 30, 2011, decrease (increase) in contingent liabilities increased $0.5 million from $0.8 million to $1.3 million, income tax benefit increased $0.1 million from $13.4 million to $13.6 million and income from continuing operations decreased $0.01 per share from $0.27 per share to $0.26 per share.

Contingent liabilities in the accompanying balance sheets now includes amounts relating to contingent value rights and other acquired contingent liabilities. The statement of cash flows has been adjusted for the restatements for the twelve months ended December 31, 2011. The only impact on the statement of cash flows is the change in the non-cash impact of contingent liabilities. The impact of the restatement as of December 31, 2011 and for the three and nine months ended September 30, 2011 is described in the table below:

	December 31, 2011
Balance sheet data:	As previously reported			Restated
Goodwill	$	14,894		$	12,238
Intangible assets, net	57,437			58,326
Total assets	122,350			120,583
Long-term portion of contingent liabilities	11,433			10,419
Deferred income taxes	2,522			2,230
Total liabilities	105,360			104,054
Accumulated deficit	(681,771		)	(682,232		)

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	Three Months Ended September 30, 2011						Nine Months Ended September 30, 2011
	As previously reported			Restated			As previously reported			Restated
Statement of Operations data:
Decrease (increase) in contingent liabilities	$	224		$	(198	)	$	(835	)	$	(1,317	)
Income tax benefit (expense)	(22		)	(22		)	13,427			13,572
Net Income (loss)	(3,756		)	(4,178		)	5,366			5,029
Basic and diluted earnings per share:
Income (loss) from continuing operations	$	(0.19	)	$	(0.21	)	$	0.27		$	0.26
Income from discontinued operations	—			—			—			—
Net Income (loss)	(0.19		)	(0.21		)	0.27			0.26
Weighted average number of common shares-basic	19,673			19,673			19,649			19,649
Weighted average number of common shares-diluted	19,673			19,673			19,649			19,686

ITEM 2. Management's Discussion and Analysis of Financial Condition and Results of Operations

Caution: This discussion and analysis may contain predictions, estimates and other forward-looking statements that involve a number of risks and uncertainties, including those discussed in Part II, Item 1A “Risk Factors.” This outlook represents our current judgment on the future direction of our business. These statements include those related to our royalty revenues, product returns, and product development. Actual events or results may differ materially from our expectations. For example, there can be no assurance that our revenues or expenses will meet any expectations or follow any trend(s), that we will be able to retain our key employees or that we will be able to enter into any strategic partnerships or other transactions. We cannot assure you that we will receive expected royalties to support our ongoing business or that our internal or partnered pipeline products will progress in their development, gain marketing approval or achieve success in the market.In addition, ongoing or future arbitration, or litigation or disputes with third parties may have a material adverse effect on us. Such risks and uncertainties, and others, could cause actual results to differ materially from any future performance suggested. We undertake no obligation to release publicly the results of any revisions to these forward-looking statements to reflect events or circumstances arising after the date of this quarterly report. This caution is made under the safe harbor provisions of Section 21E of the Securities Exchange Act of 1934, as amended.

Our trademarks, trade names and service marks referenced herein include Ligand. Each other trademark, trade name or service mark appearing in this quarterly report belongs to its owner.

References to Ligand Pharmaceuticals Incorporated (“Ligand”, the “Company”, “we” or “our”) include our wholly owned subsidiaries ─ Seragen, Inc. (“Seragen”); Nexus Equity VI LLC (“Nexus”); Pharmacopeia, LLC; Neurogen Corporation; Metabasis Therapeutics, Inc.; and CyDex Pharmaceuticals, Inc.

Overview

We are a biotechnology company that operates with a simple business model focused on developing or acquiring revenue generating assets and coupling them to a lean corporate cost structure. Our goal is to create a sustainably profitable business and generate meaningful value for our stockholders. Since a portion of our business model is based on the goal of partnering with other pharmaceutical companies to commercialize and market our assets, a significant amount of our revenue is based largely on payments made to us by partners for royalties, milestones and license fees. We recognized the important role of the drug reformulation segment in the pharmaceutical industry and in 2011 added Captisol® to our technology portfolio. Captisol is a formulation technology that has enabled six FDA approved products, including Pfizer's Vfend® IV, Baxter International's Nexterone®, and Onyx’s Kyprolis™ and is currently being used in a number of clinical-stage partner programs. In comparison to our peers, we believe we have assembled one of the largest and most diversified asset portfolios in the industry with the potential to generate significant revenue in the future. In addition, therapies in development address the unmet medical needs of patients for a broad spectrum of diseases including hepatitis, muscle wasting, Alzheimer's disease, dyslipidemia, diabetes, anemia, asthma, rheumatoid arthritis and osteoporosis. We have established multiple alliances with the world's leading pharmaceutical companies including GlaxoSmithKline, Merck, Pfizer, Baxter International, Bristol-Myers

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Squibb, Celgene, Onyx Pharmaceuticals, Lundbeck Inc., Eli Lilly & Company, Rib-X Pharmaceuticals, Inc., and The Medicines Company.

In February 2012, we announced that we had licensed the full world-wide rights to DARA (a Dual Acting Receptor Antagonist of Angiotension and Endothelin receptors) to Retrophin, LLC (“Retrophin”). Retrophin intends to develop DARA for orphan indications of severe kidney diseases including Focal Segmental Glomerulosclerosis (FSGS) as well as conduct proof-of-concept studies in resistant hypertension and diabetic nephropathy. Certain patient groups with severely compromised renal function exhibit extreme proteinuria resulting in progression to dialysis and a high mortality rate. DARA, with its unique dual blockade of angiotensin and endothelin receptors, is expected to provide meaningful clinical benefits in mitigating proteinuria in indications where there are no approved therapies. We received a net up-front payment of approximately $1 million, and may receive, net of amounts owed to third parties, over $75 million in milestones as well as 9% in royalties on potential future worldwide sales by Retrophin.

GSK has recently completed two large Phase III studies (ENABLE 1 and 2) designed to demonstrate Promacta’s value in treatment of thrombocytopenia in patients with Hepatitis C. In May 2012, GSK submitted U.S. and European regulatory applications for use of Promacta to increase platelet counts in patients with hepatitis C. In July 2012, GSK announced they had been granted priority review for this application in the U.S.

In July 2012, our licensee, Onyx Pharmaceuticals, Inc.. (“Onyx”), received accelerated approval from the U.S. Food and Drug Administration, or FDA, for Kyprolis™ (Carfilzomib) for injection. Kyprolis is formulated with Ligand’s Captisol® and is used for the treatment of patients with multiple myeloma who have received at least two prior therapies, including bortezomib and an immunomodulatory agent, and have demonstrated disease progression on or within 60 days of completion of the last therapy. The indication for Kyprolis is based on response rate. Currently, no data are available for Kyprolis that demonstrate an improvement in progression-free survival or overall survival. Under our agreement with Onyx, we are entitled to receive milestones, tiered royalties ranging between 1.5% and 3% as shown in the table below, and revenue from clinical and commercial Captisol material sales.

AGGREGATE NET SALES IN EACH CALENDAR YEAR	ROYALTY RATE
Up to, and including, $250 million	1.5	%
$251 million to $500 million	2.0	%
$501 million to $750 million	2.5	%
Above $750 million	3.0	%

The royalty rates set forth above will be applied to the total Net Sales of Product falling within the applicable range of aggregate annual Net Sales during the quarter.

In October 2012, our licensee, Merck, initiated a Phase 2b/3 adaptive clinical trial for Dinaciclib for the treatment of patients with refractory chronic lymphocytic leukemia (CLL). As a result, during the fourth quarter of 2012, we recognized a $2 million milestone payment upon initiation of the clinical study. Under our collaboration and license agreement with Merck, we are entitled to receive future milestones and royalties.

Metabasis Contingent Value Rights

In January 2010, we completed our acquisition of Metabasis. In addition to cash consideration, we issued four tradable Contingent Value Rights (“CVRs”), one CVR from each of four respective series of CVRs, for each Metabasis share. The CVRs will entitle the holder to cash payments as frequently as every six months as cash is received by us from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. We have also committed to spend at least $7 million within 30 months and $8 million within 42 months, in new research and development funding on the Metabasis programs. Through September 30, 2012, we estimate that we have spent approximately $7.3 million of the committed amount.

In January 2011, we entered into a strategic relationship with Chiva Pharmaceuticals, Inc. to develop multiple assets and technology in China and potentially worldwide. Chiva was granted licenses to begin immediate development in China of two clinical-stage HepDirect programs, Pradefovir for hepatitis B and MB01733 for hepatocellular carcinoma. Additionally, we granted Chiva a non-exclusive HepDirect technology license for the discovery, development and worldwide commercialization of new compounds in hepatitis B (HepB), hepatitis C (HepC) and hepatocellular carcinoma (HCC). Under the terms of the

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agreement, we are entitled to milestones and royalties on potential sales. In addition, we are entitled to receive a portion of any sublicensing revenue generated from sublicensing of collaboration compounds to third parties in a major world market. We received a $0.5 million license payment in March 2011, of which $0.1 million was remitted to CVR holders.

In August 2011, we entered into an amendment to the license agreement which required that a second $0.5 million licensing fee be paid in September 2011. In addition, the amendment increased royalty rates which we may receive under the license agreement to 6% of net sales of products (other than Pradefovir) and 9% of net sales for Pradefovir. In addition, the amendment removed from the license agreement a provision that afforded us the potential to earn a 10% equity position in Chiva as a milestone payment. In September 2011, Chiva paid us the $0.5 million licensing fee called for by the amendment, of which $0.1 million was remitted to CVR holders.

In September 2012, we entered into an option agreement with Viking Therapeutics, Inc. ("Viking"), which required Viking to pay a $50,000 upfront Option opening fee, 50% of which is required to be remitted to the Metabasis CVR holders pursuant to the CVR agreement. In October 2012, we remitted $6,000 to the Metabasis CVR holders, equivalent to the option fee less costs and expenses incurred in connection with the option agreement.

On September 4, 2012, the Company filed a demand for arbitration against Chiva Pharmaceuticals, Inc. (“Chiva”) with the American Arbitration Association.  The demand asserts claims for damages resulting from Chiva's breach of the October 7, 2011 Fablyn License Agreement (“Fablyn License Agreement”) for failure to tender a milestone payment and failure to pay certain patent prosecution expenses.  On October 31, 2012, the Company reached a settlement with Chiva, whereby the parties resolved all disputes that had arisen between them, including Ligand's primary claim in arbitration relating to payments due under the Fablyn License Agreement.  As part of the settlement, the parties executed mutual releases and Ligand agreed to seek dismissal of all claims asserted in the arbitration.  In return, Chiva agreed to pay Ligand $0.1 million, which has been received by the Company. 

Results of Operations

Three and Nine Months Ended September 30, 2012 and 2011

Total revenues for the three and nine months ended September 30, 2012 were $6.4 million and $17.8 million compared to $5.7 million and $17.1 million for the same periods in 2011. We reported a loss from continuing operations of $0.2 million and $5.3 million for the three and nine months ending September 30, 2012. We reported a loss from continuing operations of $4.2 million for the three months ending September 30, 2011 and income from continuing operations of $5.0 million for the nine months ended September 30, 2011.

Royalty Revenue

Royalty revenues were $3.2 million and $9.3 million for the three and nine months ended September 30, 2012, compared to $2.4 million and $6.6 million for the same periods in 2011. The increase in royalty revenue is primarily due to an increase in Promacta royalties and royalties on CyDex licensed products offset by a decrease in Avinza royalties.

Material Sales

We recorded material sales of $1.8 million and $4.2 million for the three and nine months ended September 30, 2012, compared to $1.7 million and $5.7 million for the same periods in 2011. Material sales were consistent for the three months ended September 30, 2012 compared to the same period in 2011. The decrease in material sales for the nine months ended September 30, 2012 is due to timing of customer purchases of Captisol.

Collaborative Research and Development and Other Revenues

We recorded collaborative research and development and other revenues of $1.3 million and $4.3 million for the three and nine months ended September 30, 2012, compared to $1.6 million and $4.8 million for the same periods in 2011. The decrease of $0.3 million for the three months ended September 30, 2012, compared to the same period in 2011, is primarily due to a decrease in license fees and milestones. The decrease of $0.5 million for the nine months ended September 30, 2012, compared to the same period in 2011 is due to the recognition of $1.3 million of deferred revenue related to the previous sale of royalty rights for the nine months ending September 30, 2011, partially offset by an increase in license fees and milestones of $0.8 million for the nine months ending September 30, 2012.

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Cost of Sales

Cost of sales were $0.7 million and $1.3 million for the three and nine months ended September 30, 2012, respectively, compared to $0.7 million and $2.9 million for the same periods in 2011. The decrease of $1.6 million for the nine months ended September 30, 2012, compared to the same period in 2011, is primarily due to a decrease in material sales and the variation in product mix of sales for the nine months ended September 30, 2012.

Research and Development Expenses

Research and development expenses were $2.6 million and $8.3 million for the three and nine months ended September 30, 2012, respectively, compared to $2.5 million and $7.7 million for the same periods in 2011. The increase of $0.1 million for the three months ended September 30, 2012, compared to the same period in 2011, is primarily due to timing of costs associated with internal programs. The increase of $0.6 million for the nine months ended September 30, 2012, compared to the same period in 2011, is primarily due to an increase in costs associated with internal programs.

As summarized in the table below, we are developing several proprietary products for a variety of indications. Our programs are not limited to the following, but are representative of a range of future licensing opportunities to expand our partnered asset portfolio.

Program	Disease/Indication	Development Phase
Selective Androgen Receptor Modulators (SARMs) (agonists)	Muscle wasting and frailty	Phase I
Captisol-Enabled Melphalan IV	Oncology	Pivotal
Captisol-Enabled Topiramate IV	Epilepsy/Seizures	Preclinical
Glucagon receptor antagonist	Diabetes	Preclinical

We do not provide forward-looking estimates of costs and time to complete our ongoing research and development projects as such estimates would involve a high degree of uncertainty. Uncertainties include our inability to predict the outcome of complex research, our inability to predict the results of clinical studies, regulatory requirements placed upon us by regulatory authorities such as the FDA and EMA, our inability to predict the decisions of our collaborative partners, our ability to fund research and development programs, competition from other entities of which we may become aware in future periods, predictions of market potential from products that may be derived from our research and development efforts, and our ability to recruit and retain personnel or third-party research organizations with the necessary knowledge and skills to perform certain research. Refer to “Item 1A. Risk Factors” for additional discussion of the uncertainties surrounding our research and development initiatives.

General and Administrative Expenses

General and administrative expenses were $4.4 million and $11.8 million for the three and nine months ended September 30, 2012, respectively, compared to $4.0 million and $11.3 million for the same periods in 2011. The increase of $0.4 million for the three months ended September 30, 2012, compared to the same period in 2011, is primarily due to an increase in consulting expenses and share-based compensation. The increase of $0.5 million for the nine months ended September 30, 2012, compared to the same period in 2011, is primarily due to an increase in legal and consulting expenses.

Lease Exit and Termination Costs

In September 2010, we ceased use of our facility located in Cranbury, New Jersey. As a result, during the quarter ended September 30, 2010, we recorded lease exit costs of $9.7 million for costs related to the difference between the remaining lease obligations of the abandoned operating leases, which run through August 2016, and management’s estimate of potential future sublease income, discounted to present value. Actual future sublease income may differ materially from our estimate, which would result in us recording additional expense or reductions in expense. In addition, we wrote-off approximately $5.4 million of property and equipment related to the facility closure and recorded approximately $1.8 million of severance related costs. We recorded a decrease of $15,000 in lease exit and termination costs for the three months ending September 30, 2012. We recorded $0.2 million as an increase in lease exit and termination costs for the nine months ending September 30, 2012. During the three and nine months ended September 30, 2011, we sold certain property and equipment for

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$2,000 and $0.2 million, respectively, from our former facility, which was recorded as a reduction of lease termination and exit costs.

Accretion of Deferred Gain on Sale Leaseback

On November 9, 2006, we sold real property located in San Diego, California for a sale price of $47.6 million. This property included our corporate headquarter building totaling approximately 82,500 square feet, the land on which the building was situated, and two adjacent vacant lots. As part of the sale transaction, we agreed to leaseback the building for a period of 15 years. We recognized an immediate pre-tax gain on the sale transaction of $3.1 million and deferred a gain of $29.5 million on the sale of the building. The deferred gain was being recognized on a straight-line basis over the 15 year term of the lease at a rate of approximately $2.0 million per year. In August 2009, we entered into a lease termination agreement for this building. As a result, we recognized $20.4 million of accretion of deferred gain during the quarter ended September 30, 2009, and recognized the remaining balance of the deferred gain through the term of our new building lease, which expired in December 2011. The amount of the deferred gain recognized for the three and nine months ended September 30, 2011 was $0.4 million and $1.3 million, and was fully amortized as of December 31, 2011.

Interest Expense, net

Interest expense was $0.8 million and $2.5 million, for the three and nine months ended September 30, 2012, respectively, compared to $0.7 million and $1.8 million for the same period in 2011. The increases in interest expense of $0.1 million for the three month period and $0.7 million for the nine month period ending September 30, 2012 were due to the increase in the outstanding balance of notes payable at September 30, 2012 compared to September 30, 2011. Additionally, the $20 million loan obtained to acquire CyDex in January 2011 was outstanding for a partial period for the nine months ending September 30, 2011.

Change in Contingent Liabilities

We recorded a decrease in contingent liabilities of $2.1 million and $1.2 million, respectively for the three and nine months ended September 30, 2012, compared to an increase in contingent liabilities of $0.2 million and $1.3 million for the three and nine months ended September 30, 2011. The decrease for the three months ended September 30, 2012 relates to a decrease in the liability for amounts potentially due to holders of CVRs and former license holders associated with our CyDex acquisition. The decrease for the nine months ended September 30, 2012 is due to a decrease in Metabasis CVRs of $1.1 million. Additionally, amounts potentially due to Neurogen CVR holders decreased $0.2 million. Partially offsetting, amounts potentially due to CyDex CVR holders and former license holders increased $0.1 million. The increase in contingent liabilities of $0.2 million and $1.3 million for the three and nine months ended September 30, 2011, respectively relates to our liability for amounts potentially due to holders of CVRs and former license holders associated with our Metabasis and CyDex acquisitions.

Income Taxes

We recorded income tax expense from continuing operations of $0.1 million and $0.4 million, respectively for the three and nine months ended September 30, 2012. We recorded income tax expense of $22,000 and an income tax benefit of $13.6 million for the three and nine months ended September 30, 2011, respectively. The income tax benefit for the nine months ended September 30, 2011 relates to the release of a portion of our valuation allowance against deferred tax assets which can be used to offset deferred tax liabilities recorded in connection with our acquisition of CyDex in January 2011.

Discontinued Operations

Oncology Product Line

On September 7, 2006, we and Eisai Inc., a Delaware corporation, and Eisai Co., Ltd., a Japanese company (which we collectively refer to as Eisai), entered into a purchase agreement, or the Oncology Purchase Agreement, pursuant to which Eisai agreed to acquire all of our worldwide rights in and to our oncology products, including, among other things, all related inventory, equipment, records and intellectual property, and assume certain liabilities as set forth in the Oncology Purchase Agreement. The Oncology product line included our four marketed oncology drugs: Ontak, Targretin capsules, Targretin gel and Panretin gel.

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During the three and nine months ended September 30, 2011, we recognized $0 and $3,000, respectively, of pre-tax gains due to subsequent changes in certain estimates and liabilities recorded as of the sale date. For the nine months ended September 30, 2012, there have been no changes.

Avinza Product Line

On September 6, 2006, we and King entered into a purchase agreement, or the Avinza Purchase Agreement, pursuant to which King agreed to acquire all of our rights in and to Avinza in the United States, its territories and Canada, including, among other things, all Avinza inventory, records and related intellectual property, and assume certain liabilities as set forth in the Avinza Purchase Agreement, which we collectively refer to as the Transaction.

Pursuant to the terms of the Avinza Purchase Agreement, we retained the liability for returns of product from wholesalers that had been sold by us prior to the close of the Transaction. Accordingly, as part of the accounting for the gain on the sale of Avinza, we recorded a reserve for Avinza product returns.

During the nine months ended September 30, 2012, we recognized a pre-tax gain of $3.7 million, due to subsequent changes in certain estimates and liabilities recorded as of the sale date. For the three months ended September 30, 2012 no changes were recorded. During the three and nine months ended September 30, 2011, we recognized no gain or loss due to subsequent changes in certain estimates and liabilities recorded as of the sale date.

Income Taxes

We recorded an income tax benefit of $14,000 for income taxes related to discontinued operations for the nine month period ended September 30, 2012. We did not record any provision for income taxes for the three month period ending September 30, 2012 as we did not realize any taxable income from discontinued operations. Additionally, we did not record any provision for income taxes for the three and nine month periods ending September 30, 2011 as we did not realize any taxable income from discontinued operations.

Liquidity and Capital Resources

We have financed our operations through offerings of our equity securities, borrowings from long-term debt, issuance of convertible notes, product sales and the subsequent sales of our commercial assets, royalties, collaborative research and development and other revenues, capital and operating lease transactions.

We have incurred significant losses since inception. At September 30, 2012, our accumulated deficit was $683.8 million and we had negative working capital of $12.4 million. We believe that cash flows from operations will improve due to consistent Captisol® sales, an increase in royalty revenues driven primarily from continued increases in Promacta sales, recent product approvals and regulatory developments, as well as anticipated new license and milestone revenues. In the event revenues and operating cash flows do not meet expectations, management plans to reduce discretionary expenses. However, it is possible that we may be required to seek additional financing. There can be no assurance that additional financing will be available on terms acceptable to management, or at all. We believe our available cash, cash equivalents, and short-term investments as well as our current and future royalty, license and milestone revenues will be sufficient to satisfy our anticipated operating and capital requirements, through at least the next twelve months. Our future operating and capital requirements will depend on many factors, including, but not limited to: the pace of scientific progress in our research and development programs; the potential success of these programs; the scope and results of preclinical testing and clinical trials; the time and costs involved in obtaining regulatory approvals; the costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims; competing technological and market developments; the amount of royalties on sales of the commercial products of our partners; the efforts of our collaborative partners; obligations under our operating lease agreements; and the capital requirements of any companies we acquire, including Pharmacopeia, Inc. (“Pharmacopeia”), Neurogen Corporation (“Neurogen”), Metabasis Therapeutics, Inc. (“Metabasis”) and CyDex Pharmaceuticals, Inc. (“CyDex”). Our ability to achieve our operational targets is dependent upon our ability to further implement our business plan and generate sufficient operating cash flow.

In January 2011, we entered into a $20 million secured term loan credit facility (“secured debt”) with Oxford Financial Group (“Oxford”). The loan was amended in January 2012 to increase the secured credit facility to $27.5 million. The original $20 million borrowed under the facility bears interest at a fixed rate of 8.6%. The additional $7.5 million bears interest at a fixed rate of 8.9%. Under the terms of the secured debt, we will make interest only payments through March 2013. Subsequent to the interest only payments, the note will amortize with principal and interest payments through the remaining

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term of the loan. Additionally, we must also make an additional final payment equal to 6% of the total amount borrowed which is due at maturity and is being accreted over the life of the loan. The maturity date of the term loan is August 1, 2014.

We also have a cash-collateralized revolving credit facility under which we may elect to borrow up to $10 million. Amounts borrowed under the revolving credit facility bear interest at a floating rate equal to 200 basis points above the prime rate. All outstanding amounts under the credit facility may become due and payable if we fails to maintain a cash balance equal to the amount outstanding under the credit facility. The maturity date of the revolving credit facility is March 29, 2013.

In October 2011, we filed a Registration Statement on Form S-3 with the Securities and Exchange Commission (“SEC”) for the issuance and sale of up to $30 million of equity or other securities, proceeds from which will be used for general corporate purposes. The Form S-3 provides additional financial flexibility for us to sell shares or other securties as needed at any time. As of September 30, 2012, 150,000 common shares have been issued under this registration statement for total net proceeds of approximately $2.6 million.

In connection with the acquisition of CyDex Pharmaceuticals, Inc. on January 24, 2011, we issued a series of Contingent Value Rights (“CVR”). We paid the CVR holders $4.3 million in January 2012 and may be required to pay up to an additional $4.0 million upon achievement of certain clinical and regulatory milestones. In 2011, $0.9 million was paid to the CyDex Shareholders upon completion of a licensing agreement with The Medicines Company for the Captisol enabled Intravenous formulation of Clopidogrel. An additional $2 million was paid to the CyDex Shareholders upon acceptance by the FDA of the New Drug Application submitted by Onyx and an additional $3.5 million was paid upon approval by the FDA of Kyprolis for the potential treatment of patients with relapsed and refractory multiple myeloma. In addition, we will pay CyDex shareholders, for each respective year from 2011 through 2016, 20% of all CyDex-related revenue, but only to the extent that and beginning only when CyDex-related revenue for such year exceeds $15.0 million; plus an additional 10% of all CyDex-related revenue recognized during such year, but only to the extent that and beginning only when aggregate CyDex-related revenue for such year exceeds $35.0 million. We paid $0.3 million to the CyDex shareholders in March 2012 for 20% of all 2011 CyDex-related revenue in excess of $15 million. Pursuant to the CVR Agreement, the shareholders' representative on behalf of the former CyDex shareholders filed a notice of objection with us regarding the calculation of payments due to the CyDex former shareholders for the first and second quarters of 2011. In addition, the shareholders' representative claimed that we exceeded the $35 million financial indebtedness limitation contained in the CVR Agreement. In August 2012, we executed a settlement agreement with the shareholders' representative releasing us from all claims.

We also assumed certain contractual obligations for milestone payments potentially due in connection with CAPTISOL enabled Intravenous formulation of Clopidogrel. We may be required to pay up to $4 million upon achievement of clinical and regulatory milestones.

We are also required by the CyDex CVR Agreement to dedicate at least five experienced full-time employee equivalents per year to the acquired business and to invest at least $1.5 million per year, inclusive of such employee expenses, in the acquired business, through 2015. As of September 30, 2012, we estimate we have exceeded our commitment for the year ending December 31, 2012.

Based on management’s plans, including projected increases in Captisol sales and royalty revenues, as well as anticipated new license revenue and expense reductions, if necessary, we believe our currently available cash, cash equivalents, and short-term investments as well as our current and future royalty, license and milestone revenues will be sufficient to satisfy our anticipated operating and capital requirements, through at least the next twelve months. Our future operating and capital requirements will depend on many factors, including, but not limited to: the pace of scientific progress in our research and development programs; the magnitude of these programs; the scope and results of preclinical testing and clinical trials; the time and costs involved in obtaining regulatory approvals; the costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims; competing technological and market developments; the amount of royalties on sales of our partners’ commercial products; the efforts of our collaborative partners; obligations under our operating lease agreements and lease termination agreement; and the capital requirements of any companies we may acquire, including Neurogen, Metabasis and CyDex. We believe that the actions presently being taken to generate sufficient operating cash flow provide the opportunity for us to continue as a going concern.  While we believe in the viability of our strategy to generate sufficient operating cash flow and in our ability to raise additional funds, there can be no assurances to that effect. Our ability to achieve our operational targets is dependent upon our ability to further implement our business plan and generate sufficient operating cash flow.

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Operating Activities

Operating activities used cash of $2.0 million for the nine months ended September 30, 2012, compared to $8.2 million of cash used in operating activities for the same period in 2011.

The cash used for the nine months ended September 30, 2012 reflects a net loss of $1.6 million, adjusted by $3.7 million of gain from discontinued operations and $4.7 million of non-cash items to reconcile the net loss to net cash used in operations. These reconciling items primarily reflect depreciation and amortization of $2.0 million, share-based compensation of $3.1 million, and the change in deferred income taxes of $0.4 million, partially offset by the non-cash change in the estimated fair value of contingent liabilities of $1.2 million. The cash used during the nine months ended September 30, 2012 is further impacted by changes in operating assets and liabilities due primarily to an increase in inventory of $0.8 million, a decrease in deferred revenue of $1.7 million, and a decrease in accounts payable and accrued liabilities of $3.0 million. Partially offset by decreases in accounts receivable of $4.0 million, other current assets of $0.3 million, and other long term assets of $0.3 million. Cash used in operating activities of discontinued operations was $0.6 million for the nine months ended September 30, 2012.

The cash generated for the nine months ended September 30, 2011 reflects net income of $5.0 million, adjusted by $3,000 of gain from discontinued operations and $6.8 million of non-cash items to reconcile the net income to net cash used in operations. These reconciling items primarily reflect the change in deferred income taxes of $13.9 million, accretion of deferred gain on the sale leaseback of the building of $1.3 million and non-cash lease costs of $0.1 million partially offset by the change in estimated fair value of contingent liabilities of $1.3 million, depreciation and amortization of $2.1 million, write-off of in-process research and development assets of $2.3 million and stock-based compensation of $2.6 million. The cash generated during the nine months ended September 30, 2011 is further impacted by changes in operating assets and liabilities due primarily to a decrease in other liabilities of $4.1 million, deferred revenue of $1.2 million, and accounts payable and accrued liabilities of $7.1 million, partially offset by decreases in other current assets of $4.5 million, inventory of $0.5 million, accounts receivable of $0.5 million and other long term assets of $0.6 million. None of the cash used in operating activities for the nine months ended September 30, 2011 related to discontinued operations.

Investing Activities

Investing activities provided cash of $1.3 million for the nine months ended September 30, 2012, compared to $22.9 million of cash provided by investing activities for the same 2011 period.

Cash provided by investing activities during the nine months ended September 30, 2012 primarily reflects $10 million of proceeds from the sale of short-term investments, partially offset by payment to CVR holders of $8.0 million and purchases of property, equipment and building of $0.6 million. None of the cash provided by investing activities for the nine months ended September 30, 2012 related to discontinued operations.

Cash used by investing activities during the nine months ended September 30, 2011 primarily reflects $32.0 million of cash paid for the acquisition of CyDex and $10.0 million for purchases of short-term investments, partially offset by $19.3 million of proceeds from the sale of short-term investments. None of the cash provided by investing activities for the nine months ended September 30, 2011 related to discontinued operations.

Financing Activities

Financing activities provided cash of $0.7 million for the nine months ended September 30, 2012, compared to cash provided by financing activities of $30 million for the same 2011 period.

Cash provided by financing activities for the nine months ended September 30, 2012 primarily reflects $10.0 million of repayment of debt, partially offset by proceeds from the issuance of debt of $7.5 million and proceeds from the issuance of common stock of $3.2 million.

Cash provided by financing activities for the nine months ended September 30, 2011 primarily reflects $30.0 million of proceeds from the issuance of debt, partially offset by share repurchases of $0.1 million.

None of the cash used in financing activities for the nine months ended September 30, 2012 and 2011 relates to discontinued operations.

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Other

In connection with the acquisition of Neurogen Corporation on December 23, 2009, Neurogen security holders received CVRs under four CVR agreements. The CVRs entitle Neurogen shareholders to cash payments upon the sale or licensing of certain assets and upon the achievement of a specified clinical milestone. At September 30, 2012 and December 31, 2011, the aggregate fair values of the Aplindore, VR1 and H3 CVR’s were $0.5 million and $0.7 million, respectively, and included in long-term portion of liability for contingent value rights in the accompanying balance sheets as management is unable to estimate the timing of potential future payments.

In connection with the acquisition of Metabasis Therapeutics on January 27, 2010, Metabasis security holders received CVRs under four CVR agreements. The CVRs entitle the holders to cash payments upon the sale or licensing of certain assets and upon the achievement of specified milestones. The fair value of the liability at September 30, 2012 and December 31, 2011 was $0 and $1.1 million, respectively.

In connection with the acquisition of CyDex Pharmaceuticals, Inc. on January 24, 2011, we issued a series of Contingent Value Rights and also assumed certain contingent liabilities. In 2011, $0.9 million was paid to the CyDex Shareholders upon completion of a licensing agreement with The Medicines Company for the Captisol enabled Intravenous formulation of Clopidogrel. An additional $2.0 million was paid to the CyDex Shareholders upon acceptance by the FDA of Onyx’s NDA Onyx, $4.3 million was paid in January 2011, and an additional $3.5 million was paid upon approval by the FDA of Kyprolis for the potential treatment of patients with relapsed and refractory multiple myeloma. We may be required to pay an additional $8.0 million upon achievement of certain clinical and regulatory milestones to the CyDex shareholders and former license holders. In addition, we will pay CyDex shareholders, for each respective year from 2011 through 2016, 20% of all CyDex-related revenue, but only to the extent that and beginning only when CyDex-related revenue for such year exceed $15.0 million; plus an additional 10% of all CyDex-related revenue recognized during such year, but only to the extent that and beginning only when aggregate CyDex-related revenue for such year exceeds $35.0 million. We paid $0.3 million to the CyDex shareholders in March 2012 related to 2011 CyDex-related revenue. The estimated fair value of the contingent liabilities recorded as part of the CyDex acquisiton at September 30, 2012 was $7.6 million.

Leases and off-balance sheet arrangements

We lease our office and research facilities under operating lease arrangements with varying terms through November 2021. The agreements provide for increases in annual rents based on changes in the Consumer Price Index or fixed percentage increases ranging from 3.0% to 3.5%. Commencing in January 2008, we also sublease a portion of our facilities through July 2015. The sublease agreement provides for a 3% increase in annual rents. We had no off-balance sheet arrangements at September 30, 2012 and December 31, 2011.

Contractual Obligations

As of September 30, 2012, future minimum payments due under our contractual obligations are as follows (in thousands):

	Payments Due by Period
	Total		Less than 1 year		1-3 years		3-5 years		More than 5 years
Operating lease obligations (1)	$	21,517	$	5,227	$	10,948	$	4,016	$	1,326

(1) We currently sublease two of our facilities through their respective lease terms of July 2015 and August 2016. As of September 30, 2012, we expect to receive aggregate future minimum lease payments totaling $4.0 million (nondiscounted) over the duration of the sublease agreements as follows: less than one year, $1.2 million; one to three years, $2.4 million; and three to five years, $0.3 million.

We outsource the production of Captisol to Hovione, LLC. Under the terms of the supply agreement with Hovione, the Company has ongoing minimum annual purchase commitments and is required to purchase a total of $15 million of Captisol over the term of the supply agreement which expires in December 2019. Through September 30, 2012 we have exceeded that commitment. Either party may terminate the Agreement for the uncured material breach or bankruptcy of the other party or an extended force majeure event. The Company may also terminate the supply agreement for extended supply interruption, regulatory action related to Captisol or other specified events.

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Under the terms of our merger with Metabasis, we are committed to spend at least $7 million within 30 months following the close of the transaction and $8.0 million within 42 months in new research and development funding on the Metabasis programs. Through September 30, 2012, we estimate that we have spent approximately $7.3 million of the committed amount.

We are also required under our CyDex CVR Agreement to invest at least $1.5 million per year, inclusive of employee expenses, in the acquired business, through 2015. As of September 30, 2012, we estimate we have exceeded that amount.

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ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We do not have a significant level of transactions denominated in currencies other than U.S. dollars and as a result we have very limited foreign currency exchange rate risk. We purchase Captisol from Hovione, located in Lisbon, Portugal. Payments to Hovione are denominated and paid in US dollars, however the unit price of Captisol contains an adjustment factor which is based on the sharing of foreign currency risk between the two parties. The effect of an immediate 10% change in foreign exchange rates would have no material impact on our financial condition, results of operations or cash flows.

We are exposed to market risk involving rising interest rates. To the extent interest rates rise, our interest costs could increase. An increase in interest costs of 10% would have no material impact on our financial condition, results of operations, or cash flows.

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ITEM 4. CONTROLS AND PROCEDURES

Under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, we conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, as of the end of the period covered by this report, which we refer to as the Evaluation Date.

As a result of material weaknesses in our internal control over financial reporting relating to the accounting for significant non-routine transactions and the controls over the determination of fair value of contingent liabilities, management has reassessed the effectiveness of our disclosure controls and procedures and have determined that our disclosure controls and procedures were not effective as of September 30, 2012. Despite the material weaknesses in our internal control, management believes no material inaccuracies or omissions of fact exist in this quarterly report.

Remediation Plan. As a result of the material weaknesses associated with acquisition-related accounting, we have added a corporate controller to our finance and accounting staff.  While we had processes to identify and intelligently apply accounting standards to complex transactions, we did not have adequate numbers of highly skilled accountants to provide for a detail analysis, documentation and review of the acquisition of CyDex, which closed on January 24, 2011. Additionally, we plan to enhance our controls over the determination of the fair value of contingent liabilities by including a formal review of mathematical calculations and completeness of such calculations. These material weaknesses prevented us from properly reporting the financial information for previous interim and annual periods, and we have filed restated 10-Q and 10-K reports for the applicable periods. Management will continue to review and make necessary changes to the overall design of its internal control environment, as well as to policies and procedures to improve the overall effectiveness of internal control over financial reporting.

The material weaknesses will not be remediated until the applicable remedial procedures are tested and management has concluded that the procedures and controls are operating effectively.

Changes in Internal Controls. Except as described above, there have been no changes during the last fiscal quarter in our internal control over financial reporting that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

From time to time we are subject to various lawsuits and claims with respect to matters arising out of the normal course of our business. Due to the uncertainty of the ultimate outcome of these matters, the impact on future financial results is not subject to reasonable estimates.

Securities Litigation

On June 8, 2012, a federal securities class action and shareholder derivative lawsuit was filed in the Eastern District of Pennsylvania against Genaera Corporation and its officers, directors, major shareholders and trustee (“Genaera Defendants”) for allegedly breaching their fiduciary duties to Genaera shareholders.  The lawsuit also names the Company and its CEO John Higgins as additional defendants for allegedly aiding and abetting the Genaera Defendants' various breaches of fiduciary duties based on the Company's purchase of a licensing interest in a development-stage pharmaceutical drug program from the Genaera Liquidating Trust in May 2010 and its subsequent sale of half of its interest in the transaction to Biotechnology Value Fund, Inc.  The complaint seeks unspecified damages, disgorgement, punitive damages, attorneys' fees and costs.  The Company intends to vigorously defend against the claims against it and Mr. Higgins in the lawsuit.  Due to the complex nature of the legal and factual issues involved, however, the outcome of this matter is not presently determinable. 

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ITEM 1A. RISK FACTORS

The following is a summary description of some of the many risks we face in our business. You should carefully review these risks in evaluating our business, including the businesses of our subsidiaries. You should also consider the other information described in this report.

Risks Related To Us and Our Business.

Our business has recently undergone a significant change, and we may not be successful in integrating the Captisol technology and CyDex’s other development product candidates into our existing operations or in realizing the planned results from our recently expanded product portfolio and pipeline.

In January 2011, we completed our merger with CyDex, in which we obtained the Captisol technology, in addition to other product candidates. We will need to overcome significant challenges in order to realize the benefits from this acquisition. These challenges will include the timely, efficient and successful execution of a number of tasks, including the following:

• integrating CyDex into our existing operations;

• integrating CyDex’s developmental product candidates and successfully managing the development and regulatory processes; and

• coordinating with CyDex’s and our collaborative partners concerning the development, manufacturing, regulatory and intellectual property protection strategies for Captisol and new development product candidates.

In addition, we rely on our collaborative partners for many aspects of our developmental and commercialization activities, and we are subject to risks related to their financial stability and solvency. We may not succeed in addressing these risks or any other problems encountered in connection with the acquisition of CyDex.

Furthermore, all of CyDex’s products and product candidates, as well as the technology that it outlicenses, are based on Captisol. In addition, CyDex or its partners are attempting to develop some product candidates that may contain significantly higher levels of Captisol than in any currently-approved product and has directed developers to demonstrate an adequate safety margin and specifically acceptable renal safety. If products or product candidates incorporating Captisol technology were to cause any unexpected adverse events, whether in preclinical studies, clinical trials or as commercialized products, whether as a result of Captisol or otherwise, the perception of Captisol safety could be seriously harmed. If this were to occur, we may not be able to market these products unless and until we are able to demonstrate that the adverse event was unrelated to Captisol, which we may not be able to do. Further, whether or not the adverse event was a result of Captisol, we could be required by the FDA to submit to additional regulatory reviews or approvals, including extensive safety testing or clinical testing of products using Captisol, which would be expensive and, even if we were to demonstrate that the adverse event was unrelated to Captisol, would delay our marketing of Captisol-enabled products and receipt of revenue related to those products.

Revenues based on sales of Promacta represent a substantial portion of our overall current and/or expected future revenues.

GSK is obligated to pay us royalties on its sales of Promacta. These payments are expected to be a substantial portion of our ongoing revenues for some time. As a result, any setback that may occur with respect to Promacta could significantly impair our operating results and/or reduce the market price of our stock. Setbacks for Promacta could include problems with shipping, distribution, manufacturing, product safety, marketing, government regulation, safety issues, licenses and approvals, intellectual property rights, competition with existing or new products and physician or patient acceptance of the products, as well as higher than expected total rebates, returns or discounts.

Revenues based on sales of Kyprolis represent a substantial portion of our overall expected future revenues.

Revenue from Onyx based on sales of Kyprolis are expected to be a substantial portion of our revenue in the future and any setbacks that occur with respect to Kyprolis could significantly impair our future operating results and/or reduce the market price of our stock. Setbacks for Kyprolis could include problems with shipping, distribution, manufacturing, product safety, marketing, government regulation, safety issues, licenses and approvals, intellectual property rights, competition with existing or new products and physician or patient acceptance of the products, as well as higher than expected total rebates, returns or discounts.

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Our product candidates face significant development and regulatory hurdles prior to marketing which could delay or prevent sales and/or milestone revenue.

Before we or our partners obtain the approvals necessary to sell any of our potential products, we must show through preclinical studies and human testing that each product is safe and effective. We and our partners have a number of products moving toward or currently awaiting regulatory action. Failure to show any product’s safety and effectiveness could delay or prevent regulatory approval of a product and could adversely affect our business. The clinical trials process is complex and uncertain. For example, the results of preclinical studies and initial clinical trials may not necessarily predict the results from later large-scale clinical trials. In addition, clinical trials may not demonstrate a product’s safety and effectiveness to the satisfaction of the regulatory authorities. Recently, a number of companies have suffered significant setbacks in advanced clinical trials or in seeking regulatory approvals, despite promising results in earlier trials. The FDA may also require additional clinical trials after regulatory approvals are received. Such additional trials may be expensive and time-consuming, and failure to successfully conduct those trials could jeopardize continued commercialization of a product.

The rates at which we complete our clinical trials depends on many factors, including, but are not limited to, our ability to obtain adequate supplies of the products to be tested and patient enrollment. Patient enrollment is a function of many factors, including the size of the patient population, the proximity of patients to clinical sites and the eligibility criteria for the trial. Delays in patient enrollment for our trials may result in increased costs and longer development times. For example, the trial entitled “Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedures (ELEVATE)” was suspended in October 2009 in accordance with an IDMC Recommendation. GSK terminated the ELEVATE study. In addition, our collaborative partners have rights to control product development and clinical programs for products developed under the collaborations. As a result, these collaborative partners may conduct these programs more slowly or in a different manner than expected. Moreover, even if clinical trials are completed, we or our collaborative partners still may not apply for FDA approval in a timely manner or the FDA still may not grant approval.

We rely heavily on collaborative relationships, and any disputes or litigation with our collaborative partners or termination or breach of any of the related agreements could reduce the financial resources available to us, including milestone payments and future royalty revenues.

Our strategy for developing and commercializing many of our potential products, including products aimed at larger markets, includes entering into collaborations with corporate partners and others. These collaborations have provided us with funding and research and development resources for potential products for the treatment of a variety of diseases. However, the funding provided to us by our existing collaborative partners for ongoing research and development under our existing collaborative agreements has ceased. These agreements also give our collaborative partners significant discretion when deciding whether or not to pursue any development program. Our existing collaborations may not continue or be successful, and we may be unable to enter into future collaborative arrangements to develop and commercialize our product candidates.

In addition, our collaborators may develop drugs, either alone or with others that compete with the types of drugs they are developing with us. This would result in increased competition for our programs. If products are approved for marketing under our collaborative programs, revenues we receive will depend on the manufacturing, marketing and sales efforts of our collaborative partners, who generally retain commercialization rights under the collaborative agreements. Generally, our current collaborative partners also have the right to terminate their collaborations under specified circumstances. If any of our collaborative partners breach or terminate their agreements with us or otherwise fail to conduct their collaborative activities successfully (for example, by not making required payments when due, or at all), our product development under these agreements will be delayed or terminated. Disputes or litigation may also arise with our collaborators, including disputes or litigation over ownership rights to intellectual property, know-how or technologies developed with our collaborators. Such disputes or litigation could adversely affect our rights to one or more of our product candidates. Any such dispute or litigation could delay, interrupt or terminate the collaborative research, development and commercialization of certain potential products, create uncertainty as to ownership rights of intellectual property, or could result in litigation or arbitration. The occurrence of any of these problems could be time-consuming and expensive and could adversely affect our business.

We obtain Captisol from a sole source supplier, and if this supplier were to cease to be able to supply Captisol to us, or decline to supply Captisol to us, we would be unable to continue to derive revenue or continue to develop our product candidates until we obtained an alternative source, which could take a considerable length of time.

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We currently have one supplier of Captisol, Hovione FarmaCiencia SA, or Hovione, through its agent Hovione LLC. Hovione is a major supplier of APIs and API intermediates located in Lisbon, Portugal. Hovione has other production sites in Cork, Ireland, Macau, China, and Zhejiang, China, but those sites are not yet fully qualified to make Captisol. If a major disaster were to happen at Hovione or Hovione were to suffer major production problems or were to fail to deliver Captisol to us for any other reason, there could be a significant interruption of our Captisol supply. While we carry a significant inventory of Captisol for this type of occurrence, which should permit us to satisfy our existing supply obligations through 2012 under current and anticipated demand conditions, a series of unusually large orders could rapidly deplete that inventory and cause significant problems with our licensees and disrupt our business. In addition, if we fail to supply Captisol under our supply agreements, our customers could obtain the right to have Captisol manufactured by other suppliers, which would significantly harm our business.

We rely on contract manufacturers for the manufacture of Captisol and product candidates, and if these contract manufacturers fail to perform as we expect, we will incur delays in our ability to generate revenue and substantial additional expenses in obtaining new contract manufacturers.

We do not manufacture products or product candidates, but rather contract with contract manufacturers for the manufacture of products and product candidates. With respect to any specific product or product candidate, we only contract with one contract manufacturer due to the high cost of compliance with good manufacturing practices prior to the contract manufacturer being permitted to manufacture the product or product candidate for use in humans. If a contract manufacturer is unable or unwilling to continue to manufacture for us in the future, we would be required to contract with a new contract manufacturer for the specific product or product candidate. In the case of products, this would cause us to lose revenue during the qualification process, and in the case of product candidates, this could cause a delay in the commercialization of the product candidate. In addition, in either case we would incur substantial additional expenses as a result of the new contract manufacturer becoming qualified. Further, if a contract manufacturer were to experience a delay in producing products or product candidates due to a failure to meet strict FDA manufacturing requirements or otherwise, we would also experience a delay in development and commercialization of the product candidate or, in the case of products, sales of the product. This risk is exacerbated in the case of manufacture of injectables, which require heightened sterility and other conditions as well as specialized facilities for preparation.

If we consume cash more quickly than expected, and if we are unable to raise additional capital, we may be forced to curtail operations.

Our operations have consumed substantial amounts of cash since inception. As of September 30, 2012, we had a negative working capital of $12.4 million. Clinical and preclinical development of drug candidates is a long, expensive and uncertain process. Also, we may acquire companies, businesses or products and the consummation of such acquisitions may consume additional cash. For example, as part of the consideration for our recent acquisition of CyDex, we distributed approximately $12.0 million of our cash to CyDex stockholders. In connection with the acquisition, we entered into a $20 million Loan and Security Agreement, or the Loan Agreement, with a lender. Under the terms of the Loan Agreement, we will make interest only payments through March 2013 at a fixed rate of 8.64%. Subsequent to the interest only payments, the note will amortize with principal and interest payments due through the remaining term of the loan. The loan term, including interest only payments, is 42 months.

In March 2011, we borrowed $5.0 million from Square 1 Bank and April 2011 we borrowed an additional $5.0 million from Square 1. All outstanding amounts under the loan bear interest at a floating rate equal to 200 basis points above the prime rate and may become immediately due and payable if we fail to maintain a cash balance at Square 1 equal to the amount outstanding under the credit facility. We paid $4.5 million on our revolving credit facility in January 2012, $4.0 million in March 2012, and the remaining $1.5 million in July 2012. On March 29, 2012, we entered into a Second Amendment to Loan and Security Agreement (the "Square 1 Second Amendment to Loan and Security Agreement"). The Square 1 Second Amendment to Loan and Security Agreement changed the maturity date of the revolving line of credit facility to March 28, 2013. The Square 1 Second Amendment to Loan and Security Agreement did not change the interest rate and interest payment schedule established in the Loan and Security Agreement.

     On January 23, 2012, we amended the Loan and Security Agreement (the "Amended Loan and Security Agreement"). The Amended Loan and Security Agreement increased the secured term loan credit facility from $20 million up to $30 million; we immediately borrowed $7.5 million of the additionally-authorized $10 million against two Secured Promissory Notes.  We did not elect to borrow the remaining available $2.5 million. The additional $7.5 million loan bears interest at (and the additional $2.5 million loan would bear interest at) a fixed rate of 8.9%. We must also make an additional final payment at maturity equal to 6% of the total amount borrowed under the Amended Loan and Security Agreement. 

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Amortization of the entire $27.5 million due to Oxford commences on March 1, 2013 and the maturity date of the term loans is August 1, 2014, and the other material terms of the Loan and Security Agreement remain unchanged.

In October 2011, we filed a Registration Statement on Form S-3 with the Securities and Exchange Commission (“SEC”) for the issuance and sale of up to $30 million of equity or other securities, proceeds from which will be used for general corporate purposes. The Form S-3 provides additional financial flexibility for us to sell shares or other securities as needed at any time. As of September 30, 2012, 150,000 common shares have been issued under this registration statement for total net proceeds of $2.6 million. In March 2012, we entered into a Controlled Equity Offering Sales Agreement with Cantor Fitzgerald & Co. (“Cantor”), as sales agent, to create an at-the-market equity program under which we may, from time to time, sell shares of common stock, par value $0.001 per share, up to an aggregate offering price of $30 million.

We believe that our capital resources, including our currently available cash, cash equivalents, and short-term investments as well as our current and future royalty revenues, will be adequate to fund our operations at their current levels at least for the next twelve months. However, changes may occur that would cause us to consume available capital resources before that time. Examples of relevant potential changes that could impact our capital resources include:

• the costs associated with our drug research and development activities, and additional costs we may incur if our development programs are delayed or are more expensive to implement than we currently anticipate;

• changes in collaborative relationships, including the funding we receive in connection with those relationships;

• the progress of our milestone and royalty producing activities;

• acquisitions of other businesses or technologies;

• the termination of our lease agreements;

• the costs of the closure of our operations at our Cranbury, New Jersey facility;

• the purchase of additional capital equipment;

• cash payments, including CVR payments, or refunds we may be required to make pursuant to certain agreements with third parties;

• competing technological and market developments; and

• the cost of filing, prosecuting, defending and enforcing patent claims and other intellectual property rights, and the outcome of related litigation.

Additional capital may not be available on favorable terms, or at all. If additional capital is not available, we may be required to curtail operations significantly, including but not limited to reducing our current headcount, or to obtain funds by entering into arrangements with partners or other third parties that may require us to relinquish rights to certain of our technologies, products or potential markets that we would not otherwise relinquish.

Our collaborative partners may change their strategy or the focus of their development and commercialization efforts with respect to our alliance products, the success of our alliance products could be adversely affected.

If our collaborative partners terminate their collaborations with us or do not commit sufficient resources to the development, manufacture, marketing or distribution of our alliance products, we could be required to devote additional resources to our alliance products, seek new collaborative partners or abandon such alliance products, all of which could have an adverse effect on our business.

In September 2010, we received notice from GSK that it was exercising its right to terminate the Product Development and Commercialization Agreement, dated as of March 24, 2006 and as amended, among SmithKlineBeecham Corporation, doing business as GlaxoSmithKline, Glaxo Group Limited and Pharmacopeia, LLC, as successor to Pharmacopeia Drug Discovery, Inc. The termination became effective on October 7, 2010. Absent the termination by GSK, the research term under this agreement would have terminated on March 24, 2011. Following termination, we retained rights to the current programs under this agreement and may continue to develop the programs and commercialize any products resulting from the

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programs, or we may elect to cease progressing the programs and/or seek other partners for further development and commercialization.

In September 2011, we received a notice from MedImmune (a subsidiary of AstraZeneca) that it was exercising its right to terminate the Collaboration and License Agreement, dated April 19, 2001. Upon termination, all materials and know-how related to the IL-9 antibody program by MedImmune was returned to us. MedImmune is required to discuss the granting of a royalty-bearing license to intellectual property with respect to the product licensed under the agreement. However, MedImmune has no obligation to grant such a license or retain the ability to grant such a license. The termination became effective on November 30, 2011.

In October 2011, we received notice from Merck that it was exercising its right to terminate the Collaboration and License Agreement, dated November 24, 2003. The collaboration and licensing program was related to the physiology, pharmacology, chemistry, and potential therapeutic applications and potential clinical utilities related to Vanilloid Receptors, subtype 1, also known as TRPV1. Upon termination, Merck is required to transfer and/or disclose specified materials and know-how to us (which is under an obligation to transfer certain specified materials to Merck). In addition, we will receive an exclusive, perpetual, irrevocable, royalty-free (but subject to any third party royalty obligations), fully-paid, worldwide license, with right to sub-license, under specified patents and technology for the research, development or commercialization of specified compounds and products in a limited field of use. We will also receive a non-exclusive license to all other know-how Merck deems necessary to sell the specified compounds or products. The termination became effective on April 18, 2012.

We are currently dependent upon outlicensing business and we may not be successful in entering into additional out-license agreements on favorable terms, which may adversely affect our liquidity or require us to alter development plans on our products.

We have entered into several out-licensing agreements for the development and commercialization of our products. We currently depend on our arrangements with our outlicensees to sell products using our Captisol technology. These agreements generally provide that outlicensees may terminate the agreements at will. If our outlicensees discontinue sales of products using our Captisol technology, fail to obtain regulatory approval for their products using our Captisol technology, fail to satisfy their obligations under their agreements with us, or otherwise choose to utilize a generic form of Captisol should it become available, or if we are unable to establish new licensing and marketing relationships, our financial results and growth prospects would be materially affected. Further, under most of our Captisol outlicenses, the amount of royalties we receive will be reduced or will cease when the relevant patent expires. While we have other more recent patents relating to Captisol with later expiration dates (for example, our high purity patent, U.S. Patent No. 7,635,773 is not expected to expire until 2029 and our morphology patent, U.S. Patent No. 7,629,331 is not expected to expire until 2025), the initially filed patents relating to Captisol expired in 2010 and 2011 in the U.S. and are expected to expire between 2012 and 2016 in most countries outside the U.S. If our other intellectual property rights are not sufficient to prevent a generic form of Captisol from coming to market and if in such case our outlicensees choose to terminate their agreements with us, the source of the vast majority of our Captisol revenue may cease to exist.

Although we expend considerable resources on internal research and development for our proprietary programs, we may not be successful in entering into additional out-licensing agreements under favorable terms due to several factors including:

• the difficulty in creating valuable product candidates that target large market opportunities;

• research and spending priorities of potential licensing partners;

• willingness of and the resources available to pharmaceutical and biotechnology companies to in-license product candidates for their clinical pipelines; or

• differences of opinion with potential partners on the valuation of products we are seeking to out-license.

The inability to enter into out-licensing agreements under favorable terms and to earn milestone payments, license fees and/or upfront fees may adversely affect our liquidity and may force us to curtail or delay development of some or all of our proprietary programs, which in turn may harm our business and the value of our stock.

Third party intellectual property may prevent us or our partners from developing our potential products and we may owe a portion of any payments we receive from our collaborative partners to one or more third parties.

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Our success will depend on our ability and the ability of our collaborative partners to avoid infringing the proprietary rights of others, both in the United States and in foreign countries. In addition, disputes with licensors under our license agreements may arise which could result in additional financial liability or loss of important technology and potential products and related revenue, if any. Further, the manufacture, use or sale of our potential products or our collaborative partners’ products or potential products may infringe the patent rights of others. This could impact Captisol, Avinza, Promacta, Viviant and Conbriza (bazedoxifene), Fablyn, LGD-4665, and any other products or potential products.

Several drug companies and research and academic institutions have developed technologies, filed patent applications or received patents for technologies that may be related to our business. Others have filed patent applications and received patents that conflict with patents or patent applications we have licensed for our use, either by claiming the same methods or compounds or by claiming methods or compounds that could dominate those licensed to us. In addition, we may not be aware of all patents or patent applications that may impact our ability to make, use or sell any of our potential products. For example, US patent applications may be kept confidential while pending in the United States Patent and Trademark Office and patent applications filed in foreign countries are often first published six months or more after filing.

Disagreements or litigation with our collaborative partners could delay our ability and the ability of our collaborative partners to achieve milestones or our receipt of other payments. In addition, other possible disagreements or litigation could delay, interrupt or terminate the research, development and commercialization of certain potential products being developed by either our collaborative partners or by us. The occurrence of any of the foregoing problems could be time-consuming and expensive and could adversely affect our business.

Third parties have not directly threatened an action or claim against us, although we do periodically receive other communications or have other conversations with the owners of other patents or other intellectual property. If others obtain patents with conflicting claims, we may be required to obtain licenses to those patents or to develop or obtain alternative technology. We may not be able to obtain any such licenses on acceptable terms, or at all. Any failure to obtain such licenses could delay or prevent us from pursuing the development or commercialization of our potential products.

In general, litigation claims can be expensive and time consuming to bring or defend against and could result in settlements or damages that could significantly impact our results of operations and financial condition. We cannot predict or determine the outcome of these matters or reasonably estimate the amount or range of amounts of any fines or penalties that might result from a settlement or an adverse outcome. However, a settlement or an adverse outcome could have a material adverse effect on our financial position, liquidity and results of operations.

Expirations of, challenges to or failure to secure patents and other proprietary rights may significantly hurt our business.

The initially filed patents relating to Captisol expired in 2010 and 2011 in the U.S. and are expected to expire between 2012 and 2016 in most countries outside the U.S. We have also obtained patent protection in the U.S. through 2025 on one or more Agglomerated forms of Captisol and through 2029 on one or more High Purity forms of Captisol. We have obtained patent protection on a number of combinations of APIs and Captisol through three combination patents in the U.S., and we have applied for six additional combination patents in the U.S. relating to the combination of Captisol with specific APIs. Our U.S. combination patent relating to Fosphenytoin expires June 12, 2018 and our U.S. combination patent relating to Amiodarone expires May 4, 2022. Our U.S. combination patent relating to one of our early-stage product candidates expires March 19, 2022. There is no guarantee that these patents will be sufficient to prevent competitors from creating a generic form of Captisol after 2010 and competing against us, or from developing combination patents for products that will prevent us from developing products using those APIs. In addition, most of the agreements in our Captisol outlicensing business, including our agreements with Pfizer relating to Geodon IM, Vfend IV and Cerenia, provide that once the relevant patent expires, the amount of royalties we receive will be reduced or eliminated.

Generally, our success will depend on our ability and the ability of our licensors to obtain and maintain patents and proprietary rights for our potential products both in the United States and in foreign countries. Patents may not be issued from any of these applications currently on file, or, if issued, may not provide sufficient protection. Our patent position, like that of many biotechnology and pharmaceutical companies, is uncertain and involves complex legal and technical questions for which important legal principles are unresolved. We may not develop or obtain rights to products or processes that are patentable. Even if we do obtain patents, such patents may not adequately protect the technology we own or have licensed. In addition, others may challenge, seek to invalidate, infringe or circumvent any patents we own or license and rights we receive under those patents may not provide competitive advantages to us. For example, our European patent related to Agglomerated forms of Captisol is currently being opposed.

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Any conflicts resulting from the patent rights of others could significantly reduce the coverage of our patents and limit our ability to obtain meaningful patent protection. We have had and will continue to have discussions with our current and potential collaborative partners regarding the scope and validity of our patents and other proprietary rights. If a collaborative partner or other party successfully establishes that our patent rights are invalid, we may not be able to continue our existing collaborations beyond their expiration. Any determination that our patent rights are invalid also could encourage our collaborative partners to seek early termination of our agreements. Such invalidation could adversely affect our ability to enter into new collaborations.

We may also need to initiate litigation, which could be time-consuming and expensive, to enforce our proprietary rights or to determine the scope and validity of others’ rights. If litigation occurs, a court may find our patents or those of our licensors invalid or may find that we have infringed on a competitor’s rights. In addition, if any of our competitors have filed patent applications in the United States which claim technology we also have invented, the United States Patent and Trademark Office may require us to participate in expensive interference proceedings to determine who has the right to a patent for the technology.

We also rely on unpatented trade secrets and know-how to protect and maintain our competitive position. We require our employees, consultants, collaborative partners and others to sign confidentiality agreements when they begin their relationship with us. These agreements may be breached, and we may not have adequate remedies for any breach. In addition, our competitors may independently discover our trade secrets.

Our product development involves a number of uncertainties, and we may never generate sufficient collaborative payments and royalties from the development of products to become profitable.

We were founded in 1987. We have incurred significant losses since our inception. As of September 30, 2012, our accumulated deficit was $683.8 million.

Most of our products in development will require extensive additional development, including preclinical testing and human studies, as well as regulatory approvals, before they can be marketed. We cannot predict if or when any of the products we are developing or those being developed with our partners will be approved for marketing. There are many reasons why we or our collaborative partners may fail in our efforts to develop our potential products, including the possibility that: preclinical testing or human studies may show that our potential products are ineffective or cause harmful side effects; the products may fail to receive necessary regulatory approvals from the FDA or foreign authorities in a timely manner, or at all; the products, if approved, may not be produced in commercial quantities or at reasonable costs; the products, if approved, may not achieve commercial acceptance; regulatory or governmental authorities may apply restrictions to our products, which could adversely affect their commercial success; or the proprietary rights of other parties may prevent us or our partners from marketing the products.

Any product development failures for these or other reasons, whether with our products or our partners’ products, may reduce our expected revenues, profits, and stock price.

Any future material weaknesses or deficiencies in our internal control over financial reporting could harm stockholder and business confidence on our financial reporting, our ability to obtain financing and other aspects of our business.

As described in Item 4, we identified material weaknesses as a result of improper accounting for significant non-routine transactions and the controls over the determination of fair value of contingent liabilities. Our audit committee, after consultation with management has determined that the material weaknesses were a result of inadequate staffing and review processes. As a result of the material weaknesses associated with acquisition related accounting, we have added a corporate controller to our finance and accounting staff. While we had processes to identify and apply accounting standards to complex transactions, we enhanced these processes with the addition of a resource with the ability to research and understand the nuances of complex accounting standards. Additionally, we plan to enhance our controls over the determination of the fair value of contingent liabilities by including a formal review of mathematical calculations and completeness of such calculations. Given the material weaknesses, our audit committee, after consultation with management determined that we did not maintain effective internal control over financial reporting. The existence of one or more material weaknesses or significant deficiencies could result in errors in our consolidated financial statements. Substantial costs and resources may be required to rectify any internal control deficiencies. If we fail to achieve and maintain the adequacy of our internal controls in accordance with applicable standards, we may be unable to conclude on an ongoing basis that we have effective internal controls over financial reporting. If we cannot produce reliable financial reports, our business and financial condition could be harmed, investors could lose confidence in our reported financial information, or the market price of our stock could decline significantly. In

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addition, our ability to obtain additional financing to operate and expand our business, or obtain additional financing on favorable terms, could be materially and adversely affected, which, in turn, could materially and adversely affect our business, our financial condition and the market value of our securities. Moreover, our reputation with customers, lenders, investors, securities analysts and others may be adversely affected.

We may undertake strategic acquisitions in the future and any difficulties from integrating such acquisitions could adversely affect our stock price, operating results and results of operations.

We may acquire companies, businesses and products that complement or augment our existing business. We may not be able to integrate any acquired business successfully or operate any acquired business profitably. Integrating any newly acquired business could be expensive and time-consuming. Integration efforts often take a significant amount of time, place a significant strain on managerial, operational and financial resources and could prove to be more difficult or expensive than we predict. The diversion of our management’s attention and any delay or difficulties encountered in connection with any future acquisitions we may consummate could result in the disruption of our on-going business or inconsistencies in standards and controls that could negatively affect our ability to maintain third-party relationships. Moreover, we may need to raise additional funds through public or private debt or equity financing, or issue additional shares, to acquire any businesses or products, which may result in dilution for stockholders or the incurrence of indebtedness.

As part of our efforts to acquire companies, business or product candidates or to enter into other significant transactions, we conduct business, legal and financial due diligence with the goal of identifying and evaluating material risks involved in the transaction. Despite our efforts, we ultimately may be unsuccessful in ascertaining or evaluating all such risks and, as a result, might not realize the intended advantages of the transaction. If we fail to realize the expected benefits from acquisitions we may consummate in the future, whether as a result of unidentified risks, integration difficulties, regulatory setbacks and other events, our business, results of operations and financial condition could be adversely affected. If we acquire product candidates, we will also need to make certain assumptions about, among other things, development costs, the likelihood of receiving regulatory approval and the market for such product candidates. Our assumptions may prove to be incorrect, which could cause us to fail to realize the anticipated benefits of these transactions.

In addition, we will likely experience significant charges to earnings in connection with our efforts, if any, to consummate acquisitions. For transactions that are ultimately not consummated, these charges may include fees and expenses for investment bankers, attorneys, accountants and other advisors in connection with our efforts. Even if our efforts are successful, we may incur, as part of a transaction, substantial charges for closure costs associated with elimination of duplicate operations and facilities and acquired IPR&D charges. In either case, the incurrence of these charges could adversely affect our results of operations for particular quarterly or annual periods.

Revenues based on sales of Avinza represent a substantial portion of our overall current and/or expected future revenues.

Pfizer, as successor to King, is obligated to pay us royalties based on the sales of Avinza. These payments are expected to be a substantial portion of our ongoing revenues for some time. As a result, any setback that may occur with respect to Avinza could significantly impair our operating results and/or reduce the market price of our stock. Setbacks for Avinza could include problems with shipping, distribution, manufacturing, product safety, marketing, government regulation, licenses and approvals, intellectual property rights, competition with existing or new products and physician or patient acceptance of the products, as well as higher than expected total rebates, returns or discounts.

Avinza could also face regulatory action and product safety issues. For example, the FDA previously requested expanded warnings on the Avinza label to alert doctors and patients to the dangers of using Avinza with alcohol. Changes were subsequently made to the label. The FDA also requested clinical studies to investigate the risks associated with taking Avinza with alcohol. Any additional warnings, studies and any further regulatory action could have significant adverse effects on Avinza sales.

In September 2007, King reported that Actavis, a manufacturer of generic pharmaceutical products headquartered in Iceland, had filed with the FDA an Abbreviated New Drug Application, or ANDA, with a Paragraph IV Certification pertaining to Avinza, the rights to which were acquired by King from us in February 2007. According to the report, Actavis’s Paragraph IV Certification sets forth allegations that U.S. Patent No. 6,066,339, or the 339 patent, which pertains to Avinza, and which is listed in the FDA’s Approved Drug Products With Therapeutic Equivalence Evaluations, will not be infringed by Actavis’s manufacture, use, or sale of the product for which the ANDA was submitted. The expiration date for this patent is November 2017. King, King Pharmaceuticals Research and Development, Inc., Elan Corporation, plc, or Elan, and Elan Pharma International Ltd. jointly filed suit in federal district court in New Jersey on October 18, 2007 against Actavis, Inc. and Actavis

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Elizabeth LLC for patent infringement under the 339 patent. The lawsuit was settled and dismissed without prejudice in July 2011.

On July 21, 2009, King, King Pharmaceuticals Research and Development, Inc., Elan and Elan Pharma International Ltd. jointly filed suit in federal district court in New Jersey against Sandoz Inc., or Sandoz, for patent infringement under the 339 patent. According to the complaint, Sandoz filed an ANDA for morphine sulfate extended release capsules and, in connection with the ANDA filing, Sandoz provided written certification to the FDA alleging that the claims of the 339 patent are invalid, unenforceable and/or will not be infringed by the manufacture, use or sale of Sandoz's proposed morphine product. The case was dismissed on consent of the parties in July 2012.

We may not be able to hire and/or retain key employees.

If we are unable to hire and/or retain key employees, we may not have sufficient resources to successfully manage our assets or our business, and we may not be able to perform our obligations under various contracts and commitments. Furthermore, there can be no assurance that we will be able to retain all of our key management and scientific personnel. If we fail to retain such key employees, we may not realize the anticipated benefits of our mergers. Either of these could have substantial negative impacts on our business and our stock price.

If plaintiffs bring product liability lawsuits against us or our partners, we or our partners may incur substantial liabilities and may be required to limit commercialization of our approved products and product candidates, and we may be subject to other liabilities related to the sale of our prior commercial product lines.

We and our partners face an inherent risk of product liability as a result of the clinical testing of our product candidates in clinical trials and face an even greater risk for commercialized products. Although we are not currently a party to product liability litigation, if we are sued, we may be held liable if any product or product candidate we develop causes injury or is found otherwise unsuitable during product testing, manufacturing, marketing or sale. Regardless of merit or eventual outcome, liability claims may result in decreased demand for any product candidates or products that we may develop, injury to our reputation, discontinuation of clinical trials, costs to defend litigation, substantial monetary awards to clinical trial participants or patients, loss of revenue and the inability to commercialize any products that we develop. We have product liability insurance that covers our clinical trials up to a $5.0 million annual limit. We intend to expand product liability insurance coverage to include the sale of commercial products if we obtain marketing approval for any products that we may develop. However, this insurance may be prohibitively expensive, or may not fully cover our potential liabilities. Inability to obtain sufficient insurance coverage at an acceptable cost or otherwise to protect against potential product liability claims could prevent or delay the commercialization of our product candidates. If we are sued for any injury caused by our product candidates or any future products, our liability could exceed our total assets.

In addition, we agreed to indemnify Eisai and King under certain circumstances pursuant to the asset purchase agreements we entered into with Eisai and King in connection with the sale of our prior commercial product lines.  Some of our indemnification obligations still remain and our potential liability in certain circumstances is not limited to specific dollar amounts. We cannot predict the liabilities that may arise as a result of these matters. Any claims related to our indemnification obligations to King or Eisai could materially and adversely affect our financial condition.

In addition, King assumed our obligation to make payments to Organon based on net sales of Avinza (the fair value of which was $13.1 million as of September 30, 2012).  We remain liable to Organon in the event King defaults on this obligation. Any requirement to pay a material amount to Organon, could adversely affect our business and the price of our securities.

The sale of our prior commercial product lines does not relieve us of exposure to product liability risks on products we sold prior to divesting these product lines. A successful product liability claim or series of claims brought against us may not be insured and could result in payment of significant amounts of money and divert management’s attention from running our business.

If our partners do not reach the market with our alliance products before our competitors offer products for the same or similar uses, or if our partners are not effective in marketing our alliance products, our revenues from product sales, if any, will be reduced.

We face intense competition in our development activities. Our competitors might succeed in obtaining regulatory approval for competitive products more rapidly than our partners can for our products. In addition, competitors might develop

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technologies and products that are less expensive and perceived to be safer or more effective than those being developed by us or our partners, which could impair our product development and render our technology obsolete.

We use hazardous materials, which may expose us to significant liability.

In connection with our research and development activities, we handle hazardous materials, chemicals and various radioactive compounds. To properly dispose of these hazardous materials in compliance with environmental regulations, we are required to contract with third parties. We believe that we carry reasonably adequate insurance for toxic tort claims. However, we cannot eliminate the risk or predict the exposure of accidental contamination or injury from the handling and disposing of hazardous materials, whether by us or our third-party contractors. Any accident in the handling and disposing of hazardous materials may expose us to significant liability.

Our shareholder rights plan and charter documents may hinder or prevent change of control transactions.

Our shareholder rights plan and provisions contained in our certificate of incorporation and bylaws may discourage transactions involving an actual or potential change in our ownership. In addition, our Board of Directors may issue shares of preferred stock without any further action by the stockholders. Such restrictions and issuances may have the effect of delaying or preventing a change in our ownership. If changes in our ownership are discouraged, delayed or prevented, it would be more difficult for our current Board of Directors to be removed and replaced, even if you or our other stockholders believe that such actions are in the best interests of us and our stockholders.

We may lose some or all of the value of some of our short-term investments.

We engage one or more third parties to manage some of our cash consistent with an investment policy that allows a range of investments and maturities. The investments are intended to maintain safety of principal while providing liquidity adequate to meet projected cash requirements. Risks of principal loss are to be minimized through diversified short and medium term investments of high quality, but the investments are not in every case guaranteed or fully insured. As a result of changes in the credit market, one of our short-term investments in commercial paper was in default. As a result, we were unable to recoup all of our investment in the commercial paper. In addition, from time to time we may suffer other losses on our short-term investment portfolio.

We may require additional funds to run our business and may be required to raise these funds on terms which are not favorable to us or which reduce our stock price.

We may need to complete additional equity or debt financings to fund our operations. Our inability to obtain additional financing could adversely affect our business. Financings may not be available at all or on terms favorable to us. In addition, these financings, if completed, may not meet our capital needs and could result in substantial dilution to our stockholders.

In October 2011, we filed a Registration Statement on Form S-3 with the Securities and Exchange Commission (“SEC”) for the issuance and sale of up to $30.0 million of equity or other securities, proceeds from which will be used for general corporate purposes. The Form S-3 provides additional financial flexibility for us to sell shares as needed at any time. As of September 30, 2012, 150,000 common shares have been issued under this registration statement for total net proceeds of $2.6 million.

If adequate funds are not available, we may be required to delay, reduce the scope of or eliminate one or more of our research or drug development programs. We may also be required to liquidate our business or file for bankruptcy protection. Alternatively, we may be forced to attempt to continue development by entering into arrangements with collaborative partners or others that require us to relinquish some or all of our rights to technologies or drug candidates that we would not otherwise relinquish.

Our drug development programs will require substantial additional future funding which could hurt our operational and financial condition.

Our drug development programs require substantial additional capital to successfully complete them, arising from costs to: conduct research, preclinical testing and human studies; establish pilot scale and commercial scale manufacturing processes and facilities; and establish and develop quality control, regulatory, marketing, sales and administrative capabilities to support these programs.

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Our future operating and capital needs will depend on many factors, including: the pace of scientific progress in our research and development programs and the magnitude of these programs; the scope and results of preclinical testing and human studies; the time and costs involved in obtaining regulatory approvals; the time and costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims; competing technological and market developments; our ability to establish additional collaborations; changes in our existing collaborations; the cost of manufacturing scale-up; and the effectiveness of our commercialization activities.

We expect our research and development expenditures over the next three years to continue to be significant. However, we base our outlook regarding the need for funds on many uncertain variables. Such uncertainties include regulatory approvals, the timing of events outside our direct control such as product launches by partners and the success of such product launches, negotiations with potential strategic partners, possible sale of assets or other transactions and other factors. Any of these uncertain events can significantly change our cash requirements.

While we expect to fund our research and development activities from cash generated from royalties and royalties and milestones from our partners in various past and future collaborations to the extent possible, if we are unable to do so, we may need to complete additional equity or debt financings or seek other external means of financing. These financings could depress our stock price. If additional funds are required to support our operations and we are unable to obtain them on terms favorable to us, we may be required to cease or reduce further development or commercialization of our products, to sell some or all of our technology or assets or to merge with another entity.

Our results of operations and liquidity needs could be materially negatively affected by market fluctuations and economic downturn.

Our results of operations could be materially negatively affected by economic conditions generally, both in the U.S. and elsewhere around the world. Continuing concerns over inflation, energy costs, geopolitical issues, the availability and cost of credit, the U.S. mortgage market and a declining residential real estate market in the U.S. have contributed to increased volatility and diminished expectations for the economy and the markets going forward. These factors, combined with volatile oil prices, declining business and consumer confidence and increased unemployment, have precipitated an economic recession and fears of a possible depression. Domestic and international equity markets continue to experience heightened volatility and turmoil. These events and the continuing market upheavals may have an adverse effect on us. In the event of a continuing market downturn, our results of operations could be adversely affected by those factors in many ways, including making it more difficult for us to raise funds if necessary, and our stock price may further decline.

Our investment securities consist primarily of money market funds, corporate debt obligations and U.S. government agency securities. We do not have any auction rate securities. Recently, there has been concern in the credit markets regarding the value of a variety of mortgage-backed securities and the resultant effects on various securities markets. We cannot provide assurance that our investments are not subject to adverse changes in market value. If our investments experience adverse changes in market value, we may have less capital to fund our operations.

Our stock price has been volatile and could experience a sudden decline in value.

Our common stock has experienced significant price and volume fluctuations and may continue to experience volatility in the future. As a result, you may not be able to sell your shares quickly or at the latest market price if trading in our stock is not active or the volume is low. In November 2010, we effected a 1-for-6 reverse stock split. We believe the reverse stock split will have the effect of increasing the per share trading price of our common stock. Many factors may have a significant impact on the market price of our common stock, including, but not limited to, the following factors: results of or delays in our preclinical studies and clinical trials; the success of our collaboration agreements; publicity regarding actual or potential medical results relating to products under development by us or others; announcements of technological innovations or new commercial products by us or others; developments in patent or other proprietary rights by us or others; comments or opinions by securities analysts or major stockholders; future sales of our common stock by existing stockholders; regulatory developments or changes in regulatory guidance; litigation or threats of litigation; economic and other external factors or other disaster or crises; the departure of any of our officers, directors or key employees; period-to-period fluctuations in financial results; and limited daily trading volume.

The Financial Industry Regulatory Authority, or FINRA, (formerly the National Association of Securities Dealers, Inc.) and the Securities and Exchange Commission, or SEC, have adopted certain new rules. If we were unable to continue to comply with the new rules, we could be delisted from trading on the NASDAQ Global Market, or Nasdaq, and thereafter

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trading in our common stock, if any, would be conducted through the over-the-counter market or on the Electronic Bulletin Board of FINRA. As a consequence of such delisting, an investor would likely find it more difficult to dispose of, or to obtain quotations as to the price of, our common stock. Delisting of our common stock could also result in lower prices per share of our common stock than would otherwise prevail.

Impairment charges pertaining to goodwill, identifiable intangible assets or other long-lived assets from our mergers could have an adverse impact on our results of operations and the market value of our common stock.

The total purchase price pertaining to our mergers with Pharmacopeia, Neurogen, Metabasis and CyDex have been allocated to net tangible assets, identifiable intangible assets, in process research and development and goodwill. To the extent the value of goodwill or identifiable intangible assets or other long-lived assets become impaired, we will be required to incur material charges relating to the impairment. Any impairment charges could have a material adverse impact on our results of operations and the market value of our common stock.

The occurrence of a catastrophic disaster could damage our facilities beyond insurance limits or we could lose key data which could cause us to curtail or cease operations.

We are vulnerable to damage and/or loss of vital data from natural disasters, such as earthquakes, tornadoes, power loss, fire, floods and similar events. If any disaster were to occur, our ability to operate our business could be seriously impaired. We have property, liability, and business interruption insurance which may not be adequate to cover our losses resulting from disasters or other similar significant business interruptions, and we do not plan to purchase additional insurance to cover such losses due to the cost of obtaining such coverage. Any significant losses that are not recoverable under our insurance policies could seriously impair our business, financial condition and prospects.

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ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

Not applicable.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

Not applicable.

ITEM 4. MINE SAFETY DISCLOSURES

Not applicable

ITEM 5. OTHER INFORMATION

Not applicable.

ITEM 6. EXHIBITS

The Index to Exhibits on page 49 is incorporated herein by reference as the list of exhibits required as part of this Quarterly Report.

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LIGAND PHARMACEUTICALS INCORPORATED

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

Date:	November 14, 2012	By:	/s/ John P. Sharp
			John P. Sharp
			Vice President, Finance and Chief Financial Officer

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INDEX TO EXHIBITS

Exhibit Number	Description
2.1 (1)	Agreement and Plan of Merger, by and among the Company, Pharmacopeia, Inc., Margaux Acquisition Corp. and Latour Acquisition, LLC, dated as of September 24, 2008 (Filed as Exhibit 2.1).
2.2 (2)	Agreement and Plan of Merger, by and among the Company, Neurogen Corporation and Neon Signal, LLC, dated as of August 23, 2009 (Filed as Exhibit 10.1).
2.3 (3)	Amendment to Agreement and Plan of Merger, by and among the Company, Neurogen Corporation, and Neon Signal, LLC, dated September 18, 2009 (Filed as Exhibit 10.1).
2.4 (3)	Amendment No. 2 to Agreement and Plan of Merger, by and among the Company, Neurogen Corporation, and Neon Signal, LLC, dated November 2, 2009 (Filed as Exhibit 10.2).
2.5 (4)	Amendment No. 3 to Agreement and Plan of Merger, by and among the Company, Neurogen Corporation, and Neon Signal, LLC, dated December 17, 2009 (Filed as Exhibit 10.1).
2.6 (5)	Certificate of Merger for acquisition of Neurogen Corporation (Filed as Exhibit 2.1).
2.7 (6)	Agreement and Plan of Merger, dated as of October 26, 2009, by and among the Company, Metabasis Therapeutics, Inc., and Moonstone Acquisition, Inc (Filed as Exhibit 10.1).
2.8 (7)	Amendment to Agreement and Plan of Merger, by and among the Company, Metabasis Therapeutics, Inc., Moonstone Acquisition, Inc., and David F. Hale as Stockholders’ Representative, dated November 25, 2009 (Filed as Exhibit 10.1).
2.9 (8)	Certificate of Merger for acquisition of Metabasis Therapeutics, Inc. dated January 27, 2010 (Filed as Exhibit 2.1).
2.10 (9)	Certificate of Merger, dated and filed January 24, 2011 (Filed as Exhibit 2.1).
2.11 (9)	Agreement and Plan of Merger, by and among the Company, CyDex Pharmaceuticals, Inc., and Caymus Acquisition, Inc., dated January 14, 2011 (Filed as Exhibit 10.1).
3.1 (10)	Amended and Restated Certificate of Incorporation of the Company (Filed as Exhibit 3.1).
3.2 (10)	Bylaws of the Company, as amended (Filed as Exhibit 3.3).
3.3 (11)	Amended Certificate of Designation of Rights, Preferences and Privileges of Series A Participating Preferred Stock of the Company (Filed as Exhibit 3.3).
3.4 (12)	Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company dated June 14, 2000 (Filed as Exhibit 3.5).
3.5 (13)	Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company dated September 30, 2004 (Filed as Exhibit 3.6).
3.6 (14)	Amendment of the Bylaws of the Company dated November 8, 2005 (Filed as Exhibit 3.1).
3.7 (15)	Amendment of Bylaws of the Company dated December 4, 2007 (Filed as Exhibit 3.1).
4.1 (16)	Specimen stock certificate for shares of Common Stock of the Company.
4.4 (17)	2006 Preferred Shares Rights Agreement, by and between the Company and Mellon Investor Services LLC, dated as of October 13, 2006 (Filed as Exhibit 4.1).
31.1	Certification by Principal Executive Officer, Pursuant to Rules 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
31.2	Certification by Principal Financial Officer, Pursuant to Rules 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
32.1*	Certification by Principal Executive Officer, Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
32.2*	Certification by Principal Financial Officer, Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101.1**	The following financial information from the Company's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2012, formatted in XBRL (eXtensible Business Reporting Language): (i) Condensed Consolidated Balance Sheets, (ii) Condensed Consolidated Statements of Operations, (iii) Condensed Consolidated Statements of Cash Flows, and (iv) the Notes to Condensed Consolidated Financial Statements, tagged as detailed footnotes.

(1) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on September 26, 2008.

(2) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on August 24, 2009.

(3) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on November 6, 2009

49

(4) This exhibit was previously filed as part of, and is being incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on December 17, 2009.

(5) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on December 24, 2009.

(6) This exhibit was previously filed as part of, and is being incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on October 28, 2009.

(7) This exhibit was previously filed as part of, and is being incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on December 1, 2009.

(8) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on January 28, 2010.

(9) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on January 26, 2011.

(10) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Registration Statement on Form S-4 (No. 333-58823) filed on July 9, 1998.

(11) This exhibit was previously filed as part of and is hereby incorporated by reference to same numbered exhibit filed with the Company’s Quarterly Report on Form 10-Q for the period ended March 31, 1999.

(12) This exhibit was previously filed as part of, and are hereby incorporated by reference to the numbered exhibit filed with the Company's Annual Report on Form 10-K for the year ended December 31, 2000.

(13) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Quarterly Report on Form 10-Q for the period ended June 30, 2004.

(14) This exhibit was previously filed as part of, and is being incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on November 14, 2005.

(15) This exhibit was previously filed as part of, and is hereby incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on December 6, 2007.

(16) This exhibit was previously filed as part of, and is hereby incorporated by reference to the same numbered exhibit filed with the Company’s Registration Statement on Form S-1 (No. 33-47257) filed on April 16, 1992 as amended.

(17) This exhibit was previously filed as part of, and is being incorporated by reference to the numbered exhibit filed with the Company’s Current Report on Form 8-K filed on October 17, 2006.

* These certifications are being furnished solely to accompany this quarterly report pursuant to 18 U.S.C. Section 1350, and are not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and are not to be incorporated by reference into any filing of Ligand Pharmaceuticals, Incorporated, whether made before or after the date hereof, regardless of any general incorporation language in such filing. Signed originals of these certifications have been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

** Pursuant to Rule 406T of Regulation S-T, these interactive data files are deemed not filed or part of a registration statement or prospectus for purposes of Section 11 or 12 of the Securities Act of 1933, as amended, are deemed not filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and otherwise are not subject to liability under these sections.

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EX-31.1

Exhibit 31.1

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO EXCHANGE ACT RULE 13a-14(a)/15d-14(a)

AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, John L. Higgins, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Ligand Pharmaceuticals Incorporated;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant's other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date:    November 14, 2012

/s/ John L. Higgins

John L. Higgins

President, Chief Executive Officer and Director

(Principal Executive Officer)

EX-31.2

Exhibit 31.2

CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER

PURSUANT TO EXCHANGE ACT RULE 13a-14(a)/15d-14(a)

AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, John P. Sharp, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Ligand Pharmaceuticals Incorporated;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant's other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date:    November 14, 2012

/s/ John P. Sharp

John P. Sharp

Vice President, Finance and Chief Financial Officer

(Principal Financial Officer)

EX-32.1

Exhibit 32.1

CERTIFICATION BY PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

In connection with the accompanying Quarterly Report on Form 10-Q of Ligand Pharmaceuticals Incorporated (the “Company”) for the quarter ended September 30, 2012, I, John L. Higgins, President, Chief Executive Officer and Director of the Company, hereby certify pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge and belief, that:

(1) such Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2) the information contained in such Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, fairly presents, in all material respects, the financial condition and results of operations of the Company.

The foregoing certification is being furnished solely to accompany such Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, pursuant to 18 U.S.C. Section 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

Date:	November 14, 2012	/s/ John L. Higgins
		John L. Higgins President, Chief Executive Officer and Director (Principal Executive Officer)

EX-32.2

Exhibit 32.2

CERTIFICATION BY PRINCIPAL FINANCIAL OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

In connection with the accompanying Quarterly Report on Form 10-Q of Ligand Pharmaceuticals Incorporated (the “Company”) for the quarter ended September 30, 2012, I, John P. Sharp, Vice President, Finance and Chief Financial Officer of the Company, hereby certify pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge and belief, that:

(1) such Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2) the information contained in such Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, fairly presents, in all material respects, the financial condition and results of operations of the Company.

The foregoing certification is being furnished solely to accompany such Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, pursuant to 18 U.S.C. Section 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

Date:	November 14, 2012	/s/ John P. Sharp
		John P. Sharp Vice President, Finance and Chief Financial Officer (Principal Financial Officer)

XML

Financial Instruments (Details) (Recurring [Member], USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	$ 8,058	$ 17,298
Current portion of liability for contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	323	6,879
Liability for contingent value right - Metabasis [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex		1,068
Liability for contingent value right - Neurogen [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	500	700
Long-term portion of contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	7,235	8,651
Certificates of deposit [Member]
Assets:
Assets, Short-term investments		10,000
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex		1,068
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] | Current portion of liability for contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] | Liability for contingent value right - Metabasis [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex		1,068
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] | Liability for contingent value right - Neurogen [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] | Long-term portion of contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] | Certificates of deposit [Member]
Assets:
Assets, Short-term investments		10,000
Significant Other Observable Inputs (Level 2) [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Significant Other Observable Inputs (Level 2) [Member] | Current portion of liability for contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Significant Other Observable Inputs (Level 2) [Member] | Liability for contingent value right - Metabasis [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Significant Other Observable Inputs (Level 2) [Member] | Liability for contingent value right - Neurogen [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Significant Other Observable Inputs (Level 2) [Member] | Long-term portion of contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Significant Other Observable Inputs (Level 2) [Member] | Certificates of deposit [Member]
Assets:
Assets, Short-term investments
Significant Unobservable Inputs (Level 3) [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	8,058	16,230
Significant Unobservable Inputs (Level 3) [Member] | Current portion of liability for contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	323	6,879
Significant Unobservable Inputs (Level 3) [Member] | Liability for contingent value right - Metabasis [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex
Significant Unobservable Inputs (Level 3) [Member] | Liability for contingent value right - Neurogen [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	500	700
Significant Unobservable Inputs (Level 3) [Member] | Long-term portion of contingent liabilities - CyDex [Member]
Liabilities:
Liabilities, Current portion, contingent value rights - CyDex	7,235	8,651
Significant Unobservable Inputs (Level 3) [Member] | Certificates of deposit [Member]
Assets:
Assets, Short-term investments

XML

Stockholders' Equity (Details) (USD $) In Thousands, except Share data, unless otherwise specified	9 Months Ended	12 Months Ended
	Sep. 30, 2012	Dec. 31, 2011
Shares [Rollforward]
Balance at December 31, 2011	1,146,046
Granted	710,345
Exercised	(46,799)
Forfeited	(83,374)
Cancelled	(13,481)
Balance at September 30, 2012	1,712,737	1,146,046
Exercisable at September 30, 2012	781,738
Options vested and expected to vest as of September 30, 2012	1,712,737
Weighted Average Exercise Price [Roll Forward]
Balance at December 31, 2011	$ 14.61
Granted	$ 14.73
Exercised	$ 9.96
Forfeited	$ 10.69
Cancelled	$ 39.73
Balance at September 30, 2012	$ 14.84	$ 14.61
Exercisable at September 30, 2012	$ 16.58
Options vested and expected to vest as of September 30, 2012	$ 14.77
Weighted Average Remaining Contractual Term in Years Beginning balance		7 years 11 months 16 days
Exercisable at September 30, 2012, Weighted Average Remaining Contractual Term in Years	7 years 1 month 6 days
Options vested and expected to vest as of September 30, 2012, Weighted Average Remaining Contractual Term in Years	8 years 1 month 21 days
Aggregate Intrinsic Value, Ending balance		$ 1,489
Exercisable at September 30, 2012, Aggregate Intrinsic Value	2,983
Options vested and expected to vest as of September 30, 2012, Aggregate Intrinsic Value	$ 6,729

XML

Financing Arrangements (Details) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Notes Payable, Current and Noncurrent [Abstract]
Bank line of credit, Prime + 2.0%, due March 29, 2013		$ 10,000
Total current portion of notes payable	10,272
Total long-term portion of notes payable	17,876	20,286
Bank line of credit, Prime + 2.0%, due March 29, 2013 [Member]
Notes Payable, Current and Noncurrent [Abstract]
Bank line of credit, Prime + 2.0%, due March 29, 2013		10,000
Current portion notes payable, 8.64%, due August 1, 2014 [Member]
Notes Payable, Current and Noncurrent [Abstract]
Total current portion of notes payable	7,473
Current portion notes payable, 8.9012%, due August 1, 2014 [Member]
Notes Payable, Current and Noncurrent [Abstract]
Total current portion of notes payable	2,799
Long-term portion notes payable, 8.64%, due August 1, 2014 [Member]
Notes Payable, Current and Noncurrent [Abstract]
Total long-term portion of notes payable	13,070	20,286
Long-term portion notes payable, 8.9012%, due August 1, 2014 [Member]
Notes Payable, Current and Noncurrent [Abstract]
Total long-term portion of notes payable	$ 4,806

XML

Basis of Presentation (Details 5) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Summary of Property and equipment
Property and equipment , Gross	$ 5,653	$ 5,226
Less accumulated depreciation and amortization	(4,800)	(4,771)
Property and equipment, Total	853	455
Lab and office equipment [Member]
Summary of Property and equipment
Property and equipment , Gross	4,503	4,110
Leasehold improvements [Member]
Summary of Property and equipment
Property and equipment , Gross		62
Computer equipment and software [Member]
Summary of Property and equipment
Property and equipment , Gross	$ 1,150	$ 1,054

XML

Financing Arrangements (Tables)

9 Months Ended

Sep. 30, 2012

Debt Disclosure [Abstract]

Summary of carrying values and coupon rates on financing arrangements

The carrying values and the fixed contractual coupon rates of our financing arrangements are as follows (dollars in millions):

	September 30, 2012		December 31, 2011
Bank line of credit, Prime + 2.0%, due March 29, 2013	$	—	$	10,000
Current portion notes payable, 8.64%, due August 1, 2014	$	7,473	$	—
Current portion notes payable, 8.9012%, due August 1, 2014	2,799		—
Total current portion of notes payable	$	10,272	$	10,000
Long-term portion notes payable, 8.64%, due August 1, 2014	$	13,070	$	20,286
Long-term portion notes payable, 8.9012%, due August 1, 2014	4,806		—
Total long-term portion of notes payable	$	17,876	$	20,286

XML

Stockholders' Equity (Details Textual) (USD $)	9 Months Ended		3 Months Ended		9 Months Ended				1 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012 Public Offering [Member]	Sep. 30, 2012 April 2013 [Member]	Sep. 30, 2012 Stock Options [Member]	Sep. 30, 2011 Stock Options [Member]	Sep. 30, 2012 Restricted Stock [Member]	Dec. 31, 2011 Restricted Stock [Member]	May 31, 2012 2002 Stock Incentive Plan [Member]	Sep. 30, 2012 2002 Stock Incentive Plan [Member] Stock Options [Member]	Sep. 30, 2012 Employee Stock Purchase Plan [Member]	Sep. 30, 2011 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period							71,825
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number							148,330	115,506
Increase the number of shares under the 2002 Stock Incentive Plan									1,800,000
Weighted-average grant date fair value of stock options					$ 14.73
Intrinsic value of options exercised					$ 300,000	$ 4,000
Unrecognized compensation cost					6,600,000
Weighted-average period in which cost is expected to be recognized					2 years 9 months 11 days		1 year 8 months 12 days
Shares available for future option grants										1,800,000
Weighted-average grant-date fair value of restricted stock							$ 13.75
Unrecognized compensation cost, restricted stock							1,200,000
Employee Stock Purchase Plan [Abstract]
Shares allowed to purchase in employee stock purchase plan											1,250
Offering period of shares in employee stock purchase plan											6 months
Description of purchase price of stock											equal to 85% of the lesser of fair market value on either the start date of the period or the last trading day of the period (the “Lookback Provision”).
Percentage lesser of fair market value taken as purchase price of share											85.00%
Common stock issued under amended ESSP											7,374	2,404
Proceeds Received under amended ESPP											75,000	18,000
Discount rate											15.00%
Stock-based compensation expense	3,116,000	2,646,000									29,000	700
Shares available for future purchases											89,917
Warrants [Abstract]
Warrants outstanding				163,568
Exercise price of warrants				179.40
Warrants to purchase number of shares				129,360
Entitled value when warrants exercised				100,000
Entitled value when warrants exercised, shares				981,411
Public Offering [Abstract]
Stock issued, shares			150,000
Stock issued, weighted average price per share			$ 18.19
Proceeds from issuance of common stock, net	$ 3,181,000	$ 2,000	$ 2,600,000
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value							$ 12.51	$ 10.63
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period							108,661
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value							$ 11.48
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period							4,012
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value							$ 10.57

XML

Lease Obligations (Details) (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2012 sqft
Payments expected to received from sublease agreements
Operating Lease Obligations	$ 21,517
Subleases	17,563
Corporate headquarters-San Diego, CA [Member]
Payments expected to received from sublease agreements
Square Footage	16,500
Lease Termination Date	Jul. 01, 2019
Operating Lease Obligations	4,546
Bioscience and Technology Business Center-Lawrence, KS [Member]
Payments expected to received from sublease agreements
Square Footage	1,500
Lease Termination Date	Dec. 01, 2014
Operating Lease Obligations	128
Vacated office and research facility-San Diego, CA [Member]
Payments expected to received from sublease agreements
Square Footage	52,800
Lease Termination Date	Jul. 01, 2015
Operating Lease Obligations	6,285
Vacated office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Square Footage	99,000
Lease Termination Date	Aug. 01, 2016
Operating Lease Obligations	10,558
Office and research facility-San Diego CA [Member]
Payments expected to received from sublease agreements
Square Footage	52,800
Lease Termination Date	Jul. 01, 2015
Subleases	2,552
Office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Square Footage	5,100
Lease Termination Date	Aug. 01, 2016
Subleases	1,402
Less than 1 year [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	5,227
Subleases	4,019
Less than 1 year [Member] | Corporate headquarters-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	430
Less than 1 year [Member] | Bioscience and Technology Business Center-Lawrence, KS [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	57
Less than 1 year [Member] | Vacated office and research facility-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	2,159
Less than 1 year [Member] | Vacated office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	2,581
Less than 1 year [Member] | Office and research facility-San Diego CA [Member]
Payments expected to received from sublease agreements
Subleases	876
Less than 1 year [Member] | Office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Subleases	332
One to three years [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	10,948
Subleases	8,521
One to three years [Member] | Corporate headquarters-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	1,354
One to three years [Member] | Bioscience and Technology Business Center-Lawrence, KS [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	71
One to three years [Member] | Vacated office and research facility-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	4,126
One to three years [Member] | Vacated office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	5,397
One to three years [Member] | Office and research facility-San Diego CA [Member]
Payments expected to received from sublease agreements
Subleases	1,676
One to three years [Member] | Office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Subleases	751
Three to five years [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	4,016
Subleases	3,697
Three to five years [Member] | Corporate headquarters-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	1,436
Three to five years [Member] | Bioscience and Technology Business Center-Lawrence, KS [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations
Three to five years [Member] | Vacated office and research facility-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations
Three to five years [Member] | Vacated office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	2,580
Three to five years [Member] | Office and research facility-San Diego CA [Member]
Payments expected to received from sublease agreements
Subleases
Three to five years [Member] | Office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Subleases	319
More than 5 years [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	1,326
Subleases	1,326
More than 5 years [Member] | Corporate headquarters-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations	1,326
More than 5 years [Member] | Bioscience and Technology Business Center-Lawrence, KS [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations
More than 5 years [Member] | Vacated office and research facility-San Diego, CA [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations
More than 5 years [Member] | Vacated office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Operating Lease Obligations
More than 5 years [Member] | Office and research facility-San Diego CA [Member]
Payments expected to received from sublease agreements
Subleases
More than 5 years [Member] | Office and research facility-Cranbury, NJ [Member]
Payments expected to received from sublease agreements
Subleases

XML

Business Combinations (Details) (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Company's pro forma results
Revenue			$ 17,290
Operating loss			(5,549)
Net income			$ 4,886
Basic and diluted earnings per share:
Continuing operations	$ (0.01)	$ (0.21)	$ (0.27)	$ 0.26
Income from discontinued operations (in usd per share)			$ 0.19
Net income	$ (0.01)	$ (0.21)	$ (0.08)	$ 0.26
Basic and diluted weighted average shares	19,917,676	19,673,160	19,791,793	19,648,947
CyDex [Member]
Basic and diluted earnings per share:
Continuing operations			$ 0.25
Income from discontinued operations (in usd per share)
Net income			$ 0.25
Basic and diluted weighted average shares			19,649,000

XML

Restatement of Financial Statements (Details) (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended			3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended				1 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011	Dec. 31, 2011	Sep. 30, 2011 Restatement Adjustment [Member]	Sep. 30, 2011 Restatement Adjustment [Member]	Sep. 30, 2011 As Previously Reported [Member]	Sep. 30, 2011 As Previously Reported [Member]	Dec. 31, 2011 As Previously Reported [Member]	Dec. 31, 2011 Overstatement [Member]	Jan. 24, 2011 Overstatement [Member]	Jan. 31, 2012 Understatement [Member]	Dec. 31, 2011 Understatement [Member]	Jan. 24, 2011 Understatement [Member]
Goodwill	$ 12,238		$ 12,238		$ 12,238					$ 14,894	$ 2,700	$ 2,700
Intangible assets, net	56,580		56,580		58,326					57,437				900	900
Total assets	97,506		97,506		120,583					122,350
Long-term portion of contingent liabilities	7,735		7,735		10,419					11,433	1,000	1,600
Deferred income taxes	2,662		2,662		2,230					2,522	300	300
Total liabilities	76,271		76,271		104,054					105,360
Accumulated deficit	(683,822)		(683,822)		(682,232)					(681,771)
Decrease (increase) in contingent liabilities	2,093	(198)	1,191	(1,317)		(400)	(500)	224	(835)
Income tax benefit (expense)	(142)	(22)	(445)	13,572			100	(22)	13,427				(100)
Net income (loss)	$ (194)	$ (4,178)	$ (1,590)	$ 5,029				$ (3,756)	$ 5,366
Income (loss) from continuing operations (in usd per share)	$ (0.01)	$ (0.21)	$ (0.27)	$ 0.26		$ (0.02)	$ (0.01)	$ (0.19)	$ 0.27
Income from discontinued operations (in usd per share)			$ 0.19
Net income (in usd per share)	$ (0.01)	$ (0.21)	$ (0.08)	$ 0.26				$ (0.19)	$ 0.27
Weighted average number of common shares-basic (in shares)	19,917,676	19,673,160	19,791,793	19,648,947				19,673,000	19,649,000
Weighted average number of common shares-diluted (in shares)	19,917,676	19,673,160	19,791,793	19,686,353				19,673,000	19,649,000

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Financing Arrangements (Details Textual) (USD $) In Millions, unless otherwise specified	9 Months Ended
	Sep. 30, 2012
Debt Disclosure (Additional Textual) [Abstract]
Additional final payment on borrowings	6.00%
Cash-collateralized revolving credit facility	10
Current portion notes payable, 8.64%, due August 1, 2014 [Member]
Financing Arrangements (Textual) [Abstract]
Fixed rate of interest	8.64%
Maturity date of term loan	Aug. 01, 2014
Current portion notes payable, 8.9012%, due August 1, 2014 [Member]
Financing Arrangements (Textual) [Abstract]
Fixed rate of interest	8.9012%
Maturity date of term loan	Aug. 01, 2014
Bank line of credit, Prime + 2.0%, due March 29, 2013 [Member]
Financing Arrangements (Textual) [Abstract]
Maturity date of term loan	Mar. 29, 2013
Variable rate basis	Prime
Basis spread on variable rate basis	2.00%
Long-term portion notes payable, 8.64%, due August 1, 2014 [Member]
Financing Arrangements (Textual) [Abstract]
Fixed rate of interest	8.64%
Maturity date of term loan	Aug. 01, 2014
Long-term portion notes payable, 8.9012%, due August 1, 2014 [Member]
Financing Arrangements (Textual) [Abstract]
Fixed rate of interest	8.9012%
Maturity date of term loan	Aug. 01, 2014

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Financial Instruments

9 Months Ended

Sep. 30, 2012

Investments, All Other Investments [Abstract]

Financial Instruments

Financial Instruments

The Company measures certain financial assets and liabilities at fair value on a recurring basis, including available-for-sale fixed income and equity securities and other equity securities. The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of September 30, 2012 (in thousands):

Fair Value Measurements at Reporting Date Using
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Assets:
Certificates of deposit	$	—	$	—	$	—	$	—
Liabilities:
Current portion of contingent liabilities - CyDex	$	323	$	—	$	—	$	323
Liability for contingent value rights - Metabasis	—		—		—		—
Liability for contingent value rights – Neurogen	500		—		—		500
Long-term portion of contingent liabilities - CyDex	7,235		—		—		7,235
Total liabilities	$	8,058	$	—	$	—	$	8,058

The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December 31, 2011 (in thousands):

Fair Value Measurements at Reporting Date Using
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Assets:	(Restated)						(Restated)
Certificates of deposit	$	10,000	$	10,000	$	—	$	—
Liabilities:
Current portion of contingent liabilities - CyDex	$	6,879	$	—	$	—	$	6,879
Liability for contingent value rights - Metabasis	1,068		1,068		—		—
Liability for contingent value rights – Neurogen	700		—		—		700
Long-term portion of contingent liabilities - CyDex	8,651		—		—		8,651
Total liabilities	$	17,298	$1,068		$	—	$	16,230

The Company’s short-term investments are fixed income available-for-sale securities and include Corporate Notes, Corporate Discount Commercial Paper and certificates of deposit. The fair value of the Company’s short-term investments and liability for contingent value rights- Metabasis are determined using quoted market prices in active markets.

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Lease Obligations (Details Textual)	9 Months Ended
	Sep. 30, 2012
Lease obligations (Textual) [Abstract]
Lease expiration year, Minimum	2014
Lease expiration year, Maximum	2019
Percentage of increase in annual base rent, Minimum	3.00%
Percentage of increase in annual base rent, Maximum	3.50%

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Basis of Presentation (Details 1) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Basis of Presentation [Line Items]
Share-based compensation expense total	$ 1,013	$ 950	$ 3,116	$ 2,646
Research and development expense [Member]
Basis of Presentation [Line Items]
Share-based compensation expense total	263	300	1,211	808
General and administrative expenses [Member]
Basis of Presentation [Line Items]
Share-based compensation expense total	$ 750	$ 650	$ 1,905	$ 1,838

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Basis of Presentation (Details) (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Summary of computation of basic and diluted net income (loss) per share
Net income (loss) from continuing operations	$ (194)	$ (4,178)	$ (5,260)	$ 5,026
Net income from discontinued operations			3,670	3
Net income (loss):	$ (194)	$ (4,178)	$ (1,590)	$ 5,029
Shares used to compute basic and diluted income (loss) per share	19,917,676	19,673,160	19,791,793	19,648,947
Dilutive potential common shares:
Restricted stock				37,406
Shares used to compute diluted income (loss) per share	19,917,676	19,673,160	19,791,793	19,686,353
Basic and diluted per share amounts:
Income (loss) from continuing operations (in usd per share)	$ (0.01)	$ (0.21)	$ (0.27)	$ 0.26
Income from discontinued operations (in usd per share)			$ 0.19
Net income (loss) (in usd per share)	$ (0.01)	$ (0.21)	$ (0.08)	$ 0.26

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Segment Reporting (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011	Dec. 31, 2011
Summary of segment information
Total Assets	$ 97,506		$ 97,506		$ 120,583
Net revenues from external customers	6,375	5,741	17,753	17,101
Operating income loss	(1,322)	(3,249)	(3,818)	(5,541)
Depreciation and amortization expense	638	743	1,978	2,099
Income tax expense from continuing operations	142	22	445	(13,572)
Income tax expense from discontinuing operations			14
Interest expense, net	838	699	2,460	1,762
Write-off of in-process research and development		2,282		2,282
Ligand [Member]
Summary of segment information
Total Assets	65,289		65,289		111,431
Net revenues from external customers	3,708	3,291	11,728	8,718
Operating income loss	(1,498)	(3,381)	(3,298)	(6,507)
Depreciation and amortization expense	34	134	162	407
Income tax expense from continuing operations	142	22	445	(13,572)
Income tax expense from discontinuing operations			14
Interest expense, net	838	699	2,460	1,762
Write-off of in-process research and development		2,282		2,282
CyDex [Member]
Summary of segment information
Total Assets	32,217		32,217		9,152
Net revenues from external customers	2,667	2,450	6,025	8,383
Operating income loss	176	132	(520)	966
Depreciation and amortization expense	604	609	1,816	1,692
Income tax expense from continuing operations
Income tax expense from discontinuing operations
Interest expense, net
Write-off of in-process research and development

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Basis of Presentation (Details 2)	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Summary of fair-value options awarded to employees and directors
Risk-free interest rate	0.80%	1.70%	1.00%	2.50%
Dividend yield
Expected volatility	69.00%	68.00%	69.00%	69.00%
Expected term	6 years 2 months 20 days	6 years 1 month 6 days	6 years 3 months 20 days	6 years 1 month 6 days
Forfeiture rate	8.20%	8.80%
Forfeiture rate, minimum			8.00%	8.80%
Forfeiture rate, maximum			11.20%	14.10%

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Basis of Presentation (Details 3) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Summary of investment categories
Restricted cash and investments, cost	$ 1,341	$ 11,341
Restricted cash and investments, gross unrealized gains
Restricted cash and investments, gross unrealized losses
Restricted cash and investments, estimated fair value	1,341	11,341
Certificates of deposit [Member]
Summary of investment categories
Restricted cash and investments, cost		10,000
Restricted cash and investments, gross unrealized gains
Restricted cash and investments, gross unrealized losses
Restricted cash and investments, estimated fair value		10,000
Certificates of deposit - restricted [Member]
Summary of investment categories
Restricted cash and investments, cost	1,341	1,341
Restricted cash and investments, gross unrealized gains
Restricted cash and investments, gross unrealized losses
Restricted cash and investments, estimated fair value	$ 1,341	$ 1,341

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Business Combinations

9 Months Ended

Sep. 30, 2012

Business Combinations [Abstract]

Business Combinations

Business Combinations

On January 24, 2011, the Company acquired CyDex Pharmaceuticals, Inc., a specialty pharmaceutical company developing products and licensing its Captisol® technology. Captisol is currently incorporated in six FDA-approved medications and marketed by three of CyDex’s licensees: Pfizer, Bristol-Myers Squibb, Onyx Pharmaceuticals, Inc., and Baxter International. In addition, CyDex is supporting drug development efforts with more than 40 companies worldwide.

Under the terms of the agreement, the Company paid $31.6 million to the CyDex shareholders and issued a series of Contingent Value Rights. Additionally, the Company assumed certain contractual obligations for potential milestone payments to license holders. These contingent liabilities were recorded at an initial fair value of $17.6 million. The initial fair value of the liability was determined using a discounted cash flow analysis incorporating the estimated future cash flows from potential milestones and revenue sharing. These cash flows were then discounted to present value using a discount rate of 21.6%. The liability will be evaluated at each reporting period based on events and circumstances related to the underlying milestones, and the change in fair value will be recorded in the Company’s consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. The fair value of the liability at September 30, 2012 was $7.6 million.

The Company paid the CyDex shareholders $4.3 million in January 2012, $2.0 million in December 2011, and $3.5 million in July 2012 and may be required to pay up to an additional $4.0 million upon achievement of certain clinical and regulatory milestones, net of payments made to former license holders upon achievement of milestones. Additionally, the Company assumed certain contractual obligations for milestone payments potentially due in connection with CAPTISOL enabled intravenous formulation of Clopidogrel. We may be required to pay up to $4.0 million upon achievement of certain milestones to former license holders. In addition, the Company will pay CyDex shareholders, for each respective year from 2011 through 2016, 20% of all CyDex-related revenue, but only to the extent that and beginning only when CyDex-related revenue for such year exceeds $15.0 million; plus an additional 10% of all CyDex-related revenue recognized during such year, but only to the extent that and beginning only when aggregate CyDex-related revenue for such year exceeds $35.0 million. The Company paid $0.3 million to the CyDex shareholders in March 2012 for 20% of all 2011 CyDex-related revenue in excess of $15 million.

Ligand is required by the CyDex Contingent Value Rights Agreement (“CVR”) to dedicate at least five experienced full-time employee equivalents per year to the acquired business and to invest at least $1.5 million per year, inclusive of such employee expenses, in the acquired business, through 2015. As of September 30, 2012, the Company estimates it has exceeded this amount.

Had the merger with CyDex been completed as of the beginning of 2011, the Company’s pro forma results for the nine months ended September 30, 2011 would have been as follows:

(in thousands, except per share data)	(Restated)
Revenue	$	17,290
Operating loss	(5,549		)
Net income	4,886
Basic and diluted earnings per share:
Continuing operations	$	0.25
Discontinued operations	—
Net income	$	0.25
Basic and diluted weighted average shares	19,649

The primary adjustments relate to interest expense on long-term debt, the loss of interest income due to the timing of transaction related payments and amortization of intangible assets. The above pro forma information was determined based on historical results adjusted for the purchase price allocation and estimated related changes in income associated with the merger of CyDex.

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Basis of Presentation (Details 4) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Summary of other current assets
Prepaid expenses	$ 889	$ 905
Advanced manufacturing payments	2	312
Other receivables	124	127
Other current assets, Total	$ 1,015	$ 1,344

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AVINZA Co-Promotion (Details) (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2012
Summary of co-promote termination liability
Net present value of payments based on estimated future net Avinza product sales as of December 31, 2011	$ 21,452
Assumed payments made by King or assignee	(2,533)
Fair value adjustments	(5,844)
Total co-promote termination liability as of September 30, 2012	13,075
Less: current portion of co-promote termination liability as of September 30, 2012	4,431
Long-term portion of co-promote termination liability as of September 30, 2012	$ 8,644

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Condensed Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Current assets:
Cash and cash equivalents	$ 7,046	$ 7,041
Short-term investments		10,000
Accounts receivable	2,157	6,110
Inventory	2,548	1,301
Deferred income taxes	237	237
Other current assets	1,015	1,344
Current portion of co-promote termination payments receivable	4,431	6,197
Total current assets	17,434	32,230
Restricted cash and investments	1,341	1,341
Property and equipment, net	853	455
Intangible assets, net	56,580	58,326
Goodwill	12,238	12,238
Long-term portion of co-promote termination payments receivable	8,644	15,255
Other assets	416	738
Total assets	97,506	120,583
Current liabilities:
Accounts payable	6,027	11,065
Accrued liabilities	5,381	5,054
Current portion of contingent liabilities	323	6,879
Bank line of credit		10,000
Current portion of note payable	10,272
Current portion of co-promote termination liability	4,431	6,197
Current portion of lease exit obligations	2,987	3,208
Current portion of deferred revenue	458	1,240
Total current liabilities	29,879	43,643
Long-term portion of note payable	17,876	20,286
Long-term portion of co-promote termination liability	8,644	15,255
Long-term portion of deferred revenue, net	2,538	3,466
Long-term portion of lease exit obligations	6,534	8,367
Deferred income taxes	2,662	2,230
Long-term portion of contingent liabilities	7,735	10,419
Other long-term liabilities	403	388
Total liabilities	76,271	104,054
Commitments and contingencies
Common stock subject to conditional redemption; 0 and 112,371 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively		8,344
Stockholders' equity:
Common stock, $0.001 par value; 33,333,333 shares authorized; 21,082,678 and 20,682,506 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively	21	21
Additional paid-in capital	747,316	732,676
Accumulated deficit	(683,822)	(682,232)
Treasury stock, at cost; 1,118,222 shares at September 30, 2012 and December 31, 2011, respectively	(42,280)	(42,280)
Total stockholders' equity	21,235	8,185
Total liabilities and stockholders' equity	$ 97,506	$ 120,583

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Segment Reporting (Details Textual)	9 Months Ended
	Sep. 30, 2012 segment
Segment Reporting (Textual) [Abstract]
Number of reportable segments	2

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Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Operating activities
Net income (loss)	$ (1,590)	$ 5,029
Less: gain from discontinued operations	3,670	3
Income (loss) from continuing operations	(5,260)	5,026
Adjustments to reconcile net income (loss) to net cash used in operating activities, including effects of business acquired:
Non-cash change in estimated fair value of contingent liabilities	(1,191)	1,317
Accretion of deferred gain on sale leaseback		(1,277)
Depreciation and amortization	1,978	2,099
Non-cash lease costs		(135)
Stock-based compensation	3,116	2,646
Deferred income taxes	446	(13,905)
Write-off in-process research and development		2,282
Other	348	201
Changes in operating assets and liabilities, net of acquisition:
Accounts receivable	3,953	476
Inventory	(798)	455
Other current assets	329	4,545
Other long term assets	322	566
Accounts payable and accrued liabilities	(3,009)	(7,110)
Other liabilities	15	(4,129)
Deferred revenue	(1,710)	(1,246)
Net cash used in operating activities of continuing operations	(1,461)	(8,189)
Net cash used in operating activities of discontinued operations	(550)
Net cash used in operating activities	(2,011)	(8,189)
Investing activities
Acquisition of CyDex, net of cash acquired		(32,024)
Payments to CVR holders	(8,049)
Purchases of property, equipment and building	(633)	(116)
Proceeds from sale of property, and equipment and building	17
Purchases of short-term investments		(10,000)
Proceeds from sale of short-term investments	10,000	19,346
Other, net		(59)
Net cash provided by (used in) investing activities	1,335	(22,853)
Financing activities
Proceeds from issuance of debt	7,500	30,000
Repayment of debt	(10,000)
Proceeds from issuance of common stock, net	3,181	2
Share repurchases		(55)
Net cash provided by financing activities	681	29,947
Net increase in cash and cash equivalents	5	(1,095)
Cash and cash equivalents at beginning of period	7,041	3,346
Cash and cash equivalents at end of period	7,046	2,251
Supplemental Disclosure of cash flow information
Interest paid	1,854	1,749
Taxes paid	$ 15	$ 27

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Basis of Presentation (Details 7) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Accrued Liabilities
Compensation	$ 1,157	$ 1,806
Professional fees	485	355
Other	3,739	2,893
Accrued liabilities	5,381	5,054
Other Long-Term Liabilities
Deposits	284	388
Other	119	0
Other long-term liabilities	$ 403	$ 388

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AVINZA Co-Promotion (Tables)

9 Months Ended

Sep. 30, 2012

Co Promotion [Abstract]

Summary of co-promote termination liability

A summary of the co-promote termination liability as of September 30, 2012 is as follows (in thousands):

Net present value of payments based on estimated future net Avinza product sales as of December 31, 2011	$	21,452
Assumed payments made by King or assignee	(2,533		)
Fair value adjustments	(5,844		)
Total co-promote termination liability as of September 30, 2012	13,075
Less: current portion of co-promote termination liability as of September 30, 2012	4,431
Long-term portion of co-promote termination liability as of September 30, 2012	$	8,644

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Basis of Presentation (Details Textual) (USD $)	3 Months Ended		9 Months Ended			9 Months Ended	12 Months Ended	9 Months Ended			12 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011	Dec. 31, 2011	Sep. 30, 2012 Accounts Receivable [Member] Customer Concentration Risk [Member] customer	Dec. 31, 2011 Accounts Receivable [Member] Customer Concentration Risk [Member] customer	Sep. 30, 2012 Equipment [Member]	Sep. 30, 2012 Equipment [Member] Minimum [Member]	Sep. 30, 2012 Equipment [Member] Maximum [Member]	Dec. 31, 2011 IPR&D MEDI-528 [Member]	Dec. 31, 2011 IPR&D TRPV1 [Member]
Basis of Presentation (Textual) [Abstract]
Accumulated deficit	$ (683,822,000)		$ (683,822,000)		$ (682,232,000)
Working capital	(12,400,000)		(12,400,000)
Period for which available resources are sufficient to satisfy company's anticipated operating and capital requirements			12 months
Common shares included in computation	0	0	0	37,406
Common shares excluded from computation			2,000,000	1,600,000
Period allowed for return of products, minimum			30 days
Period allowed for return of products, maximum			90 days
Maturity period of cash and cash equivalents			three months or less
Maturity period of cash and cash equivalents, maximum			3 months
Maturity period of short term investments			more than three months
Maturity period of short term investments, minimum			3 months
FDIC insured amount	250,000,000		250,000,000
Cash deposits	6,800,000		6,800,000		13,100,000
Concentration risk, number of customers						1	2
Concentration risk, percentage of accounts receivable						60.00%	67.00%
Accounts receivable outstanding considered past due after period, minimum			30 days
Accounts receivable outstanding considered past due after period, maximum			90 days
Allowance for doubtful accounts	0		0		0
Estimated useful life of assets								three to ten years	P3Y	P10Y
Amortization expense			1,700,000	1,900,000
Finite-Lived Intangible Assets, Net, Amortization Expense, Fiscal Year Maturity [Abstract]
Amortization Expense 2012	2,300,000		2,300,000
Amortization Expense 2013	2,300,000		2,300,000
Amortization Expense 2014	2,300,000		2,300,000
Amortization Expense 2015	2,300,000		2,300,000
Amortization Expense 2016	2,300,000		2,300,000
Impairment of IPR&D											1,100,000	1,200,000
Deferred revenue	900,000		900,000		1,200,000
Amount included in current portion of deferred revenue	400,000		400,000
Amount included in long-term portion of deferred revenue	$ 500,000		$ 500,000

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Segment Reporting (Tables)

9 Months Ended

Sep. 30, 2012

Segment Reporting [Abstract]

Summary of segment information

Segment information was as follows (in thousands):

Balance Sheet Data:	As of September 30, 2012
	Ligand			CyDex			Total
Total assets	$	65,289		$	32,217		$	97,506
	As of December 31, 2011
	Ligand			CyDex			Total
	(Restated)			(Restated)			(Restated)
Total assets	$	111,431		$	9,152		$	120,583
Operating Data:	For the three months ended September 30, 2012
	Ligand			CyDex			Total
Net revenues from external customers	$	3,708		$	2,667		$	6,375
Operating income (loss)	(1,498		)	176			(1,322		)
Depreciation and amortization expense	34			604			638
Income tax expense from continuing operations	142			—			142
Interest expense, net	838			—			838
	For the three months ended September 30, 2011
	Ligand			CyDex			Total
Net revenues from external customers	$	3,291		$	2,450		$	5,741
Operating income (loss)	(3,381		)	132			(3,249		)
Depreciation and amortization expense	134			609			743
Income tax expense from continuing operations	22			—			22
Interest expense, net	699			—			699
Write-off of in-process research and development	2,282						2,282
	For the nine months ended September 30, 2012
	Ligand			CyDex			Total
Net revenues from external customers	$	11,728		$	6,025		$	17,753
Operating loss	(3,298		)	(520		)	(3,818		)
Depreciation and amortization expense	162			1,816			1,978
Income tax expense from continuing operations	445			—			445
Income tax benefit from discontinuing operations	14			—			14
Interest expense, net	2,460			—			2,460
	For the nine months Ended September 30, 2011
	Ligand			CyDex			Total
	(Restated)			(Restated)			(Restated)
Net revenues from external customers	$	8,718		$	8,383		$	17,101
Operating loss	(6,507		)	966			(5,541		)
Depreciation and amortization expense	407			1,692			2,099
Income tax expense from continuing operations	(13,572		)	—			(13,572		)
Interest expense, net	1,762			—			1,762
Write off of in-process research and development	2,282			—			2,282

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Basis of Presentation

9 Months Ended

Sep. 30, 2012

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Basis of Presentation

Basis of Presentation

Ligand Pharmaceuticals Incorporated, a Delaware corporation (the "Company" or "Ligand"), is a biotechnology company that focuses on drug discovery and early-stage development and partnering of pharmaceuticals that address critical unmet medical needs or that are more effective and/or safer than existing therapies, more convenient to administer and are cost effective. The Company sold its Oncology Product Line (“Oncology”) and Avinza Product Line (“Avinza”) on October 25, 2006 and February 26, 2007, respectively. The operating results for Oncology and Avinza have been presented in the accompanying consolidated financial statements as “Discontinued Operations”.

The Company has incurred significant losses since its inception. At September 30, 2012, the Company’s accumulated deficit was $683.8 million and the Company had negative working capital of $12.4 million. Based on recent product approvals and regulatory developments, as well as management’s plans including expense reductions, if necessary, the Company believes its currently available cash, cash equivalents, and short-term investments as well as its current and future royalty, license and milestone revenues will be sufficient to satisfy its anticipated operating and capital requirements through at least the next twelve months. The Company’s future operating and capital requirements will depend on many factors, including, but not limited to: the pace of scientific progress in its research and development programs; the potential success of these programs; the scope and results of preclinical testing and clinical trials; the time and costs involved in obtaining regulatory approvals; the costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims; competing technological and market developments; the amount of royalties on sales of the commercial products of its partners; the efforts of its collaborative partners; obligations under its operating lease agreements; and the capital requirements of any companies the Company previously acquired, including Pharmacopeia, Inc. (“Pharmacopeia”), Neurogen Corporation (“Neurogen”), Metabasis Therapeutics, Inc. (“Metabasis”) and CyDex Pharmaceuticals, Inc. (“CyDex”). Management’s plans and efforts may not fully address any significant adverse impact from any or all of these factors and the Company may be required to obtain additional financing, which may not be available at acceptable terms, or at all.

Principles of Consolidation

The condensed consolidated financial statements include the Company’s wholly owned subsidiaries, Seragen, Inc. (“Seragen”), Nexus Equity VI LLC (“Nexus”), Pharmacopeia, Neurogen, Metabasis and CyDex. All significant intercompany accounts and transactions have been eliminated in consolidation.

Basis of Presentation

The Company’s accompanying unaudited consolidated condensed financial statements as of September 30, 2012 and for the three and nine months endedSeptember 30, 2012 and 2011 have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial information. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for annual financial statements. The Company’s consolidated condensed balance sheet at December 31, 2011 has been derived from the audited financial statements at that date, but does not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation of the financial position and results of operations of the Company, and its subsidiaries have been included. Operating results for the three and nine months ended September 30, 2012 are not necessarily indicative of the results that may be expected for the year ending December 31, 2012. These financial statements should be read in conjunction with the consolidated financial statements and notes therein included in the Company’s amended annual report on Form 10-K/A for the year ended December 31, 2011.

As discussed in Note 11, the Company has restated its previously issued condensed consolidated financial statements as of December 31, 2011 and for the three and nine months ended September 30, 2011 included in this Form 10-Q.

Use of Estimates

The preparation of consolidated financial statements in conformity with generally accepted accounting principles requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and liabilities, at the date of the consolidated financial statements, and the reported amounts of revenue and expenses during the reporting period. The Company’s critical accounting policies are those that are both most important to the Company’s financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results may materially vary from these estimates.

Income (Loss) Per Share

Basic earnings per share is calculated by dividing net income or loss by the weighted average number of common shares and vested restricted stock units outstanding. Diluted earnings per share is computed by dividing net income or loss by the weighted average number of common shares and vested restricted stock units outstanding and the weighted average number of dilutive common stock equivalents, including stock options and non-vested restricted stock units. Common stock equivalents are only included in the diluted earnings per share calculation when their effect is dilutive. For the three and nine months ended September 30, 2012, no potential common shares are included in the computation of any diluted per share amounts, including income (loss) per share from discontinued operations and net loss per share, as the Company reported a loss from continuing operations. For the nine months ended September 30, 2011, 37,406 common shares are included in the computation of diluted income per share. Potential common shares, the shares that would be issued upon the exercise of outstanding stock options and warrants and the vesting of restricted shares that would be excluded from the computation of diluted loss per share, were 2.0 million and 1.6 million at September 30, 2012 and 2011, respectively.

The following table sets forth the computation of basic and diluted net income (loss) per share for the periods indicated (in thousands, except per share amounts):

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2012			2011			2012			2011
				(Restated)						(Restated)
Net income (loss) from continuing operations	$	(194	)	$	(4,178	)	$	(5,260	)	$	5,026
Net income from discontinued operations	—			—			3,670			3
Net income (loss)	(194		)	(4,178		)	(1,590		)	5,029
Shares used to compute basic and diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,648,947
Dilutive potential common shares:
Restricted stock	—			—			—			37,406
Shares used to compute diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,686,353
Basic and diluted per share amounts:
Income (loss) from continuing operations	$	(0.01	)	$	(0.21	)	$	(0.27	)	$	0.26
Income from discontinued operations	—			—			0.19			—
Net income (loss)	$	(0.01	)	$	(0.21	)	$	(0.08	)	$	0.26

Revenue Recognition

Royalties on sales of products commercialized by the Company’s partners are recognized in the quarter reported by the respective partner.

Material sales revenue is recognized upon transfer of title, which normally passes to the buyer upon shipment to the customer. The Company’s credit and exchange policy includes provisions for the return of product between 30 to 90 days, depending on the specific terms of the individual agreement, when that product (1) does not meet specifications, (2) is damaged in shipment (in limited circumstances where title does not transfer until delivery), or (3) is exchanged for an alternative grade of Captisol.

Revenue from research funding under the Company’s collaboration agreements is earned and recognized on a percentage-of-completion basis as research hours are incurred in accordance with the provisions of each agreement.

Nonrefundable, up-front license fees and milestone payments with standalone value that are not dependent on any future performance by the Company under the Company’s collaboration agreements are recognized as revenue upon the earlier of when payments are received or collection is assured, but are deferred if the Company has continuing performance obligations. If the Company is unable to determine the stand alone value under multiple-element arrangements, revenue is recognized over the period of services or performance. Amounts received under multiple-element arrangements requiring ongoing services or performance by the Company are recognized over the period of such services or performance.

Revenue from milestones are recognized when earned, as evidenced by written acknowledgement from the collaborator, provided that (i) the milestone event is substantive, its achievability was not reasonably assured at the inception of the agreement, and the Company has no further performance obligations relating to that event, and (ii) collectability is reasonably assured. If these criteria are not met, the milestone payment is recognized over the remaining period of the Company’s performance obligations under the arrangement.

Income Taxes

The Company recognizes liabilities or assets for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements. These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. A valuation allowance is established when management determines that it is more likely than not that all or a portion of a deferred tax asset will not be realized. Management evaluates the realizability of its net deferred tax assets on a quarterly basis and valuation allowances are provided, as necessary. During this evaluation, management reviews its forecasts of income in conjunction with other positive and negative evidence surrounding the realizability of its deferred tax assets to determine if a valuation allowance is required. Adjustments to the valuation allowance will increase or decrease the Company’s income tax provision or benefit. Management also applies the relevant guidance to determine the amount of income tax expense or benefit to be allocated among continuing operations, discontinued operations, and items charged or credited directly to stockholders’ equity.

A tax position must meet a minimum probability threshold before a financial statement benefit is recognized. The minimum threshold is a tax position that is more likely than not to be sustained upon examination by the applicable taxing authority, including resolution of any related appeals or litigation processes, based on the technical merits of the position.  The Company recognizes interest and penalties related to uncertain tax positions in income tax expense.

Accounting for Share-Based Compensation

Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests. Compensation cost for consultant awards is recognized over each separate tranche’s vesting period. The following table summarizes share-based compensation expense recorded as components of research and development expenses and general and administrative expenses for the periods indicated (in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2012		2011		2012		2011
Share-based compensation expense as a component of:
Research and development expenses	$	263	$	300	$	1,211	$	808
General and administrative expenses	750		650		1,905		1,838
	$	1,013	$	950	$	3,116	$	2,646

The fair-value for options that were awarded to employees and directors was estimated at the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions:

	Three Months Ended		Nine Months Ended
	September 30,		September 30,
	2012	2011	2012	2011
Risk-free interest rate	0.8%	1.7%	1.0%	2.5%
Dividend yield	—	—	—	—
Expected volatility	69%	68%	69%	69%
Expected term	6.2 years	6.1 years	6.3 years	6.1 years
Forfeiture rate	8.2%	8.8%	8.0%-11.2%	8.8%-14.1%

The expected term of the employee and non-employee director options is the estimated weighted-average period until exercise or cancellation of vested options (forfeited unvested options are not considered) based on historical experience. The expected term for consultant awards is the remaining period to contractual expiration.

Volatility is a measure of the expected amount of variability in the stock price over the expected life of an option expressed as a standard deviation. In selecting this assumption, management used the historical volatility of the Company's stock price over a period approximating the expected term.

Cash, Cash Equivalents and Short-term Investments

Cash and cash equivalents consist of cash and highly liquid securities with maturities at the date of acquisition of three months or less. Non-restricted equity and debt securities with a maturity of more than three months are considered short term investments. Restricted cash and investments consist of certificates of deposit held with financial institutions as collateral under a facility lease and third-party service provider arrangement. The following table summarizes the various investment categories at September 30, 2012 and December 31, 2011 (in thousands):

	Cost		Gross unrealized gains		Gross unrealized losses		Estimated fair value
September 30, 2012
Certificates of deposit	$	—	$	—	$	—	$	—
Certificates of deposit - restricted	1,341		—		—		1,341
	$	1,341	$	—	$	—	$	1,341
December 31, 2011
Certificates of deposit	$	10,000	$	—	$	—	$	10,000
Certificates of deposit - restricted	1,341		—		—		1,341
	$	11,341	$	—	$	—	$	11,341

Concentrations of Credit Risk

Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash equivalents and investments and accounts receivable.

The Company invests its excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. The Company has established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates. The Company has not experienced any significant losses on its cash equivalents, short-term investments or restricted investments for the periods ending September 30, 2012 and December 31, 2011.

As of September 30, 2012 and December 31, 2011, cash deposits held at financial institutions in excess of FDIC insured amounts of $250,000 were approximately $6.8 million and $13.1 million, respectively.

Accounts receivable from one customer was 60% and accounts receivable from two customers was 67% of total accounts receivable at September 30, 2012 and December 31, 2011, respectively. 

The Company currently obtains Captisol from a sole-source supplier.  If this supplier was not able to supply the requested amounts of Captisol, the Company would be unable to continue to derive revenues from the sale of Captisol until it obtained an alternative source, which might take a considerable length of time.

Allowance for Doubtful Accounts

The Company maintains an allowance for doubtful accounts based on the best estimate of the amount of probable losses in the Company’s existing accounts receivable. Accounts receivable that are outstanding longer than their contractual payment terms, ranging from 30 to 90 days, are considered past due. When determining the allowance for doubtful accounts, several factors are taken into consideration, including historical write-off experience and review of specific customer accounts for collectability. Account balances are charged off against the allowance after collection efforts have been exhausted and the potential for recovery is considered remote. There was no allowance for doubtful accounts included in the balance sheets at September 30, 2012 and December 31, 2011.

Inventory

Inventory is stated at the lower of cost or market. The Company determines cost using the first-in, first-out method. The Company analyzes its inventory levels periodically and writes down inventory to its net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements.

Other Current Assets

Other current assets consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Prepaid expenses	$	889	$	905
Advanced manufacturing payments	2		312
Other receivables	124		127
	$	1,015	$	1,344

Property and Equipment

Property and equipment is stated at cost and consists of the following (in thousands):

	September 30,			December 31,
	2012			2011
Lab and office equipment	$	4,503		$	4,110
Leasehold improvements	—			62
Computer equipment and software	1,150			1,054
	5,653			5,226
Less accumulated depreciation and amortization	(4,800		)	(4,771		)
	$	853		$	455

Depreciation of equipment is computed using the straight-line method over the estimated useful lives of the assets, which range from three to ten years. Leasehold improvements are amortized using the straight-line method over their estimated useful lives or their related lease term, whichever is shorter.

Goodwill and Other Identifiable Intangible Assets

Goodwill and other identifiable intangible assets consist of the following (in thousands):

	September 30,			December 31,
	2012			2011
				(Restated)
Acquired in-process research and development	$	13,036		$	13,036
Complete technology	15,227			15,227
Trade name	2,642			2,642
Customer relationships	29,600			29,600
Goodwill	12,238			12,238
	72,743			72,743
Accumulated amortization	(3,925		)	(2,179		)
	$	68,818		$	70,564

Intangible assets related to IPR&D are considered to be indefinite-lived until the completion or abandonment of the associated research and development efforts. During the period the assets are considered to be indefinite-lived, they will not be amortized but will be tested for impairment on an annual basis and between annual tests if the Company becomes aware of any events occurring or changes in circumstances that would indicate a reduction in the fair value of the IPR&D projects below their respective carrying amounts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Amortization expense of $1.7 million and $1.9 million was recognized for the nine months endedSeptember 30, 2012 and 2011, respectively. Estimated amortization expense for the years ending December 31, 2012 through 2016 is $2.3 million per year.

Impairment of Long-Lived Assets

Management reviews long-lived assets for impairment annually or whenever events or changes in circumstances indicate the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured as the amount by which the carrying amount of the assets exceeds the fair value of the assets. Fair value for the Company’s long-lived assets is determined using the expected cash flows discounted at a rate commensurate with the risk involved. As of September 30, 2012, management does not believe there have been any events or circumstances indicating that the carrying amount of its long-lived assets may not be recoverable.

During 2011, the impairment analysis performed by management resulted in the write-off of certain acquired in process research and development assets.  The Company recorded a non-cash impairment charge of $1.1 million for the write-off of IPR&D and interests in future milestones and royalties for MEDI-528, an IL-9 antibody program by AstraZeneca's subsidiary, MedImmune.  The asset was impaired upon receipt of notice from MedImmune in September that it was exercising its right to terminate the collaboration and license agreement. 

Additionally, in 2011, the Company recorded a non-cash impairment charge of $1.2 million for the write-off of IPR&D and interests in future milestones for TRPV1, a collaborative research and licensing program between the Company and Merck, related to the physiology, pharmacology, chemistry and potential therapeutic applications and potential clinical utilities related to Vanilloid Receptors, subtype 1. The asset was impaired upon receipt of notice from Merck in October 2011 that it was exercising its right to terminate the collaboration and license agreement. Subsequent to the termination of the agreement, the Company will receive an exclusive, perpetual, irrevocable, royalty-free (but subject to any third party royalty obligations), fully-paid world-wide license, with the right to sub-license, under specified patents and technology for the research, development, or commercialization of specified compounds and products in a limited field of use.

Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Compensation	$	1,157	$	1,806
Professional fees	485		355
Other	3,739		2,893
	$	5,381	$	5,054

Other Long-Term Liabilities

Other long-term liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Deposits	$	284	$	388
Other	119		—
	$	403	$	388

Sale of Royalty Rights

The Company previously sold to third parties the rights to future royalties of certain of its products. As part of the underlying royalty agreements, the partners have the right to offset a portion of any future royalty payments owed to the Company to the extent of previous milestone payments. Accordingly, the Company deferred a portion of the revenue associated with each tranche of royalty right sold, equal to the pro-rata share of the potential royalty offset. Such amounts associated with the offset rights against future royalty payments will be recognized as revenue upon receipt of future royalties from the respective partners. As of September 30, 2012 and December 31, 2011, the Company had deferred $0.9 million and $1.2 million, respectively, of revenue related to the sale of royalty rights. As of September 30, 2012, $0.4 million is included in current portion of deferred revenue and $0.5 million is included in long-term portion of deferred revenue.

Recently Adopted Accounting Pronouncements

In June 2011, the FASB issued ASU No. 2011-05, Comprehensive Income (Topic 220) - Presentation of Comprehensive Income. This ASU amends Topic 220, Comprehensive Income, to allow an entity the option to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. In both choices, an entity is required to present each component of net income along with total net income, each component of other comprehensive income along with a total for other comprehensive income, and a total amount for comprehensive income. ASU No. 2011-05 eliminates the option to present the components of other comprehensive income as part of the statement of changes in shareholders’ investment. The amendments to the Codification in the ASU do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income. The ASU was effective for fiscal years beginning after December 15, 2011 for the Company. In 2012, the Company has elected to present comprehensive income in a separate statement.

In September 2011, the FASB issued ASU 2011-08, Intangibles – Goodwill and other: testing for goodwill impairment, which, among other things, amends Accounting Standards Codification 350 Intangibles – Goodwill and Other, to allow entities to use a qualitative approach to test goodwill for impairment. ASU 2011-08 permits an entity to first perform a qualitative assessment to determine whether it is more likely than not that the fair value of a reporting unit is less than its carrying value. If it is concluded that this is the case, it is necessary to perform the currently prescribed two-step goodwill impairment test. Otherwise, the two-step goodwill impairment test is not required. Our adoption of this standard had no impact on our consolidated financial position, results of operations or cash flows.

In December 2011, the FASB issued ASU 2011-12, Deferral of the Effective Date for Amendments to the Presentation of Reclassifications of Items Out of Accumulated Other Comprehensive Income in ASU 2011-12. The amendments in ASU 2011-12 defer the changes in ASU 2011-05 that relate to the presentation of reclassification adjustments out of accumulated other comprehensive income. The amendments in this ASU are effective for public entities for fiscal years, and interim periods within those years, beginning after December 15, 2011. See above for the provisions of ASU 2011-05.

XML

Condensed Consolidated Balance Sheets (Parenthetical) (USD $)	Sep. 30, 2012	Dec. 31, 2011
Statement of Financial Position [Abstract]
Common stock subject to conditional redemption, shares issued		112,371
Common stock subject to conditional redemption, shares outstanding		112,371
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	33,333,333	33,333,333
Common stock, shares issued	21,082,678	20,682,506
Common stock, shares outstanding	21,082,678	20,682,506
Treasury stock, shares	1,118,222	1,118,222

XML

Restatement of Financial Statements

9 Months Ended

Sep. 30, 2012

Accounting Changes and Error Corrections [Abstract]

Restatement of Financial Statements

Restatement of Financial Statements

The Company restated its previously issued consolidated financial statements as of December 31, 2011, to correct errors in the calculation of certain contingent liabilities related to the acquisition of CyDex. Specifically, the initial fair value of the contingent liability was overstated by $1.6 million resulting in an initial overstatement of goodwill by $2.7 million, an understatement of the income tax benefit of $0.1 million, and overstatement of the deferred tax liability of $0.3 million, and an understatement of intangible assets of $0.9 million. As of December 31, 2011, goodwill was overstated by $2.7 million, intangible assets were understated by $0.9 million, long-term portion of contingent liabilities was overstated by $1.0 million and deferred income taxes was overstated by $0.3 million. For the three months ended September 30, 2011, decrease (increase) in contingent liabilities increased $0.4 million from a decrease in contingent liabilities of $0.2 million to an increase in contingent liabilities of $0.2 million and loss from continuing operations increased $0.02 per share from $0.19 per share to $0.21 per share. For the nine months ended September 30, 2011, decrease (increase) in contingent liabilities increased $0.5 million from $0.8 million to $1.3 million, income tax benefit increased $0.1 million from $13.4 million to $13.6 million and income from continuing operations decreased $0.01 per share from $0.27 per share to $0.26 per share.

Contingent liabilities in the accompanying balance sheets now includes amounts relating to contingent value rights and other acquired contingent liabilities. The statement of cash flows has been adjusted for the restatements for the twelve months ended December 31, 2011. The only impact on the statement of cash flows is the change in the non-cash impact of contingent liabilities. The impact of the restatement as of December 31, 2011 and for the three and nine months ended September 30, 2011 is described in the table below:

	December 31, 2011
Balance sheet data:	As previously reported			Restated
Goodwill	$	14,894		$	12,238
Intangible assets, net	57,437			58,326
Total assets	122,350			120,583
Long-term portion of contingent liabilities	11,433			10,419
Deferred income taxes	2,522			2,230
Total liabilities	105,360			104,054
Accumulated deficit	(681,771		)	(682,232		)

	Three Months Ended September 30, 2011						Nine Months Ended September 30, 2011
	As previously reported			Restated			As previously reported			Restated
Statement of Operations data:
Decrease (increase) in contingent liabilities	$	224		$	(198	)	$	(835	)	$	(1,317	)
Income tax benefit (expense)	(22		)	(22		)	13,427			13,572
Net Income (loss)	(3,756		)	(4,178		)	5,366			5,029
Basic and diluted earnings per share:
Income (loss) from continuing operations	$	(0.19	)	$	(0.21	)	$	0.27		$	0.26
Income from discontinued operations	—			—			—			—
Net Income (loss)	(0.19		)	(0.21		)	0.27			0.26
Weighted average number of common shares-basic	19,673			19,673			19,649			19,649
Weighted average number of common shares-diluted	19,673			19,673			19,649			19,686

XML

Document and Entity Information	9 Months Ended
	Sep. 30, 2012	Nov. 06, 2012
Document and Entity Information [Abstract]
Entity Registrant Name	LIGAND PHARMACEUTICALS INC
Entity Central Index Key	0000886163
Document Type	10-Q
Document Period End Date	Sep. 30, 2012
Amendment Flag	false
Document Fiscal Year Focus	2012
Document Fiscal Period Focus	Q3
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		19,964,456

XML

Basis of Presentation (Policies)

9 Months Ended

Sep. 30, 2012

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Principles of Consolidation

Principles of Consolidation

The condensed consolidated financial statements include the Company’s wholly owned subsidiaries, Seragen, Inc. (“Seragen”), Nexus Equity VI LLC (“Nexus”), Pharmacopeia, Neurogen, Metabasis and CyDex. All significant intercompany accounts and transactions have been eliminated in consolidation.

Basis of Presentation

Basis of Presentation

The Company’s accompanying unaudited consolidated condensed financial statements as of September 30, 2012 and for the three and nine months endedSeptember 30, 2012 and 2011 have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial information. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for annual financial statements. The Company’s consolidated condensed balance sheet at December 31, 2011 has been derived from the audited financial statements at that date, but does not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation of the financial position and results of operations of the Company, and its subsidiaries have been included. Operating results for the three and nine months ended September 30, 2012 are not necessarily indicative of the results that may be expected for the year ending December 31, 2012. These financial statements should be read in conjunction with the consolidated financial statements and notes therein included in the Company’s amended annual report on Form 10-K/A for the year ended December 31, 2011.

Use of Estimates

Use of Estimates

The preparation of consolidated financial statements in conformity with generally accepted accounting principles requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and liabilities, at the date of the consolidated financial statements, and the reported amounts of revenue and expenses during the reporting period. The Company’s critical accounting policies are those that are both most important to the Company’s financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results may materially vary from these estimates.

Income (Loss) Per Share

Income (Loss) Per Share

Basic earnings per share is calculated by dividing net income or loss by the weighted average number of common shares and vested restricted stock units outstanding. Diluted earnings per share is computed by dividing net income or loss by the weighted average number of common shares and vested restricted stock units outstanding and the weighted average number of dilutive common stock equivalents, including stock options and non-vested restricted stock units. Common stock equivalents are only included in the diluted earnings per share calculation when their effect is dilutive. For the three and nine months ended September 30, 2012, no potential common shares are included in the computation of any diluted per share amounts, including income (loss) per share from discontinued operations and net loss per share, as the Company reported a loss from continuing operations. For the nine months ended September 30, 2011, 37,406 common shares are included in the computation of diluted income per share. Potential common shares, the shares that would be issued upon the exercise of outstanding stock options and warrants and the vesting of restricted shares that would be excluded from the computation of diluted loss per share, were 2.0 million and 1.6 million at September 30, 2012 and 2011, respectively.

The following table sets forth the computation of basic and diluted net income (loss) per share for the periods indicated (in thousands, except per share amounts):

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2012			2011			2012			2011
				(Restated)						(Restated)
Net income (loss) from continuing operations	$	(194	)	$	(4,178	)	$	(5,260	)	$	5,026
Net income from discontinued operations	—			—			3,670			3
Net income (loss)	(194		)	(4,178		)	(1,590		)	5,029
Shares used to compute basic and diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,648,947
Dilutive potential common shares:
Restricted stock	—			—			—			37,406
Shares used to compute diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,686,353
Basic and diluted per share amounts:
Income (loss) from continuing operations	$	(0.01	)	$	(0.21	)	$	(0.27	)	$	0.26
Income from discontinued operations	—			—			0.19			—
Net income (loss)	$	(0.01	)	$	(0.21	)	$	(0.08	)	$	0.26

Revenue Recognition

Revenue Recognition

Royalties on sales of products commercialized by the Company’s partners are recognized in the quarter reported by the respective partner.

Material sales revenue is recognized upon transfer of title, which normally passes to the buyer upon shipment to the customer. The Company’s credit and exchange policy includes provisions for the return of product between 30 to 90 days, depending on the specific terms of the individual agreement, when that product (1) does not meet specifications, (2) is damaged in shipment (in limited circumstances where title does not transfer until delivery), or (3) is exchanged for an alternative grade of Captisol.

Revenue from research funding under the Company’s collaboration agreements is earned and recognized on a percentage-of-completion basis as research hours are incurred in accordance with the provisions of each agreement.

Nonrefundable, up-front license fees and milestone payments with standalone value that are not dependent on any future performance by the Company under the Company’s collaboration agreements are recognized as revenue upon the earlier of when payments are received or collection is assured, but are deferred if the Company has continuing performance obligations. If the Company is unable to determine the stand alone value under multiple-element arrangements, revenue is recognized over the period of services or performance. Amounts received under multiple-element arrangements requiring ongoing services or performance by the Company are recognized over the period of such services or performance.

Revenue from milestones are recognized when earned, as evidenced by written acknowledgement from the collaborator, provided that (i) the milestone event is substantive, its achievability was not reasonably assured at the inception of the agreement, and the Company has no further performance obligations relating to that event, and (ii) collectability is reasonably assured. If these criteria are not met, the milestone payment is recognized over the remaining period of the Company’s performance obligations under the arrangement.

Income Taxes

Income Taxes

The Company recognizes liabilities or assets for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements. These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. A valuation allowance is established when management determines that it is more likely than not that all or a portion of a deferred tax asset will not be realized. Management evaluates the realizability of its net deferred tax assets on a quarterly basis and valuation allowances are provided, as necessary. During this evaluation, management reviews its forecasts of income in conjunction with other positive and negative evidence surrounding the realizability of its deferred tax assets to determine if a valuation allowance is required. Adjustments to the valuation allowance will increase or decrease the Company’s income tax provision or benefit. Management also applies the relevant guidance to determine the amount of income tax expense or benefit to be allocated among continuing operations, discontinued operations, and items charged or credited directly to stockholders’ equity.

A tax position must meet a minimum probability threshold before a financial statement benefit is recognized. The minimum threshold is a tax position that is more likely than not to be sustained upon examination by the applicable taxing authority, including resolution of any related appeals or litigation processes, based on the technical merits of the position.  The Company recognizes interest and penalties related to uncertain tax positions in income tax expense.

Accounting for Share-Based Compensation

Accounting for Share-Based Compensation

Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests. Compensation cost for consultant awards is recognized over each separate tranche’s vesting period. The following table summarizes share-based compensation expense recorded as components of research and development expenses and general and administrative expenses for the periods indicated (in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2012		2011		2012		2011
Share-based compensation expense as a component of:
Research and development expenses	$	263	$	300	$	1,211	$	808
General and administrative expenses	750		650		1,905		1,838
	$	1,013	$	950	$	3,116	$	2,646

The fair-value for options that were awarded to employees and directors was estimated at the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions:

	Three Months Ended		Nine Months Ended
	September 30,		September 30,
	2012	2011	2012	2011
Risk-free interest rate	0.8%	1.7%	1.0%	2.5%
Dividend yield	—	—	—	—
Expected volatility	69%	68%	69%	69%
Expected term	6.2 years	6.1 years	6.3 years	6.1 years
Forfeiture rate	8.2%	8.8%	8.0%-11.2%	8.8%-14.1%

The expected term of the employee and non-employee director options is the estimated weighted-average period until exercise or cancellation of vested options (forfeited unvested options are not considered) based on historical experience. The expected term for consultant awards is the remaining period to contractual expiration.

Volatility is a measure of the expected amount of variability in the stock price over the expected life of an option expressed as a standard deviation. In selecting this assumption, management used the historical volatility of the Company's stock price over a period approximating the expected term.

Cash, Cash Equivalents and Short-term Investments

Cash, Cash Equivalents and Short-term Investments

Cash and cash equivalents consist of cash and highly liquid securities with maturities at the date of acquisition of three months or less. Non-restricted equity and debt securities with a maturity of more than three months are considered short term investments. Restricted cash and investments consist of certificates of deposit held with financial institutions as collateral under a facility lease and third-party service provider arrangement. The following table summarizes the various investment categories at September 30, 2012 and December 31, 2011 (in thousands):

	Cost		Gross unrealized gains		Gross unrealized losses		Estimated fair value
September 30, 2012
Certificates of deposit	$	—	$	—	$	—	$	—
Certificates of deposit - restricted	1,341		—		—		1,341
	$	1,341	$	—	$	—	$	1,341
December 31, 2011
Certificates of deposit	$	10,000	$	—	$	—	$	10,000
Certificates of deposit - restricted	1,341		—		—		1,341
	$	11,341	$	—	$	—	$	11,341

Concentrations of Credit Risk

Concentrations of Credit Risk

Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash equivalents and investments and accounts receivable.

The Company invests its excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. The Company has established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates. The Company has not experienced any significant losses on its cash equivalents, short-term investments or restricted investments for the periods ending September 30, 2012 and December 31, 2011.

As of September 30, 2012 and December 31, 2011, cash deposits held at financial institutions in excess of FDIC insured amounts of $250,000 were approximately $6.8 million and $13.1 million, respectively.

Accounts receivable from one customer was 60% and accounts receivable from two customers was 67% of total accounts receivable at September 30, 2012 and December 31, 2011, respectively. 

The Company currently obtains Captisol from a sole-source supplier.  If this supplier was not able to supply the requested amounts of Captisol, the Company would be unable to continue to derive revenues from the sale of Captisol until it obtained an alternative source, which might take a considerable length of time.

Allowance for Doubtful Accounts

Allowance for Doubtful Accounts

The Company maintains an allowance for doubtful accounts based on the best estimate of the amount of probable losses in the Company’s existing accounts receivable. Accounts receivable that are outstanding longer than their contractual payment terms, ranging from 30 to 90 days, are considered past due. When determining the allowance for doubtful accounts, several factors are taken into consideration, including historical write-off experience and review of specific customer accounts for collectability. Account balances are charged off against the allowance after collection efforts have been exhausted and the potential for recovery is considered remote. There was no allowance for doubtful accounts included in the balance sheets at September 30, 2012 and December 31, 2011.

Inventory

Inventory

Inventory is stated at the lower of cost or market. The Company determines cost using the first-in, first-out method. The Company analyzes its inventory levels periodically and writes down inventory to its net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements.

Other Current Assets

Other Current Assets

Other current assets consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Prepaid expenses	$	889	$	905
Advanced manufacturing payments	2		312
Other receivables	124		127
	$	1,015	$	1,344

Property and Equipment

Property and Equipment

Property and equipment is stated at cost and consists of the following (in thousands):

	September 30,			December 31,
	2012			2011
Lab and office equipment	$	4,503		$	4,110
Leasehold improvements	—			62
Computer equipment and software	1,150			1,054
	5,653			5,226
Less accumulated depreciation and amortization	(4,800		)	(4,771		)
	$	853		$	455

Depreciation of equipment is computed using the straight-line method over the estimated useful lives of the assets, which range from three to ten years. Leasehold improvements are amortized using the straight-line method over their estimated useful lives or their related lease term, whichever is shorter.

Goodwill and Other Identifiable Intangible Assets

Goodwill and Other Identifiable Intangible Assets

Goodwill and other identifiable intangible assets consist of the following (in thousands):

	September 30,			December 31,
	2012			2011
				(Restated)
Acquired in-process research and development	$	13,036		$	13,036
Complete technology	15,227			15,227
Trade name	2,642			2,642
Customer relationships	29,600			29,600
Goodwill	12,238			12,238
	72,743			72,743
Accumulated amortization	(3,925		)	(2,179		)
	$	68,818		$	70,564

Intangible assets related to IPR&D are considered to be indefinite-lived until the completion or abandonment of the associated research and development efforts. During the period the assets are considered to be indefinite-lived, they will not be amortized but will be tested for impairment on an annual basis and between annual tests if the Company becomes aware of any events occurring or changes in circumstances that would indicate a reduction in the fair value of the IPR&D projects below their respective carrying amounts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Amortization expense of $1.7 million and $1.9 million was recognized for the nine months endedSeptember 30, 2012 and 2011, respectively. Estimated amortization expense for the years ending December 31, 2012 through 2016 is $2.3 million per year.

Impairment of Long-Lived Assets

Impairment of Long-Lived Assets

Management reviews long-lived assets for impairment annually or whenever events or changes in circumstances indicate the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured as the amount by which the carrying amount of the assets exceeds the fair value of the assets. Fair value for the Company’s long-lived assets is determined using the expected cash flows discounted at a rate commensurate with the risk involved. As of September 30, 2012, management does not believe there have been any events or circumstances indicating that the carrying amount of its long-lived assets may not be recoverable.

Accrued Liabilities

Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Compensation	$	1,157	$	1,806
Professional fees	485		355
Other	3,739		2,893
	$	5,381	$	5,054

Other Long-Term Liabilities

Other Long-Term Liabilities

Other long-term liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Deposits	$	284	$	388
Other	119		—
	$	403	$	388

Sale of Royalty Rights

Sale of Royalty Rights

The Company previously sold to third parties the rights to future royalties of certain of its products. As part of the underlying royalty agreements, the partners have the right to offset a portion of any future royalty payments owed to the Company to the extent of previous milestone payments. Accordingly, the Company deferred a portion of the revenue associated with each tranche of royalty right sold, equal to the pro-rata share of the potential royalty offset. Such amounts associated with the offset rights against future royalty payments will be recognized as revenue upon receipt of future royalties from the respective partners. As of September 30, 2012 and December 31, 2011, the Company had deferred $0.9 million and $1.2 million, respectively, of revenue related to the sale of royalty rights. As of September 30, 2012, $0.4 million is included in current portion of deferred revenue and $0.5 million is included in long-term portion of deferred revenue.

Recently Adopted Accounting Pronouncements

Recently Adopted Accounting Pronouncements

In June 2011, the FASB issued ASU No. 2011-05, Comprehensive Income (Topic 220) - Presentation of Comprehensive Income. This ASU amends Topic 220, Comprehensive Income, to allow an entity the option to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. In both choices, an entity is required to present each component of net income along with total net income, each component of other comprehensive income along with a total for other comprehensive income, and a total amount for comprehensive income. ASU No. 2011-05 eliminates the option to present the components of other comprehensive income as part of the statement of changes in shareholders’ investment. The amendments to the Codification in the ASU do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income. The ASU was effective for fiscal years beginning after December 15, 2011 for the Company. In 2012, the Company has elected to present comprehensive income in a separate statement.

In September 2011, the FASB issued ASU 2011-08, Intangibles – Goodwill and other: testing for goodwill impairment, which, among other things, amends Accounting Standards Codification 350 Intangibles – Goodwill and Other, to allow entities to use a qualitative approach to test goodwill for impairment. ASU 2011-08 permits an entity to first perform a qualitative assessment to determine whether it is more likely than not that the fair value of a reporting unit is less than its carrying value. If it is concluded that this is the case, it is necessary to perform the currently prescribed two-step goodwill impairment test. Otherwise, the two-step goodwill impairment test is not required. Our adoption of this standard had no impact on our consolidated financial position, results of operations or cash flows.

In December 2011, the FASB issued ASU 2011-12, Deferral of the Effective Date for Amendments to the Presentation of Reclassifications of Items Out of Accumulated Other Comprehensive Income in ASU 2011-12. The amendments in ASU 2011-12 defer the changes in ASU 2011-05 that relate to the presentation of reclassification adjustments out of accumulated other comprehensive income. The amendments in this ASU are effective for public entities for fiscal years, and interim periods within those years, beginning after December 15, 2011. See above for the provisions of ASU 2011-05.

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Condensed Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenues:
Royalties	$ 3,213	$ 2,431	$ 9,256	$ 6,597
Material sales	1,818	1,679	4,150	5,713
Collaborative research and development and other revenues	1,344	1,631	4,347	4,791
Total revenues	6,375	5,741	17,753	17,101
Operating costs and expenses:
Cost of sales	683	703	1,273	2,851
Research and development	2,647	2,471	8,315	7,693
General and administrative	4,382	3,962	11,824	11,261
Write-off of in-process research and development		2,282		2,282
Lease exit and termination costs	(15)	(2)	159	(168)
Total operating costs and expenses	7,697	9,416	21,571	23,919
Accretion of deferred gain on sale leaseback		426		1,277
Loss from operations	(1,322)	(3,249)	(3,818)	(5,541)
Other income (expense):
Interest expense, net	(838)	(699)	(2,460)	(1,762)
Decrease (increase) in contingent liabilities	2,093	(198)	1,191	(1,317)
Other, net	15	(10)	272	74
Total other income (expense), net	1,270	(907)	(997)	(3,005)
Income (loss) before income taxes	(52)	(4,156)	(4,815)	(8,546)
Income tax benefit (expense)	(142)	(22)	(445)	13,572
Income (loss) from continuing operations	(194)	(4,178)	(5,260)	5,026
Discontinued operations:
Income tax benefit on discontinued operations			14
Discontinued operations			3,670	3
Net income (loss):	(194)	(4,178)	(1,590)	5,029
Basic and diluted per share amounts:
Income (loss) from continuing operations (in usd per share)	$ (0.01)	$ (0.21)	$ (0.27)	$ 0.26
Discontinued operations (in usd per share)			$ 0.19
Net income (loss) (in usd per share)	$ (0.01)	$ (0.21)	$ (0.08)	$ 0.26
Weighted average number of common shares-basic (in shares)	19,917,676	19,673,160	19,791,793	19,648,947
Weighted average number of common shares-diluted (in shares)	19,917,676	19,673,160	19,791,793	19,686,353
AVINZA Product Line
Discontinued operations:
Gain on sale of Product Line, net			3,656
Oncology Product Line
Discontinued operations:
Gain on sale of Product Line, net				$ 3

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Segment Reporting

9 Months Ended

Sep. 30, 2012

Segment Reporting [Abstract]

Segment Reporting

Segment Reporting

Under Accounting Standards Codification 280, “Segment Reporting”, operating segments are defined as components of an enterprise about which separate financial information is available that is regularly evaluated by the entity’s chief operating decision maker, in deciding how to allocate resources and in assessing performance. The Company has evaluated this Codification and has identified two reportable segments: the development and commercialization of drugs using Captisol technology by CyDex Pharmaceuticals, Inc. and the traditional biotechnology operations including drug discovery and development of Ligand Pharmaceuticals, Inc. We evaluate performance based on the operating profit (loss) of the respective business segments. The segment results may not represent actual results that would be expected if they were independent, stand-alone businesses. Segment information was as follows (in thousands):

Balance Sheet Data:	As of September 30, 2012
	Ligand			CyDex			Total
Total assets	$	65,289		$	32,217		$	97,506
	As of December 31, 2011
	Ligand			CyDex			Total
	(Restated)			(Restated)			(Restated)
Total assets	$	111,431		$	9,152		$	120,583
Operating Data:	For the three months ended September 30, 2012
	Ligand			CyDex			Total
Net revenues from external customers	$	3,708		$	2,667		$	6,375
Operating income (loss)	(1,498		)	176			(1,322		)
Depreciation and amortization expense	34			604			638
Income tax expense from continuing operations	142			—			142
Interest expense, net	838			—			838
	For the three months ended September 30, 2011
	Ligand			CyDex			Total
Net revenues from external customers	$	3,291		$	2,450		$	5,741
Operating income (loss)	(3,381		)	132			(3,249		)
Depreciation and amortization expense	134			609			743
Income tax expense from continuing operations	22			—			22
Interest expense, net	699			—			699
Write-off of in-process research and development	2,282						2,282
	For the nine months ended September 30, 2012
	Ligand			CyDex			Total
Net revenues from external customers	$	11,728		$	6,025		$	17,753
Operating loss	(3,298		)	(520		)	(3,818		)
Depreciation and amortization expense	162			1,816			1,978
Income tax expense from continuing operations	445			—			445
Income tax benefit from discontinuing operations	14			—			14
Interest expense, net	2,460			—			2,460
	For the nine months Ended September 30, 2011
	Ligand			CyDex			Total
	(Restated)			(Restated)			(Restated)
Net revenues from external customers	$	8,718		$	8,383		$	17,101
Operating loss	(6,507		)	966			(5,541		)
Depreciation and amortization expense	407			1,692			2,099
Income tax expense from continuing operations	(13,572		)	—			(13,572		)
Interest expense, net	1,762			—			1,762
Write off of in-process research and development	2,282			—			2,282

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Lease Obligations

9 Months Ended

Sep. 30, 2012

Leases [Abstract]

Lease obligations

Lease obligations

The Company leases office and laboratory facilities in California, Kansas, and New Jersey. These leases expire between 2014 and 2019 and are subject to annual increases which range from 3.0% and 3.5%. The Company currently subleases office and laboratory space in California and New Jersey. The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of September 30, 2012 (in thousands):

Operating lease obligations:	Square Footage	Lease Termination Date	Less than 1 year		1-3 years		3-5 years		More than 5 years		Total
Corporate headquarters-San Diego, CA	16,500	July 2019	$	430	$	1,354	$	1,436	$	1,326	$	4,546
Bioscience and Technology Business Center-Lawrence, KS	1,500	December 2014	57		71		—		—		128
Vacated office and research facility-San Diego, CA	52,800	July 2015	2,159		4,126		—		—		6,285
Vacated office and research facility-Cranbury, NJ	99,000	August 2016	2,581		5,397		2,580		—		10,558
Total operating lease obligations			$	5,227	$	10,948	$	4,016	$	1,326	$	21,517
Sublease payments expected to be received:			Less than 1 year		1-3 years		3-5 years		More than 5 years		Total
Office and research facility-San Diego, CA	52,800	July 2015	$	876	$	1,676	$	—	$	—	$	2,552
Office and research facility-Cranbury, NJ	5,100	August 2016	332		751		319		—		1,402
Net operating lease obligations			$	4,019	$	8,521	$	3,697	$	1,326	$	17,563

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Lease Obligations (Tables)

9 Months Ended

Sep. 30, 2012

Leases [Abstract]

Payments expected to received from sublease agreements

The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of September 30, 2012 (in thousands):

Operating lease obligations:	Square Footage	Lease Termination Date	Less than 1 year		1-3 years		3-5 years		More than 5 years		Total
Corporate headquarters-San Diego, CA	16,500	July 2019	$	430	$	1,354	$	1,436	$	1,326	$	4,546
Bioscience and Technology Business Center-Lawrence, KS	1,500	December 2014	57		71		—		—		128
Vacated office and research facility-San Diego, CA	52,800	July 2015	2,159		4,126		—		—		6,285
Vacated office and research facility-Cranbury, NJ	99,000	August 2016	2,581		5,397		2,580		—		10,558
Total operating lease obligations			$	5,227	$	10,948	$	4,016	$	1,326	$	21,517
Sublease payments expected to be received:			Less than 1 year		1-3 years		3-5 years		More than 5 years		Total
Office and research facility-San Diego, CA	52,800	July 2015	$	876	$	1,676	$	—	$	—	$	2,552
Office and research facility-Cranbury, NJ	5,100	August 2016	332		751		319		—		1,402
Net operating lease obligations			$	4,019	$	8,521	$	3,697	$	1,326	$	17,563

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Basis of Presentation (Tables)

9 Months Ended

Sep. 30, 2012

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Summary of computation of basic and diluted net income (loss) per share

The following table sets forth the computation of basic and diluted net income (loss) per share for the periods indicated (in thousands, except per share amounts):

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2012			2011			2012			2011
				(Restated)						(Restated)
Net income (loss) from continuing operations	$	(194	)	$	(4,178	)	$	(5,260	)	$	5,026
Net income from discontinued operations	—			—			3,670			3
Net income (loss)	(194		)	(4,178		)	(1,590		)	5,029
Shares used to compute basic and diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,648,947
Dilutive potential common shares:
Restricted stock	—			—			—			37,406
Shares used to compute diluted income (loss) per share	19,917,676			19,673,160			19,791,793			19,686,353
Basic and diluted per share amounts:
Income (loss) from continuing operations	$	(0.01	)	$	(0.21	)	$	(0.27	)	$	0.26
Income from discontinued operations	—			—			0.19			—
Net income (loss)	$	(0.01	)	$	(0.21	)	$	(0.08	)	$	0.26

Schedule for accounting for share-based compensation

The following table summarizes share-based compensation expense recorded as components of research and development expenses and general and administrative expenses for the periods indicated (in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2012		2011		2012		2011
Share-based compensation expense as a component of:
Research and development expenses	$	263	$	300	$	1,211	$	808
General and administrative expenses	750		650		1,905		1,838
	$	1,013	$	950	$	3,116	$	2,646

Summary of fair-value options awarded to employees and directors

The fair-value for options that were awarded to employees and directors was estimated at the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions:

	Three Months Ended		Nine Months Ended
	September 30,		September 30,
	2012	2011	2012	2011
Risk-free interest rate	0.8%	1.7%	1.0%	2.5%
Dividend yield	—	—	—	—
Expected volatility	69%	68%	69%	69%
Expected term	6.2 years	6.1 years	6.3 years	6.1 years
Forfeiture rate	8.2%	8.8%	8.0%-11.2%	8.8%-14.1%

Summary of investment categories

The following table summarizes the various investment categories at September 30, 2012 and December 31, 2011 (in thousands):

	Cost		Gross unrealized gains		Gross unrealized losses		Estimated fair value
September 30, 2012
Certificates of deposit	$	—	$	—	$	—	$	—
Certificates of deposit - restricted	1,341		—		—		1,341
	$	1,341	$	—	$	—	$	1,341
December 31, 2011
Certificates of deposit	$	10,000	$	—	$	—	$	10,000
Certificates of deposit - restricted	1,341		—		—		1,341
	$	11,341	$	—	$	—	$	11,341

Summary of other current assets

Other current assets consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Prepaid expenses	$	889	$	905
Advanced manufacturing payments	2		312
Other receivables	124		127
	$	1,015	$	1,344

Summary of property and equipment

Property and equipment is stated at cost and consists of the following (in thousands):

	September 30,			December 31,
	2012			2011
Lab and office equipment	$	4,503		$	4,110
Leasehold improvements	—			62
Computer equipment and software	1,150			1,054
	5,653			5,226
Less accumulated depreciation and amortization	(4,800		)	(4,771		)
	$	853		$	455

Summary of goodwill and other identifiable intangible assets

Goodwill and other identifiable intangible assets consist of the following (in thousands):

	September 30,			December 31,
	2012			2011
				(Restated)
Acquired in-process research and development	$	13,036		$	13,036
Complete technology	15,227			15,227
Trade name	2,642			2,642
Customer relationships	29,600			29,600
Goodwill	12,238			12,238
	72,743			72,743
Accumulated amortization	(3,925		)	(2,179		)
	$	68,818		$	70,564

Summary of accrued liabilities

Accrued liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Compensation	$	1,157	$	1,806
Professional fees	485		355
Other	3,739		2,893
	$	5,381	$	5,054

Summary of other long-term liabilities

Other long-term liabilities consist of the following (in thousands):

	September 30,		December 31,
	2012		2011
Deposits	$	284	$	388
Other	119		—
	$	403	$	388

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Litigation

9 Months Ended

Sep. 30, 2012

Litigation Disclosure [Abstract]

Litigation

Litigation

From time to time the Company is subject to various lawsuits and claims with respect to matters arising out of the normal course of its business. If, based on the Company’s assessment, it is probable that a liability has been incurred and can be reasonably estimated, then such loss is accrued and charged to operations. Management believes all costs that can be reasonably estimated will not exceed the related existing accruals.

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Financing Arrangements

9 Months Ended

Sep. 30, 2012

Debt Disclosure [Abstract]

Financing Arrangements

Financing Arrangements

The Company has a secured term loan credit facility (“secured debt”). Under the terms of the secured debt, the Company will make interest only payments through March 2013. Subsequent to the interest only payments, the note will amortize with principal and interest payments through the remaining term of the loan. Additionally, the Company must also make an additional final payment equal to 6% of the total amount borrowed which is due at maturity and is being accreted over the life of the loan. The Company also has a cash-collateralized revolving credit facility under which the Company may elect to borrow up to $10 million. All outstanding amounts under the credit facility may become due and payable if the Company fails to maintain a cash balance equal to the amount outstanding under the credit facility. The carrying values and the fixed contractual coupon rates of our financing arrangements are as follows (dollars in millions):

	September 30, 2012		December 31, 2011
Bank line of credit, Prime + 2.0%, due March 29, 2013	$	—	$	10,000
Current portion notes payable, 8.64%, due August 1, 2014	$	7,473	$	—
Current portion notes payable, 8.9012%, due August 1, 2014	2,799		—
Total current portion of notes payable	$	10,272	$	10,000
Long-term portion notes payable, 8.64%, due August 1, 2014	$	13,070	$	20,286
Long-term portion notes payable, 8.9012%, due August 1, 2014	4,806		—
Total long-term portion of notes payable	$	17,876	$	20,286

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Stockholders' Equity

9 Months Ended

Sep. 30, 2012

Equity [Abstract]

Stockholders' Equity

Stockholders’ Equity

On May 31, 2012, the Company’s stockholders approved the amendment and restatement of the Company’s 2002 Stock Incentive Plan to increase the number of shares available for issuance by 1.8 million shares.

Stock Option Activity

The following is a summary of the Company’s stock option plan activity and related information:

	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term in Years	Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2011	1,146,046		$	14.61	7.96	$	1,489
Granted	710,345		14.73
Exercised	(46,799	)	9.96
Forfeited	(83,374	)	10.69
Cancelled	(13,481	)	39.73
Balance at September 30, 2012	1,712,737		14.84
Exercisable at September 30, 2012	781,738		16.58		7.10	2,983
Options vested and expected to vest as of September 30, 2012	1,712,737		14.77		8.1	6,729

The weighted-average grant date fair value of all stock options granted during the nine months endedSeptember 30, 2012 was $14.73 per share. The total intrinsic value of all options exercised during the nine months endedSeptember 30, 2012 and 2011 was approximately $0.3 million and $4,000, respectively. As of September 30, 2012, there was $6.6 million of total unrecognized compensation cost related to nonvested stock options. That cost is expected to be recognized over a weighted-average period of 2.8 years.

As of September 30, 2012, 1.8 million shares were available for future option grants or direct issuance under the Company’s 2002 Stock Incentive Plan, as amended.

Restricted Stock Activity

Restricted stock activity for the nine months ended September 30, 2012 is as follows:

	Shares		Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2011	115,506		$	10.63
Granted	108,661		13.75
Vested	(71,825	)	11.48
Forfeited	(4,012	)	10.57
Nonvested at September 30, 2012	148,330		$	12.51

The weighted-average grant-date fair value of restricted stock granted during the nine months ended September 30, 2012 was $13.75 per share. As of September 30, 2012, there was $1.2 million of total unrecognized compensation cost related to nonvested restricted stock. That cost is expected to be recognized over a weighted-average period of 1.7 years.

Employee Stock Purchase Plan

The Company’s Employee Stock Purchase Plan, as amended and restated (the “Amended ESPP”) allows participants to purchase up to 1,250 shares of Ligand common stock during each offering period, but in no event may a participant purchase more than 1,250 shares of common stock during any calendar year. The length of each offering period is six months, and employees are eligible to participate in the first offering period beginning after their hire date.

The Amended ESPP allows employees to purchase Ligand common stock at the end of each six month period at a price equal to 85% of the lesser of fair market value on either the start date of the period or the last trading day of the period (the “Lookback Provision”). The 15% discount and the Lookback Provision make the Amended ESPP compensatory.  There were 7,374 and 2,404 shares of common stock issued and $75,000 and $18,000 of proceeds received under the Amended ESPP during the nine months ended September 30, 2012 and 2011, respectively. The Company recorded compensation expense related to the ESPP of $29,000 and $700 for the nine months endedSeptember 30, 2012 and 2011, respectively. As of September 30, 2012, 89,917 shares were available for future purchases under the Amended ESPP.

Warrants

As of September 30, 2012, 163,568 warrants with an exercise price of $179.40 per warrant and an expiration date of April 2013 were outstanding to purchase an aggregate of 129,360 shares of the Company’s common stock. If exercised, these warrants are also entitled to receive $0.1 million in cash and 981,411 of each of the Company's four contingent value rights issued to Neurogen shareholders in December 2009.  The series of warrants was assumed in the acquisition of Neurogen Corporation.

Public Offering

During the quarter ended September 30, 2012, the Company issued, pursuant to an at-the-market registered public offering, 150,000 common shares at a weighted average price of $18.19 per share. Total net proceeds to the Company after underwriting discounts and expenses were approximately $2.6 million.

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Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement

9 Months Ended

Sep. 30, 2012

Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement [Abstract]

Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement

Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement

In April 1996, the Company and Pfizer entered into a settlement agreement with respect to a lawsuit filed in December 1994 by the Company against Pfizer. In connection with a collaborative research agreement the Company entered into with Pfizer in 1991, Pfizer purchased shares of the Company’s common stock. Under the terms of the settlement agreement, at the option of either the Company or Pfizer, milestone and royalty payments owed to the Company can be satisfied by Pfizer by transferring to the Company shares of the Company’s common stock at an exchange ratio of $74.25 per share, for revenue related to lasofoxifene and drolofoxifene. The remaining common stock issued and outstanding to Pfizer following the settlement was reclassified as common stock subject to conditional redemption (between liabilities and equity) since Pfizer has the option to settle milestone and royalties payments owed to the Company with the Company’s shares, and such option is not within the Company’s control. The remaining shares of the Company’s common stock that could be redeemed totaled 112,371 and are reflected at the exchange ratio price of $74.25. Pfizer has notified Ligand that the development of the two compounds covered under the 1996 settlement agreement have been terminated and thus the Company reclassified the shares and the current carrying amount of $8.3 million to permanent equity in the first quarter of 2012.

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Basis of Presentation (Details 6) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Summary of Goodwill and Other Identifiable Intangible Assets
Goodwill	$ 12,238	$ 12,238
Intangible Assets, Net	72,743	72,743
Accumulated amortization	(3,925)	(2,179)
Goodwill and other identifiable intangible assets	68,818	70,564
Acquired in-process research and development [Member]
Summary of Goodwill and Other Identifiable Intangible Assets
Identifiable Intangible Assets	13,036	13,036
Complete technology [Member]
Summary of Goodwill and Other Identifiable Intangible Assets
Identifiable Intangible Assets	15,227	15,227
Trade name [Member]
Summary of Goodwill and Other Identifiable Intangible Assets
Identifiable Intangible Assets	2,642	2,642
Customer relationships [Member]
Summary of Goodwill and Other Identifiable Intangible Assets
Identifiable Intangible Assets	$ 29,600	$ 29,600

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Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement (Details) (USD $) In Thousands, except Share data, unless otherwise specified	1 Months Ended	9 Months Ended
	Apr. 30, 1996	Sep. 30, 2012	Mar. 31, 2012	Dec. 31, 2011
Common Stock Subject to Conditional Redemption - Pfizer Settlement Agreement (Textual) [Abstract]
Date of settlement agreement		April 1996
Exchange ratio of common shares	$ 74.25
Common stock redeemed				112,371
Reclassification to permanent equity			$ 8,300	$ 8,344

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Financial Instruments (Tables)

9 Months Ended

Sep. 30, 2012

Investments, All Other Investments [Abstract]

Summary of the assets and liabilities measured at fair value on recurring basis

The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of September 30, 2012 (in thousands):

Fair Value Measurements at Reporting Date Using
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Assets:
Certificates of deposit	$	—	$	—	$	—	$	—
Liabilities:
Current portion of contingent liabilities - CyDex	$	323	$	—	$	—	$	323
Liability for contingent value rights - Metabasis	—		—		—		—
Liability for contingent value rights – Neurogen	500		—		—		500
Long-term portion of contingent liabilities - CyDex	7,235		—		—		7,235
Total liabilities	$	8,058	$	—	$	—	$	8,058

The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December 31, 2011 (in thousands):

Fair Value Measurements at Reporting Date Using
			Quoted Prices in Active Markets for Identical Assets		Significant Other Observable Inputs		Significant Unobservable Inputs
	Total		(Level 1)		(Level 2)		(Level 3)
Assets:	(Restated)						(Restated)
Certificates of deposit	$	10,000	$	10,000	$	—	$	—
Liabilities:
Current portion of contingent liabilities - CyDex	$	6,879	$	—	$	—	$	6,879
Liability for contingent value rights - Metabasis	1,068		1,068		—		—
Liability for contingent value rights – Neurogen	700		—		—		700
Long-term portion of contingent liabilities - CyDex	8,651		—		—		8,651
Total liabilities	$	17,298	$1,068		$	—	$	16,230

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Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2012

Equity [Abstract]

Stock option plan activity

The following is a summary of the Company’s stock option plan activity and related information:

	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term in Years	Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2011	1,146,046		$	14.61	7.96	$	1,489
Granted	710,345		14.73
Exercised	(46,799	)	9.96
Forfeited	(83,374	)	10.69
Cancelled	(13,481	)	39.73
Balance at September 30, 2012	1,712,737		14.84
Exercisable at September 30, 2012	781,738		16.58		7.10	2,983
Options vested and expected to vest as of September 30, 2012	1,712,737		14.77		8.1	6,729

Restricted stock activity

Restricted stock activity for the nine months ended September 30, 2012 is as follows:

	Shares		Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2011	115,506		$	10.63
Granted	108,661		13.75
Vested	(71,825	)	11.48
Forfeited	(4,012	)	10.57
Nonvested at September 30, 2012	148,330		$	12.51

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Stockholders' Equity (Details 1) (Restricted Stock [Member], USD $)	9 Months Ended
	Sep. 30, 2012
Restricted Stock [Member]
Shares [Rollforward]
Nonvested at December 31, 2011	115,506
Granted	108,661
Vested	(71,825)
Forfeited	(4,012)
Nonvested at September 30, 2012	148,330
Weighted-Average Grant Date Fair Value [Roll Forward]
Nonvested at December 31, 2011	$ 10.63
Granted	$ 13.75
Vested	$ 11.48
Forfeited	$ 10.57
Nonvested at September 30, 2012	$ 12.51

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AVINZA Co-Promotion (Details Textual)	Sep. 30, 2012
AVINZA Co-Promotion (Textual) [Abstract]
Percentage of net sales payable as royalty	6.50%
Scenario, Forecast [Member]
AVINZA Co-Promotion (Textual) [Abstract]
Percentage of net sales payable as royalty	6.00%

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Condensed Consolidated Statements of Comprehensive Income (Unaudited) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Statement of Other Comprehensive Income [Abstract]
Net income (loss)	$ (194)	$ (4,178)	$ (1,590)	$ 5,029
Unrealized net loss on available-for-sale securities				(31)
Comprehensive income (loss)	$ (194)	$ (4,178)	$ (1,590)	$ 4,998

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AVINZA Co-Promotion

9 Months Ended

Sep. 30, 2012

Co Promotion [Abstract]

AVINZA Co-Promotion

AVINZA Co-Promotion

In February 2003, Ligand and Organon Pharmaceuticals USA Inc. (“Organon”) announced that they had entered into an agreement for the co-promotion of Avinza. Subsequently in January 2006, Ligand signed an agreement with Organon that terminated the Avinza co-promotion agreement between the two companies and returned Avinza co-promotion rights to Ligand. In consideration of the early termination, Ligand agreed to make quarterly royalty payments to Organon equal to 6.5% of Avinza net sales through December 31, 2012 and thereafter 6.0% through patent expiration, currently anticipated to be November of 2017.

In February 2007, Ligand and King Pharmaceuticals, Inc., (“King”), executed an agreement pursuant to which King acquired all of the Company’s rights in and to Avinza. King also assumed the Company’s co-promote termination obligation to make royalty payments to Organon based on net sales of Avinza. In connection with King’s assumption of this obligation, Organon did not consent to the legal assignment of the co-promote termination obligation to King. Accordingly, Ligand remains liable to Organon in the event of King’s default of the obligation. Therefore, Ligand recorded an asset as of February 26, 2007 to recognize King’s assumption of the obligation, while continuing to carry the co-promote termination liability in the Company’s consolidated financial statements to recognize Ligand’s legal obligation as primary obligor to Organon. This asset represents a non-interest bearing receivable for future payments to be made by King and is recorded at its fair value. The receivable and liability will remain equal and adjusted each quarter for changes in the fair value of the obligation including for any changes in the estimate of future net Avinza product sales. This receivable will be assessed on a quarterly basis for impairment (e.g. in the event King defaults on the assumed obligation to pay Organon).

On a quarterly basis, management reviews the carrying value of the co-promote termination liability. Due to assumptions and judgments inherent in determining the estimates of future net Avinza sales through November 2017, the actual amount of net Avinza sales used to determine the current fair value of the Company’s co-promote termination asset and liability may be materially different from current estimates.

A summary of the co-promote termination liability as of September 30, 2012 is as follows (in thousands):

Net present value of payments based on estimated future net Avinza product sales as of December 31, 2011	$	21,452
Assumed payments made by King or assignee	(2,533		)
Fair value adjustments	(5,844		)
Total co-promote termination liability as of September 30, 2012	13,075
Less: current portion of co-promote termination liability as of September 30, 2012	4,431
Long-term portion of co-promote termination liability as of September 30, 2012	$	8,644

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Restatement of Financial Statements (Tables)

9 Months Ended

Sep. 30, 2012

Accounting Changes and Error Corrections [Abstract]

Schedule of Prior Period Restatement

The impact of the restatement as of December 31, 2011 and for the three and nine months ended September 30, 2011 is described in the table below:

	December 31, 2011
Balance sheet data:	As previously reported			Restated
Goodwill	$	14,894		$	12,238
Intangible assets, net	57,437			58,326
Total assets	122,350			120,583
Long-term portion of contingent liabilities	11,433			10,419
Deferred income taxes	2,522			2,230
Total liabilities	105,360			104,054
Accumulated deficit	(681,771		)	(682,232		)

	Three Months Ended September 30, 2011						Nine Months Ended September 30, 2011
	As previously reported			Restated			As previously reported			Restated
Statement of Operations data:
Decrease (increase) in contingent liabilities	$	224		$	(198	)	$	(835	)	$	(1,317	)
Income tax benefit (expense)	(22		)	(22		)	13,427			13,572
Net Income (loss)	(3,756		)	(4,178		)	5,366			5,029
Basic and diluted earnings per share:
Income (loss) from continuing operations	$	(0.19	)	$	(0.21	)	$	0.27		$	0.26
Income from discontinued operations	—			—			—			—
Net Income (loss)	(0.19		)	(0.21		)	0.27			0.26
Weighted average number of common shares-basic	19,673			19,673			19,649			19,649
Weighted average number of common shares-diluted	19,673			19,673			19,649			19,686

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Business Combinations (Details Textual) (USD $) In Millions, unless otherwise specified	1 Months Ended			7 Months Ended	9 Months Ended
	Jan. 31, 2012	Dec. 31, 2011	Jan. 31, 2011 medications company licensee	Jul. 31, 2012	Sep. 30, 2012 employee	Jan. 24, 2011
Business Combinations (Textual) [Abstract]
Number of FDA-approved medications			6
Number of licensees			3
Minimum number of companies supported by CyDex for drug development efforts			40
Cash paid to CyDex shareholders						$ 31.6
Contingent Value Rights fair value						17.6
Discounted to present value using a discount rate						21.60%
Fair Value of Contingent liability					7.6
Paid to CyDex shareholders	4.3	2.0		3.5	0.3
Percentage of related revenue					20.00%
Amount exceeds to get related revenue for CyDex share holders					15.0
Percentage of related revenue additional					10.00%
Aggregate CyDex-related revenue					35.0
Payments to Acquire Businesses, Net of Cash Acquired	4.3	2.0		3.5	0.3
Percentage of related revenue, current year					20.00%
Amount excess of CyDex-related revenue					15
Number of employees required					5
Investments for acquiring employees					1.5
Clinical and Regulatory Milestones [Member]
Business Combinations (Textual) [Abstract]
Additional amount required to pay	4.0
Milestones with Former License Holders [Member]
Business Combinations (Textual) [Abstract]
Additional amount required to pay	$ 4.0

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Business Combinations (Tables)

9 Months Ended

Sep. 30, 2012

Business Combinations [Abstract]

Company's pro forma results

Had the merger with CyDex been completed as of the beginning of 2011, the Company’s pro forma results for the nine months ended September 30, 2011 would have been as follows:

(in thousands, except per share data)	(Restated)
Revenue	$	17,290
Operating loss	(5,549		)
Net income	4,886
Basic and diluted earnings per share:
Continuing operations	$	0.25
Discontinued operations	—
Net income	$	0.25
Basic and diluted weighted average shares	19,649