Fair Value Measurements (Details) € in Millions, £ in Millions, $ in Millions			12 Months Ended
	Aug. 19, 2019 USD ($)	Aug. 19, 2019 GBP (£)	Dec. 31, 2021 USD ($) units	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2019 EUR (€)
Derivative Instruments, Gain (Loss) [Line Items]
Gain (Loss) on Cash Flow Hedge Ineffectiveness, Net			$ 24	$ 29
Derivative, Notional Amount			9,378	11,349
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, after Tax			(208)	77
Cost of Goods and Services Sold			3,711	3,465	$ 3,116
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, after Tax			38	60
Interest Expense			341	361	473
Other Operating Income (Expense), Net			(218)	(362)	(358)
Gain (Loss) on Derivative Used in Net Investment Hedge, after Tax			137	19
Foreign exchange (gain) loss			(27)	(32)	(358)
Derivative Asset, Fair Value, Gross Asset			394	242
Derivative Liability, Fair Value, Gross Liability			1,071	1,262
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Equity Securities, FV-NI			10	414
Derivative Asset			169	109
Licensing arrangements, asset			(114)	(218)
Business Combination, Contingent Consideration, Liability			486	196	354
Cash			293	150
Proceeds from royalty rights transfer			0	0	256
Debt Instrument, Fair Value Disclosure			10,196	10,774
Other Noncurrent Liabilities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Licensing arrangements, liability			143	253
November 2019 Aggregate Offering [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Long-term Debt					1,000	€ 900
December 2027 Notes [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Long-term Debt			$ 1,021	1,105
Debt Instrument, Interest Rate, Stated Percentage			0.625%
Licensing arrangement assets (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Discount Rate, Fair Value Input			15.00%
Euro-denominated outstanding debt [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Debt Instrument, Fair Value Disclosure			$ 1,020	1,118
BTG Acquisition [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Proceeds from royalty rights transfer					256
Fair Value, Inputs, Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Licensing arrangements, asset			(246)
Licensing arrangements, liability			281
Fair Value, Measurements, Recurring [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money Market Funds, at Carrying Value			1,632	1,584
Equity Securities, FV-NI			10	414
Derivative Asset			394	242
Licensing arrangements, asset			(246)	(365)
Assets, Fair Value Disclosure			2,282	2,605
Foreign Currency Contracts, Liability, Fair Value Disclosure			1,071	1,262
Business Combination, Contingent Consideration, Liability			486	196
Licensing arrangements, liability			281	407
Financial and Nonfinancial Liabilities, Fair Value Disclosure			1,838	1,865
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money Market Funds, at Carrying Value			1,632	1,584
Equity Securities, FV-NI			10	414
Derivative Asset			0	0
Licensing arrangements, asset			0	0
Assets, Fair Value Disclosure			1,642	1,998
Foreign Currency Contracts, Liability, Fair Value Disclosure			0	0
Business Combination, Contingent Consideration, Liability			0	0
Licensing arrangements, liability			0	0
Financial and Nonfinancial Liabilities, Fair Value Disclosure			0	0
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money Market Funds, at Carrying Value			0	0
Equity Securities, FV-NI			0	0
Derivative Asset			394	242
Licensing arrangements, asset			0	0
Assets, Fair Value Disclosure			394	242
Foreign Currency Contracts, Liability, Fair Value Disclosure			1,071	1,262
Business Combination, Contingent Consideration, Liability			0	0
Licensing arrangements, liability			0	0
Financial and Nonfinancial Liabilities, Fair Value Disclosure			1,071	1,262
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Money Market Funds, at Carrying Value			0	0
Equity Securities, FV-NI			0	0
Derivative Asset			0	0
Licensing arrangements, asset			(246)	(365)
Assets, Fair Value Disclosure			246	365
Foreign Currency Contracts, Liability, Fair Value Disclosure			0	0
Business Combination, Contingent Consideration, Liability			486	196
Licensing arrangements, liability			281	407
Financial and Nonfinancial Liabilities, Fair Value Disclosure			767	603
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Licensing arrangement assets (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Licensing arrangements, asset			(163)		(518)
Fair Value of Assets Acquired				(175)
Proceeds from Royalties Received			44	22
Increase (Decrease) in Fair Value Adjustments on Other Assets (Liabilities) Carried at Fair Value under Fair Value Option			246	365
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Licensing arrangement liabilities (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Licensing arrangements, liability			281	407	571
Fair Value of Assets Acquired				(186)
Proceeds from Royalties Received				22
Payments for Royalties			(166)
Increase (Decrease) in Fair Value Adjustments on Other Assets (Liabilities) Carried at Fair Value under Fair Value Option			41
Designated as Hedging Instrument [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments in Hedges, Assets, at Fair Value			352	162
Derivative Instruments in Hedges, Liabilities, at Fair Value			1,049	1,191
Designated as Hedging Instrument [Member] | Other Noncurrent Liabilities [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments in Hedges, Liabilities, at Fair Value			$ 1,011	1,094
Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member)
Derivative Instruments, Gain (Loss) [Line Items]
Forward Currency Contracts, Time to Maturity | units			60
Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Other Noncurrent Assets [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments in Hedges, Assets, at Fair Value			$ 169	109
Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Other Current Liabilities [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments in Hedges, Liabilities, at Fair Value			32	44
Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Other Noncurrent Liabilities [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments in Hedges, Liabilities, at Fair Value			6	54
Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Prepaid Expenses and Other Current Assets [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments in Hedges, Assets, at Fair Value			183	53
Not Designated as Hedging Instrument [Member] | Other Nonoperating Income (Expense) [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments			(16)	73	(343)
Foreign Currency Transaction Gain (Loss), before Tax			(12)	(105)	(15)
Foreign exchange (gain) loss			(27)	(32)	(358)
Net gain (loss) from foreign currency transaction exposures			12	105	15
Not Designated as Hedging Instrument [Member] | BTG Acquisition [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Payments for Hedge, Investing Activities				294
Not Designated as Hedging Instrument [Member] | BTG Acquisition [Member] | Other Nonoperating Income (Expense) [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments				(323)
Not Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member)
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, Notional Amount			3,892	4,946
Not Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Other Current Liabilities [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments Not Designated as Hedging Instruments, Liability, at Fair Value			22	71
Not Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Prepaid Expenses and Other Current Assets [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Instruments Not Designated as Hedging Instruments, Asset, at Fair Value			$ 42	79
Not Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | BTG Acquisition [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, Cash Received on Hedge	$ 4,303	£ 3,312
Weighted Average (Member) | Licensing arrangement assets (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Discount Rate, Fair Value Input			15.00%
Weighted Average (Member) | Licensing arrangement liabilities (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Discount Rate, Fair Value Input			13.00%
Minimum [Member] | Licensing arrangement liabilities (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Discount Rate, Fair Value Input			12.00%
Maximum [Member] | Licensing arrangement liabilities (Member)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Discount Rate, Fair Value Input			15.00%
Cash Flow Hedging [Member] | Foreign Exchange Contract (Member) | Cost of Sales [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Foreign Currency Cash Flow Hedge Gain (Loss) to be Reclassified During Next 12 Months			$ 127
Cash Flow Hedging [Member] | Interest Rate Contract [Member] | Interest Expense [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Interest Rate Cash Flow Hedge Gain (Loss) to be Reclassified During Next 12 Months, Net			(5)
Cash Flow Hedging [Member] | Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member)
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, Notional Amount			3,996	4,531
Cash Flow Hedging [Member] | Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Cost of Sales [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification and Tax			(268)	99	(150)
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, Tax			60	(22)	34
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, after Tax			(208)	77	(117)
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, before Tax			54	83	73
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, Tax			12	19	16
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, after Tax			(42)	(64)	(56)
Cash Flow Hedging [Member] | Designated as Hedging Instrument [Member] | Interest Rate Contract [Member] | Interest Expense [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification and Tax			0	0	0
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, Tax			0	0	0
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, after Tax			0	0	0
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, before Tax			5	5	3
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, Tax			(1)	(1)	(1)
Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, after Tax			4	4	2
Net Investment Hedging [Member] | Foreign Exchange Contract (Member) | Interest Expense [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative Used in Net Investment Hedge Gain (Loss) to be Reclassified During Next 12 Months, Net			3
Net Investment Hedging [Member] | Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member)
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, Notional Amount			493	1,004
Net Investment Hedging [Member] | Designated as Hedging Instrument [Member] | Foreign Exchange Contract (Member) | Interest Expense [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Other Comprehensive Income (Loss), Net Investment Hedge, Gain (Loss), before Reclassification and Tax			56	37	(68)
Other Comprehensive Income (Loss), Derivative, Excluded Component, Increase (Decrease), before Adjustments, Tax			(13)	(8)	15
Other Comprehensive Income (Loss), Derivative, Excluded Component, Increase (Decrease), before Adjustments, after Tax			43	29	(53)
Other Comprehensive Income (Loss), Net Investment Hedge, Gain (Loss), Reclassification, before Tax			(13)	24	43
Other Comprehensive Income (Loss), Net Investment Hedge, Gain (Loss), after Reclassification, Tax			3	5	10
Gain (Loss) on Derivative Used in Net Investment Hedge, after Tax			(10)	19	33
Net Investment Hedging [Member] | Designated as Hedging Instrument [Member] | Foreign currency denominated in debt [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, Notional Amount			997	868
Net Investment Hedging [Member] | Designated as Hedging Instrument [Member] | Foreign currency denominated in debt [Member] | Interest Expense [Member]
Derivative Instruments, Gain (Loss) [Line Items]
Other Comprehensive Income (Loss), Net Investment Hedge, Gain (Loss), before Reclassification and Tax			82	(89)	(14)
Other Comprehensive Income (Loss), Derivative, Excluded Component, Increase (Decrease), before Adjustments, Tax			(19)	21	3
Other Comprehensive Income (Loss), Derivative, Excluded Component, Increase (Decrease), before Adjustments, after Tax			64	(68)	(11)
Other Comprehensive Income (Loss), Net Investment Hedge, Gain (Loss), Reclassification, before Tax			0	0	0
Other Comprehensive Income (Loss), Net Investment Hedge, Gain (Loss), after Reclassification, Tax			0	0	0
Gain (Loss) on Derivative Used in Net Investment Hedge, after Tax			$ 0	$ 0	$ 0