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Income Taxes (Tables)
 12 Months Ended
Dec. 31, 2021
Income Tax Disclosure [Abstract]  
Tax rate
The reconciliation of income taxes at the federal statutory rate to the actual expense (benefit) for income taxes is as follows:
Year Ended December 31,
202120202019
U.S. federal statutory income tax rate21.0 %(21.0)%21.0 %
State income taxes, net of federal benefit2.5 %16.6 %6.7 %
Domestic taxes on foreign earnings6.8 %155.4 %21.9 %
Effect of foreign taxes(14.3)%(40.7)%(47.6)%
Acquisition-related(8.1)%(16.7)%12.2 %
Research credit(3.0)%(43.0)%(4.2)%
Valuation allowance0.8 %(42.0)%1.1 %
Goodwill impairment charges— %3.7 %— %
Compensation-related(0.6)%(7.7)%(0.3)%
Non-deductible expenses0.4 %64.4 %3.6 %
Uncertain tax positions1.2 %(96.8)%1.4 %
Intra-entity asset transfers— %10.2 %(597.0)%
Return to provision(5.7)%(37.3)%(0.2)%
Change in tax rates1.9 %51.8 %(0.2)%
Other, net0.4 %6.0 %(2.4)%
3.3 %2.9 %(584.0)%
Summary of Income Tax Contingencies [Table Text Block] A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows:
 Year Ended December 31,
(in millions)202120202019
Beginning Balance$261 $455 $427 
Additions based on positions related to the current year8 28 30 
Additions based on positions related to prior years41 6 45 
Reductions for tax positions of prior years(36)(186)(34)
Settlements with taxing authorities(2)(27)(4)
Statute of limitation expirations(17)(15)(9)
Ending Balance$255 $261 $455 
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Our Income (loss) before income taxes consisted of the following:
Year Ended December 31,
(in millions)202120202019
Domestic$(648)$(660)$(1,145)
Foreign1,724 581 1,832 
$1,076 $(79)$687 
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Significant components of our deferred tax assets and liabilities are as follows:
 As of December 31,
 (in millions)
20212020
 Deferred Tax Assets:
 
(reclassified)(1)
Inventory costs and related reserves$10 $10 
Tax benefit of net operating losses and credits620 557 
Reserves and accruals324 308 
Restructuring-related charges14 23 
Litigation and product liability reserves127 82 
Investment write-down31 — 
Compensation related130 134 
Federal benefit of uncertain tax positions8 9 
Intangible assets3,546 3,551 
Capitalized R&D67 4 
Property, plant and equipment14 — 
Other35 (10)
 4,926 4,668 
Less: valuation allowance(1,014)(887)
 3,912 3,781 
 Deferred Tax Liabilities:
  
Property, plant and equipment— 1 
Unrealized gains and losses on derivative financial instruments79 12 
Investment write-up— 34 
79 47 
 Net Deferred Tax Assets
3,833 3,734 
Prepaid on intercompany profit205 194 
 Net Deferred Tax Assets and Prepaid on Intercompany Profit$4,038 $3,928 
Our deferred tax assets, deferred tax liabilities and prepaid on intercompany profit, are included in the following locations within our accompanying consolidated balance sheets (in millions):
Location on Consolidated Balance SheetsAs of December 31,
Component20212020
Prepaid on intercompany profitPrepaid income taxes$205 $194 
Non-current deferred tax assetAssets held for sale— 2 
Non-current deferred tax assetDeferred tax assets4,142 4,210 
Deferred Tax Assets and Prepaid on Intercompany Profit 4,348 4,406 
Non-current deferred tax liabilityDeferred tax liabilities310 330 
Non-current deferred tax liability
Liabilities held for sale in Other current liabilities
— 148 
Deferred Tax Liabilities 310 478 
Net Deferred Tax Assets and Prepaid on Intercompany Profit$4,038 $3,928 
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] The related expense (benefit) for income taxes consisted of the following:
Year Ended December 31,
(in millions)202120202019
Current
  Federal$18 $(29)$120 
  State33 (35)54 
  Foreign127 151 101 
178 87 275 
Deferred
  Federal(256)(26)(146)
  State(3)(6)(18)
  Foreign117 (53)(4,124)
(142)(85)(4,288)
$36 $2 $(4,013)