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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2020
Income Tax Disclosure [Abstract]  
Tax rate
The reconciliation of income taxes at the federal statutory rate to the actual expense (benefit) for income taxes is as follows:

Year Ended December 31,
202020192018
(reclassified)(1)
(reclassified)(1)
U.S. federal statutory income tax rate(21.0)%21.0 %21.0 %
State income taxes, net of federal benefit16.6 %6.7 %0.1 %
Domestic taxes on foreign earnings155.4 %21.9 %0.5 %
Effect of foreign taxes(40.7)%(47.6)%(8.4)%
Acquisition-related(16.7)%12.2 %2.1 %
Research credit(43.0)%(4.2)%(2.6)%
Valuation allowance(42.0)%1.1 %(5.2)%
Goodwill impairment charges3.7 %— %— %
Compensation-related(7.7)%(0.3)%(1.0)%
Non-deductible expenses64.4 %3.6 %0.8 %
Uncertain tax positions(96.8)%1.4 %(22.0)%
TCJA net impact— %— %(4.7)%
Intra-entity asset transfers10.2 %(597.0)%— %
Return to provision(37.3)%(0.2)%(0.2)%
Change in tax rates51.8 %(0.2)%0.5 %
Other, net6.0 %(2.4)%1.6 %
2.9 %(584.0)%(17.5)%
(1)    Due to the disclosure of additional rate reconciling items in 2020, we have reclassified select items in prior years to align with the new categories disclosed in the current year.
Summary of Income Tax Contingencies [Table Text Block] A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows:
 Year Ended December 31,
(in millions)202020192018
Beginning Balance$455 $427 $1,238 
Additions based on positions related to the current year28 30 79 
Additions based on positions related to prior years45 
Reductions for tax positions of prior years(186)(34)(433)
Settlements with taxing authorities(27)(4)(459)
Statute of limitation expirations(15)(9)(3)
Ending Balance$261 $455 $427 
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Our Income (loss) before income taxes consisted of the following:
Year Ended December 31,
(in millions)202020192018
Domestic$(660)$(1,145)$35 
Foreign581 1,832 1,387 
$(79)$687 $1,422 
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Significant components of our deferred tax assets and liabilities are as follows:
 As of December 31,
 (in millions)
20202019
 Deferred Tax Assets:
  
Inventory costs and related reserves$10 $— 
Tax benefit of net operating loss and credits557 545 
Reserves and accruals308 258 
Restructuring-related charges23 20 
Litigation and product liability reserves82 168 
Investment write-down— 42 
Compensation related134 121 
Federal benefit of uncertain tax positions10 
Intangible assets3,551 3,447 
Other(6)— 
 4,668 4,611 
Less: valuation allowance(887)(915)
 3,781 3,696 
 Deferred Tax Liabilities:
  
Property, plant and equipment16 
Unrealized gains and losses on derivative financial instruments12 52 
Investment write-up34 — 
Inventory costs and related reserves— 
Other— 25 
47 95 
 Net Deferred Tax Assets
3,734 3,601 
Prepaid on intercompany profit194 195 
 Net Deferred Tax Assets and Prepaid on Intercompany Profit$3,928 $3,796 

Our deferred tax assets, deferred tax liabilities and prepaid on intercompany profit, are included in the following locations within our accompanying consolidated balance sheets (in millions):
Location on Consolidated Balance SheetsAs of December 31,
Component20202019
Prepaid on intercompany profitPrepaid income taxes$194 $195 
Non-current deferred tax assetAssets held for sale— 
Non-current deferred tax assetDeferred tax assets4,210 4,196 
Deferred Tax Assets and Prepaid on Intercompany Profit 4,406 4,391 
Non-current deferred tax liabilityDeferred tax liabilities330 595 
Non-current deferred tax liability
Liabilities held for sale in Other current liabilities
148 — 
Deferred Tax Liabilities 478 595 
Net Deferred Tax Assets and Prepaid on Intercompany Profit$3,928 $3,796 
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
The related expense (benefit) for income taxes consisted of the following:
Year Ended December 31,
(in millions)202020192018
Current
  Federal$(29)$120 $(221)
  State(35)54 (27)
  Foreign151 101 160 
87 275 (87)
Deferred
  Federal(26)(146)(124)
  State(6)(18)
  Foreign(53)(4,124)(42)
(85)(4,288)(162)
$2 $(4,013)$(249)