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OTHER EXPENSE (INCOME), NET
 12 Months Ended
Dec. 31, 2020
Other Income and Expenses [Abstract]  
OTHER EXPENSE (INCOME), NET OTHER EXPENSE (INCOME), NET
Other expense (income), net for the years 2020, 2019 and 2018 consists of:
(in millions)202020192018
Litigation and other matters$422 $1,401 $(27)
Acquired in-process research and development costs32 41 1 
Net (gain) loss on sales of assets(1)(31)6 
Acquisition-related costs— 8 1 
Other, net1 (5)(1)
Other expense (income), net$454 $1,414 $(20)
In 2020, Litigation and other matters of $422 million includes net charges related to the U.S. Securities Litigation, the SEC Investigation and the Canadian Securities Litigation and related opt-outs. In 2020, Litigation and other matters also includes an insurance recovery related to a certain litigation matter. In 2019, Litigation and other matters of $1,401 million includes the settlement of a legacy U.S. securities class action matter (which is subject to an objector’s appeal of the final court approval). In 2018, Litigation and other matters of $27 million includes a favorable adjustment of $40 million related to the Salix legacy litigation matter. These matters and other significant matters are discussed in further detail in Note 20, "LEGAL PROCEEDINGS".
In 2020 and 2019, Acquired in-process research and development costs of $32 million and $41 million, primarily consist of costs associated with the upfront payments to enter into certain exclusive licensing agreements. In 2019, Net (gain) loss on sales of assets includes $20 million related to the achievement of a milestone related to a certain product.