OPHTHALMIC IMAGING SYSTEMS                                             CONTACTS:
                                                                  GIL ALLON, CEO
221 LATHROP WAY, SUITE I                                      ARIEL SHENHAR, CFO
SACRAMENTO, CA 95815                                              (916) 646-2020
                                                              INVESTOR RELATIONS
                                                     TODD FROMER / GARTH RUSSELL
                                                                  KCSA Worldwide
                                                     212-896-1215 / 212-896-1250

                                                           FOR IMMEDIATE RELEASE
                                                           ---------------------

                       MEDIVISION SELLS 310,000 SHARES OF
                    OPHTHALMIC IMAGING SYSTEMS' COMMON STOCK


SACRAMENTO, Calif., December 20, 2005 -- Ophthalmic Imaging Systems (OTCBB:OISI)
(OIS), a leading provider of ophthalmic digital imaging systems, announced today
that MediVision Medical Imaging Ltd., its major shareholder, sold 310,000 shares
of OIS's common stock to the clients of an  institutional  investor at the price
per share of $1.45.  As a result of this sale,  the public  float  increases  to
approximately 5.1 million shares.

The institution  manages  separate  accounts and a micro-cap value  partnership,
which primarily invests in micro-cap U.S. stocks with market capitalization less
than $300 million.  The institution  pursues a long-term  buy-and-hold  strategy
with its investments.

Gil Allon,  Chief Executive Officer of Ophthalmic  Imaging Systems,  said, "I am
pleased to  announce  MediVision's  sale of OIS shares to another  institutional
investor. This is one more example of OIS management and MediVision's commitment
to  introducing  new  institutional  investors to the OIS story and increase the
Company's  liquidity.  MediVision has specifically  targeted long-term investors
that possess a solid  knowledge of micro- and small-cap  equities.  We recognize
the importance of increasing the awareness of OIS to the investment community as
the Company  continues to grow.  We believe that by  increasing  OIS'  liquidity
combined with its continued strong financial performance,  OIS shares will reach
a higher valuations."

About Ophthalmic Imaging Systems
Ophthalmic  Imaging Systems, a majority-owned  subsidiary of MediVision,  is the
leading  provider of ophthalmic  digital imaging  systems.  The Company designs,
develops,  manufactures  and markets  digital  imaging  systems and  informatics
solutions  for the eye care  market.  With over twenty  years in the  ophthalmic
imaging  business,  the  Company has  consistently  introduced  new,  innovative
technology.  The Company, together with MediVision,  co-market and support their
products  through an  extensive  network of  dealers,  distributors,  and direct
representatives.

Statements   in  this  press  release   which  are  not   historical   data  are
forward-looking statements which involve known and unknown risks, uncertainties,
or other  factors  not  under the  Company's  control,  which  may cause  actual
results,  performance, or achievements of the Company to be materially different
from  the  results,   performance,   or  other  expectations  implied  by  these
forward-looking statements. These factors include, but are not limited to, those
detailed in the  Company's  periodic  filings with the  Securities  and Exchange
Commission.