-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Utku3kh/KBsD3e9Wym6vz9l/Rn63X3ehqt29zBHSilE5rX1VELq1RTFfMXtuu2Gq
 ogPvDowXeMQRwr3ggkQkrg==

<SEC-DOCUMENT>0000885317-10-000003.txt : 20100610
<SEC-HEADER>0000885317-10-000003.hdr.sgml : 20100610
<ACCEPTANCE-DATETIME>20100610115805
ACCESSION NUMBER:		0000885317-10-000003
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100610
DATE AS OF CHANGE:		20100610
EFFECTIVENESS DATE:		20100610

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OPHTHALMIC IMAGING SYSTEMS
		CENTRAL INDEX KEY:			0000885317
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				943035367
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-88531-7L
		FILM NUMBER:		10889465

	BUSINESS ADDRESS:	
		STREET 1:		221 LATHROP WAY
		STREET 2:		SUITE 1
		CITY:			SACRAMENTO
		STATE:			CA
		ZIP:			95815
		BUSINESS PHONE:		9166462020

	MAIL ADDRESS:	
		STREET 1:		221 LATHROP WAY
		STREET 2:		SUITE 1
		CITY:			SACRAMENTO
		STATE:			CA
		ZIP:			95815

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OPHTHALMIC IMAGING SYSTEMS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000885317</cik>
        <entityName>OPHTHALMIC IMAGING SYSTEMS</entityName>
        <issuerAddress>
            <street1>221 LATHROP WAY</street1>
            <street2>SUITE I</street2>
            <city>SACRAMENTO</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>95815</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>916-646-2020</issuerPhoneNumber>
        <jurisdictionOfInc>CALIFORNIA</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>OPHTHALMIC IMAGING SYSTEMS INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gil</firstName>
                <lastName>Allon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ariel</firstName>
                <lastName>Shenhar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Uri</firstName>
                <lastName>Ram</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jonathan</firstName>
                <lastName>Phillips</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Greer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eric</firstName>
                <lastName>Maurincomme</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Uri</firstName>
                <lastName>Geiger</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Menachem</firstName>
                <lastName>Inbar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ophthalmic Imaging Systems</street1>
                <street2>221 Lathrop Way, Suite I</street2>
                <city>Sacramento</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$5,000,001 - $25,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000910680-09-000328</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-06-24</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5999875</totalOfferingAmount>
            <totalAmountSold>5999875</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>$3,999,908 for 1st installment on 6/24/2009 and $1,999,967 for 2nd installment on 5/26/2010</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>70000</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>OPHTHALMIC IMAGING SYSTEMS</issuerName>
                <signatureName>Gil Allon</signatureName>
                <nameOfSigner>Gil Allon</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2010-06-10</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----