-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GyMF7X/sDFG28AYbi64jGGdMoBjK1UgUsglTHD20DpgG9uo2PQ6ilZOCodVH9936
 4lYQsR7pCvIz6CAqmChDPg==

<SEC-DOCUMENT>0001104659-03-014007.txt : 20030703
<SEC-HEADER>0001104659-03-014007.hdr.sgml : 20030703
<ACCEPTANCE-DATETIME>20030703135524
ACCESSION NUMBER:		0001104659-03-014007
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030701
FILED AS OF DATE:		20030703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			YETTER WAYNE P
		CENTRAL INDEX KEY:			0001215120

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21481
		FILM NUMBER:		03774866

	MAIL ADDRESS:	
		STREET 1:		C/O SYNAVANT INC
		STREET 2:		3445 PEACHTREE ROAD NE SUITE 1400
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30326

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TRANSKARYOTIC THERAPIES INC
		CENTRAL INDEX KEY:			0000885259
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				043027191
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		195 ALBANY ST
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6173490200
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>j2748_4.xml
<DESCRIPTION>4
<TEXT>
<XML>
<?xml version="1.0" encoding="utf-8" standalone="no"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
  <periodOfReport>2003-07-01</periodOfReport>
  <notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000885259</issuerCik>
        <issuerName>TRANSKARYOTIC THERAPIES INC</issuerName>
        <issuerTradingSymbol>TKTK</issuerTradingSymbol>
  </issuer>
  <reportingOwner>
    <reportingOwnerId>
            <rptOwnerCik>0001215120</rptOwnerCik>
            <rptOwnerName>YETTER WAYNE P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
      <isDirector>1</isDirector>
      <isOfficer>0</isOfficer>
      <isTenPercentOwner>0</isTenPercentOwner>
      <isOther>0</isOther>
    </reportingOwnerRelationship>
  </reportingOwner>
  <derivativeSecurity>
    <securityTitle>
      <value>Employee Stock Option (Right to Purchase)</value>
    </securityTitle>
    <conversionOrExercisePrice>
      <value>11.08</value>
    </conversionOrExercisePrice>
    <transactionDate>
      <value>2003-07-01</value>
    </transactionDate>
    <transactionCoding>
      <transactionFormType>4</transactionFormType>
      <transactionCode>A</transactionCode>
      <equitySwapInvolved>0</equitySwapInvolved>
    </transactionCoding>
    <transactionTimeliness>
      <value/>
    </transactionTimeliness>
    <transactionAmounts>
      <transactionShares>
        <value>10000</value>
      </transactionShares>
      <transactionValue>
        <value>0</value>
      </transactionValue>
      <transactionAcquiredDisposedCode>
        <value>A</value>
      </transactionAcquiredDisposedCode>
    </transactionAmounts>
    <exerciseDate>
      <value>2004-07-01</value>
      <footnoteId id="F1"/>
    </exerciseDate>
    <expirationDate>
      <value>2013-07-01</value>
    </expirationDate>
    <underlyingSecurity>
      <underlyingSecurityTitle>
        <value>Common Stock</value>
      </underlyingSecurityTitle>
      <underlyingSecurityShares>
        <value>10000</value>
      </underlyingSecurityShares>
    </underlyingSecurity>
    <postTransactionAmounts>
      <sharesOwnedFollowingTransaction>
        <value>10000</value>
      </sharesOwnedFollowingTransaction>
    </postTransactionAmounts>
    <ownershipNature>
      <directOrIndirectOwnership>
        <value>D</value>
      </directOrIndirectOwnership>
    </ownershipNature>
  </derivativeSecurity>
  <footnotes>
    <footnote id="F1">Option vests in three approximately equal installments beginning on July 1, 2004.</footnote>
  </footnotes>
  <ownerSignature>
    <signatureName>/s/ Wayne Yetter</signatureName>
    <signatureDate>2003-07-02</signatureDate>
  </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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