EXHIBIT 23.2

            Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statements
(Form S-3 No. 333-51772 and Form S-8 Nos. 333-82221, 333-19915, 333-19917,
333-59910 and 333-104820) of Transkaryotic Therapies, Inc. and in the related
Prospectuses of our report dated April 29, 2005, with respect to Transkaryotic
Therapies, Inc.'s management's assessment of the effectiveness of internal
control over financial reporting, and the effectiveness of internal control over
financial reporting of Transkaryotic Therapies, Inc., included in this Form
10-K/A.

                                              /s/ Ernst & Young LLP

Boston, Massachusetts
April 29, 2005