CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Cash flows from operating activities:
Net loss	$ (231,156)	$ (162,602)	$ (274,158)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation, amortization and impairment charges	12,755	8,814	4,136
Stock-based compensation	37,020	32,403	35,421
Deferred executive compensation expense		119	963
Benefit from intraperiod tax allocation	(4,586)
Gain on disposition of stock		(4,768)
Repayment of interest related to facility lease obligation	(3,297)
Increase (decrease) from:
Accounts receivable	(7,290)	(7,092)	(1,305)
Inventory	1,096	(560)	(413)
Other current assets	7,544	(17,536)	(2,113)
Other assets	(4,834)	2,645	(2,714)
Accounts payable	5,458	(137)	2,478
Accrued compensation and benefits	4,235	8,317	913
Accrued product development expenses	8,174	(2,782)	2,679
Other accrued expenses	8,162	2,570	1,340
Other liabilities	7,206	2,644	14,834
Deferred revenue	268	82,801	10
Deferred executive compensation paid		(2,630)	(3,953)
Net cash used in operating activities	(159,245)	(57,794)	(221,882)
Cash flows from investing activities:
Proceeds from maturities of marketable securities			45,000
Change in restricted cash			(10,319)
Investment in property and equipment	(17,205)	(2,787)	(8,543)
Proceeds from disposition of stock		4,768
Net cash provided by (used in) investing activities	(17,205)	1,981	26,138
Cash flows from financing activities:
Proceeds from royalty financing	50,000
Royalty financing fees paid	(2,905)
Proceeds from issuance of convertible debt, including equity component		200,000
Convertible debt fees paid		(7,079)
Proceeds from issuance of warrants		27,580
Purchase of convertible bond hedges		(43,220)
Repayment of long-term debt	(1,377)	(9,100)	(2,100)
Principal payments under capital lease obligations			(15)
Proceeds from issuance of common stock, net of issuance costs			310,037
Reimbursements of amounts related to facility lease obligation	6,365		2,741
Proceeds from issuance of common stock pursuant to stock option and purchase plans	4,436	3,695	6,284
Payment of tax withholding obligations related to stock compensation	(2,262)	(816)	(3,363)
Net cash provided by financing activities	54,257	171,060	313,584
Effect of exchange rates on cash	393	262	(40)
Net increase (decrease) in cash and cash equivalents	(121,800)	115,509	117,800
Cash and cash equivalents, beginning of year	352,688	237,179	119,379
Cash and cash equivalents, end of year	230,888	352,688	237,179
Supplemental disclosures:
Interest paid	7,259	8,077	153
Income taxes paid	238	185	17
Capitalization of construction-in-progress related to facility lease obligation	32,639	96,558	96,671
Non-cash transaction - property and equipment included in accounts payable or accruals	5,267	$ 298	$ 738
Non-cash transaction - marketable equity securities recorded at fair market value	$ 11,407