CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue:
Product revenue, net	$ 112,527	$ 55,720	$ 45,238
License, collaboration and other revenue	6,277	49,692	323
Total revenue	118,804	105,412	45,561
Operating expenses:
Cost of product revenue	2,114	5,224	9,612
Research and development expense	171,216	120,593	162,900
Selling, general and administrative expense	162,750	139,790	146,615
Total operating expenses	336,080	265,607	319,127
Loss from operations	(217,276)	(160,195)	(273,566)
Other income (expense):
Interest income	82	85	130
Interest expense	(18,149)	(8,075)	(153)
Gain on disposition of stock		4,768
Foreign exchange gain (loss)	793	1,445	(130)
Other expense, net	(17,274)	(1,777)	(153)
Loss before provision for income taxes	(234,550)	(161,972)	(273,719)
Benefit from (provision for) income taxes	3,394	(630)	(439)
Net loss	$ (231,156)	$ (162,602)	$ (274,158)
Net loss per share - basic and diluted	$ (1.23)	$ (0.87)	$ (1.49)
Weighted-average number of shares of common stock outstanding - basic and diluted	188,669	186,835	183,575