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License and Collaboration Agreements - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Apr. 30, 2015
Sep. 30, 2015
Sep. 30, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Cash received from Japanese tax authorities $ 15,800,000    
Otsuka Pharmaceutical Co. Ltd      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Term of license fee     10 years
Otsuka Pharmaceutical Co. Ltd | Japan      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Refundable withholding tax   $ 15,800,000 $ 15,800,000
Otsuka Pharmaceutical Co. Ltd | License agreement      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Proceeds from license fees     77,500,000
Revenue recognized during the period   1,300,000 2,600,000
Otsuka Pharmaceutical Co. Ltd | License agreement | Maximum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Additional milestone payments   80,000,000 80,000,000
Medinol Ltd. | License agreement      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Milestone payments for clinical trials     3,800,000
Medinol Ltd. | License agreement | Maximum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Additional milestone payments   $ 34,800,000 $ 34,800,000