CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Revenue:
Product revenue, net	$ 27,543	$ 14,499	$ 79,262	$ 34,371
License revenue	1,527	183	3,038	4,206
Total revenue	29,070	14,682	82,300	38,577
Operating expenses:
Cost of product revenue	483	594	1,666	4,277
Research and development expense	48,219	27,600	126,401	87,948
Selling, general and administrative expense	36,744	33,622	118,916	99,411
Total operating expenses	85,446	61,816	246,983	191,636
Loss from operations	(56,376)	(47,134)	(164,683)	(153,059)
Other income (expense):
Interest income	20	19	61	63
Interest expense	(5,228)	(3,720)	(12,897)	(4,312)
Foreign exchange gain	291	881	906	836
Other income (expense), net	(4,917)	(2,820)	(11,930)	(3,413)
Loss before provision for income taxes	(61,293)	(49,954)	(176,613)	(156,472)
Benefit from (provision for) income taxes	5,842	(154)	5,328	(379)
Net loss	$ (55,451)	$ (50,108)	$ (171,285)	$ (156,851)
Net loss per share - basic and diluted	$ (0.29)	$ (0.27)	$ (0.91)	$ (0.84)
Weighted-average number of shares of common stock outstanding - basic and diluted	188,921	187,034	188,456	186,703