CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2014	Sep. 30, 2013	Sep. 30, 2014	Sep. 30, 2013
Revenue:
Product revenue, net	$ 14,499	$ 16,658	$ 34,371	$ 36,956
License revenue	183	66	4,203	228
Service revenue		8	3	24
Total revenue	14,682	16,732	38,577	37,208
Operating expenses:
Cost of product revenue	594	415	4,277	913
Research and development expense	27,600	45,145	87,948	127,076
Selling, general and administrative expense	33,622	37,395	99,411	108,977
Total operating expenses	61,816	82,955	191,636	236,966
Loss from operations	(47,134)	(66,223)	(153,059)	(199,758)
Other income (expense):
Interest income	19	40	63	120
Interest expense	(3,720)	(37)	(4,312)	(118)
Foreign exchange gain (loss)	881	(9)	836	16
Other income (expense), net	(2,820)	(6)	(3,413)	18
Loss before provision for income taxes	(49,954)	(66,229)	(156,472)	(199,740)
Provision for income taxes	154	110	379	255
Net loss	$ (50,108)	$ (66,339)	$ (156,851)	$ (199,995)
Net loss per share - basic and diluted	$ (0.27)	$ (0.36)	$ (0.84)	$ (1.09)
Weighted-average number of shares of common stock outstanding - basic and diluted	187,034	185,238	186,703	182,859