CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Revenue:
Product revenue, net	$ 11,881	$ 13,934	$ 19,872	$ 20,298
License revenue	231	69	4,020	162
Service revenue	2	8	3	16
Total revenue	12,114	14,011	23,895	20,476
Operating expenses:
Cost of product revenue	2,395	228	3,683	497
Research and development expense	31,794	40,668	60,348	81,931
Selling, general and administrative expense	34,199	42,101	65,790	71,583
Total operating expenses	68,388	82,997	129,821	154,011
Loss from operations	(56,274)	(68,986)	(105,926)	(133,535)
Other income (expense):
Interest income	21	31	44	80
Interest expense	(558)	(39)	(591)	(80)
Foreign exchange gain (loss)	(4)	95	(45)	25
Other income (expense), net	(541)	87	(592)	25
Loss before provision for income taxes	(56,815)	(68,899)	(106,518)	(133,510)
Provision for income taxes	106	86	225	145
Net loss	$ (56,921)	$ (68,985)	$ (106,743)	$ (133,655)
Net loss per share - basic and diluted	$ (0.30)	$ (0.37)	$ (0.57)	$ (0.74)
Weighted-average number of shares of common stock outstanding - basic and diluted	186,815	184,726	186,535	181,651