CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenue:
Product revenue, net	$ 45,238
License and collaboration revenue	296	514	25,189
Service revenue	27	44	111
Total revenue	45,561	558	25,300
Operating expenses:
Cost of product revenue	9,612
Research and development expense	162,900	144,709	77,743
Selling, general and administrative expense	146,615	60,909	24,380
Total operating expenses	319,127	205,618	102,123
Loss from operations	(273,566)	(205,060)	(76,823)
Other income (expense):
Interest income	130	240	167
Interest expense	(153)	(199)	(232)
Revaluation of warrant liability		(15,924)	(46,715)
Foreign exchange gain (loss)	(130)	71
Other income (expense), net	(153)	(15,812)	(46,780)
Loss before provision for income taxes	(273,719)	(220,872)	(123,603)
Provision for income taxes	439
Net loss	$ (274,158)	$ (220,872)	$ (123,603)
Net loss per share - basic and diluted	$ (1.49)	$ (1.34)	$ (0.93)
Weighted-average number of shares of common stock outstanding - basic and diluted	183,575	164,964	132,375