-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, CPjHERh/s7MvQG6DRdZ9d227gC5asmz3KqC2afdHQrwjI/ucgYIez7JSWQ9uqV+u pkOWh4Ow7eh4/gLUoV4ZMA== 0001157523-03-002771.txt : 20030707 0001157523-03-002771.hdr.sgml : 20030704 20030707094659 ACCESSION NUMBER: 0001157523-03-002771 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20030707 ITEM INFORMATION: Other events ITEM INFORMATION: Financial statements and exhibits FILED AS OF DATE: 20030707 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ARIAD PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000884731 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 223106987 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 333-76486 FILM NUMBER: 03776196 BUSINESS ADDRESS: STREET 1: 26 LANDSDOWNE ST CITY: CAMBRIDGE STATE: MA ZIP: 02139 BUSINESS PHONE: 6174940400 MAIL ADDRESS: STREET 1: 26 LANDSDOWNE CITY: CAMBRIDGE STATE: MA ZIP: 02139 8-K 1 a4427973.txt ARIAD PHARAMCEUTICALS 8-K SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 7, 2003 ARIAD PHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 0-21696 22-3106987 (State or Other Jurisdiction (Commission File Number) (I.R.S. Employer of Incorporation) Identification No.) 26 LANDSDOWNE STREET CAMBRIDGE, MASSACHUSETTS 02139 (Address of principal executive offices and zip code) Registrant's telephone number, including area code: (617) 494-0400 ITEM 5. OTHER EVENTS On July 7, 2003, the Registrant disseminated a Press Release announcing the results of pre-clinical studies demonstrating the potency and activity of AP23464, its product candidate to treat life-threatening forms of blood cancer. The information contained in the Press Release dated July 7, 2003, is incorporated herein by reference and attached as Exhibit 99.1 hereto. ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS. (c) Exhibits. 99.1 The Registrant's Press Release dated July 7, 2003. Signatures Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. ARIAD PHARMACEUTICALS, INC. By: /s/ Edward M. Fitzgerald ------------------------ Edward M. Fitzgerald Senior Vice President and Chief Financial Officer Date: July 7, 2003 EXHIBIT INDEX ------------- Exhibit Number Description Sequential Page Number - ------- ----------- --------------------------- 99.1 The Registrant's Press 4 Release dated July 7, 2003. EX-99 3 a4427973_ex991.txt ARIAD EXHIBIT 99.1 Exhibit 99.1 ARIAD Reports Studies Profiling Potency and Activity of Its Molecularly Targeted Product for Blood Cancer CAMBRIDGE, Mass.--(BUSINESS WIRE)--July 7, 2003-- Highlighted at UK Cancer Research International Conference ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA) today announced, for the first time, results of pre-clinical studies demonstrating the potency and activity of AP23464, its product candidate to treat life-threatening forms of blood cancer: AP23464 is over 10-fold more potent than imatinib (Gleevec(TM)), the leading product for chronic myeloid leukemia (CML), in blocking the activity of the key cancer-causing protein responsible for Gleevec's efficacy. Furthermore, unlike Gleevec, AP23464 is designed to block additional leukemia therapeutic targets that become increasingly important in patients who no longer respond to Gleevec - an outcome that occurs in approximately 75% of advanced-stage CML patients treated with Gleevec for two years. In spite of these limitations, sales of Gleevec are estimated to reach approximately $1 billion in 2003. Based on its targeting of oncogenic proteins, AP23464 may provide a compelling alternative to Gleevec - both for Gleevec-resistant patients and as primary therapy for certain forms of leukemia. "The success of Gleevec, described as a 'magic cancer bullet,' highlights the importance of selecting the right therapeutic targets for new cancer therapies. We are focused on development of our molecularly targeted drug for blood cancer to be ARIAD's next product candidate to enter clinical trials," said Harvey J. Berger, M.D., chairman and chief executive officer of ARIAD. The malignant transformation in bone marrow cells that leads to certain forms of leukemia is dependent on the activity the Abl protein. Dr. David Baltimore's research group discovered the cancer-causing properties of the Abl protein in the mid-1980's. Dr. Baltimore is one of ARIAD's founding scientific advisors. Recent clinical studies have found that genetic variants of Abl develop during Gleevec treatment. While Gleevec does not affect these variant proteins or the Src protein, an important cell-signaling partner of Abl, AP23464 is designed to block these proteins. The papers by Brunton, V., et al, "Src tyrosine kinase-dependent adhesion changes in a model of colon cancer metastasis," and Sawyer, T., et al, "Novel, picomolar potent, dual inhibitors of Src and Abl kinase: Drug development for cancer metastasis and leukemia therapy," are being presented this week at the UK Cancer Research International Cancer Conference (ICC). More information about the program is available at the ICC web site (http://www.beatson.gla.ac.uk/conf/). The history of the development of Gleevec is described by Daniel Vasella, the chief executive of Novartis, in his recently published book, Magic Cancer Bullet - How a Tiny Orange Pill Is Rewriting Medical History, New York, HarperCollins Publishers, 2003. ARIAD is engaged in the discovery and development of breakthrough medicines that regulate cell signaling with small molecules. The Company is developing a comprehensive approach to the treatment of cancer and is primarily focused on a series of product candidates for targeted oncology indications. ARIAD also has an exclusive license to pioneering technology and patents related to the discovery, development and use of drugs that regulate NF-(kappa)B cell-signaling activity, which has been implicated in many major diseases. Additional information about ARIAD can be found on the web at http://www.ariad.com. Gleevec(TM) is a trademark of Novartis AG. Some of the matters discussed herein are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are identified by the use of words such as "anticipate," "estimate," "expect," "project," "intend," "plan," "believe," and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. Such statements are based on management's current expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcome of events, timing and performance to differ materially from those expressed or implied by such forward-looking statements. These risks include, but are not limited to, risks and uncertainties regarding the Company's ability to conduct preclinical and clinical studies of its product candidates and the results of such studies, regulatory oversight, intellectual property claims, the timing, scope, cost and outcome of legal proceedings, future capital needs, key employees, dependence on the Company's collaborators and manufacturers, markets, economic conditions, products, services, prices, reimbursement rates, competition and other risks detailed in the Company's public filings with the Securities and Exchange Commission, including ARIAD's Annual Report on Form 10-K for the fiscal year ended December 31, 2002. The information contained in this document is believed to be current as of the date of original issue. The Company does not intend to update any of the forward-looking statements after the date of this document to conform these statements to actual results or to changes in the Company's expectations, except as required by law. CONTACT: ARIAD Pharmaceuticals Tom Pearson, 610/407-9260 Kathy Lawton, 617/621-2345 -----END PRIVACY-ENHANCED MESSAGE-----