-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, BeHjpVb1YUP57GH7b0OquD28y0U7Cy4OGEPZ0IwdQ50f9b+yM5c7Z5SkuCzPmKjj 1qAh/cXPiP9EoT50GfPkAw== 0001157523-02-001092.txt : 20020926 0001157523-02-001092.hdr.sgml : 20020926 20020926080217 ACCESSION NUMBER: 0001157523-02-001092 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20020926 ITEM INFORMATION: Other events ITEM INFORMATION: Financial statements and exhibits FILED AS OF DATE: 20020926 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ARIAD PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000884731 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 223106987 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 333-76486 FILM NUMBER: 02772559 BUSINESS ADDRESS: STREET 1: 26 LANDSDOWNE ST CITY: CAMBRIDGE STATE: MA ZIP: 02139 BUSINESS PHONE: 6174940400 MAIL ADDRESS: STREET 1: 26 LANDSDOWNE CITY: CAMBRIDGE STATE: MA ZIP: 02139 8-K 1 a4256630.txt ARIAD PHARMACEUTICALS 8-K SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 26, 2002 ARIAD PHARMACEUTICALS, INC. --------------------------- (Exact Name of Registrant as Specified in its Charter) Delaware 0-21696 22-3106987 -------- ------- ---------- (State or Other Jurisdiction (Commission File Number) (I.R.S. Employer of Incorporation) Identification No.) 26 LANDSDOWNE STREET CAMBRIDGE, MASSACHUSETTS 02139 (Address of principal executive offices and zip code) Registrant's telephone number, including area code: (617) 494-0400 ITEM 5. OTHER EVENTS On September 26, 2002, the Registrant publicly disseminated a press release announcing that it has initiated studies of one class of its lead anti-cancer drugs for use in a newly emerging medical technology - drug-delivery stents - to reduce reblockage of coronary arteries following coronary antioplasty and stenting. The information contained in the press release dated September 26, 2002 is incorporated herein by reference and attached as Exhibit 99.1 hereto. ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS. (c) Exhibits. 99.1 The Registrant's Press Release dated September 26, 2002. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. ARIAD PHARMACEUTICALS, INC. By: --------------------------------- Edward M. Fitzgerald Senior Vice President and Chief Financial Officer Date: September 26, 2002 2 EXHIBIT INDEX Exhibit Number Description Sequential Page Number - ------- ----------- ---------------------- 99.1 The Registrant's Press Release dated [4] September 26, 2002. "ARIAD Announces New Use of its Lead Anti-Cancer Drug Delivered in Coronary Stents for Treatment of Coronary Artery Disease" 3 EX-99 3 a4256630-991.txt EXHIBIT 99.1 EXHIBIT 99.1 FOR IMMEDIATE RELEASE CONTACT: Tom Pearson (610) 407-9260 Kathy Lawton (617) 621-2345 ARIAD ANNOUNCES NEW USE OF ITS LEAD ANTI-CANCER DRUG DELIVERED IN CORONARY STENTS FOR TREATMENT OF CORONARY ARTERY DISEASE Invited Presentation at Drug-delivery Stent Summit Cambridge, MA, September 26, 2002 -- ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA) today announced that it has initiated studies of one class of its lead anti-cancer drugs for use in a newly emerging medical technology - drug-delivery stents - to reduce reblockage of coronary arteries following coronary angioplasty and stenting. These findings are being presented in an invited lecture by Tim Clackson, Ph. D., senior vice president, science and technology of ARIAD, at the annual Transcatheter Cardiovascular Therapeutics meeting being held this week in Washington, D.C. ARIAD has pioneered the discovery and development of inhibitors of the protein mTOR (also known as sirolimus analogs), which block the proliferation and migration of vascular smooth muscle cells - the primary cause of narrowing and reblockage of injured coronary arteries. ARIAD's lead mTOR inhibitor, AP23573, blocks cancer cell growth and proliferation and is in pre-IND development for the treatment of cancer. "The development of drug-delivery stents incorporating one of our proprietary sirolimus analogs represents a major opportunity for us," said Harvey J. Berger, M.D., chairman and chief executive officer of ARIAD. "Because of the potency of our mTOR inhibitors and the availability of a clinical candidate for this application, we are in active discussions with potential commercial partners that could open up this market for us." Coronary stents are wire-mesh scaffolds that are inserted into opened arteries to prevent reblockage of the vessel. Approximately two million stents are implanted yearly, close to half of them in the United States. While stenting reduces the incidence of reblockage, scar tissue often forms around the stent and reblocks the artery. This is estimated to occur in 20 to 30 percent of patients who receive stents that do not release drugs to prevent reblockage. Recent clinical trials found extremely low reblockage rates in patients treated with stents that deliver sirolimus itself. If ongoing clinical trials with such stents confirm these clinical results, stents that deliver drugs are likely to become the next-generation standard-of-care for patients with coronary artery disease. In that case, drug-delivery stents have been estimated to increase the worldwide stent market from approximately $2 billion per year to as much as $5 billion annually. Further information about the annual Transcatheter Cardiovascular Therapeutics meeting is available on the web at http://www.tctmd.com. ARIAD is engaged in the discovery and development of breakthrough medicines that regulate cell signaling with small molecules. The Company is developing a comprehensive approach to the treatment of cancer and blood diseases and has seven product candidates in development. ARIAD also has an exclusive license to pioneering technology and patents related to the discovery, development and use of drugs that regulate NF-(kappa)B cell-signaling activity, which has been implicated in many major diseases. Additional information about ARIAD can be found on the web at http://www.ariad.com. Some of the matters discussed herein are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are identified by the use of words such as "anticipate," "estimate," "expect," "project," "intend," "plan," "believe," and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. Such statements are based on management's current expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcome of events, timing and performance to differ materially from those expressed or implied by such forward-looking statements. These risks include, but are not limited to, risks and uncertainties regarding the Company's ability to conduct preclinical and clinical studies of its product candidates and the results of such studies, regulatory oversight, intellectual property claims, the timing, scope, cost and outcome of legal proceedings, future capital needs, key employees, dependence on the Company's collaborators and manufacturers, markets, economic conditions, products, services, prices, reimbursement rates, competition and other risks detailed in the Company's public filings with the Securities and Exchange Commission, including ARIAD's Annual Report on Form 10-K for the fiscal year ended December 31, 2001. The information contained in this document is believed to be current as of the date of original issue. The Company does not intend to update any of the forward-looking statements after the date of this document to conform these statements to actual results or to changes in the Company's expectations, except as required by law. ### -----END PRIVACY-ENHANCED MESSAGE-----