CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Cash flows from operating activities:
Net income (loss)	$ 56,061	$ (115,835)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation, amortization and impairment charges	7,300	5,762
Stock-based compensation	9,377	19,078
Repayment of interest related to facility lease obligation	(2,572)	0
Reclassification of currency translation adjustment and pension obligation adjustments to earnings upon sale of European operations	2,939	0
Gain on the Incyte transaction	(131,575)	0
Increase (decrease) from:
Accounts receivable	(7,448)	(6,022)
Inventory	(1,122)	(347)
Other current assets	(1,027)	12,151
Other assets	1,522	527
Accounts payable	(6,789)	97
Accrued compensation and benefits	(10,593)	(7,585)
Current portion of long-term facility lease obligation	0	393
Accrued product development expenses	(69)	5,484
Other accrued expenses	7,514	1,381
Other liabilities	(23,908)	2,828
Deferred revenue	2,643	3,471
Net cash used in operating activities	(97,747)	(78,617)
Cash flows from investing activities:
Investment in property and equipment	(31,504)	(2,700)
Proceeds from the Incyte transaction, net of $4,484 of cash transferred	144,847	0
Net cash provided by (used in) investing activities	113,343	(2,700)
Cash flows from financing activities:
Repayment of long-term debt	(2,889)	0
Reimbursements of amounts related to facility lease obligation	26,759	15
Proceeds from issuance of common stock pursuant to stock option and purchase plans	4,074	2,620
Payment of tax withholding obligations related to stock compensation	(1,337)	(174)
Net cash provided by financing activities	26,607	2,461
Effect of exchange rates on cash	(44)	134
Net increase (decrease) in cash and cash equivalents	42,159	(78,722)
Cash and cash equivalents, beginning of period	230,888	352,688
Cash and cash equivalents, end of period	273,047	273,966
Supplemental disclosures:
Capitalization of construction-in-progress related to facility lease obligation	8,068	22,911
Non-cash transaction – property and equipment included in accounts payable or accruals	4,054	587
Non-cash transaction – sublease tenant improvements related to facility lease obligation	11,788	0
Non-cash transaction – marketable equity securities recorded at fair market value	$ (5,909)	$ 0