License and Collaboration Agreements - Additional Information (Detail) - License agreement	1 Months Ended		6 Months Ended	12 Months Ended
	Dec. 31, 2014	Jan. 31, 2014 trial	Jun. 30, 2016 USD ($) product	Dec. 31, 2015 USD ($)
Otsuka Pharmaceutical Co. Ltd
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Amount received upon execution of the agreement				$ 77,500,000
Additional milestone payments (up to)			$ 80,000,000
Term of license fee	10 years
Otsuka Pharmaceutical Co. Ltd | Japan
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Refundable withholding tax				$ 15,800,000
Medinol Ltd.
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Additional milestone payments (up to)			$ 34,800,000.0
Term of license fee			15 years
Number of registration trials initiated | trial		2
Number of products required to be successful, developed and commercialized under agreement | product			2