CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenue:
Product revenue, net	$ 65,326	$ 27,818	$ 98,960	$ 51,719
License, collaboration and other revenue	2,799	1,420	4,763	1,510
Total revenue	68,125	29,238	103,723	53,229
Operating expenses:
Cost of product revenue	1,108	488	1,594	1,183
Research and development expense	42,864	38,739	86,943	78,183
Selling, general and administrative expense	34,242	48,622	70,219	82,172
Transaction costs	1,482	0	1,482	0
Restructuring charges	92	0	3,010	0
Total operating expenses	79,788	87,849	163,248	161,538
Loss from operations	(11,663)	(58,611)	(59,525)	(108,309)
Other income (expense), net:
Interest income	31	22	55	41
Interest expense	(5,401)	(3,813)	(10,348)	(7,668)
Other Income, net	128,664	0	128,664	0
Foreign exchange (loss) gain	(29)	(458)	(779)	615
Other income (expense), net	123,265	(4,249)	117,592	(7,012)
Income (loss) before provision for income taxes	111,602	(62,860)	58,067	(115,321)
Provision for income taxes	1,754	300	2,006	514
Net income (loss)	$ 109,848	$ (63,160)	$ 56,061	$ (115,835)
Net income (loss) per share:
Basic (in usd per share)	$ 0.57	$ (0.33)	$ 0.29	$ (0.62)
Diluted (in usd per share)	$ 0.56	$ (0.33)	$ 0.29	$ (0.62)
Shares used in net income (loss) per share calculations:
Basic (in shares)	191,485	188,598	190,894	188,220
Diluted (in shares)	194,569	188,598	193,504	188,220