CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities:
Net loss	$ (53,787)	$ (52,676)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation, amortization and impairment charges	3,520	2,859
Stock-based compensation	6,719	8,434
Repayment of interest related to facility lease obligation	(1,286)	0
Increase (decrease) from:
Accounts receivable	(5,915)	(2,872)
Inventory	(92)	274
Other current assets	(2,223)	(1,338)
Other assets	40	7
Accounts payable	(4,007)	2,465
Accrued compensation and benefits	(11,076)	(12,817)
Current portion of long-term facility lease obligation	0	(112)
Accrued product development expenses	(1,116)	3,556
Other accrued expenses	2,079	2,996
Other liabilities	3,102	(4)
Deferred revenue	(1,053)	(966)
Net cash used in operating activities	(65,095)	(50,194)
Cash flows from investing activities:
Investment in property and equipment	(15,300)	(754)
Net cash used in investing activities	(15,300)	(754)
Cash flows from financing activities:
Royalty financing fees paid	(1,501)	0
Repayment of long-term debt	(973)	0
Reimbursements of amounts related to facility lease obligation	12,792	861
Proceeds from issuance of common stock pursuant to stock option and purchase plans	777	1,320
Payment of tax withholding obligations related to stock compensation	(617)	(130)
Net cash provided by financing activities	10,478	2,051
Effect of exchange rates on cash	(44)	225
Net decrease in cash and cash equivalents	(69,961)	(48,672)
Cash and cash equivalents, beginning of period	230,888	352,688
Cash and cash equivalents, end of period	160,927	304,016
Supplemental disclosures:
Income taxes paid	2	0
Capitalization of construction-in-progress related to facility lease obligation	3,956	20,662
Non-cash transaction – property and equipment included in accounts payable or accruals	7,461	1,090
Non-cash transaction – sublease tenant improvements related to facility lease obligation	1,440	0
Non-cash transaction – marketable equity securities recorded at fair market value	$ (3,986)	$ 0