CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenue:
Product revenue, net	$ 33,633	$ 23,901
License, collaboration and other revenue	1,964	90
Total revenue	35,597	23,991
Operating expenses:
Cost of product revenue	486	695
Research and development expense	44,079	39,444
Selling, general and administrative expense	35,977	33,550
Restructuring charges	2,918	0
Total operating expenses	83,460	73,689
Loss from operations	(47,863)	(49,698)
Other income (expense), net:
Interest income	24	19
Interest expense	(4,946)	(3,856)
Foreign exchange (loss) gain	(750)	1,073
Other expense, net	(5,672)	(2,764)
Loss before provision for income taxes	(53,535)	(52,462)
Provision for income taxes	252	214
Net loss	$ (53,787)	$ (52,676)
Net loss per share – basic and diluted (in usd per share)	$ (0.28)	$ (0.28)
Weighted-average number of shares of common stock outstanding – basic and diluted (in shares)	190,304	187,837