UNITED STATES
        SECURITIES AND EXCHANGE COMMISSION
              Washington, D.C. 20549

                   SCHEDULE 13D

     Under the Securities Exchange Act of 1934
              (Amendment No.  5    )*

       Centigram Communication Corp.
(Name of Issuer)

Common Stock
(Title of Class of Securities)

152317103
(CUSIP Number)

Kathleen S. Tillotson, Esq., Kopp Investment Advisors, 7701 France Ave.
So., Suite 500
Edina, MN 55435 (612) 841-0400
(Name, Address and Telephone Number of Person Authorized to Receive
Notices and Communications)

  10/14/99
(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d- 1(b)(3) or (4), check the following box [      ].

Check the following box if a fee is being paid with the statement [      ].  (A
fee is not required only if the reporting person: (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class
of securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.
(See Rule 13d-7.))

The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).




                   SCHEDULE 13D

CUSIP No       152317103                Page 1 of 2

     l) Name of Reporting Person
        S.S. or I.R.S. Identification No. of Person

               Kopp Holding Company
               I.D. No. 41-1875362

     2) Check the appropriate box if a Member of a Group

         (a)

         (b)

     3) SEC Use Only

     4) Source of Funds

               Not applicable - indirect beneficial ownership

     5) Check Box if Disclosure of Legal Proceedings is Required
          Pursuant to Items 2(d) or 2(e)     [   ]

     6) Citizenship or Place of Organization

               Minnesota

     Number of shares         7) Sole Voting Power:    0
     Beneficially Owned
     by Each Reporting
     Person With:             8) Shared Voting Power:  0

                         9) Sole Dispositive Power:    0

                         10) Shared Dispositive Power:  0

     11) Aggregate Amount Beneficially Owned by Each Reporting
           Person

                    1,491,769

     12)  Check Box if the Aggregate Amount in Row (11) Excludes
            Certain Shares*      [  ]

     13)  Percent of Class Represented by Amount in Row (11)

                    24.9%

     14)  Type of Reporting Person HC

                   SCHEDULE 13D

CUSIP No.      152317103                Page 2 of 2

     l) Name of Reporting Person
         S.S. or I.R.S. Identification No. of Person

               LeRoy C. Kopp

     2) Check the appropriate box if a Member of a Group

         (a)

         (b)

     3) SEC Use Only

     4) Source of Funds

               PF, OO

     5) Check Box if Disclosure of Legal Proceedings is Required
          Pursuant to Items 2(d) or 2(e)    [  ]

     6) Citizenship or Place of Organization

               United States

     Number of shares         7) Sole Voting Power:    83,000
     Beneficially Owned
     by Each Reporting
     Person With:             8) Shared Voting Power:  0

                         9) Sole Dispositive Power:    83,000

                         10) Shared Dispositive Power:  0

     11) Aggregate Amount Beneficially Owned by Each Reporting
           Person
                      1,574,769

     12)  Check Box if the Aggregate Amount in Row (11) Excludes
            Certain Shares*         [       ]

     13)  Percent of Class Represented by Amount in Row (11)

                    26.3%

     14)  Type of Reporting Person IN




Item 1.  Security and Issuer

     This statement relates to the common stock, par value $.001 per share
("Common Stock"), of Centigram Communication Corp., a Delaware
corporation ("Company"), whose principal executive offices are located at 91
East Tasman Drive, San Jose, CA  95134.  The approximate aggregate
percentage of shares of Common Stock reported beneficially owned by each
person herein is based on 5,992,000 shares outstanding, which is the total
number of shares of Common Stock outstanding as of August 27, 1999, as
reflected in the Company's quarterly report on Form 10-Q filed with the
Securities and Exchange Commission ("Commission") for the fiscal quarter
ended July 31, 1999.  Unless otherwise indicated, the holdings reported
herein are as of the close of business on October 20, 1999.

Item 2.  Identity and Background

     (a) This statement is filed by Kopp Holding Company ("KHC"),
solely as the parent corporation of Kopp Investment Advisors, Inc. ("KIA")
(a registered investment adviser) and therefore the indirect beneficial owner
of the shares beneficially owned by KIA and by LeRoy C. Kopp individually
with respect to shares of Common Stock beneficially owned directly by him
and indirectly by him by virtue of his ownership of all of the stock of KHC.
The foregoing persons are sometimes referred to as "Reporting Persons."
Certain information concerning the directors and executive officers of the
corporate Reporting Person is set forth on Schedule A attached hereto and
incorporated herein by reference.  Any disclosures with respect to persons
other than the Reporting Persons are made on information and belief after
making inquiry to the appropriate party.

     (b) The business address of each of the Reporting Persons and
directors and executive officers is 7701 France Avenue South, Suite 500,
Edina, MN 55435.

     ( c) The principal business of KIA is that of an investment advisor
managing discretionary accounts owned by numerous third-party clients,
including the Kopp Emerging Growth Fund, a registered investment company
incorporated under Minnesota law.  KHC is a holding company engaged,
through subsidiaries, in the investment industry.  The principal occupation of
Mr. Kopp is serving as the president of KHC and KIA.

     (d) None of the persons referred to in paragraph (a) above has, during
the last five years, been convicted in a criminal proceeding (excluding traffic
violations and/or similar misdemeanors).

     (e)  None of the persons referred to in paragraph (a) above has, during
the last five years, been a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction and as a result of such
proceeding was or is subject to a judgment, decree, or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.


     (f)  KIA and KHC are Minnesota corporations.  Mr. Kopp and all
other directors and executive officers of the Reporting Persons are citizens of
the United States.

Item 3.  Source and Amount of Funds or Other Consideration

     The net investment cost (including commissions, if any) of the shares
of Common Stock directly or indirectly beneficially owned by Mr. Kopp,
which includes shares beneficially owned by the other Reporting Person, at
October 20, 1999, was $21,668,624.43.  Shares beneficially owned by KHC
were purchased with the investment capital of KIA or the investment capital
of the owners of the discretionary accounts managed by KIA.  The shares
beneficially owned directly by Mr. Kopp were purchased with his investment
capital or the funds of an employee benefit plan or 501(c)(3) corporation.  See
Item 5 below.

Item 4.  Purpose of Transaction

     The Reporting Persons acquired the shares of Common Stock for
investment purposes, and the Reporting Persons intend to evaluate the
performance of such securities as an investment in the ordinary course of
business.  The Reporting Persons pursue an investment objective of long term
capital appreciation.  In pursuing this investment objective, the Reporting
Persons analyze the management, operations  and markets of companies in
which they invest, including the Company, on a continual basis through
analysis of research and discussions with industry and market observers and
with representatives of such companies.

     Each Reporting Person that owns shares of Common Stock assesses
the Company's business, financial condition, and results of operations as well
as economic conditions and securities markets in general and those for the
Company's shares in particular.  Depending on such assessments, one or
more of such Reporting Persons may acquire additional shares or may sell or
otherwise dispose of all or some of the shares of Common Stock.  Such
actions will depend on a variety of factors, including current and anticipated
trading prices for the Common Stock, alternative investment opportunities,
and general economic, financial market, and industry conditions.

     The Reporting Persons understand that prior purchases of shares of
Common Stock, if any, by persons named in Schedule A to this statement
were made for the purpose of each such person's personal investment.

     Except as described in this Item 4, none of the Reporting Persons nor
any other person named in Schedule A has any plans or proposals that relate
to, or would result in, any matter required to be disclosed in response to
paragraphs (a) through (j), inclusive, of Item 4 of Schedule 13D.  The shares
of Common Stock were not acquired for the purpose, nor with the effect, of
changing or influencing the control of the Company.




Item 5.  Interest in Securities of the Issuer

     (a) Through its own investment account, KIA is the direct owner of
50,000 shares, or less than 1%, of the Common Stock.  By virtue of limited
powers of attorney and/or investment advisory agreements, KIA is the
beneficial owner of 1,441,769 shares, or 24.1%, of the Common Stock. KIA
has sole voting power over its investment account and, by special agreement,
over a small percentage of the shares managed for clients.  Under its standard
investment agreement, KIA does not vote its clients' shares.  By virtue of the
relationships described in Item 2 of this statement, KHC and Mr. Kopp  have
indirect beneficial ownership of the shares beneficially owned by KIA.

     Mr. Kopp's direct beneficial ownership comprises Common Stock
held in the Kopp Investment Advisors Profit Sharing Plan ("Plan"), for which
he serves as trustee; held in the LeRoy C. Kopp Individual Retirement
Account ("IRA"); and held directly by him.  The Plan is the direct owner of
3,000 shares, or less than .1%, of the Common Stock.  The IRA is the direct
owner of 20,000 shares, or less than .5%, of the Common Stock.  Mr. Kopp
owns directly 60,000 shares, or approximately 1%, of the Common Stock.  In
the aggregate, including the shares beneficially owned by KIA, Mr. Kopp
may be deemed beneficially to own a total of 1,574,769 shares, or 26.3%, of
the Common Stock.

     (b) KIA has sole power to vote 505,000 shares of the Common Stock.
Pursuant to the limited powers of attorney granted to KIA by its clients,
which generally are terminable immediately upon notice, KIA in effect shares
with the majority of its clients the power to dispose of the Common Stock
owned by them.  KIA has sole power to dispose of 350,000 shares.   In effect
Mr. Kopp has sole power to dispose of and to vote the Common Stock
beneficially owned directly by him.

     ( c) The Reporting Persons have no transactions in the Common Stock
within the past 60 days.  The transactions of KIA will be reported on
Schedule 13G from time to time.

     (d) With the exception of the clients of KIA and the employees of
KHC, no person other than each respective record owner of shares of
Common Stock is known to have the right to receive or the power to direct
the receipt of dividends from or the proceeds of the sale of such shares of
Common Stock.

     (e) Not applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationships with
Respect to Securities of the Issuer

     KIA, KHC, Mr. Kopp, and the Kopp Emerging Growth Fund have an
agreement with the Company pertaining to the Company's shareholder rights
plan.  Except as otherwise expressly disclosed herein, there are no contracts,
arrangements, understandings, or relationships (legal or otherwise) among the
persons named in Item 2 hereof or between such persons and any other
person with respect to the Common Stock.  The filing of this Schedule shall
NOT be construed as an admission that a Reporting Person or any other
person is a beneficial owner of any shares of Common Stock for any purpose,
including for purposes of Sections 13, 14 or 16 of the Securities Exchange
Act of 1934, as amended from time to time.

Item 7.  Material to Be Filed as Exhibits

     Exhibit 1 - A written agreement relating to the filing of this statement
pursuant to Rule 13d-1(f).
                    Signatures

     After reasonable inquiry and to the best of our knowledge and belief,
the undersigned certify that the information set forth in this statement is
true, complete, and correct.


Dated:                10/25/99


KOPP HOLDING COMPANY

BY:

TITLE:            Secretary/Treasurer

LEROY C. KOPP


                     Exhibit 1

              JOINT FILING AGREEMENT

     In accordance with Rule 13d-1(f) under the Securities Exchange Act
of 1934, as amended, the undersigned hereby agree to the joint filing with all
other Reporting Persons (as such term is defined in the Schedule 13D) on
behalf of each of them of a statement on Schedule 13D (including
amendments thereto) with respect to the Common Stock (as defined) and to
the attachment of this agreement to the Schedule 13D as Exhibit 1 thereto.
IN WITNESS WHEREOF, the undersigned hereby execute this Agreement
this     25th         day of   October 1999   .


KOPP HOLDING COMPANY

BY:

TITLE:            President

LEROY C. KOPP




                    Schedule A

List of Directors, Executive Officers, and Control Persons

LeRoy C. Kopp, individually, and as sole director and
         president of Kopp Holding Company

Donald B. Cornelius as chief financial officer of KHC
                          

Kopp Investment Advisors - Schedule B

Daily Trade Report
"August 16, 1999 thru October 14, 1999"

Trade	Reporting
Date	Person	Activity	Quantity	Symbol	Price

10-14-99	KIA	SELL	7000	cgrm	10.00
10-14-99	KIA	SELL	30000	cgrm	10.00
10-14-99	KIA	SELL	1000	cgrm	10.00
10-14-99	KIA	SELL	2000	cgrm	9.88
10-13-99	KOPPX	SELL	27500	cgrm	9.91
10-13-99	KIA	SELL	500	cgrm	9.99
10-12-99	KOPPX	SELL	2500	cgrm	10.31
10-08-99	KOPPX	SELL	5000	cgrm	10.38
10-07-99	KIA	SELL	1500	cgrm	10.46
10-06-99	KIA	SELL	1000	cgrm	10.25
09-29-99	KIA	SELL	500	cgrm	10.44
09-27-99	KIA	SELL	1500	cgrm	10.69
09-21-99	KIA	SELL	5000	cgrm	10.31
09-13-99	KOPPX	BUY	5000	cgrm	12.00
09-10-99	KOPPX	BUY	10000	cgrm	11.18
09-09-99	KIA	BUY	2500	cgrm	10.50
09-09-99	KIA	BUY	700	cgrm	11.00
09-09-99	KIA	BUY	200	cgrm	11.00
09-08-99	KIA	SELL	100	cgrm	10.63
09-07-99	KOPPX	BUY	10000	cgrm	10.94
09-03-99	KOPPX	BUY	10000	cgrm	11.25
09-02-99	KIA	SELL	1500	cgrm	10.50
09-02-99	KIA	BUY	1600	cgrm	10.44
09-02-99	KIA	BUY	500	cgrm	10.63
09-02-99	KIA	BUY	2900	cgrm	10.75
09-02-99	KIA	BUY	500	cgrm	10.75
09-02-99	KIA	BUY	100	cgrm	11.09
09-02-99	KIA	BUY	3300	cgrm	11.00
09-02-99	KIA	BUY	1100	cgrm	10.97
09-02-99	KIA	SELL	800	cgrm	10.73
09-01-99	KIA	BUY	5000	cgrm	10.56
09-01-99	KIA	SELL	400	cgrm	10.30
09-01-99	KIA	BUY	5000	cgrm	10.63
08-27-99	KIA	BUY	10000	cgrm	11.20
08-27-99	KIA	BUY	2000	cgrm	10.00
08-27-99	KIA	BUY	500	cgrm	10.22
08-27-99	KIA	BUY	2100	cgrm	10.25
08-27-99	KIA	BUY	1400	cgrm	10.50
08-26-99	KIA	BUY	2000	cgrm	9.88
08-26-99	KIA	BUY	1000	cgrm	10.00
08-26-99	KIA	BUY	5000	cgrm	9.88
08-26-99	KIA	BUY	1500	cgrm	9.75
08-26-99	KIA	BUY	500	cgrm	9.88
08-25-99	KIA	BUY	5000	cgrm	9.38
08-24-99	KIA	BUY	10000	cgrm	9.34
08-24-99	KIA	BUY	10000	cgrm	9.34
08-24-99	KIA	BUY	1000	cgrm	9.44
08-23-99	KOPPX	BUY	7500	cgrm	9.31
08-20-99	KIA	BUY	2500	cgrm	9.25
08-20-99	KIA	BUY	2500	cgrm	9.25
08-20-99	KIA	BUY	1000	cgrm	9.63
08-20-99	KIA	BUY	1000	cgrm	9.63
08-19-99	KIA	BUY	500	cgrm	9.01
08-19-99	KIA	BUY	300	cgrm	9.00
08-19-99	KIA	BUY	500	cgrm	9.00
08-19-99	KIA	BUY	1000	cgrm	9.00
08-19-99	KIA	BUY	700	cgrm	9.00
08-18-99	KIA	BUY	1000	cgrm	8.88
08-18-99	KIA	BUY	2000	cgrm	8.94
08-18-99	KIA	BUY	150	cgrm	9.03
08-18-99	KIA	BUY	500	cgrm	9.00
08-18-99	KIA	BUY	1350	cgrm	9.25
08-17-99	KIA	BUY	1000	cgrm	8.75
08-17-99	KIA	BUY	1000	cgrm	8.88
08-16-99	KIA	SELL	2000	cgrm	8.63
08-16-99	KIA	SELL	800	cgrm	8.50